Abstract:
:The viral dynamics in human immunodeficiency virus type 1 (HIV-1) infection have been studied extensively using mathematical modeling, but data from other primate lentivirus systems are scarce. This study was initiated to increase the understanding of the differences and similarities between the different primate lentiviruses. Four cynomolgus macaques were infected with SIVmac251. Six months after infection the monkeys received a 7-day course of subcutaneous, quadruple antiretroviral therapy with zidovudine, lamivudine, tenofovir, and ritonavir-boosted lopinavir. Plasma virus levels were determined before therapy, daily during the first 10 days of therapy, and after 14 days using a sensitive commercial reverse transcriptase assay. All four monkeys showed a rapid and uniform decline in plasma virus load between day 1 and day 4 of treatment (first-phase decay). Two mathematical models, a piecewise linear regression analysis and a nonlinear model, were used to estimate the rate of viral decay in plasma and gave similar results. The mean half-life for plasma virus was 0.47 days (range, 0.37 to 0.50) and reflects the underlying decline of virus-producing CD4+ lymphocytes. This is the fastest primate lentivirus decay described hitherto. The rapid decay may be due to the high antiviral potency of the therapy or to intrinsic differences between simian immunodeficiency virus (SIV) infection in macaques and HIV-1 infection in humans.
journal_name
J Viroljournal_title
Journal of virologyauthors
Brandin E,Thorstensson R,Bonhoeffer S,Albert Jdoi
10.1128/JVI.00394-06subject
Has Abstractpub_date
2006-10-01 00:00:00pages
9861-4issue
19eissn
0022-538Xissn
1098-5514pii
80/19/9861journal_volume
80pub_type
杂志文章abstract::The phylogeny of reptilian herpesviruses (HVs) relative to mammalian and avian HVs was investigated by using available gene sequences and by alignment of encoded amino acid sequences and derivation of trees by maximum-likelihood and Bayesian methods. Phylogenetic loci were obtained for green turtle HV (GTHV) primarily...
journal_title:Journal of virology
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doi:10.1128/JVI.79.2.725-731.2005
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abstract::The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...
journal_title:Journal of virology
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doi:10.1128/JVI.01184-06
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journal_title:Journal of virology
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doi:10.1128/JVI.23.3.645-658.1977
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.17.2.538-549.1976
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.7.3209-3212.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.16.8621-8632.2003
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.31.1.1-7.1979
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.6.3904-3908.1992
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.53.2.440-446.1985
更新日期:1985-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.2.515-523.1984
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.11.7603-7608.1994
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.5.1276-1280.1975
更新日期:1975-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.74.3.1486-1494.2000
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.5.2433-2436.1990
更新日期:1990-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.13.3.608-613.1974
更新日期:1974-03-01 00:00:00
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.3.1855-1862.1996
更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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