Abstract:
:Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.
journal_name
J Viroljournal_title
Journal of virologyauthors
Vigant F,Hollmann A,Lee J,Santos NC,Jung ME,Lee Bdoi
10.1128/JVI.02907-13subject
Has Abstractpub_date
2014-02-01 00:00:00pages
1849-53issue
3eissn
0022-538Xissn
1098-5514pii
JVI.02907-13journal_volume
88pub_type
杂志文章abstract::The genome of influenza A virus consists of eight single-strand negative-sense RNA segments, each comprised of a coding region and a noncoding region. The noncoding region of the NS segment is thought to provide the signal for packaging; however, we recently showed that the coding regions located at both ends of the h...
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更新日期:2017-07-12 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.31.2.277-280.1979
更新日期:1979-08-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01296-10
更新日期:2010-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1980-11-01 00:00:00