Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses.

abstract：:Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...

journal_title：Journal of virology

authors： Bostik P,Wu P,Dodd GL,Villinger F,Mayne AE,Bostik V,Grimm BD,Robinson D,Kung HJ,Ansari AA

更新日期：2001-12-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important infectious disease agent of pigs worldwide, causing reproductive failure in pregnant sows and respiratory problems in nursing and growing pigs. PRRSV infection is characterized by a prolonged viremia of 30 or more days and an extended pe...

journal_title：Journal of virology

authors： Xiao Z,Batista L,Dee S,Halbur P,Murtaugh MP

更新日期：2004-06-01 00:00:00

abstract：:The immune response to bovine herpesvirus 1 (BHV-1) infection can protect cattle from subsequent challenge with the virus. This protection involves a variety of defensive strategies, and the activation of most of these defenses requires the recognition of viral proteins by the cellular immune system. To identify some ...

journal_title：Journal of virology

authors： Hutchings DL,van Drunen Littel-van den Hurk S,Babiuk LA

更新日期：1990-10-01 00:00:00

abstract：:Aichi virus, a member of the family Picornaviridae, encodes a leader (L) protein of 170 amino acids (aa). The Aichi virus L protein exhibits no significant sequence homology to those of other picornaviruses. In this study, we investigated the function of the Aichi virus L protein in virus growth. In vitro translation ...

journal_title：Journal of virology

authors： Sasaki J,Nagashima S,Taniguchi K

更新日期：2003-10-01 00:00:00

abstract：:Integrated retroviruses or retroviral vectors may be transcriptionally inactive although their promoter-enhancer regions are able to direct transcription in the host cell. We have used single-gene retroviral vectors with a long terminal repeat-directed neo marker gene to determine if the level of transcription relates...

journal_title：Journal of virology

authors： Duch M,Paludan K,Jørgensen P,Pedersen FS

更新日期：1994-09-01 00:00:00

abstract：:To facilitate the determination of the genomic location of the vaccinia virus gene(s) encoding alpha-amanitin resistance (alpha r) (Villarreal et al., J. Virol. 51:359-366, 1984), a collection of alpha r, temperature-sensitive (ts) mutants were isolated. The premise of these experiments was that mutants might be found...

journal_title：Journal of virology

authors： Villarreal EC,Hruby DE

更新日期：1986-01-01 00:00:00

abstract：:Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that which is required for reverse transcription. Human immunodefic...

journal_title：Journal of virology

authors： Hofmann H,Logue EC,Bloch N,Daddacha W,Polsky SB,Schultz ML,Kim B,Landau NR

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:Molluscum contagiosum virus (MOCV), the only circulating human-specific poxvirus, has a worldwide distribution and causes benign skin lesions that may persist for months in young children and severe infections in immunosuppressed adults. Studies of MOCV are restricted by the lack of an efficient animal model...

journal_title：Journal of virology

authors： Mendez-Rios JD,Yang Z,Erlandson KJ,Cohen JI,Martens CA,Bruno DP,Porcella SF,Moss B

更新日期：2016-04-14 00:00:00

abstract：:We report the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (Daubentonia madagascariensis), a strepsirrhine primate from Madagascar. Phylogenetic analyses indicate that PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy vir...

journal_title：Journal of virology

authors： Han GZ,Worobey M

更新日期：2012-07-01 00:00:00

abstract：:Polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. Thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-strand...

journal_title：Journal of virology

authors： Rodger SM,Schnagl RD,Holmes IH

更新日期：1975-11-01 00:00:00

abstract：:We previously reported that the adenovirus type 5 E3 14.5-kilodalton protein (14.5K) forms a complex with E3 10.4K and that both proteins are required to down-regulate the epidermal growth factor receptor in adenovirus-infected human cells. Both proteins are also required to prevent cytolysis by tumor necrosis factor ...

journal_title：Journal of virology

authors： Krajcsi P,Tollefson AE,Anderson CW,Wold WS

更新日期：1992-03-01 00:00:00

abstract：:The phosphoprotein (P) of the nonsegmented negative-sense RNA viruses is a multimeric modular protein that is essential for RNA transcription and replication. Despite great variability in length and sequence, the architecture of this protein is conserved among the different viral families, with a long N-terminal intri...

journal_title：Journal of virology

authors： Gérard FCA,Jamin M,Blackledge M,Blondel D,Bourhis JM

更新日期：2020-02-28 00:00:00

abstract：:In this report, we describe the isolation, molecular genetic mapping, and phenotypic characterization of vaccinia virus mutants resistant to cytosine arabinoside (araC) and phosphonoacetic acid (PAA). At 37 degrees C, 8 microM araC was found to prevent macroscopic plaque formation by wild-type virus and to cause a 10(...

journal_title：Journal of virology

authors： Taddie JA,Traktman P

更新日期：1993-07-01 00:00:00

abstract：:Herpesviruses are capable of several types of infection of a host cell. To investigate the early events which ultimately determine the nature of the virus-host cell interaction, a system was established utilizing temperature-sensitive mutants of herpes simplex virus type 2. Four mutants have been isolated which fail t...

journal_title：Journal of virology

authors： Koment RW,Rapp F

更新日期：1975-04-01 00:00:00

abstract：:Several lines of evidence suggest that various cofactors may be required for prion replication. PrP binds to polyanions, and RNAs were shown to promote the conversion of PrP(C) into PrP(Sc) in vitro. In the present study, we investigated strain-specific differences in RNA requirement during in vitro conversion and the...

journal_title：Journal of virology

authors： Saá P,Sferrazza GF,Ottenberg G,Oelschlegel AM,Dorsey K,Lasmézas CI

更新日期：2012-10-01 00:00:00

abstract：:Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...

journal_title：Journal of virology

authors： Wan XF,Ferguson L,Oliva J,Rubrum A,Eckard L,Zhang X,Woolums AR,Lion A,Meyer G,Murakami S,Ma W,Horimoto T,Webby R,Ducatez MF,Epperson W

更新日期：2020-08-31 00:00:00

abstract：:We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. ...

journal_title：Journal of virology

authors： Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C

更新日期：2013-12-01 00:00:00

abstract：:Positional homologs to the UL51 open reading frame of herpes simplex virus type 1 have been identified throughout the herpesvirus family. However, no respective protein has so far been described for any of the herpesviruses. With rabbit antisera directed against oligopeptides predicted to comprise antigenic regions of...

journal_title：Journal of virology

authors： Lenk M,Visser N,Mettenleiter TC

更新日期：1997-07-01 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (pRb) can associate with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded by polyomavirus (Py T Ag). Although pRb function is critical for regulating progression from G1 to S phase, a role for pRb in S phase has not been demonstra...

journal_title：Journal of virology

authors： Reynisdóttir I,Bhattacharyya S,Zhang D,Prives C

更新日期：1999-04-01 00:00:00

abstract：:Although hepatitis A virus (HAV) is typically transmitted by the fecal-oral route, little is known of its interactions with cells of the gastrointestinal tract. We studied the replication of HAV in polarized cultures of Caco-2 cells, a human cell line which retains many differentiated functions of small intestinal epi...

journal_title：Journal of virology

authors： Blank CA,Anderson DA,Beard M,Lemon SM

更新日期：2000-07-01 00:00:00

abstract：:A rapid assay for retroviral reverse transcriptase activity released into the culture medium by infected cells was developed. With the assay, 4,000 clonally infected cell lines could be tested in a few hours. We have adapted the assay for use as a screen for the detection of spontaneous viral mutants. Mutants of Molon...

journal_title：Journal of virology

authors： Goff S,Traktman P,Baltimore D

更新日期：1981-04-01 00:00:00

abstract：:The T-helper cell response to the internal proteins of rabies virus was investigated. The rabies virus nucleoprotein was shown to be a major target antigen for T-helper cells that cross-react between rabies and rabies-related viruses. T-helper cells were assayed in vitro by testing virus-induced lymphocytes for lympho...

journal_title：Journal of virology

authors： Ertl HC,Dietzschold B,Gore M,Otvos L Jr,Larson JK,Wunner WH,Koprowski H

更新日期：1989-07-01 00:00:00

abstract：:We have characterized an inhibitory RNA element in the human immunodeficiency virus type 1 (HIV-1) gag coding sequence that prevents gag expression. The inhibition exerted by this element could be overcome by the presence of the Rev-responsive element in cis and of Rev protein in trans. To understand the mechanism of ...

journal_title：Journal of virology

authors： Schwartz S,Campbell M,Nasioulas G,Harrison J,Felber BK,Pavlakis GN

更新日期：1992-12-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not a...

journal_title：Journal of virology

authors： Stanway G,Hughes PJ,Westrop GD,Evans DM,Dunn G,Minor PD,Schild GC,Almond JW

更新日期：1986-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous human pathogen associated with Burkitt's lymphoma and nasopharyngeal carcinoma. Although the EBV genome harbors more than a hundred genes, a full transcription map with EBV polyadenylation profiles remains unknown. To elucidate the 3' ends of all EBV transcripts genome-wide, we...

journal_title：Journal of virology

authors： Majerciak V,Yang W,Zheng J,Zhu J,Zheng ZM

更新日期：2019-01-04 00:00:00

abstract：:The limited efficiency of in vivo gene transfer by replication-deficient retroviral vectors remains an obstacle to achieving effective gene therapy for solid tumors. One approach to circumvent this problem is the use of replication-competent retroviral vectors. However, the application of such vectors is at a comparat...

journal_title：Journal of virology

authors： Paar M,Schwab S,Rosenfellner D,Salmons B,Günzburg WH,Renner M,Portsmouth D

更新日期：2007-07-01 00:00:00

abstract：:H9N2 influenza viruses are panzootic in domestic poultry in Eurasia and since 1999 have caused transient infections in humans and pigs. To investigate the zoonotic potential of H9N2 viruses, we studied the evolution of the viruses in live-poultry markets in Hong Kong in 2003. H9N2 was the most prevalent influenza viru...

journal_title：Journal of virology

authors： Choi YK,Ozaki H,Webby RJ,Webster RG,Peiris JS,Poon L,Butt C,Leung YH,Guan Y

更新日期：2004-08-01 00:00:00

abstract：UNLABELLED:The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the HIV-1 membrane and induce its disruption and/or deformation during the process. Howeve...

journal_title：Journal of virology

authors： Apellániz B,Rujas E,Carravilla P,Requejo-Isidro J,Huarte N,Domene C,Nieva JL

更新日期：2014-11-01 00:00:00

abstract：:Envelope glycoprotein (Env) reactivity (ER) describes the propensity of human immunodeficiency virus type 1 (HIV-1) Env to change conformation from the metastable unliganded state in response to the binding of ligands (antibodies and soluble CD4 [sCD4]) or incubation in the cold. To investigate Env properties that fav...

journal_title：Journal of virology

authors： McGee K,Haim H,Korioth-Schmitz B,Espy N,Javanbakht H,Letvin N,Sodroski J

更新日期：2014-01-01 00:00:00