Abstract:
:The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.
journal_name
J Viroljournal_title
Journal of virologyauthors
Jáuregui P,Crespo H,Glaria I,Luján L,Contreras A,Rosati S,de Andrés D,Amorena B,Towers GJ,Reina Rdoi
10.1128/JVI.00440-12subject
Has Abstractpub_date
2012-09-01 00:00:00pages
9504-9issue
17eissn
0022-538Xissn
1098-5514pii
JVI.00440-12journal_volume
86pub_type
杂志文章abstract:UNLABELLED:The risk of transmission of transmissible spongiform encephalopathies (TSE) between different species has been notoriously unpredictable because the mechanisms of transmission are not fully understood. A transmission barrier between species often prevents infection of a new host with a TSE agent. Nonetheless...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02296-14
更新日期:2015-05-01 00:00:00
abstract::Interaction between viral proteins is necessary for viral replication and viral particle assembly. We used the yeast two-hybrid assay to identify interactions among all the mature proteins of the hepatitis C virus. The interaction between NS3 and NS3 was one of the strongest viral protein-protein interactions detected...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.1.205-214.2001
更新日期:2001-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) strains can be separated into genetic subtypes based on phylogenetic analysis of the envelope gene. Once it had been shown that population-wide intrasubtype genetic variation of HIV-1 strains increases in the course of the AIDS epidemic, it remained uncertain whether HIV-1 s...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6332-6338.1997
更新日期:1997-09-01 00:00:00
abstract::We previously reported that CD4C/human immunodeficiency virus (HIV)(Nef) transgenic (Tg) mice, expressing Nef in CD4(+) T cells and cells of the macrophage/dendritic cell (DC) lineage, develop a severe AIDS-like disease, characterized by depletion of CD4(+) T cells, as well as lung, heart, and kidney diseases. In orde...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00125-09
更新日期:2009-10-01 00:00:00
abstract::Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of a neutralizing antibody response to avoid the appearance of neutralization-resistant virus variants. Despite the fact t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.13.5896-5901.2000
更新日期:2000-07-01 00:00:00
abstract::The mammalian tripartite motif protein, TRIM5α, recognizes retroviral capsids entering the cytoplasm and blocks virus infection. Depending on the particular TRIM5α protein and retrovirus, complete disruption of the TRIM5α RING domain decreases virus-restricting activity to various degrees. TRIM5α exhibits RING domain-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00341-11
更新日期:2011-08-01 00:00:00
abstract::The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26 nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection. We asked whether HCMV infection leads to changes in the ex...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00961-08
更新日期:2008-09-01 00:00:00
abstract::Cell extracts from murine A9 or human HeLa cells containing wild-type copies the NS1 polypeptide of minute virus of mice (MVM), produced from a recombinant vaccinia virus, can support the resolution of viral 3' termini from palindromic junction fragments of dimeric, replicative-form MVM DNA. Resolution resulted in the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.3.1579-1589.1993
更新日期:1993-03-01 00:00:00
abstract::The isolation of a temperature phage specific for the photosynthetic bacterium Rhodopseudomonas spheroides is reported. This phage, Rphi-1, establishes a state of lysogeny and can be induced from the prophage state by exposure to mitomycin C or UV irradiation. Mutants of Rphi-1 which grow on a standard laboratory stra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.5.1288-1292.1974
更新日期:1974-11-01 00:00:00
abstract::Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.4211-4215.1991
更新日期:1991-08-01 00:00:00
abstract::The structural instability of inactivated foot-and-mouth disease virus (FMDV) hinders the development of vaccine industry. Here we found that some transition metal ions like Cu2+ and Ni2+ could specifically bind to FMDV capsids at capacities about 7089 and 3448 metal ions per capsid, respectively. These values are abo...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02431-20
更新日期:2021-01-13 00:00:00
abstract::A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.7.5.619-624.1971
更新日期:1971-05-01 00:00:00
abstract::In previous studies, we demonstrated that single-chain variable fragments (scFvs) from anti-human immunodeficiency virus (HIV) Env monoclonal antibodies act as entry inhibitors when tethered to the surface of target cells by a glycosyl-phosphatidylinositol (GPI) anchor. Interestingly, even if a virus escapes inhibitio...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02080-17
更新日期:2018-03-14 00:00:00
abstract::AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00526-18
更新日期:2018-08-29 00:00:00
abstract::Penetration of the nervous systems of suckling mice by prototype strains of the three mammalian reovirus serotypes was studied after footpad inoculation of a dose (10(7) PFU) representing 3.5 x 10(3) 50% lethal doses (LD50) for reovirus type 3 Dearing and less than 1 LD50 for reoviruses type 1 Lang and type 2 Jones. T...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.1.123-131.1991
更新日期:1991-01-01 00:00:00
abstract::African swine fever virus (ASFV) is a complex, cytoplasmic double-stranded DNA (dsDNA) virus that is currently expanding throughout the world. Currently, circulating virulent genotype II Armenia/07-like viruses cause fatal disease in pigs and wild boar, whereas attenuated strains induce infections with various levels ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02298-18
更新日期:2019-05-29 00:00:00
abstract::Vectors derived from lentiviruses provide a promising gene delivery system. We examined the in vivo gene transfer efficiency and tissue or cell tropism of a feline immunodeficiency virus (FIV)-based lentiviral vector pseudotyped with the glycoproteins from Ross River Virus (RRV). RRV glycoproteins were efficiently inc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.18.9378-9388.2002
更新日期:2002-09-01 00:00:00
abstract::Dengue virus (DV) infection can cause either a self-limiting flu-like disease or a threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, and B cells, can be infected by DV. However, despite the role of T lymphocytes in the control of DV replication, the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02181-17
更新日期:2018-04-27 00:00:00
abstract::Antibodies present in two peritoneal exudates of rats bearing abdominal tumors induced by UR2-transformed rat cells were characterized. The ability to immunoprecipitate p68gag-ros and to inhibit the protein and phospholipid kinase activities of this protein was investigated. One of the exudates specifically inhibited ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.60.2.765-767.1986
更新日期:1986-11-01 00:00:00
abstract::Extrachromosomal DNA purified from mink cells acutely infected with the Snyder-Theilen strain of feline sarcoma virus (FeSV) was digested with restriction endonucleases, and the DNA fragments were electrophoretically separated, transferred to a solid substrate, and hybridized with radiolabeled DNA transcripts compleme...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.32.3.860-875.1979
更新日期:1979-12-01 00:00:00
abstract::Poxviruses express proteins that limit host immune responses to infection. For example, the molluscum contagiosum virus MC160 protein inhibits tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation. This event correlates with MC160-induced IKK1 protein degradation, suggesting a mechanism for the above-me...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02009-08
更新日期:2009-04-01 00:00:00
abstract:UNLABELLED:Infection of the lower respiratory tract by influenza A viruses results in increases in inflammation and immune cell infiltration in the lung. The dynamic relationships among the lung microenvironments, the lung, and systemic host responses during infection remain poorly understood. Here we used extensive sy...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00817-15
更新日期:2015-09-01 00:00:00
abstract::The viral dynamics in human immunodeficiency virus type 1 (HIV-1) infection have been studied extensively using mathematical modeling, but data from other primate lentivirus systems are scarce. This study was initiated to increase the understanding of the differences and similarities between the different primate lent...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00394-06
更新日期:2006-10-01 00:00:00
abstract::Viral myocarditis is an important human disease, and reovirus-induced murine myocarditis provides an excellent model system for study. Cardiac myocytes, like neurons in the central nervous system, are not replenished, yet there is no cardiac protective equivalent to the blood-brain barrier. Thus, cardiac myocytes may ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01172-07
更新日期:2007-12-01 00:00:00
abstract::We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count, <100/microl) and stable viral...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8494-8501.2000
更新日期:2000-09-01 00:00:00
abstract::In latent infection, Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1)-specific binding to KSHV terminal repeat DNA mediates multicopy episome persistence. We now use electrophoretic mobility shift assays to investigate LANA1 binding to its 20-bp cognate sequence. Mutations at...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.24.14033-14038.2004
更新日期:2004-12-01 00:00:00
abstract::Homologous recombination is an important biological process that facilitates genome rearrangement and repair of DNA double-strand breaks (DSBs). The induction of Epstein-Barr virus (EBV) lytic replication induces ataxia telangiectasia-mutated (ATM)-dependent DNA damage checkpoint signaling, leading to the clustering o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00049-09
更新日期:2009-07-01 00:00:00
abstract::The tetrameric paramyxovirus hemagglutinin-neuraminidase (HN) protein mediates attachment to sialic acid-containing receptors as well as cleavage of the same moiety via its neuraminidase (NA) activity. The X-ray crystallographic structure of an HN dimer from Newcastle disease virus (NDV) suggests that a single site in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.12.6913-6922.2003
更新日期:2003-06-01 00:00:00
abstract::New zonal centrifuges can conveniently process as much as five orders of magnitude (10(5)) greater sample volumes than conventional swinging-bucket rotors. The continuous-sample-flow-with-banding versions may be used in series with ancillary purification procedures. Here we have studied the combined process: absorptio...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.1.6.1207-1216.1967
更新日期:1967-12-01 00:00:00
abstract::APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.10.4673-4682.2006
更新日期:2006-05-01 00:00:00