Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:The pluripotent cytokine tumor necrosis factor alpha (TNF-alpha) binds to its cognate TNF receptor I (TNF-RI) to stimulate inflammation via activation of the NF-kappaB transcription factor. To prevent the detrimental effects of TNF-alpha in keratinocytes infected with the molluscum contagiosum virus (MCV), this poxvir...

journal_title：Journal of virology

authors： Nichols DB,Shisler JL

更新日期：2006-01-01 00:00:00

abstract：:It has become evident that naturally occurring CD25(+) regulatory T cells (T(reg) cells) not only influence self-antigen specific immune response but also dampen foreign antigen specific immunity. This report extends our previous findings by demonstrating that immunity to certain herpes simplex virus (HSV) vaccines is...

journal_title：Journal of virology

authors： Toka FN,Suvas S,Rouse BT

更新日期：2004-12-01 00:00:00

abstract：:Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picornaviral polyprotein processing results in intermediate and mature products whic...

journal_title：Journal of virology

authors： Probst C,Jecht M,Gauss-Müller V

更新日期：1998-10-01 00:00:00

abstract：:To study the variability of human immunodeficiency virus type 1 (HIV-1), we used immunotoxins to select for variants within a population of H9 cells persistently infected with a molecular clone of HIV-1 designated NL4-3. Chimeric immunotoxin CD4-PE40 (a chimeric fusion protein consisting of the amino-terminal two doma...

journal_title：Journal of virology

authors： Fang H,Pincus SH

更新日期：1995-01-01 00:00:00

abstract：:Two strains of minute virus of mice (MVM) show different host cell specificities. The prototype strain MVM(p) grows in fibroblasts, whereas the immunosuppressive variant MVM(i) grows in T lymphocytes. In this study, we have mapped on the viral genome a cell type-specific determinant: it is located between 69 and 85 ma...

journal_title：Journal of virology

authors： Antonietti JP,Sahli R,Beard P,Hirt B

更新日期：1988-02-01 00:00:00

abstract：:Measles virus has two glycoproteins. The larger glycoprotein (HA) is composed of 76,000-dalton subunits that are bound by disulfide bonds. The smaller glycoprotein (F) appears to contain a glucosamine-rich portion that is linked to an unglycosylated protein by disulfide bonds. ...

journal_title：Journal of virology

authors： Hardwick JM,Bussell RH

更新日期：1978-02-01 00:00:00

abstract：:We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules. We show that SQLs do not interfere with virus entry. In fact, concentrations of up to 20 times t...

journal_title：Journal of virology

authors： Bonnenfant S,Thomas CM,Vita C,Subra F,Deprez E,Zouhiri F,Desmaële D,D'Angelo J,Mouscadet JF,Leh H

更新日期：2004-06-01 00:00:00

abstract：:We have previously shown that delivery of the porcine type I interferon gene (poIFN-α/β) with a replication-defective human adenovirus vector (adenovirus 5 [Ad5]) can sterilely protect swine challenged with foot-and-mouth disease virus (FMDV) 1 day later. However, the need of relatively high doses of Ad5 limits the ap...

journal_title：Journal of virology

authors： Diaz-San Segundo F,Dias CC,Moraes MP,Weiss M,Perez-Martin E,Owens G,Custer M,Kamrud K,de los Santos T,Grubman MJ

更新日期：2013-05-01 00:00:00

abstract：:SE21Q1b, a Rous sarcoma virus mutant which packages cellular rather than viral RNA, is competent for infection of quail cells and can transmit defective transforming retrovirus genes. Stably transformed recipient clones have been obtained by using this mutant. ...

journal_title：Journal of virology

authors： Linial M

更新日期：1981-04-01 00:00:00

abstract：:Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

journal_title：Journal of virology

authors： Hersperger AR,Siciliano NA,Eisenlohr LC

更新日期：2012-07-01 00:00:00

abstract：:In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show t...

journal_title：Journal of virology

authors： Demogines A,Farzan M,Sawyer SL

更新日期：2012-06-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) gag polyprotein is processed by the viral protease to yield the structural proteins of the virus. One of these structural proteins, p15, and its protease cleavage products, p7 and p6, are believed to be responsible for the viral RNA binding which is prerequisite for assembly of i...

journal_title：Journal of virology

authors： Sheng N,Erickson-Viitanen S

更新日期：1994-10-01 00:00:00

abstract：:During lytic infection, the genome of herpes simplex virus 1 (HSV-1) is associated with limited levels of histones but does not form a regular repeating nucleosomal structure. However, the previous observation that chromatin remodeling factors are recruited into viral replication compartments indicates that chromatin ...

journal_title：Journal of virology

authors： Cliffe AR,Knipe DM

更新日期：2008-12-01 00:00:00

abstract：:Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquitinates p53, targetin...

journal_title：Journal of virology

authors： Zhang Z,Evers DL,McCarville JF,Dantonel JC,Huong SM,Huang ES

更新日期：2006-04-01 00:00:00

abstract：:The relative contribution of measles virus hemagglutinin (H)- or fusion protein (F)-specific antibodies to virus neutralization (VN) has not been demonstrated. We have depleted these specific antibodies from sera collected from young adults, who had been vaccinated during childhood, by prolonged incubation with viable...

journal_title：Journal of virology

authors： de Swart RL,Yüksel S,Osterhaus AD

更新日期：2005-09-01 00:00:00

abstract：:The role of the 5' nontranslated region in the replication of hepatitis A virus (HAV) was studied by analyzing the translation and replication of chimeric RNAs containing the encephalomyocarditis virus (EMCV) internal ribosome entry segment (IRES) and various lengths (237, 151, or 98 nucleotides [nt]) of the 5'-termin...

journal_title：Journal of virology

authors： Jia XY,Tesar M,Summers DF,Ehrenfeld E

更新日期：1996-05-01 00:00:00

abstract：:Koala retrovirus (KoRV) is of an interest to virologists due to its currently active endogenization into the koala (Phascolarctos cinereus) genome. Although KoRV has frequently been isolated in wild and captive koala populations, its pathogenesis and transmission remain to be fully characterized, and most previous res...

journal_title：Journal of virology

authors： Hashem MA,Maetani F,Kayesh MEH,Eiei T,Mochizuki K,Ito A,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-05-18 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluor...

journal_title：Journal of virology

authors： González-Magaldi M,Postigo R,de la Torre BG,Vieira YA,Rodríguez-Pulido M,López-Viñas E,Gómez-Puertas P,Andreu D,Kremer L,Rosas MF,Sobrino F

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:Microtubule transport of circovirus from the periphery of the cell to the nucleus is essential for viral replication in early infection. How the microtubule is recruited to the viral cargo remains unclear. In this study, we observed that circovirus trafficking is dependent on microtubule polymerization and t...

journal_title：Journal of virology

authors： Cao J,Lin C,Wang H,Wang L,Zhou N,Jin Y,Liao M,Zhou J

更新日期：2015-03-01 00:00:00

abstract：:Intercellular adhesion molecule 1 (ICAM-1) mediates binding and entry of major group human rhinoviruses (HRVs). Whereas the entry pathway of minor group HRVs has been studied in detail and is comparatively well understood, the pathway taken by major group HRVs is largely unknown. Use of immunofluorescence microscopy, ...

journal_title：Journal of virology

authors： Khan AG,Pickl-Herk A,Gajdzik L,Marlovits TC,Fuchs R,Blaas D

更新日期：2010-04-01 00:00:00

abstract：:We used virus assay and in situ hybridization with a cloned fragment of the murine cytomegalovirus (MCMV) genome to study MCMV infection of circulating leukocytes harvested from 3-week-old BALB/c, C57BL/6, and C3H mice infected with MCMV intraperitoneally. Infectious virus or MCMV DNA was detected in leukocytes on day...

journal_title：Journal of virology

authors： Bale JF Jr,O'Neil ME

更新日期：1989-06-01 00:00:00

abstract：:In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...

journal_title：Journal of virology

authors： Cuppels DA,Van Etten JL,Burbank DE,Lane LC,Vidaver AK

更新日期：1980-07-01 00:00:00

abstract：:We characterized a number of important features of the structure of the cohesive overlap region of the DNA genome of duck hepatitis B virus. The 5'-terminal nucleotide of minus-strand DNA was localized to nucleotide 2537, a G residue within the 12-base repeat sequence DR1. This G residue was shown to be the site of a ...

journal_title：Journal of virology

authors： Lien JM,Petcu DJ,Aldrich CE,Mason WS

更新日期：1987-12-01 00:00:00

abstract：:The immune response to bovine herpesvirus 1 (BHV-1) infection can protect cattle from subsequent challenge with the virus. This protection involves a variety of defensive strategies, and the activation of most of these defenses requires the recognition of viral proteins by the cellular immune system. To identify some ...

journal_title：Journal of virology

authors： Hutchings DL,van Drunen Littel-van den Hurk S,Babiuk LA

更新日期：1990-10-01 00:00:00

abstract：:We previously described a monoclonal antibody (Y8-10C2) that binds influenza virus hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8-10C2 binds to the globular domain of HA and found evidence that its epitope is located at the interface of adjacent subunits. We further showed t...

journal_title：Journal of virology

authors： Yewdell JW,Taylor A,Yellen A,Caton A,Gerhard W,Bächi T

更新日期：1993-02-01 00:00:00

abstract：:SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 antagonism occurred ...

journal_title：Journal of virology

authors： Trautz B,Pierini V,Wombacher R,Stolp B,Chase AJ,Pizzato M,Fackler OT

更新日期：2016-11-14 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear import of viral nucleic acids occurs in the absence of cell division. A number of viral factors that are present in HIV-1 preintegration complexes (PICs) have been assigned functions in nuclear import, including a...

journal_title：Journal of virology

authors： Dvorin JD,Bell P,Maul GG,Yamashita M,Emerman M,Malim MH

更新日期：2002-12-01 00:00:00

abstract：:A member of the family Circoviridae, porcine circovirus type 2 (PCV2), is associated with postweaning multisystemic wasting syndrome (PMWS), a recent emerging disease worldwide. PCV2 is also found in clinically asymptomatic animals. This paradoxical finding makes the syndrome etiology challenging. We developed new ass...

journal_title：Journal of virology

authors： Khaiseb S,Sydler T,Zimmermann D,Pospischil A,Sidler X,Brugnera E

更新日期：2011-11-01 00:00:00

abstract：:UR2 is a newly characterized avian sarcoma virus whose genome contains a unique sequence that is not related to the sequences of other avian sarcoma virus transforming genes thus far identified. This unique sequence, termed ros, is fused to part of the viral gag gene. The product of the fused gag-ros gene of UR2 is a ...

journal_title：Journal of virology

authors： Feldman RA,Wang LH,Hanafusa H,Balduzzi PC

更新日期：1982-04-01 00:00:00