Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4.

abstract：:The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55(Gag) polyprotein. This rearrangement is thought to facilitate the establishment of specific CA-CA interactions that are required for the formation ...

journal_title：Journal of virology

authors： Rue SM,Roos JW,Amzel LM,Clements JE,Barber SA

更新日期：2003-07-01 00:00:00

abstract：:9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) is more potent and has a more prolonged inhibitory effect against Epstein-Barr virus (EBV) in vitro than does acyclovir (ACV). To assess the mechanism of this difference, we first compared the extent of phosphorylation of the two drugs in superinfected Ra...

journal_title：Journal of virology

authors： Lin JC,Nelson DJ,Lambe CU,Choi EI

更新日期：1986-11-01 00:00:00

abstract：:Little is known about the transmission or tropism of the newly discovered human retrovirus, human T-cell lymphotropic virus type 3 (HTLV-3). Here, we examine the entry requirements of HTLV-3 using independently expressed Env proteins. We observed that HTLV-3 surface glycoprotein (SU) binds efficiently to both activate...

journal_title：Journal of virology

authors： Jones KS,Huang YK,Chevalier SA,Afonso PV,Petrow-Sadowski C,Bertolette DC,Gessain A,Ruscetti FW,Mahieux R

更新日期：2009-05-01 00:00:00

abstract：:Skin fibroblast cultures were established from eight individuals. These cell cultures, together with WI-38 cells, were examined for susceptibility to transformation by SV40 virus. Four transformation-susceptible cell lines (TS), established from patients with Down's syndrome, were found to be three to four times more ...

journal_title：Journal of virology

authors： Potter CW,Potter AM,Oxford JS

更新日期：1970-03-01 00:00:00

abstract：:TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 ...

journal_title：Journal of virology

authors： Maggi F,Pistello M,Vatteroni M,Presciuttini S,Marchi S,Isola P,Fornai C,Fagnani S,Andreoli E,Antonelli G,Bendinelli M

更新日期：2001-12-01 00:00:00

abstract：UNLABELLED:Gammaherpesviruses establish persistent, systemic infections and cause cancers. Murid herpesvirus 4 (MuHV-4) provides a unique window into the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), whic...

journal_title：Journal of virology

authors： Lawler C,Tan CS,Simas JP,Stevenson PG

更新日期：2016-09-29 00:00:00

abstract：:The envelope protein E of flaviviruses mediates both receptor-binding and membrane fusion. At the virion surface, 180 copies of E are tightly packed and organized in a herringbone-like icosahedral structure, whereas in noninfectious subviral particles, 60 copies are arranged in a T=1 icosahedral symmetry. In both case...

journal_title：Journal of virology

authors： Kiermayr S,Stiasny K,Heinz FX

更新日期：2009-09-01 00:00:00

abstract：:The antibiotic tunicamycin, which blocks the synthesis of glycoproteins, inhibited the production of infectious herpes simplex virus. In the presence of this drug, [14C]glucosamine and [3H]mannose incorporation was reduced in infected cells, whereas total protein synthesis was not affected. Gel electrophoresis of [2-3...

journal_title：Journal of virology

authors： Pizer LI,Cohen GH,Eisenberg RJ

更新日期：1980-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) protease (PR) makes five obligatory cleavages in the viral Gag polyprotein precursor. The cleavage events release the virion structural proteins from the precursor and allow the virion to undergo maturation to become infectious. The protease cleavage between the matrix p...

journal_title：Journal of virology

authors： Lee SK,Harris J,Swanstrom R

更新日期：2009-09-01 00:00:00

abstract：:The simian virus 40 (SV40) core origin of replication consists of three functional domains. The sequence 5'-CACTACTTCTGGAATAG-3' with an imperfect inverted repeat (underlined), a palindrome with four 5'-GAGGC-3' pentanucleotide repeats, and a 17-base-pair A + T-rich segment. We have been able to assign primary functio...

journal_title：Journal of virology

authors： Parsons R,Anderson ME,Tegtmeyer P

更新日期：1990-02-01 00:00:00

abstract：:The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now repor...

journal_title：Journal of virology

authors： Jung JU,Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:In December 2016, a low-pathogenic avian influenza (LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in the states of New York and Pennsylvania. One person with occupational exposure to infected cats became in...

journal_title：Journal of virology

authors： Belser JA,Pulit-Penaloza JA,Sun X,Brock N,Pappas C,Creager HM,Zeng H,Tumpey TM,Maines TR

更新日期：2017-07-12 00:00:00

abstract：:T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici...

journal_title：Journal of virology

authors： Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

更新日期：1999-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacte...

journal_title：Journal of virology

authors： Madden CR,Finegold MJ,Slagle BL

更新日期：2002-11-01 00:00:00

abstract：:Immunogenic regions of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) were previously mapped by examining polyclonal sera from HIV-infected patients and rodent polyclonal and monoclonal antibodies (MAbs) to peptides of gp41. To define the epitopes within these regions to which infected h...

journal_title：Journal of virology

authors： Xu JY,Gorny MK,Palker T,Karwowska S,Zolla-Pazner S

更新日期：1991-09-01 00:00:00

abstract：:The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation in the reverse transcriptase (RT) gene are frequently found in viral isolates from patients treated with the nucleoside ...

journal_title：Journal of virology

authors： Diallo K,Marchand B,Wei X,Cellai L,Götte M,Wainberg MA

更新日期：2003-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) is one of five viral nuclear proteins that are essential for EBV-induced immortalization of primary human B lymphocytes in vitro. Previous studies have implied that EBNA-3C acts as a transcription factor. Using transient transfection assays, we demonstrate that EBN...

journal_title：Journal of virology

authors： Marshall D,Sample C

更新日期：1995-06-01 00:00:00

abstract：:Newcastle disease virus (NDV) California strain reportedly grows poorly in L cells but replicates very well in chicken embryo cells. NDV-infected L cell cultures show a characteristic virus growth curve with respect to uridine incorporation, but plaque assays of the virus produced 24 h postinfection (PI) show no infec...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1974-07-01 00:00:00

abstract：:Tomato bushy stunt virus (TBSV), a tombusvirus with a nonsegmented, plus-stranded RNA genome, codes for two essential replicase proteins. The sequence of one of the replicase proteins, namely p33, overlaps with the N-terminal domain of p92, which contains the signature motifs of RNA-dependent RNA polymerases (RdRps) i...

journal_title：Journal of virology

authors： Rajendran KS,Nagy PD

更新日期：2003-09-01 00:00:00

abstract：:Adenovirus genomes consist of linear DNA molecules containing inverted terminal repeat sequences (ITRs) of 100 to 200 base pairs. The importance of identical termini for viability of adenoviruses was investigated. The viral strains used in this study were wild-type adenovirus type 5 (Ad5) and a variant Ad2 strain with...

journal_title：Journal of virology

authors： Lippé R,Graham FL

更新日期：1989-12-01 00:00:00

abstract：:Open reading frame P (ORF P), located at the 3' terminus of the 8.5-kb DNA sequence transcribed during latency and almost completely antisense to the gamma(1)34.5 gene, is naturally repressed by infected cell protein 4 (ICP4), the major herpes simplex virus 1 regulatory protein. Earlier studies on cells infected with ...

journal_title：Journal of virology

authors： Randall G,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:The large-particle fraction from the cytoplasm of chick embryo fibroblasts infected with Semliki Forest virus was found to catalyze the incorporation of the 5'-triphosphates of guanosine, adenine, cytidine, and uridine into an acid-insoluble alkali-labile product. The conditions affecting the preparation and assay of ...

journal_title：Journal of virology

authors： Martin EM,Sonnabend JA

更新日期：1967-02-01 00:00:00

abstract：:Vpu is a 16-kDa membrane-associated phosphoprotein that is expressed from the same, singly spliced message as the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor, gp160. Previous studies suggest that Vpu functions in the late stages of viral replication, possibly in virus egression from the...

journal_title：Journal of virology

authors： Geraghty RJ,Panganiban AT

更新日期：1993-07-01 00:00:00

abstract：:A host-mediated RNA-editing event allows hepatitis delta virus (HDV) to express two essential proteins, the small delta antigen (HDAg-S) and the large delta antigen (HDAg-L), from a single open reading frame. One or several members of the ADAR (adenosine deaminases that act on RNA) family are thought to convert the ad...

journal_title：Journal of virology

authors： Sato S,Wong SK,Lazinski DW

更新日期：2001-09-01 00:00:00

abstract：:Infection of macaque monkeys with simian immunodeficiency virus (SIV) is probably the best animal model currently available for studying acquired immunodeficiency syndrome. In this report, we describe three infectious molecular clones of SIVmac and one of human immunodeficiency virus type 2 (HIV-2) and their use in th...

journal_title：Journal of virology

authors： Naidu YM,Kestler HW 3rd,Li Y,Butler CV,Silva DP,Schmidt DK,Troup CD,Sehgal PK,Sonigo P,Daniel MD

更新日期：1988-12-01 00:00:00

abstract：UNLABELLED:Triggering the amoebal phagocytosis process is a sine qua non condition for most giant viruses to initiate their replication cycle and consequently to promote their progeny formation. It is well known that the amoebal phagocytosis process requires the recognition of particles of >500 nm, and most amoebal gia...

journal_title：Journal of virology

authors： Arantes TS,Rodrigues RA,Dos Santos Silva LK,Oliveira GP,de Souza HL,Khalil JY,de Oliveira DB,Torres AA,da Silva LL,Colson P,Kroon EG,da Fonseca FG,Bonjardim CA,La Scola B,Abrahão JS

更新日期：2016-05-12 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:Mutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples...

journal_title：Journal of virology

authors： Muñoz de Rueda P,Casado J,Patón R,Quintero D,Palacios A,Gila A,Quiles R,León J,Ruiz-Extremera A,Salmerón J

更新日期：2008-07-01 00:00:00

abstract：:Understanding how viral components collaborate to convert the human immunodeficiency virus type 1 genome from single-stranded RNA into double-stranded DNA is critical to the understanding of viral replication. Not only must the correct reactions be carried out, but unwanted side reactions must be avoided. After minus-...

journal_title：Journal of virology

authors： Driscoll MD,Hughes SH

更新日期：2000-10-01 00:00:00