Abstract:
:The polypeptides of three paramyxoviruses (simian virus 5, Newcastle disease virus, and Sendai virus) were separated by polyacrylamide gel electrophoresis. Glycoproteins were identified by the use of radioactive glucosamine as a carbohydrate precursor. The protein patterns reveal similarities among the three viruses. Each virus contains at least five or six proteins, two of which are glycoproteins. Four of the proteins found in each virus share common features with corresponding proteins in the other two viruses, including similar molecular weights. These four proteins are the nucleocapsid protein (molecular weight 56,000 to 61,000), a larger glycoprotein (molecular weight 65,000 to 74,000), a smaller glycoprotein (molecular weight 53,000 to 56,000), and a major protein which is the smallest protein in each virion (molecular weight 38,000 to 41,000).
journal_name
J Viroljournal_title
Journal of virologyauthors
Mountcastle WE,Compans RW,Choppin PWdoi
10.1128/JVI.7.1.47-52.1971subject
Has Abstractpub_date
1971-01-01 00:00:00pages
47-52issue
1eissn
0022-538Xissn
1098-5514journal_volume
7pub_type
杂志文章abstract::Influenza A(H7N9) viruses have caused a large number of zoonotic infections since their emergence in 2013. They remain a public health concern due to the repeated high levels of infection with these viruses and their perceived pandemic potential. A major factor that determines influenza A virus fitness and therefore t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02293-16
更新日期:2017-05-12 00:00:00
abstract::The E1A gene of highly oncogenic type 12 adenovirus (Ad12) possesses a segment unique to this serotype and comprising 60 base pairs contiguous with and separating conserved regions 2 and 3 in the gene. A similar but slightly longer segment is also present in the E1A gene of highly oncogenic simian adenovirus type 7 (D...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.877-887.1994
更新日期:1994-02-01 00:00:00
abstract::Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.19.10628-10635.2004
更新日期:2004-10-01 00:00:00
abstract::We have devised an enrichment scheme for the isolation of export-competent derivatives of pseudorabies virus glycoprotein gIII signal peptide mutants. Enrichment is based upon a growth advantage imparted upon gIII-containing virions compared with virions lacking the glycoprotein. Each of identified derivatives suppres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.2787-2794.1994
更新日期:1994-05-01 00:00:00
abstract::Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.9.5838-5842.1995
更新日期:1995-09-01 00:00:00
abstract::Proliferative cell nuclear antigen (PCNA), a conserved plant protein as well as an important replication factor, is induced in response to geminivirus infection in the resting cells of the phloem tissues. The biochemical role of PCNA in rolling circle replication (RCR) of geminivirus DNA has not been explored in detai...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.21.11890-11903.2004
更新日期:2004-11-01 00:00:00
abstract::The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.9.4390-4398.1990
更新日期:1990-09-01 00:00:00
abstract::Integrated retroviruses or retroviral vectors may be transcriptionally inactive although their promoter-enhancer regions are able to direct transcription in the host cell. We have used single-gene retroviral vectors with a long terminal repeat-directed neo marker gene to determine if the level of transcription relates...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.9.5596-5601.1994
更新日期:1994-09-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a herpesvirus commonly associated with several malignancies, particularly in immunocompromised hosts. As a strategy for stimulating immunity against EBV for the treatment of EBV-associated tumors, we have genetically engineered dendritic cells (DC) to express EBV antigens, such as latent me...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.12.10416-10425.1999
更新日期:1999-12-01 00:00:00
abstract::The DNA sensing pathway triggers innate immune responses against DNA virus infection, and NF-κB signaling plays a critical role in establishing innate immunity. We report here that the herpes simplex virus 1 (HSV-1) ubiquitin-specific protease (UL36USP), which is a deubiquitinase (DUB), antagonizes NF-κB activation, d...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02417-16
更新日期:2017-02-14 00:00:00
abstract::Most mammalian rotaviruses contain tripeptide amino acid sequences in outer capsid proteins VP4 and VP7 which have been shown to act as ligands for integrins alpha2beta1 and alpha4beta1. Peptides containing these sequences and monoclonal antibodies directed to these integrins block rotavirus infection of cells. Here w...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.1.228-236.2000
更新日期:2000-01-01 00:00:00
abstract:UNLABELLED:Cavally virus (CavV) and related viruses in the family Mesoniviridae diverged profoundly from other nidovirus lineages but largely retained the characteristic set of replicative enzymes conserved in the Coronaviridae and Roniviridae. The expression of these enzymes in virus-infected cells requires the extens...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02040-14
更新日期:2014-12-01 00:00:00
abstract::ts5, a temperature-sensitive mutant of influenza B virus, belongs to one of seven recombination groups. When the mutant infected MDCK cells at the nonpermissive temperature (37.5 degrees C), infectious virus was produced at very low levels compared with the yield at the permissive temperature (32 degrees C) and hemagg...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.6.3264-3273.1993
更新日期:1993-06-01 00:00:00
abstract::Vesicular stomatitis virus (VSV) has served for several decades as the prototype rhabdovirus and a model RNA virus. Extensive studies upheld the original view of VSV genetics with simply five genes (N, P, M, G, and L), each encoding a single unique protein. We now report the first unambiguous demonstration of the exis...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.6.3103-3110.1993
更新日期:1993-06-01 00:00:00
abstract::Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV UL111A gene encodes cmvIL-10, an ortholog of human interleukin-10 that h...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01981-17
更新日期:2018-02-12 00:00:00
abstract::Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to restriction in animal movements. Therefore, many new types of vaccines, par...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01514-13
更新日期:2013-09-01 00:00:00
abstract::Recent environmental and metagenomic studies have considerably increased the repertoire of archaeal viruses and suggested that they play important roles in nutrient cycling in the biosphere. However, very little is known about how they regulate their life cycles and interact with their hosts. Here, we report that the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00841-20
更新日期:2020-07-30 00:00:00
abstract::Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune responses through the actions of their V proteins. The V protein mediates interference with the interferon regulatory RNA helicase MDA5 to avoid cellular antiviral responses. Analysis of the interaction i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00153-09
更新日期:2009-07-01 00:00:00
abstract::The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as all six MHV subgenomic mRNAs found in MHV-infected cells. In contrast, monoclonal antibodies to the MHV E2 or E1 envelope gl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.11.4280-4287.1988
更新日期:1988-11-01 00:00:00
abstract::Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02459-08
更新日期:2009-04-01 00:00:00
abstract::Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.2.1017-1026.2005
更新日期:2005-01-01 00:00:00
abstract::Two forms of herpes simplex virus glycoprotein gD were recombined into Autographa californica nuclear polyhedrosis virus (baculovirus) and expressed in infected Spodoptera frugiperda (Sf9) cells. Each protein was truncated at residue 306 of mature gD. One form, gD-1(306t), contains the coding sequence of Patton strain...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.766-775.1994
更新日期:1994-02-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) clade C causes >50% of all HIV infections worldwide, and an estimated 90% of all transmissions occur mucosally with R5 strains. A pathogenic R5 simian-human immunodeficiency virus (SHIV) encoding HIV clade C env is highly desirable to evaluate candidate AIDS vaccines in nonh...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00558-06
更新日期:2006-09-01 00:00:00
abstract::Phylogenetic analyses demonstrate significant diversity in worldwide circulating strains of human immunodeficiency virus type 1 (HIV-1). Detailed studies have revealed a complex pattern of intersubtype recombinations, as well as evidence of sub-subtypes circulating in various populations. In this study, we characteriz...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.22.12438-12445.2004
更新日期:2004-11-01 00:00:00
abstract::In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus. Hepatic HBV replication was not affected by overexpression of the envelope or X gene products when these animals were cross...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.10.7056-7061.1996
更新日期:1996-10-01 00:00:00
abstract::Phage P22 can integrate as prophage into a recombination-deficient (Rec(-)) strain of Salmonella typhimurium. At 37 C, the integration efficiency is only 10% that in Rec(+) infection, but at 25 C the efficiencies in Rec(-) and Rec(+) hosts are similar. Rec(-) lysogens cannot be induced by ultraviolet irradiation or by...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.7.702-709.1968
更新日期:1968-07-01 00:00:00
abstract::This study describes a method for increasing the immunogenicity of influenza virus vaccines by exploiting the natural anti-Gal antibody to effectively target vaccines to antigen-presenting cells (APC). This method is based on enzymatic engineering of carbohydrate chains on virus envelope hemagglutinin to carry the alp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00647-07
更新日期:2007-09-01 00:00:00
abstract::In varicella-zoster virus (VZV)-infected primary human brain vascular adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-β,) STAT1, and STAT2 transcripts as well as STAT1 and STAT2 protein were decreased. IFN-α transcript levels were increased but not secreted IFN-α protein levels. Compared to IFN-α-treat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01945-14
更新日期:2014-10-01 00:00:00
abstract::The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia virus type I (HTLV-I) infection. The HTLV-I regulatory protein Tax and the envelope protein gp46 have been implicated ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.6.3134-3141.1993
更新日期:1993-06-01 00:00:00
abstract::In latent infection, Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1)-specific binding to KSHV terminal repeat DNA mediates multicopy episome persistence. We now use electrophoretic mobility shift assays to investigate LANA1 binding to its 20-bp cognate sequence. Mutations at...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.24.14033-14038.2004
更新日期:2004-12-01 00:00:00