Nuclear subcompartmentalization of simian virus 40 large T antigen: evidence for in vivo regulation of biochemical activities.

Abstract:

:Simian virus 40 large T antigen (large T) in the early and the late phases of infection differs significantly in its sequence-specific DNA-binding and ATPase activities, indicating that different large-T populations participate in virus-specific events at various stages of the infectious cycle. To further characterize these large-T populations, we have analyzed nuclear subclasses of large T, isolated from their in vivo location, for their biochemical activities. We show that chromatin- and nuclear matrix-associated large-T molecules exhibit different simian virus 40 control region (ORI) DNA-binding and ATPase activities. The association of large T with a certain nuclear substructure, therefore, subcompartmentalizes large-T molecules exerting different biochemical activities. Nuclear subcompartmentalization thus may provide a higher-order level for the regulation of biochemical activities of large T in vivo.

journal_name

J Virol

journal_title

Journal of virology

authors

Schirmbeck R,Deppert W

doi

10.1128/JVI.63.5.2308-2316.1989

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

2308-16

issue

5

eissn

0022-538X

issn

1098-5514

journal_volume

63

pub_type

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