Transfer of defective avian tumor virus genomes by a Rous sarcoma virus RNA packaging mutant.

abstract：:The adaptive immune system generates CD8 cytotoxic T lymphocytes (CTLs) as a major component of the protective response against viruses. Knowledge regarding the nature of the peptide sequences presented by HLA class I molecules and recognized by CTLs is thus important for understanding host-pathogen interactions. In t...

journal_title：Journal of virology

authors： Varela-Calvino R,Skowera A,Arif S,Peakman M

更新日期：2004-12-01 00:00:00

abstract：:NS5A of the hepatitis C virus (HCV) is a highly phosphorylated protein involved in resistance against interferon and required most likely for replication of the viral genome. Phosphorylation of this protein is mediated by a cellular kinase(s) generating multiple proteins with different electrophoretic mobilities. In t...

journal_title：Journal of virology

authors： Koch JO,Bartenschlager R

更新日期：1999-09-01 00:00:00

abstract：:The E3 complex transcription unit of adenovirus encodes four major mRNAs (a, c, f, and h) and two minor (d and e) mRNAs with overlapping exons, alternative splice sites, and two polyadenylation sites, termed E3A (upstream) and E3B (downstream). mRNAs a and d use the E3A polyadenylation site, and mRNAs c, e, f, and h u...

journal_title：Journal of virology

authors： Brady HA,Scaria A,Wold WS

更新日期：1992-10-01 00:00:00

abstract：:Murine leukemia viruses isolated from radiation-induced BALB/c leukemias were characterized with respect to viral proteins and RNA. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the viral structural proteins revealed that for p12, p15, p30, and gp70, three of four electrophoretic variants of...

journal_title：Journal of virology

authors： Ellis RW,Hopkins N,Fleissner E

更新日期：1980-02-01 00:00:00

abstract：:Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensit...

journal_title：Journal of virology

authors： Vigant F,Hollmann A,Lee J,Santos NC,Jung ME,Lee B

更新日期：2014-02-01 00:00:00

abstract：:In herpes simplex virus type 2, the mRNAs of ICP4 and ICP22/47 are divergently transcribed and their transcription initiation sites are separated by 750 base pairs (L. J. Whitton and J. B. Clements, Nucleic Acids Res. 12:2061-2078, 1984). This 750-base-pair region contains many recognized cis-acting elements, includin...

journal_title：Journal of virology

authors： Smith CA,Marchetti ME,Edmonson P,Schaffer PA

更新日期：1989-05-01 00:00:00

abstract：:The replication of the simian herpesvirus SA8 in Vero cells was examined. The time course of replication of the simian herpesvirus SA8 was found to be similar to that of the herpes simplex viruses. Infectious progeny virions were first detectable by 6 h postinfection and were readily released into the extracellular fl...

journal_title：Journal of virology

authors： Eberle R,Hilliard JK

更新日期：1984-05-01 00:00:00

abstract：:Influenza virus defective interfering (DI) particles are naturally occurring noninfectious virions typically generated during in vitro serial passages in cell culture of the virus at a high multiplicity of infection. DI particles are recognized for the role they play in inhibiting viral replication and for the impact ...

journal_title：Journal of virology

authors： Saira K,Lin X,DePasse JV,Halpin R,Twaddle A,Stockwell T,Angus B,Cozzi-Lepri A,Delfino M,Dugan V,Dwyer DE,Freiberg M,Horban A,Losso M,Lynfield R,Wentworth DN,Holmes EC,Davey R,Wentworth DE,Ghedin E,INSIGHT FLU002 S

更新日期：2013-07-01 00:00:00

abstract：UNLABELLED:Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing mumps cases. However, rece...

journal_title：Journal of virology

authors： Pickar A,Xu P,Elson A,Li Z,Zengel J,He B

更新日期：2014-04-01 00:00:00

abstract：:Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses that contained the three structural protein gene...

journal_title：Journal of virology

authors： Kawano H,Rostapshov V,Rosen L,Lai CJ

更新日期：1993-11-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed for the maintenance of MCC cells is still missing. ...

journal_title：Journal of virology

authors： Houben R,Shuda M,Weinkam R,Schrama D,Feng H,Chang Y,Moore PS,Becker JC

更新日期：2010-07-01 00:00:00

abstract：:Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present in blood following intrarectal SIV inoculation provided evidence for selective amplification of a subset of viruses ...

journal_title：Journal of virology

authors： Trivedi P,Horejsh D,Hinds SB,Hinds PW II,Wu MS,Salvato MS,Pauza CD

更新日期：1996-10-01 00:00:00

abstract：:Retroelements are important evolutionary forces but can be deleterious if left uncontrolled. Members of the human APOBEC3 family of cytidine deaminases can inhibit a wide range of endogenous, as well as exogenous, retroelements. These enzymes are structurally organized in one or two domains comprising a zinc-coordinat...

journal_title：Journal of virology

authors： Bulliard Y,Turelli P,Röhrig UF,Zoete V,Mangeat B,Michielin O,Trono D

更新日期：2009-12-01 00:00:00

abstract：:The sheep genome harbors approximately 20 endogenous retroviruses (enJSRVs) highly related to the exogenous Jaagsiekte sheep retrovirus (JSRV). One of the enJSRV loci, enJS56A1, acts as a unique restriction factor by blocking JSRV in a transdominant fashion at a late stage of the retroviral cycle. To better understand...

journal_title：Journal of virology

authors： Murcia PR,Arnaud F,Palmarini M

更新日期：2007-02-01 00:00:00

abstract：:Circulating leukocytes are important in dissemination of cytomegalovirus (CMV) infection in humans. In the mouse model of murine CMV infection (MCMV), it has been shown that infection peaks on days 5 to 7 after experimental infection, when 0.01 to 0.1% of the circulating leukocytes contain viral DNA. In our laboratory...

journal_title：Journal of virology

authors： Collins TM,Quirk MR,Jordan MC

更新日期：1994-10-01 00:00:00

abstract：:Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against papillomavirus, a double-stranded DNA virus. By analogy, we reason that polyamid...

journal_title：Journal of virology

authors： Gumpper RH,Li W,Castañeda CH,Scuderi MJ,Bashkin JK,Luo M

更新日期：2018-03-28 00:00:00

abstract：:Herpes simplex virus VP22 is a major tegument protein of unknown function. Very recently, we reported that the predominant effect of deleting the VP22 gene was on the expression, localization, and virion incorporation of ICP0. In addition, the Delta22 virus replicated poorly in epithelial MDBK cells. We have also prev...

journal_title：Journal of virology

authors： Potel C,Elliott G

更新日期：2005-11-01 00:00:00

abstract：:A cloned segment of the polyoma virus genome encoding the small T antigen has been fused, in the correct phase for translation, to the 5' end of the beta-galactosidase gene. The hybrid gene, cloned in Escherichia coli, produces a protein resembling the small T antigen. ...

journal_title：Journal of virology

authors： Horwich A,Koop AH,Eckhart W

更新日期：1980-10-01 00:00:00

abstract：:Mutations at amino acids 143, 148, and 155 in HIV-1 integrase (IN) define primary resistance pathways in subjects failing raltegravir (RAL)-containing treatments. Although each pathway appears to be genetically distinct, shifts in the predominant resistant virus population have been reported under continued drug press...

journal_title：Journal of virology

authors： Fransen S,Gupta S,Frantzell A,Petropoulos CJ,Huang W

更新日期：2012-07-01 00:00:00

abstract：:Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis. We find that necroptosis requires sensing of the genomic RNA within incoming virus particles via cytoplasmic RNA sensors to produce t...

journal_title：Journal of virology

authors： Berger AK,Hiller BE,Thete D,Snyder AJ,Perez E Jr,Upton JW,Danthi P

更新日期：2017-02-28 00:00:00

abstract：:A single phosphorylation event at T-antigen residue Thr124 regulates initiation of simian virus 40 DNA replication. To explore this regulatory process, a series of peptides were synthesized, centered on Thr124. These peptides contain a nuclear localization signal (NLS) and a recognition site for cyclin/Cdk kinases. Wh...

journal_title：Journal of virology

authors： Kim RJ,Moine S,Reese DK,Bullock PA

更新日期：2002-12-01 00:00:00

abstract：:Distinct functional CD8+ T-cell populations have been observed during human immunodeficiency virus (HIV) infection. One of these functions is the inhibition of viral replication by a noncytotoxic mechanism, which was shown to be mediated by the CD8+CD28+ subpopulation. On the other hand, CD8+ T cells exert an HIV-spec...

journal_title：Journal of virology

authors： Fiorentino S,Dalod M,Olive D,Guillet JG,Gomard E

更新日期：1996-03-01 00:00:00

abstract：:Influenza virus particles bind rapidly to vesicular stomatitis, Sindbis, or Rauscher murine leukemia virus particles, forming mixed aggregates demonstrable by electron microscopy. The normal hemagglutinating property of influenza virus is inhibited by these viruses, providing a rapid quantitative assay. Prior treatmen...

journal_title：Journal of virology

authors： Compans RW

更新日期：1974-11-01 00:00:00

abstract：UNLABELLED:The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 pl...

journal_title：Journal of virology

authors： Pattabhi S,Wilkins CR,Dong R,Knoll ML,Posakony J,Kaiser S,Mire CE,Wang ML,Ireton RC,Geisbert TW,Bedard KM,Iadonato SP,Loo YM,Gale M Jr

更新日期：2015-12-16 00:00:00

abstract：:The full repertoire of hepatitis B virus (HBV) peptides that bind to the common HLA class I molecules found in areas with a high prevalence of chronic HBV infection has not been determined. This information may be useful for designing immunotherapies for chronic hepatitis B. We identified amino acid residues under pos...

journal_title：Journal of virology

authors： Abbott WG,Tsai P,Leung E,Trevarton A,Ofanoa M,Hornell J,Gane EJ,Munn SR,Rodrigo AG

更新日期：2010-01-01 00:00:00

abstract：:The capsid mRNA transcripts of human bocavirus 1 (HBoV1) can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the alternative translation regulation mechanism of capsid mRNA transcripts is largely unknown. Here we report that the polycistronic capsid mRNA transcri...

journal_title：Journal of virology

authors： Liu X,Hao S,Chen Z,Xu H,Wang H,Huang M,Guan W

更新日期：2018-10-12 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) efficiently enters cells of Old World monkeys but encounters a block before reverse transcription. This restriction is mediated by a dominant repressive factor. Recently, a member of the tripartite motif (TRIM) family proteins, TRIM5alpha, was identified as a blocking factor...

journal_title：Journal of virology

authors： Nakayama EE,Miyoshi H,Nagai Y,Shioda T

更新日期：2005-07-01 00:00:00

abstract：:We are exploring the use of interferon (IFN) genes for somatic cell gene therapy and have investigated the possibility of transforming cells into low constitutive IFN producers over prolonged periods of time without impeding cell survival or replication. Here we report the possibility of conferring a permanent antivir...

journal_title：Journal of virology

authors： Seif I,De Maeyer E,Riviere I,De Maeyer-Guignard J

更新日期：1991-02-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00