Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.

abstract：:Vaccinia virus, a poxvirus, produces structurally distinct forms of virions for which the immediate events following cell entry are ill-defined. We provide evidence that intracellular mature virus (IMV) enters both permissive and nonpermissive T-cell lines and that introduction of CCR5 into nonpermissive mouse fibrobl...

journal_title：Journal of virology

authors： Rahbar R,Murooka TT,Hinek AA,Galligan CL,Sassano A,Yu C,Srivastava K,Platanias LC,Fish EN

更新日期：2006-07-01 00:00:00

abstract：:Influenza A virus (IAV) replication relies on an intricate interaction between virus and host cells. How the cellular proteins are usurped for IAV replication remains largely obscure. The aim of this study was to search for novel and potential cellular factors that participate in IAV replication. ZBTB25, a transcripti...

journal_title：Journal of virology

authors： Chen SC,Jeng KS,Lai MMC

更新日期：2017-09-27 00:00:00

abstract：:CH/S is a virulent porcine epidemic diarrhea virus (PEDV) strain and is used as the virulent strain to evaluate the protection rates of vaccines against PEDV infection in China. Here, we report the complete genome sequence of strain CH/S, which may aid in understanding the molecular characteristics of this strain. ...

journal_title：Journal of virology

authors： Chen J,Wang C,Shi H,Qiu HJ,Liu S,Shi D,Zhang X,Feng L

更新日期：2011-11-01 00:00:00

abstract：:During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this co...

journal_title：Journal of virology

authors： Serio TR,Cahill N,Prout ME,Miller G

更新日期：1998-10-01 00:00:00

abstract：:Mitochondria are crucial to proper neuronal function and overall brain health. Mitochondrial dysfunction within the brain has been observed in many neurodegenerative diseases, including prion disease. Several markers of decreased mitochondrial activity during prion infection have been reported, yet the bioenergetic re...

journal_title：Journal of virology

authors： Faris R,Moore RA,Ward A,Sturdevant DE,Priola SA

更新日期：2017-08-24 00:00:00

abstract：:Vesicular stomatitis virus Indiana strain G protein (VSVind.G) is the most commonly used envelope glycoprotein to pseudotype lentiviral vectors (LV) for experimental and clinical applications. Recently, G proteins derived from other vesiculoviruses (VesG), for example, Cocal virus, have been proposed as alternative LV...

journal_title：Journal of virology

authors： Munis AM,Tijani M,Hassall M,Mattiuzzo G,Collins MK,Takeuchi Y

更新日期：2018-11-12 00:00:00

abstract：:The adaptive immune system generates CD8 cytotoxic T lymphocytes (CTLs) as a major component of the protective response against viruses. Knowledge regarding the nature of the peptide sequences presented by HLA class I molecules and recognized by CTLs is thus important for understanding host-pathogen interactions. In t...

journal_title：Journal of virology

authors： Varela-Calvino R,Skowera A,Arif S,Peakman M

更新日期：2004-12-01 00:00:00

abstract：:Synthesis of the vesicular stomatitis virus membrane matrix protein and the glycoprotein is inhibited to a greater extent than the synthesis of the nucleocapsid protein, the nonstructural protein, and the large protein when the rate of peptide chain initiation is reduced by exposure of vesicular stomatitis virus-infec...

journal_title：Journal of virology

authors： Nuss DL,Koch G

更新日期：1975-01-01 00:00:00

abstract：:Resistance to human immunodeficiency virus type 1 protease (HIV PR) inhibitors results primarily from the selection of multiple mutations in the protease region. Because many of these mutations are selected for the ability to decrease inhibitor binding in the active site, they also affect substrate binding and potenti...

journal_title：Journal of virology

authors： Dauber DS,Ziermann R,Parkin N,Maly DJ,Mahrus S,Harris JL,Ellman JA,Petropoulos C,Craik CS

更新日期：2002-02-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is a key sensor for recognizing nucleic acids derived from RNA viruses and triggers beta interferon (IFN-β) production. Because of its important role in antiviral innate immunity, the activity of RIG-I must be tightly controlled. Here, we used yeast two-hybrid screening to identi...

journal_title：Journal of virology

authors： Li MT,Di W,Xu H,Yang YK,Chen HW,Zhang FX,Zhai ZH,Chen DY

更新日期：2013-09-01 00:00:00

abstract：:The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this study, we demonstrate...

journal_title：Journal of virology

authors： Akari H,Arold S,Fukumori T,Okazaki T,Strebel K,Adachi A

更新日期：2000-03-01 00:00:00

abstract：:The avian and Nelson Bay reoviruses are two of only a limited number of nonenveloped viruses capable of inducing cell-cell membrane fusion. These viruses encode the smallest known membrane fusion proteins (p10). We now show that a region of moderate hydrophobicity we call the hydrophobic patch (HP), present in the sma...

journal_title：Journal of virology

authors： Shmulevitz M,Epand RF,Epand RM,Duncan R

更新日期：2004-03-01 00:00:00

abstract：:Three distinct strains of murine rotavirus were adapted to growth in cell culture. These strains are genetically related but not identical; they are serotypically heterogeneous. The cultivatable strains were substantially more infectious (approximately 10(6)-fold) for suckling mice than heterologous simian rotaviruses...

journal_title：Journal of virology

authors： Greenberg HB,Vo PT,Jones R

更新日期：1986-02-01 00:00:00

abstract：:The efficiency of processing of polyoma viral RNA and of its export from nucleus to cytoplasm was measured in primary mouse kidney cells by comparing the initial rates of incorporation of [3H]uridine into cytoplasmic and nuclear viral RNA. Appropriate methods of cell fractionation were chosen to maximize yields of cyt...

journal_title：Journal of virology

authors： Acheson NH

更新日期：1981-02-01 00:00:00

abstract：:It was recently shown that the 7a protein of severe acute respiratory syndrome coronavirus induces biochemical changes associated with apoptosis. In this study, the mechanism by which the 7a protein induces apoptosis was examined. The 7a protein was tested for the ability to inhibit cellular gene expression because se...

journal_title：Journal of virology

authors： Kopecky-Bromberg SA,Martinez-Sobrido L,Palese P

更新日期：2006-01-01 00:00:00

abstract：:Infection of microglia and other cells of the macrophage/monocyte lineage in the central nervous system (CNS) by human immunodeficiency virus type I (HIV-1) underlies the development of giant cell encephalitis (GCE). It is currently unknown whether GCE depends on the emergence of virus populations specifically adapted...

journal_title：Journal of virology

authors： Wang TH,Donaldson YK,Brettle RP,Bell JE,Simmonds P

更新日期：2001-12-01 00:00:00

abstract：:Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves the exposure of structures that are buried within the structural models. The presence of functional...

journal_title：Journal of virology

authors： Nelson CD,Minkkinen E,Bergkvist M,Hoelzer K,Fisher M,Bothner B,Parrish CR

更新日期：2008-11-01 00:00:00

abstract：:BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at the antigen challenge site both initially and a...

journal_title：Journal of virology

authors： Tumpey TM,Fenton R,Molesworth-Kenyon S,Oakes JE,Lausch RN

更新日期：2002-08-01 00:00:00

abstract：:The Arabidopsis flowering locus T (FT) gene encodes the mobile florigen essential for floral induction. While movement of the FT protein has been shown to occur within plants, systemic spread of FT mRNA remains to be unequivocally demonstrated. Utilizing novel RNA mobility assay vectors based on two distinct movement-...

journal_title：Journal of virology

authors： Li C,Zhang K,Zeng X,Jackson S,Zhou Y,Hong Y

更新日期：2009-04-01 00:00:00

abstract：:Cells nonproductively transformed by a variant of the Snyder-Theilen strain of feline sarcoma virus (FeSV) expressed an 85,000-dalton polyprotein (P85) with associated tyrosine-specific protein kinase activity. We identified within this polyprotein a single tyrosine acceptor site for its enzyme activity. This acceptor...

journal_title：Journal of virology

authors： Blomberg J,Van de Ven WJ,Reynolds FH Jr,Nalewaik RP,Stephenson JR

更新日期：1981-06-01 00:00:00

abstract：:Mixed infection of a cell by vesicular stomatitis virus (VSV) and retroviruses results in the production of progeny virions bearing the genome of one virus encapsidated by the envelope proteins of the other. The mechanism for the phenomenon of pseudotype formation is not clear, although specific recognition of a viral...

journal_title：Journal of virology

authors： Emi N,Friedmann T,Yee JK

更新日期：1991-03-01 00:00:00

abstract：UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) regulatory protein ICP0 promotes viral gene expression and replication, we screened cells overexpressing ICP0 for ICP0-binding host cell proteins. Tandem affinity purification of transiently expressed ICP0 coupled with mass spe...

journal_title：Journal of virology

authors： Sato Y,Kato A,Maruzuru Y,Oyama M,Kozuka-Hata H,Arii J,Kawaguchi Y

更新日期：2016-01-06 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Numerous experimental studies have demonstrated that CD8(+) T cells contribute to immunity against influenza by limiting viral replication. It is therefore surprising that rigorous statistical tests have failed to find evidence of positive selection in the epitopes targeted by CD8(+) T cells. Here we use a n...

journal_title：Journal of virology

authors： Machkovech HM,Bedford T,Suchard MA,Bloom JD

更新日期：2015-11-01 00:00:00

abstract：:Brome mosaic virus (BMV) RNA replication is directed by two virus-encoded proteins, 1a and 2a. The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1, which has been implicated in capping viral RNAs. In this study, we examined the enzymatic activities of BMV 1a expressed in yeast, ...

journal_title：Journal of virology

authors： Ahola T,Ahlquist P

更新日期：1999-12-01 00:00:00

abstract：:The phosphoprotein, P, of vesicular stomatitis virus (VSV) is a key subunit of the viral RNA-dependent RNA polymerase complex. The protein is phosphorylated at multiple sites in two different domains. We recently showed that specific serine and threonine residues within the amino-terminal acidic domain I of P protein ...

journal_title：Journal of virology

authors： Hwang LN,Englund N,Das T,Banerjee AK,Pattnaik AK

更新日期：1999-07-01 00:00:00

abstract：:In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 (HIV-1) isolates by HIV-2- and simian immunodeficiency virus (SIV)-positive sera, extensive cross-neutralization of HIV-2NIH-Z, SIVMAC251, and SIVAGM208K occurs with high titer, suggesting conservation of epitopes and m...

journal_title：Journal of virology

authors： Robert-Guroff M,Aldrich K,Muldoon R,Stern TL,Bansal GP,Matthews TJ,Markham PD,Gallo RC,Franchini G

更新日期：1992-06-01 00:00:00

abstract：:The sheep genome harbors approximately 20 endogenous retroviruses (enJSRVs) highly related to the exogenous Jaagsiekte sheep retrovirus (JSRV). One of the enJSRV loci, enJS56A1, acts as a unique restriction factor by blocking JSRV in a transdominant fashion at a late stage of the retroviral cycle. To better understand...

journal_title：Journal of virology

authors： Murcia PR,Arnaud F,Palmarini M

更新日期：2007-02-01 00:00:00

abstract：:The E1 helicase of papillomaviruses is required for replication of the viral double-stranded DNA genome, in conjunction with cellular factors. DNA replication is initiated at the viral origin by the assembly of E1 monomers into oligomeric complexes that have unwinding activity. In vivo, this process is catalyzed by th...

journal_title：Journal of virology

authors： Titolo S,Brault K,Majewski J,White PW,Archambault J

更新日期：2003-05-01 00:00:00

abstract：:Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats. Infectious virus, which was abundantly present in fresh urine samples of carrier rats, entered the brains of recipient rats via the olfactory route. Thus, susceptible farm animals possibly acquire the virus fr...

journal_title：Journal of virology

authors： Sauder C,Staeheli P

更新日期：2003-12-01 00:00:00