Epstein-Barr virus (EBV) antigens processed and presented by B cells, B blasts, and macrophages trigger T-cell-mediated inhibition of EBV-induced B-cell transformation.

Abstract:

:The ability of B cells, B blasts, and macrophages to present Epstein-Barr virion antigens to autologous T cells and trigger their capacity to inhibit Epstein-Barr virus-induced B-cell transformation was tested. Macrophages were as efficient as B cells and B blasts in presenting the virus to T lymphocytes. This function required antigen processing, because it was inhibited by chloroquine treatment and by fixation of the antigen-presenting cells immediately after viral exposure but not 18 h later. T cells exposed to the purified Epstein-Barr virus envelope antigen gp350 coupled to immunostimulating complexes also showed inhibitory function. These results suggest that recognition of processed virion antigens elicits the generation of T-cell-mediated inhibition of Epstein-Barr virus-induced B-cell transformation.

journal_name

J Virol

journal_title

Journal of virology

authors

Bejarano MT,Masucci MG,Morgan A,Morein B,Klein G,Klein E

doi

10.1128/JVI.64.3.1398-1401.1990

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

1398-401

issue

3

eissn

0022-538X

issn

1098-5514

journal_volume

64

pub_type

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