Rapid viral decay in simian immunodeficiency virus-infected macaques receiving quadruple antiretroviral therapy.

Abstract:

:The viral dynamics in human immunodeficiency virus type 1 (HIV-1) infection have been studied extensively using mathematical modeling, but data from other primate lentivirus systems are scarce. This study was initiated to increase the understanding of the differences and similarities between the different primate lentiviruses. Four cynomolgus macaques were infected with SIVmac251. Six months after infection the monkeys received a 7-day course of subcutaneous, quadruple antiretroviral therapy with zidovudine, lamivudine, tenofovir, and ritonavir-boosted lopinavir. Plasma virus levels were determined before therapy, daily during the first 10 days of therapy, and after 14 days using a sensitive commercial reverse transcriptase assay. All four monkeys showed a rapid and uniform decline in plasma virus load between day 1 and day 4 of treatment (first-phase decay). Two mathematical models, a piecewise linear regression analysis and a nonlinear model, were used to estimate the rate of viral decay in plasma and gave similar results. The mean half-life for plasma virus was 0.47 days (range, 0.37 to 0.50) and reflects the underlying decline of virus-producing CD4+ lymphocytes. This is the fastest primate lentivirus decay described hitherto. The rapid decay may be due to the high antiviral potency of the therapy or to intrinsic differences between simian immunodeficiency virus (SIV) infection in macaques and HIV-1 infection in humans.

journal_name

J Virol

journal_title

Journal of virology

authors

Brandin E,Thorstensson R,Bonhoeffer S,Albert J

doi

10.1128/JVI.00394-06

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

9861-4

issue

19

eissn

0022-538X

issn

1098-5514

pii

80/19/9861

journal_volume

80

pub_type

杂志文章
  • Integrating reptilian herpesviruses into the family herpesviridae.

    abstract::The phylogeny of reptilian herpesviruses (HVs) relative to mammalian and avian HVs was investigated by using available gene sequences and by alignment of encoded amino acid sequences and derivation of trees by maximum-likelihood and Bayesian methods. Phylogenetic loci were obtained for green turtle HV (GTHV) primarily...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.79.2.725-731.2005

    authors: McGeoch DJ,Gatherer D

    更新日期:2005-01-01 00:00:00

  • Identification of an essential domain in the herpesvirus VP1/2 tegument protein: the carboxy terminus directs incorporation into capsid assemblons.

    abstract::The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01184-06

    authors: Lee JI,Luxton GW,Smith GA

    更新日期:2006-12-01 00:00:00

  • Bacteriophage T4 virion dihydrofolate reductase: approaches to quantitation and assessment of function.

    abstract::This paper is concerned with the physiological role(s) of T4 phage-coded dihydrofolate reductase, which functions both in DNA precursor metabolism and as a virion protein. (i) We have detected enzyme activity in noninfectious particles produced under restrictive conditions by gene 11 mutants. This supports the conclus...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.23.3.645-658.1977

    authors: Mosher RA,DiRenzo AB,Mathews CK

    更新日期:1977-09-01 00:00:00

  • Level of specific prereplicative mRNA's during bacteriophage T4 regA-, 43- and T4 43- infection of Escherichia coli B.

    abstract::The role of the T4 bacteriophage regA gene in stabilizing early mRNA was investigated by assaying the level of functional mRNA from eight prereplicative genes (56 [dCMP hydroxymethylase], cd [dCMP deaminase], 1 [deoxynucleotide kinase], rIIA, rIIB, 46 [DNA arrest], and 45) during extended infection of Escherichia coli...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.17.2.538-549.1976

    authors: Trimble RB,Maley

    更新日期:1976-02-01 00:00:00

  • New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors.

    abstract::We prepared retrovirus packaging cell lines containing gag-pol genes from spleen necrosis virus (expressed from a cytomegalovirus promoter and the simian virus 40 (SV40) polyadenylation sequences) and, on a separate vector, either the env gene from spleen necrosis virus (expressed from the Rous sarcoma virus promoter ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.63.7.3209-3212.1989

    authors: Dougherty JP,Wisniewski R,Yang SL,Rhode BW,Temin HM

    更新日期:1989-07-01 00:00:00

  • Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity.

    abstract::The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation in the reverse transcriptase (RT) gene are frequently found in viral isolates from patients treated with the nucleoside ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.77.16.8621-8632.2003

    authors: Diallo K,Marchand B,Wei X,Cellai L,Götte M,Wainberg MA

    更新日期:2003-08-01 00:00:00

  • Glycopeptides of murine leukemia viruses. I. Comparison of two ecotropic viruses.

    abstract::The glycopeptides obtained by pronase digestion of two ecotropic strains of murine leukemia virus (MuLV) were compared by gel filtration. Four different glycopeptide size classes, designated G(1), G(2), G(3), and G(4), with molecular weights of approximately 5,100, 2,900, 2,200, and 1,500, respectively, were shown to ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.31.1.1-7.1979

    authors: Kemp MC,Basak S,Compans RW

    更新日期:1979-07-01 00:00:00

  • Efficient production of human immunodeficiency virus proteins in transgenic mice.

    abstract::Transgenic mice containing the complete human immunodeficiency virus (HIV) coding sequences fused to the mouse mammary tumor virus long terminal repeat were generated. They were found to produce high levels of authentic gag and env HIV proteins in several tissues known to support mouse mammary tumor virus-driven trans...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.66.6.3904-3908.1992

    authors: Jolicoeur P,Laperrière A,Beaulieu N

    更新日期:1992-06-01 00:00:00

  • Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.

    abstract::The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revea...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00315-09

    authors: Kapil P,Atkinson R,Ramakrishna C,Cua DJ,Bergmann CC,Stohlman SA

    更新日期:2009-06-01 00:00:00

  • Inverse relationship between constitutive gamma interferon production and human T-cell lymphoma/leukemia virus expression in cultured T lymphocytes.

    abstract::Particular interest in human T lymphocyte lymphoma/leukemia virus (HTLV) derives from the close association of HTLV with several types of human mature T lymphocyte malignancies and the strong possibility that HTLV is the causative agent of this group of leukemias and lymphomas. This is the first report to show that HT...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.53.2.440-446.1985

    authors: Moore JL,Poiesz BJ,Zamkoff KW,Merl SA,Hanna S,Gazdar AF,Comis RL

    更新日期:1985-02-01 00:00:00

  • ATP is required for initiation of poliovirus RNA synthesis in vitro: demonstration of tyrosine-phosphate linkage between in vitro-synthesized RNA and genome-linked protein.

    abstract::Poliovirus replicase- and host factor-catalyzed copying of 3'-terminal polyadenylic acid [poly(A)] of poliovirion RNA was studied. Host factor-stimulated synthesis of polyuridylic acid [poly(U)] by the replicase required ATP in addition to UTP. ATP was not required for the oligouridylic acid-primed copying of 3'-termi...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.50.2.515-523.1984

    authors: Morrow CD,Hocko J,Navab M,Dasgupta A

    更新日期:1984-05-01 00:00:00

  • A transcriptionally controlled trans-processing assay: putative identification of a vaccinia virus-encoded proteinase which cleaves precursor protein P25K.

    abstract::Vaccinia virus maturation into infectious particles appears to be dependent on the proteolytic processing of at least five viral proteins, each containing a conserved AG*X cleavage motif and each requiring proper association with the previrion particle. To identify the responsible proteinase, a transcriptionally contr...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.11.7603-7608.1994

    authors: Whitehead SS,Hruby DE

    更新日期:1994-11-01 00:00:00

  • Heteroduplex mapping of heat-resistant deletion mutants of bacteriophage t5.

    abstract::The bacteriophage T5 is known to spontaneously generate deletion mutants (st mutants) exhibiting enhanced resistance to heat inactivation in citrate buffer. A series of such mutants has been isolated and the deletions visualized by electron microscopy of heteroduplex molecules. The deletions are found to cluster in on...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.15.5.1276-1280.1975

    authors: Scheible PP,Rhoades M

    更新日期:1975-05-01 00:00:00

  • Intracellular forms of human NOTCH1 functionally activate essential Epstein-Barr virus major latent promoters in the Burkitt's lymphoma BJAB cell line but repress these promoters in Jurkat cells.

    abstract::We have demonstrated that intracellular forms of NOTCH1 transactivate two major Epstein-Barr virus (EBV) latent promoters, the LMP1 and Cp1 promoters in an EBV-negative B-cell line, BJAB. Truncated intracellular NOTCH1 associated with the nuclear membrane (DeltaE) transactivates the LMP1 promoter fivefold; however, th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.3.1486-1494.2000

    authors: Cotter M,Callahan J,Aster J,Robertson E

    更新日期:2000-02-01 00:00:00

  • Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.

    abstract::The poliovirus polyprotein is cotranslationally linked to myristic acid at its amino-terminal glycine residue. We investigated the role of myristoylation in the viral replication cycle by site-directed mutagenesis of this glycine codon. Synthetic full-length RNA transcripts carrying a Gly-to-Ala mutation (G4002A) gave...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.64.5.2433-2436.1990

    authors: Kräusslich HG,Hölscher C,Reuer Q,Harber J,Wimmer E

    更新日期:1990-05-01 00:00:00

  • A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells.

    abstract::Human cytomegalovirus (HCMV) has emerged as a clinically opportunistic pathogen that targets multiple types of ocular cells and tissues, including the iris region of the uveal tract during anterior uveitis. In this report, we used primary cultures of human iris stroma (HIS) cells derived from human eye donors to inves...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00109-15

    authors: Baldwin J,Maus E,Zanotti B,Volin MV,Tandon R,Shukla D,Tiwari V

    更新日期:2015-05-01 00:00:00

  • Production and reactivity of immune sera specific for HADEN virus polypeptide antigens.

    abstract::Antisera were prepared against the three structural polypeptides of HADEN virus dissociated with sodium dodecyl sulfate. These immunological reagents were used in immunofluorescence tests to study the kinetics and location of polypeptide antigen appearance in infected cells. These sera did not neutralize virus infecti...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.13.3.608-613.1974

    authors: Croft GF,Hoggan MD,Johnson FB

    更新日期:1974-03-01 00:00:00

  • Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency.

    abstract::Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV, also designated human herpesvirus 8) can establish a latent infection in the infected host. During latency a small number of genes are expressed. One of those genes encodes latency-associated nuclear antigen (LANA), which is constitutively expres...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.78.12.6585-6594.2004

    authors: Lan K,Kuppers DA,Verma SC,Robertson ES

    更新日期:2004-06-01 00:00:00

  • Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease.

    abstract::Engineered alphavirus vectors expressing reporters of infection have been used for a number of years due to their relatively low costs for analysis of virus replication and the capacity to utilize imaging systems for longitudinal measurements of growth within single animals. In general, these vectors have been derived...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02990-13

    authors: Sun C,Gardner CL,Watson AM,Ryman KD,Klimstra WB

    更新日期:2014-02-01 00:00:00

  • Evidence for coronavirus discontinuous transcription.

    abstract::Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (M...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.4.2615-2623.1994

    authors: Jeong YS,Makino S

    更新日期:1994-04-01 00:00:00

  • Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B.

    abstract::NS5A of the hepatitis C virus (HCV) is a highly phosphorylated protein involved in resistance against interferon and required most likely for replication of the viral genome. Phosphorylation of this protein is mediated by a cellular kinase(s) generating multiple proteins with different electrophoretic mobilities. In t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.9.7138-7146.1999

    authors: Koch JO,Bartenschlager R

    更新日期:1999-09-01 00:00:00

  • Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein.

    abstract::Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models for transmission, we developed neuroblastoma cell lines overexpressing type A mouse prion protein, MoPrP(C)-A, and then t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.1.320-325.2000

    authors: Nishida N,Harris DA,Vilette D,Laude H,Frobert Y,Grassi J,Casanova D,Milhavet O,Lehmann S

    更新日期:2000-01-01 00:00:00

  • Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients.

    abstract::The degree of genetic variability in the hypervariable region 1 of hepatitis C virus (HCV) was analyzed by cloning and sequencing HCV genomes obtained in paired samples of serum, liver tissue, and peripheral blood mononuclear cells (PBMC) from four chronic hepatitis C patients. Genetic variability in serum was higher ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.72.2.1640-1646.1998

    authors: Navas S,Martín J,Quiroga JA,Castillo I,Carreño V

    更新日期:1998-02-01 00:00:00

  • The genome of turkey herpesvirus.

    abstract::Here we present the first complete genomic sequence of Marek's disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative proteins and resembles alphaherpesviruses in genomic organization and gene content. HVT is very similar to MDV1 and MDV2 within ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.2.971-978.2001

    authors: Afonso CL,Tulman ER,Lu Z,Zsak L,Rock DL,Kutish GF

    更新日期:2001-01-01 00:00:00

  • Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challenge.

    abstract::Neutralizing antibodies may have critical importance in immunity against human immunodeficiency virus type 1 (HIV-1) infection. However, the amount of protective antibody needed at mucosal surfaces has not been fully established. Here, we evaluated systemic and mucosal pharmacokinetics (PK) and pharmacodynamics (PD) o...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01361-13

    authors: Klein K,Veazey RS,Warrier R,Hraber P,Doyle-Meyers LA,Buffa V,Liao HX,Haynes BF,Shaw GM,Shattock RJ

    更新日期:2013-11-01 00:00:00

  • Appearance of the bona fide spiral tubule of ORF virus is dependent on an intact 10-kilodalton viral protein.

    abstract::Parapoxviruses can be morphologically distinguished from other poxviruses in conventional negative staining electron microscopy (EM) by their ovoid appearance and the spiral tubule surrounding the virion's surface. However, this technique may introduce artifacts. We have examined Orf virus (ORFV; the prototype species...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.78.15.8085-8093.2004

    authors: Spehner D,De Carlo S,Drillien R,Weiland F,Mildner K,Hanau D,Rziha HJ

    更新日期:2004-08-01 00:00:00

  • Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.

    abstract::The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human immunodeficiency virus. The topology of membrane-inserted Vpu was investigated by using in vitro-synthesized Vpu cotran...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.67.8.5056-5061.1993

    authors: Maldarelli F,Chen MY,Willey RL,Strebel K

    更新日期:1993-08-01 00:00:00

  • A novel mechanism for persistence of human cytomegalovirus in macrophages.

    abstract::Human cytomegalovirus (HCMV) infection of monocyte-derived macrophages (MDM) results in delayed and nonlytic productive viral growth. During late stages of replication, infectious virus remains cell associated in cytoplasmic vacuoles. In order to understand HCMV survival and persistence in MDM, we examined mechanisms ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.70.3.1855-1862.1996

    authors: Fish KN,Britt W,Nelson JA

    更新日期:1996-03-01 00:00:00

  • Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptide.

    abstract::The envelope of class I viruses can be a target for potent viral inhibitors, such as the human immunodeficiency virus type 1 (HIV-1) inhibitor enfuvirtide, which are derived from the C-terminal heptad repeat (HR2) of the transmembrane (TM) subunit. Resistance to an HR2-based peptide inhibitor of a model retrovirus, su...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.80.1.353-359.2006

    authors: Amberg SM,Netter RC,Simmons G,Bates P

    更新日期:2006-01-01 00:00:00

  • Permanent cell lines that show temperature-dependent expression of adenovirus virus-associated RNA.

    abstract::Temperature-sensitive COS cells, clone E540, have been stably transformed at a restrictive temperature with plasmid pVA1, which contains the adenovirus type 5 virus-associated (VA) genes in addition to the Neor marker. Transformed cell clones, named EVA cells, contained adenovirus DNA in an integrated form while grown...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.63.12.5445-5450.1989

    authors: Martínez C,de la Luna S,Peláez F,Lopez-Turiso A,Valcárcel J,de Haro C,Ortín J

    更新日期:1989-12-01 00:00:00