Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

Abstract:

:We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. These findings indicate that both 2F9 and YS110 are potential therapeutic agents for MERS-CoV infection. YS110, in particular, is a good candidate for immediate testing as a therapeutic modality for MERS.

journal_name

J Virol

journal_title

Journal of virology

authors

Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C

doi

10.1128/JVI.02448-13

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

13892-9

issue

24

eissn

0022-538X

issn

1098-5514

pii

JVI.02448-13

journal_volume

87

pub_type

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