Induction of rabies virus-specific T-helper cells by synthetic peptides that carry dominant T-helper cell epitopes of the viral ribonucleoprotein.

abstract：:The small envelope protein of hepatitis B virus is the major component of the viral coat and is also secreted from cells as a 20-nm subviral particle, even in the absence of other viral proteins. Such empty envelope particles are composed of approximately 100 copies of this polypeptide and host-derived lipids and are ...

journal_title：Journal of virology

authors： Mangold CM,Streeck RE

更新日期：1993-08-01 00:00:00

abstract：:Marburg virus, a filovirus, causes severe hemorrhagic fever with hitherto poorly understood molecular pathogenesis. We have investigated here the vectorial transport of the surface protein GP of Marburg virus in polarized epithelial cells. To this end, we established an MDCKII cell line that was able to express GP per...

journal_title：Journal of virology

authors： Sänger C,Mühlberger E,Ryabchikova E,Kolesnikova L,Klenk HD,Becker S

更新日期：2001-02-01 00:00:00

abstract：:The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J. ...

journal_title：Journal of virology

authors： He J,Choe S,Walker R,Di Marzio P,Morgan DO,Landau NR

更新日期：1995-11-01 00:00:00

abstract：:ZEBRA is an Epstein-Barr virus (EBV) transcriptional activator that mediates a genetic switch between the latent and lytic states of the virus by binding to the promoters of genes involved in lytic DNA replication and activating their transcription. A computer survey revealed that 9 of 23 potential or known ZEBRA-resp...

journal_title：Journal of virology

authors： Carey M,Kolman J,Katz DA,Gradoville L,Barberis L,Miller G

更新日期：1992-08-01 00:00:00

abstract：:Most current diagnostic tests for transmissible spongiform encephalopathies (TSE) rely on the presence of proteinase K (PK)-resistant PrP(Sc) (PrP-res) in postmortem tissues as an indication of TSE disease. However, a number of studies have highlighted a discrepancy between TSE infectivity and PrP-res levels in both n...

journal_title：Journal of virology

authors： Dobie K,Barron R

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:The live attenuated measles virus vaccine is highly immunostimulatory. Identification and characterization of its components that activate the innate immune response might provide new strategies and agents for the rational design and development of chemically defined adjuvants. In this study, we report on th...

journal_title：Journal of virology

authors： Ho TH,Kew C,Lui PY,Chan CP,Satoh T,Akira S,Jin DY,Kok KH

更新日期：2015-11-25 00:00:00

abstract：:Using less stringent hybridization conditions and cloned viral DNA probes representing the avian sarcoma virus gag, pol, env, and long terminal repeat (LTR) gene sequences, we detected related sequences in two avian species purportedly lacking all endogenous avian leukosis viruses, the ev- chicken and the Japanese qua...

journal_title：Journal of virology

authors： Dunwiddie CT,Resnick R,Boyce-Jacino M,Alegre JN,Faras AJ

更新日期：1986-09-01 00:00:00

abstract：:A more complete assessment of ovine prion strain diversity will be achieved by complementing biological strain typing in conventional and ovine PrP transgenic mice with a biochemical analysis of the resultant PrPSc. This will provide a correlation between ovine prion strain phenotype and the molecular nature of differ...

journal_title：Journal of virology

authors： Thackray AM,Hopkins L,Spiropoulos J,Bujdoso R

更新日期：2008-11-01 00:00:00

abstract：:The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to human cells through the interaction of E2 with the tetraspanin CD81, a putative viral receptor component. We have analyzed four different E2 protei...

journal_title：Journal of virology

authors： Roccasecca R,Ansuini H,Vitelli A,Meola A,Scarselli E,Acali S,Pezzanera M,Ercole BB,McKeating J,Yagnik A,Lahm A,Tramontano A,Cortese R,Nicosia A

更新日期：2003-02-01 00:00:00

abstract：UNLABELLED:Enteroviruses (EVs) are a genetically and antigenically diverse group of viruses infecting humans. A mostly distinct set of EV variants have additionally been documented to infect wild apes and several, primarily captive, Old World monkey (OWM) species. To investigate the prevalence and genetic characteristi...

journal_title：Journal of virology

authors： Van Nguyen D,Harvala H,Ngole EM,Delaporte E,Woolhouse ME,Peeters M,Simmonds P

更新日期：2014-06-01 00:00:00

abstract：:Recent studies have established the presence of human T-cell lymphoma/leukemia virus type I (HTLV-I) in Melanesia. An HTLV-I strain, PNG-1, has now been isolated from a healthy member of the Hagahai, a remote, recently contacted group in Papua New Guinea. To further characterize PNG-1, we employed polymerase chain rea...

journal_title：Journal of virology

authors： Sherman MP,Saksena NK,Dube DK,Yanagihara R,Poiesz BJ

更新日期：1992-04-01 00:00:00

abstract：:The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel vi...

journal_title：Journal of virology

authors： Loh J,Zhao G,Presti RM,Holtz LR,Finkbeiner SR,Droit L,Villasana Z,Todd C,Pipas JM,Calgua B,Girones R,Wang D,Virgin HW

更新日期：2009-12-01 00:00:00

abstract：:ICP4 is a herpesvirus-encoded protein that is expressed during the immediate-early phase of productive infection and is required for efficient transcription of viral genes during the early and late phases of infection. Previous studies have shown that ICP4 is a component of specific protein-DNA complexes but have not ...

journal_title：Journal of virology

authors： Kattar-Cooley P,Wilcox KW

更新日期：1989-02-01 00:00:00

abstract：:Antibody-dependent enhancement of flavivirus infection, which except for dengue virus is without clear proof in vivo, is still under debate. Recently, postexposure immunoglobulin prophylaxis against tick-borne encephalitis virus, a flavivirus, was claimed to possibly have worsened the outcome of infection due to antib...

journal_title：Journal of virology

authors： Kreil TR,Eibl MM

更新日期：1997-04-01 00:00:00

abstract：:During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT...

journal_title：Journal of virology

authors： Watson ZL,Washington SD,Phelan DM,Lewin AS,Tuli SS,Schultz GS,Neumann DM,Bloom DC

更新日期：2018-07-31 00:00:00

abstract：:Lysyl-tRNA synthetase (LysRS) is packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag, and this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1. The Gag/LysRS interaction is detected at detergent-resistant membran...

journal_title：Journal of virology

authors： Halwani R,Cen S,Javanbakht H,Saadatmand J,Kim S,Shiba K,Kleiman L

更新日期：2004-07-01 00:00:00

abstract：:Efforts to induce broadly reactive immunity against human immunodeficiency virus type 1 (HIV-1) have been impaired by the extent of sequence variation exhibited by this lentivirus. Cytotoxic T lymphocytes (CTL) specific for other viruses such as influenza virus have been shown to mediate immunity against divergent vir...

journal_title：Journal of virology

authors： Johnson RP,Hammond SA,Trocha A,Siliciano RF,Walker BD

更新日期：1994-05-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) has been shown to progress through a number of changes that lead to the emergence of pathogenic viral variants in macaques initially infected with a mildly cytopathic variant, SIVMneCL8. One of these late-stage isolates, SIVMne170, replicates to high levels in vivo and causes a rapi...

journal_title：Journal of virology

authors： Voronin Y,Overbaugh J,Emerman M

更新日期：2005-12-01 00:00:00

abstract：:Temperature-sensitive (ts) mutants of the T4 phage rII gene were islated and used in temperature shift experiments that revelaed two different expressions for the normal rII (rII+) gene function in vivo: (i) an early expression (0 to 12 min postinfection at 30 C) that prevents restriction of T4 growth in Escherichia c...

journal_title：Journal of virology

authors： Heere LJ,Karam JD

更新日期：1975-10-01 00:00:00

abstract：:Vaccinia virus, the basis of the smallpox vaccine, is one of the largest viruses to replicate in humans. We have used in situ atomic force microscopy (AFM) to directly visualize fully hydrated, intact intracellular mature vaccinia virus (IMV) virions and chemical and enzymatic treatment products thereof. The latter in...

journal_title：Journal of virology

authors： Malkin AJ,McPherson A,Gershon PD

更新日期：2003-06-01 00:00:00

abstract：:Multispecific CD8(+) T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of responses at early time points. Additionally, the influence of early therapy on these responses and their relationships to...

journal_title：Journal of virology

authors： Lauer GM,Lucas M,Timm J,Ouchi K,Kim AY,Day CL,Schulze Zur Wiesch J,Paranhos-Baccala G,Sheridan I,Casson DR,Reiser M,Gandhi RT,Li B,Allen TM,Chung RT,Klenerman P,Walker BD

更新日期：2005-10-01 00:00:00

abstract：:Normal levels of the hypermodified pyrimidine, alpha-putrescinylthymine, which is formed from hydhydroxymethyluracil at the polynucleotide level (Maltman et al., J. Virol. 34:354-359, 1984), are not required in bacteriophage luminal diameterW-14 DNA for the DNA to serve as a replicative template in luminal diameterW-1...

journal_title：Journal of virology

authors： Miller PB,Warren RA

更新日期：1984-12-01 00:00:00

abstract：:The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming abilit...

journal_title：Journal of virology

authors： Gazdar AF,Russell E,Sarma PS,Sarin PS,Hall W,Chopra HC

更新日期：1973-10-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：:H5N1 highly pathogenic avian influenza virus (HPAIV) has continued to spread and poses a significant threat to both animal and human health. Current influenza vaccine strategies have limitations that prevent their effective use for widespread inoculation of animals in the field. Vaccine strains of Newcastle disease vi...

journal_title：Journal of virology

authors： Ge J,Deng G,Wen Z,Tian G,Wang Y,Shi J,Wang X,Li Y,Hu S,Jiang Y,Yang C,Yu K,Bu Z,Chen H

更新日期：2007-01-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several neoplastic diseases: Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV replicates actively, via a controlled gene expression program, but can also remain latent. It had been thought that the transition...

journal_title：Journal of virology

authors： Prasad A,Lu M,Lukac DM,Zeichner SL

更新日期：2012-04-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF b...

journal_title：Journal of virology

authors： Shuh M,Derse D

更新日期：2000-12-01 00:00:00

abstract：:The transmission bottleneck is defined as the number of viral particles that transmit from one host to establish an infection in another. Genome sequence data have been used to evaluate the size of the transmission bottleneck between humans infected with the influenza virus; however, the methods used to make these est...

journal_title：Journal of virology

authors： Ghafari M,Lumby CK,Weissman DB,Illingworth CJR

更新日期：2020-06-16 00:00:00

abstract：:Immediate-early viral gene products of human cytomegalovirus (HCMV) are derived from several genomic loci and largely serve to establish a cellular environment conducive to viral replication. We have further examined an unusual immediate-early transcript known as the 5-kb RNA, concluding that it is a stable intron enc...

journal_title：Journal of virology

authors： Kulesza CA,Shenk T

更新日期：2004-12-01 00:00:00

abstract：:The simian picornaviruses were isolated from various primate tissues during the development of general tissue culture methods in the 1950s to 1970s or from specimens derived from primates used in biomedical research. Twenty simian picornavirus serotypes are recognized, and all are presently classified within the Enter...

journal_title：Journal of virology

authors： Oberste MS,Maher K,Pallansch MA

更新日期：2002-02-01 00:00:00