Comparison of transformation and T antigen induction in human cell lines.

abstract：:Deletion of the terminal repeats (TR) from herpesvirus saimiri (HVS) renders it unable to produce infectious virus or generate plaques. However, a TR-deleted HVS bacterial artificial chromosome can form replication compartments. Complementation of this mutant shows that one copy of the TR, plus the right junction of t...

journal_title：Journal of virology

authors： White RE,Carline L,Allday MJ

更新日期：2007-06-01 00:00:00

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:Rhesus monkey rhadinovirus (RRV) is a close relative of Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8). RRV serves as an in vitro and an in vivo model for KSHV, and the mapping of its transcription program during lytic replication is significant since it represents de novo infection in the absence...

journal_title：Journal of virology

authors： DeWire SM,McVoy MA,Damania B

更新日期：2002-10-01 00:00:00

abstract：:Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced an...

journal_title：Journal of virology

authors： Emini EA,Hughes JV,Perlow DS,Boger J

更新日期：1985-09-01 00:00:00

abstract：:Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses. There are two ZAP isoforms arising from alternative splicing, which differ only at the C termini. It was recently reported that the long isoform (ZAPL) promotes proteasomal degradation of influenza A vir...

journal_title：Journal of virology

authors： Tang Q,Wang X,Gao G

更新日期：2017-01-03 00:00:00

abstract：:The double-stranded-DNA bacteriophages employ powerful molecular motors to translocate genomic DNA into preformed capsids during the packaging step in phage assembly. Bacillus subtilis bacteriophage 29 has an oligomeric prohead RNA (pRNA) that is an essential component of its packaging motor. The crystal structure of ...

journal_title：Journal of virology

authors： Zhao W,Saha M,Ke A,Morais MC,Jardine PJ,Grimes S

更新日期：2012-11-01 00:00:00

abstract：:Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing immunity, but in most cases do not confer protection against divergent viruses. In this report we demonstrate that a mul...

journal_title：Journal of virology

authors： Voss G,Manson K,Montefiori D,Watkins DI,Heeney J,Wyand M,Cohen J,Bruck C

更新日期：2003-01-01 00:00:00

abstract：:The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivators which mediate the switch from latent to lytic replication in EBV-infected cells. DNA viruses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus replication. Here we have examined the ef...

journal_title：Journal of virology

authors： Swenson JJ,Mauser AE,Kaufmann WK,Kenney SC

更新日期：1999-08-01 00:00:00

abstract：:We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) WJ-1 strain, isolated from Muscovy ducks. This is the first complete genome sequence of DTMUV reported in southern China. Compared with the other strains (TA, GH-2, YY5, and ZJ-407) that were previously found in eastern China, WJ-1 bears a ...

journal_title：Journal of virology

authors： Zhu W,Chen J,Wei C,Wang H,Huang Z,Zhang M,Tang F,Xie J,Liang H,Zhang G,Su S

更新日期：2012-12-01 00:00:00

abstract：:Unintegrated linear and closed circular DNAs of B- and N-tropic endogenous BALB/c murine leukemia virus (MuLV) were extracted from newly infected mouse cells and cleaved with EcoRI, XhoI, PvuI, HindIII, SalI, XbaI, KpnI, SmaI, and PstI restriction endonucleases. The DNA fragments were separated by electrophoresis and ...

journal_title：Journal of virology

authors： Rassart E,Jolicoeur P

更新日期：1980-09-01 00:00:00

abstract：:Although picornavirus RNA genomes contain a 3'-terminal poly(A) tract that is critical for their replication, the impact of encephalomyocarditis virus (EMCV) infection on the host poly(A)-binding protein (PABP) remains unknown. Here, we establish that EMCV infection stimulates site-specific PABP proteolysis, resulting...

journal_title：Journal of virology

authors： Kobayashi M,Arias C,Garabedian A,Palmenberg AC,Mohr I

更新日期：2012-10-01 00:00:00

abstract：:Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) binds complement component C3b and protects virus from complement-mediated neutralization. Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 fr...

journal_title：Journal of virology

authors： Hook LM,Lubinski JM,Jiang M,Pangburn MK,Friedman HM

更新日期：2006-04-01 00:00:00

abstract：:The small envelope protein (E) plays a role of central importance in the assembly of coronaviruses. This was initially established by studies demonstrating that cellular expression of only E protein and the membrane protein (M) was necessary and sufficient for the generation and release of virus-like particles. To inv...

journal_title：Journal of virology

authors： Kuo L,Hurst KR,Masters PS

更新日期：2007-03-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：:While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectiveness of RNA silencing. As a result, most plant genes involved in antiviral silencing were identified by using debilitated viruses lacking silen...

journal_title：Journal of virology

authors： Zhang X,Zhang X,Singh J,Li D,Qu F

更新日期：2012-06-01 00:00:00

abstract：:In clinical trials, HIV-1 broadly neutralizing antibodies (bnAbs) effectively lower plasma viremia and delay virus reemergence. The presence of less neutralization-susceptible strains prior to treatment decreases the efficacy of these antibody-based treatments, but neutralization sensitivity often cannot be predicted ...

journal_title：Journal of virology

authors： Registre L,Moreau Y,Ataca ST,Pulukuri S,Henrich TJ,Lin N,Sagar M

更新日期：2020-01-06 00:00:00

abstract：:The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in pho...

journal_title：Journal of virology

authors： Dackiw AP,Zakrzewski K,Nathens AB,Cheung PY,Fingerote R,Levy GA,Rotstein OD

更新日期：1995-09-01 00:00:00

abstract：:The herpes simplex virus type 1 genome contains three origins of DNA replication: two copies of oriS and one copy of oriL. Although oriS has been characterized extensively, characterization of oriL has been severely limited by the inability to amplify oriL sequences in an undeleted form in Escherichia coli. We report ...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1995-03-01 00:00:00

abstract：:p21((WAF1/SDII/CIP1)) (p21) arrests cell growth by inhibiting cyclin-depend kinases. To explore the potential of using p21 for the gene therapy of cervical cancer, we infected human papillomavirus (HPV)-positive cervical cancer cells (HeLa, SiHa, and Z172) and HPV-negative cervical cancer cells (C33A) with recombinant...

journal_title：Journal of virology

authors： Tsao YP,Huang SJ,Chang JL,Hsieh JT,Pong RC,Chen SL

更新日期：1999-06-01 00:00:00

abstract：:The gene encoding glycoprotein B (gB) of murine cytomegalovirus (MCMV) strain Smith was identified, sequenced, and expressed by recombinant vaccinia virus. The gB gene was found adjacent to the polymerase gene, as it is in the genome of human cytomegalovirus (HCMV). The open reading frame consists of 2,784 nucleotides...

journal_title：Journal of virology

authors： Rapp M,Messerle M,Bühler B,Tannheimer M,Keil GM,Koszinowski UH

更新日期：1992-07-01 00:00:00

abstract：:Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,9...

journal_title：Journal of virology

authors： Pevenstein SR,Williams RK,McChesney D,Mont EK,Smialek JE,Straus SE

更新日期：1999-12-01 00:00:00

abstract：:The intracellular assembly of the transmissible gastroenteritis coronavirus (TGEV) was studied in infected swine testis (ST) cells at different postinfection times by using ultrathin sections of conventionally embedded infected cells, freeze-substitution, and methods for detecting viral proteins and RNA at the electro...

journal_title：Journal of virology

authors： Risco C,Muntión M,Enjuanes L,Carrascosa JL

更新日期：1998-05-01 00:00:00

abstract：:The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was present in the differentiated strata of several native squamous epithelia susceptible to HPV infection. I...

journal_title：Journal of virology

authors： Genovese NJ,Banerjee NS,Broker TR,Chow LT

更新日期：2008-05-01 00:00:00

abstract：:The hepatitis C virus (HCV) core protein is known to be a multifunctional protein, besides being a component of viral nucleocapsids. Previously, we have shown that the core protein binds to the cytoplasmic domain of lymphotoxin beta receptor, which is a member of tumor necrosis factor receptor (TNFR) family. In this s...

journal_title：Journal of virology

authors： Zhu N,Khoshnan A,Schneider R,Matsumoto M,Dennert G,Ware C,Lai MM

更新日期：1998-05-01 00:00:00

abstract：:The development of cancer vaccines requires approaches to induce expansion and functional differentiation of tumor antigen-specific cytotoxic T lymphocyte (CTL) effectors which posses cytolytic capability and produce cytokines. Efficient induction of such cells is hindered by the poor immunogenicity of tumor antigens ...

journal_title：Journal of virology

authors： Efferson CL,Schickli J,Ko BK,Kawano K,Mouzi S,Palese P,García-Sastre A,Ioannides CG

更新日期：2003-07-01 00:00:00

abstract：:The structural proteins of mature LPP-1 particles and the patterns of protein synthesis after LPP-1 infection have been examined by electrophoresis on sodium dodecyl sulfate polyacrylamide gels. Structural proteins account for 35% of the LPP-1 genome, and proteins that would require about 65% of the total coding capac...

journal_title：Journal of virology

authors： Sherman LA,Haselkorn R

更新日期：1970-12-01 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:T-even bacteriophages were grown and purified in bulk quantities. The protein coats were disrupted into their component substructures by treatment with 67% dimethyl sulfoxide (DMSO). Tail fibers and tubes were purified on glycerol-CsCl-D(2)O gradients and examined with respect to sedimentation properties, subunit mole...

journal_title：Journal of virology

authors： Cummings DJ,Kusy AR,Chapman VA,DeLong SS,Stone KR

更新日期：1970-10-01 00:00:00

abstract：:Poliovirus (PV) is easily transferred to humans orally; however, no rodent model for oral infections has been developed because of the alimentary tract's low sensitivity to the virus. Here we showed that PV is inactivated by the low pH of the gastric contents in mice. The addition of 3% NaHCO3 to the viral inoculum in...

journal_title：Journal of virology

authors： Ohka S,Igarashi H,Nagata N,Sakai M,Koike S,Nochi T,Kiyono H,Nomoto A

更新日期：2007-08-01 00:00:00

abstract：:A protamine-like protein named P6.9 is thought to play a role in the condensation of genomes of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) during an infection. Previous studies have shown that P6.9 is phosphorylated immediately upon synthesis and dephosphorylated upon the entry of th...

journal_title：Journal of virology

authors： Liu X,Zhao H,Fang Z,Yuan M,Yang K,Pang Y

更新日期：2012-11-01 00:00:00