Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies.

abstract：:The active site serine of the acetylesterase of influenza C virus was localized to amino acid 71 of the hemagglutinin-esterase protein by affinity labeling with 3H-labeled diisopropylfluorophosphate. This serine and the adjacent amino acids (Phe-Gly-Asp-Ser) are part of a consensus sequence motif found in serine hydro...

journal_title：Journal of virology

authors： Vlasak R,Muster T,Lauro AM,Powers JC,Palese P

更新日期：1989-05-01 00:00:00

abstract：:The kinetics of retroviral DNA and RNA synthesis are parameters vital to understanding viral growth, especially for human immunodeficiency virus (HIV), which encodes several of its own regulatory genes. We have established a single-cycle growth condition for HIV in H9 cells, a human CD4+ lymphocyte line. The full-leng...

journal_title：Journal of virology

authors： Kim SY,Byrn R,Groopman J,Baltimore D

更新日期：1989-09-01 00:00:00

abstract：:A short sequence, located between the A14L and A15L open reading frames (ORFs) of vaccinia virus, was predicted to encode a hydrophobic protein of 53 amino acids that is conserved in orthopoxviruses, leporipoxviruses, yatapoxiruses, and molluscipoxviruses. We constructed a recombinant vaccinia virus with a 10-codon ep...

journal_title：Journal of virology

authors： Betakova T,Wolffe EJ,Moss B

更新日期：2000-05-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) is an important pathogen of cattle, and infection is usually initiated via the ocular or nasal cavity. Following acute infection, the primary site for BHV-1 latency is the sensory neuron. Reactivation from latency occurs sporadically, resulting in virus shedding and transmission to uninfec...

journal_title：Journal of virology

authors： Inman M,Lovato L,Doster A,Jones C

更新日期：2002-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* p...

journal_title：Journal of virology

authors： Drappier M,Opperdoes FR,Michiels T

更新日期：2017-06-26 00:00:00

abstract：:In an attempt to identify the molecules involved in the pathogenesis of prion diseases, we performed cDNA subtraction on the brain tissues of mice affected with an experimental prion disease and the unaffected control. The genes identified as being upregulated in the prion-affected brain tissue included those encoding...

journal_title：Journal of virology

authors： Kopacek J,Sakaguchi S,Shigematsu K,Nishida N,Atarashi R,Nakaoke R,Moriuchi R,Niwa M,Katamine S

更新日期：2000-01-01 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origin includes a poly(T...

journal_title：Journal of virology

authors： Kwun HJ,Guastafierro A,Shuda M,Meinke G,Bohm A,Moore PS,Chang Y

更新日期：2009-12-01 00:00:00

abstract：:The induction of alpha/beta interferon (IFN-alpha/beta) genes constitutes one of the first responses of the cell to virus infection. The IFN-beta gene is constitutively repressed in uninfected cells and is transiently activated after virus infection. In this work we demonstrate that histone deacetylation regulates the...

journal_title：Journal of virology

authors： Shestakova E,Bandu MT,Doly J,Bonnefoy E

更新日期：2001-04-01 00:00:00

abstract：:Influenza viral complementary RNA (cRNA), i.e., viral mRNA was radioactive when purified from the cytoplasmic fraction of cordycepin-treated canine kidney cells that were incubated with [methyl-3H]methionine during infection. Approximately 55 to 60% of the methyl-3H radioactivity was in internal N6-methyladenosine, a ...

journal_title：Journal of virology

authors： Krug RM,Morgan MA,Shatkin AJ

更新日期：1976-10-01 00:00:00

abstract：:The transmembrane fusion (F) glycoprotein of measles virus is an important target antigen of human HLA class I- and class II-restricted cytotoxic T lymphocytes (CTL). Genetically engineered F proteins and nested sets of synthetic peptides spanning the F protein were used to determine sequences of F recognized by a num...

journal_title：Journal of virology

authors： van Binnendijk RS,Versteeg-van Oosten JP,Poelen MC,Brugghe HF,Hoogerhout P,Osterhaus AD,Uytdehaag FG

更新日期：1993-04-01 00:00:00

abstract：:Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PM...

journal_title：Journal of virology

authors： Scherer M,Stamminger T

更新日期：2016-06-10 00:00:00

abstract：:As nonacademic careers in science have become less and less "alternative," one field that has consistently attracted early-career virologists is public health research. The desire to make tangible contributions to public health needs and better protect the public from infectious disease often motivates the transition....

journal_title：Journal of virology

authors： Konopka-Anstadt JL,Burns CC

更新日期：2017-04-13 00:00:00

abstract：:Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquitinates p53, targetin...

journal_title：Journal of virology

authors： Zhang Z,Evers DL,McCarville JF,Dantonel JC,Huong SM,Huang ES

更新日期：2006-04-01 00:00:00

abstract：:The bacteriophage PRD1 is a lipid-bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they contain the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. We report here ...

journal_title：Journal of virology

authors： Gerendasy DD,Ito J

更新日期：1987-02-01 00:00:00

abstract：:We have expressed the human immunodeficiency virus type 1 (HIV-1) protease (PR) in bacteria as a Gag-PR polyprotein (J. Luban and S.P. Goff, J. Virol. 65:3203-3212, 1991). The protein displays enzymatic activity, cleaving the Gag polyprotein precursor Pr55gag to the expected products. The PR enzyme is only active as a...

journal_title：Journal of virology

authors： Luban J,Lee C,Goff SP

更新日期：1993-06-01 00:00:00

abstract：:Several independent cell lines transformed by simian virus 40 carry a species of viral RNA of 900,000 to 1,000,000 daltons. A viral RNA species of similar size is found early in the lytic cycle. Late in the viral lytic cycle, two prominent viral RNA species of about 600,000 and 900,000 daltons are seen. The larger lat...

journal_title：Journal of virology

authors： Weinberg RA,Ben-Ishai Z,Newbold JE

更新日期：1974-06-01 00:00:00

abstract：:The Birnaviridae family, responsible for major economic losses to poultry and aquaculture, is composed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome that replicate in discrete cytoplasmic virus factories (VFs). Reassortment is common; however, the underlying mechanism remains unknown give...

journal_title：Journal of virology

authors： Campbell EA,Reddy VRAP,Gray AG,Wells J,Simpson J,Skinner MA,Hawes PC,Broadbent AJ

更新日期：2020-06-16 00:00:00

abstract：:HeLa cell nuclei, isolated 17 h after infection with human adenovirus type 2 (Ad2), were treated with 200 mM ammonium sulfate. The extract (S200 fraction) contained 50 to 70% of the nonintegrated Ad2 DNA, which was in the form of nucleoprotein complexes. These complexes contained native, intact Ad2 DNA (with the excep...

journal_title：Journal of virology

authors： Wilhelm J,Brison O,Kedinger C,Chambon P

更新日期：1976-07-01 00:00:00

abstract：UNLABELLED:Enterovirus A71 (EV-A71) is a major cause of hand, foot, and mouth disease (HFMD) and is particularly prevalent in parts of Southeast Asia, affecting thousands of children and infants each year. Revealing the evolutionary and epidemiological dynamics of EV-A71 through time and space is central to understandi...

journal_title：Journal of virology

authors： Geoghegan JL,Tan le V,Kühnert D,Halpin RA,Lin X,Simenauer A,Akopov A,Das SR,Stockwell TB,Shrivastava S,Ngoc NM,Uyen le TT,Tuyen NT,Thanh TT,Hang VT,Qui PT,Hung NT,Khanh TH,Thinh le Q,Nhan le NT,Van HM,Viet do C

更新日期：2015-09-01 00:00:00

abstract：:The common virus integration site (VIS) Evi11 was recently identified within the gene encoding the hematopoietic G-protein-coupled peripheral cannabinoid receptor Cnr2 (also referred to as Cb2). Here we show that Cnr2 is a frequent target (12%) for insertion of Cas-Br-M murine leukemia virus (MuLV) in primary tumors i...

journal_title：Journal of virology

authors： Valk PJ,Vankan Y,Joosten M,Jenkins NA,Copeland NG,Löwenberg B,Delwel R

更新日期：1999-05-01 00:00:00

abstract：:Several early genes of murine cytomegalovirus (MCMV) encode proteins that mediate immune evasion by interference with the major histocompatibility complex class I (MHC-I) pathway of antigen presentation to cytolytic T lymphocytes (CTL). Specifically, the m152 gene product gp37/40 causes retention of MHC-I molecules in...

journal_title：Journal of virology

authors： Holtappels R,Thomas D,Podlech J,Geginat G,Steffens HP,Reddehase MJ

更新日期：2000-02-01 00:00:00

abstract：:It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However, the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic viruses are not well understood. We have recently shown th...

journal_title：Journal of virology

authors： Alves-Peixoto P,Férez M,Knudson CJ,Melo-Silva CR,Stotesbury C,Wong EB,Correia-Neves M,Sigal LJ

更新日期：2020-02-14 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:RNA plant viruses use various translational regulatory mechanisms to control their gene expression. Translational enhancement of viral mRNAs that leads to higher levels of protein synthesis from specific genes may be essential for the virus to successfully compete for cellular translational machinery. The control elem...

journal_title：Journal of virology

authors： Koh DC,Liu DX,Wong SM

更新日期：2002-02-01 00:00:00

abstract：:Meq is the major Marek's disease virus (MDV)-encoded oncoprotein and is essential for T-cell lymphomagenesis. Meq and several noncoding RNAs, including three microRNA (MiR) clusters, are expressed from the repeats of the MDV genome during latent infection of T cells. To investigate the state of the chromatin in this a...

journal_title：Journal of virology

authors： Brown AC,Nair V,Allday MJ

更新日期：2012-02-01 00:00:00

abstract：:Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and Guillain-Barré syndrome in adults. The molecular mechanisms regulating ZIKV infection and pathogenic outcomes are incompletely understood. Signaling by the mechanistic (mammalian) target of ra...

journal_title：Journal of virology

authors： Sahoo BR,Pattnaik A,Annamalai AS,Franco R,Pattnaik AK

更新日期：2020-10-27 00:00:00

abstract：:A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medica...

journal_title：Journal of virology

authors： Uraki R,Kiso M,Shinya K,Goto H,Takano R,Iwatsuki-Horimoto K,Takahashi K,Daniels RS,Hungnes O,Watanabe T,Kawaoka Y

更新日期：2013-02-01 00:00:00

abstract：:Retroviral recombination can occur between two viral RNA molecules (intermolecular) or between two sequences within the same RNA molecule (intramolecular). The rate of retroviral intramolecular recombination is high. Previous studies showed that, after a single round of replication, 50 to 60% of retroviral recombinati...

journal_title：Journal of virology

authors： Li T,Zhang J

更新日期：2002-10-01 00:00:00

abstract：:SER virus, a paramyxovirus that is closely related to simian virus 5 (SV5), is unusual in that it fails to induce syncytium formation. The SER virus F protein has an unusually long cytoplasmic tail (CT), and it was previously observed that truncations or specific mutations of this domain result in enhanced syncytium f...

journal_title：Journal of virology

authors： Seth S,Goodman AL,Compans RW

更新日期：2004-08-01 00:00:00