Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.


:We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. These findings indicate that both 2F9 and YS110 are potential therapeutic agents for MERS-CoV infection. YS110, in particular, is a good candidate for immediate testing as a therapeutic modality for MERS.


J Virol


Journal of virology


Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C




Has Abstract


2013-12-01 00:00:00














  • Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex.

    abstract::The nuclear egress complex (NEC) is required for efficient translocation of newly synthesized herpesvirus nucleocapsids from the nucleus to the cytosol. It consists of the type II membrane protein pUL34 which interacts with pUL31 at the inner nuclear membrane (INM). To map regions within pUL34 required for nuclear mem...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Paßvogel L,Trübe P,Schuster F,Klupp BG,Mettenleiter TC

    更新日期:2013-04-01 00:00:00

  • Proteins of the group B arbovirus Kunjin.

    abstract::Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Westaway EG,Reedman BM

    更新日期:1969-11-01 00:00:00

  • Four EBNA2 domains are important for EBNALP coactivation.

    abstract::EBNA2 transcriptional activation and regulated EBNALP coactivation are critical for Epstein-Barr virus-infected primary B-lymphocyte growth transformation. EBNALP coactivation requires the EBNA2 acidic activation domain (E2AD); EBNALP can bind to E2AD. EBNALP has now been found to bind less well to EBNA2 amino acids 1...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Peng CW,Zhao B,Kieff E

    更新日期:2004-10-01 00:00:00

  • Draft genome sequence of four coccolithoviruses: Emiliania huxleyi virus EhV-88, EhV-201, EhV-207, and EhV-208.

    abstract::The Coccolithoviridae are a group of viruses which infect the marine coccolithophorid microalga Emiliania huxleyi. The Emiliania huxleyi viruses (known as EhVs) described herein have 160- to 180-nm diameter icosahedral structures, have genomes of approximately 400 kbp, and consist of more than 450 predicted coding seq...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Nissimov JI,Worthy CA,Rooks P,Napier JA,Kimmance SA,Henn MR,Ogata H,Allen MJ

    更新日期:2012-03-01 00:00:00

  • Transient Oral Human Cytomegalovirus Infections Indicate Inefficient Viral Spread from Very Few Initially Infected Cells.

    abstract::Cytomegalovirus (CMV) is acquired by the oral route in children, and primary infection is associated with abundant mucosal replication, as well as the establishment of latency in myeloid cells that results in lifelong infection. The efficiency of primary CMV infection in humans following oral exposure, however, is unk...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Mayer BT,Krantz EM,Swan D,Ferrenberg J,Simmons K,Selke S,Huang ML,Casper C,Corey L,Wald A,Schiffer JT,Gantt S

    更新日期:2017-05-26 00:00:00

  • Bone marrow depletion by 89Sr complements a preleukemic defect in a long terminal repeat variant of Moloney murine leukemia virus.

    abstract::We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An en...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Li QX,Fan H

    更新日期:1991-08-01 00:00:00

  • PrPC Governs Susceptibility to Prion Strains in Bank Vole, While Other Host Factors Modulate Strain Features.

    abstract::Bank vole is a rodent species that shows differential susceptibility to the experimental transmission of different prion strains. In this work, the transmission features of a panel of diverse prions with distinct origins were assayed both in bank vole expressing methionine at codon 109 (Bv109M) and in transgenic mice ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Espinosa JC,Nonno R,Di Bari M,Aguilar-Calvo P,Pirisinu L,Fernández-Borges N,Vanni I,Vaccari G,Marín-Moreno A,Frassanito P,Lorenzo P,Agrimi U,Torres JM

    更新日期:2016-11-14 00:00:00

  • Organization of capsid-associated tegument components in Kaposi's sarcoma-associated herpesvirus.

    abstract:UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Dai X,Gong D,Wu TT,Sun R,Zhou ZH

    更新日期:2014-11-01 00:00:00

  • Transformation of T-lymphocyte subsets by Marek's disease herpesvirus.

    abstract::Marek's disease herpesvirus (MDV)-transformed lymphoblastoid tumor cell lines were characterized for the presence of the surface markers. Monoclonal antibodies were used for CD3 (T-cell receptor [TCR] complex), TCR1, TCR2, and TCR3, CD4, CD8, and Ia antigen by indirect fluorescence staining followed by microscopic exa...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Schat KA,Chen CL,Calnek BW,Char D

    更新日期:1991-03-01 00:00:00

  • Reinvestigating the role of IgM in rabies virus postexposure vaccination.

    abstract::B cells secreting IgG antibodies, but not IgM, are thought to be solely responsible for vaccine-induced protection against rabies virus (RABV) infections in postexposure settings. In this report, we reinvestigated the potential for IgM to mediate protection in a mouse model of RABV vaccination. Immunocompetent mice im...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Dorfmeier CL,Shen S,Tzvetkov EP,McGettigan JP

    更新日期:2013-08-01 00:00:00

  • Nucleotide sequence changes in polyoma virus A gene mutants.

    abstract::The mutational alterations in polyoma virus mutants ts-a and ts-25E which cause their large T-antigens to be thermolabile have been identified. In ts-a, a G leads to A transition at nucleotide 2193 causes the replacement of Ala (GCT) by Thr (ACT). In ts-25E, a G leads to T transversion at nucleotide 2883 causes the re...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Thomas T,Vollmer P,Folk WR

    更新日期:1981-03-01 00:00:00

  • Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro.

    abstract::Cyclosporine (CsA) and its derivatives potently suppress hepatitis C virus (HCV) replication. Recently, CsA-resistant HCV replicons have been identified in vitro. We examined the dependence of the wild-type and CsA-resistant replicons on various cyclophilins for replication. A strong correlation between CsA resistance...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yang F,Robotham JM,Nelson HB,Irsigler A,Kenworthy R,Tang H

    更新日期:2008-06-01 00:00:00

  • Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors

    abstract::Second-site revertants from replication-incompetent molecular clones of human immunodeficiency virus (HIV) contain base substitutions adjacent to the TATA motif. The altered TATA box motifs were analyzed for their effect(s) on virus infectivity, long terminal repeat (LTR)-directed expression in transient transfection ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kashanchi F,Shibata R,Ross EK,Brady JN,Martin MA

    更新日期:1994-05-01 00:00:00

  • Simian virus 40 gene A regulation of cellular DNA synthesis. II. In nonpermissive cells.

    abstract::The stimulation of host macromolecular synthesis and induction into the cell cycle of serum-deprived G0-G1-arrested mouse embryo fibroblasts were examined after infection of resting cells with wild-type simian virus 40 or with viral mutants affecting T antigen (tsA58) or small t antigen (dl884). At various times after...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Hiscott JB,Defendi V

    更新日期:1981-02-01 00:00:00

  • A Novel A(H7N2) Influenza Virus Isolated from a Veterinarian Caring for Cats in a New York City Animal Shelter Causes Mild Disease and Transmits Poorly in the Ferret Model.

    abstract::In December 2016, a low-pathogenic avian influenza (LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in the states of New York and Pennsylvania. One person with occupational exposure to infected cats became in...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Belser JA,Pulit-Penaloza JA,Sun X,Brock N,Pappas C,Creager HM,Zeng H,Tumpey TM,Maines TR

    更新日期:2017-07-12 00:00:00

  • A wild-type porcine encephalomyocarditis virus containing a short poly(C) tract is pathogenic to mice, pigs, and cynomolgus macaques.

    abstract::Previous studies using wild-type Encephalomyocarditis virus (EMCV) and Mengo virus, which have long poly(C) tracts (61 to 146 C's) at the 5' nontranslated region of the genome, and variants of these viruses genetically engineered to truncate or substitute the poly(C) tracts have produced conflicting data on the role o...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: LaRue R,Myers S,Brewer L,Shaw DP,Brown C,Seal BS,Njenga MK

    更新日期:2003-09-01 00:00:00

  • Cytomegalovirus encodes a positive regulator of antigen presentation.

    abstract::Murine cytomegalovirus encodes three regulators of antigen presentation to antiviral CD8 T cells. According to current paradigms, all three regulators are committed to the inhibition of the presentation of antigenic peptides. Whereas m152/gp40 catalyzes the retention of peptide-loaded major histocompatibility complex ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Holtappels R,Gillert-Marien D,Thomas D,Podlech J,Deegen P,Herter S,Oehrlein-Karpi SA,Strand D,Wagner M,Reddehase MJ

    更新日期:2006-08-01 00:00:00

  • Genetic variation during lytic reovirus infection: high-passage stocks of wild-type reovirus contain temperature-sensitive mutants.

    abstract::Wild-type clones of reovirus serotypes 1 (Lang), 2 (Jones), and 3 (Dearing) were serially passaged in L cells at a high multiplicity of infection, and the virus population was examined at passage levels 2, 5, and 11 for the presence of temperature-sensitive (ts) mutants. By passage 11 all three serotypes contained ts ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ahmed R,Chakraborty PR,Fields BN

    更新日期:1980-04-01 00:00:00

  • Prasinoviruses of the marine green alga Ostreococcus tauri are mainly species specific.

    abstract::Prasinoviruses infecting unicellular green algae in the order Mamiellales (class Mamiellophyceae) are commonly found in coastal marine waters where their host species frequently abound. We tested 40 Ostreococcus tauri viruses on 13 independently isolated wild-type O. tauri strains, 4 wild-type O. lucimarinus strains, ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Clerissi C,Desdevises Y,Grimsley N

    更新日期:2012-04-01 00:00:00

  • Novel pathway for induction of latent virus from resting CD4(+) T cells in the simian immunodeficiency virus/macaque model of human immunodeficiency virus type 1 latency.

    abstract::Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in cellular reservoirs, particularly the latent reservoir in resting CD4(+) T lymphocytes. We previously established a simian i...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Shen A,Yang HC,Zhou Y,Chase AJ,Boyer JD,Zhang H,Margolick JB,Zink MC,Clements JE,Siliciano RF

    更新日期:2007-02-01 00:00:00

  • Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the region coding for the carboxyl terminus of the T antigen.

    abstract::Nucleotide sequence analysis of two simian virus 40 early mutants dl1263 and dl1265, which lack a DNA segment around map positions 0.21 and 0.18, respectively (C. Cole, T. Landers, S. Goff, S. MAnteuil-Brutlag, and P. Berg, J. Virol. 24:277--294, 1977), revealed in-phase deletions of 33 nucleotide pairs for dl1263 and...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Van Heuverswyn H,Cole C,Berg P,Fiers W

    更新日期:1979-06-01 00:00:00

  • Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation.

    abstract::Paramyxoviral RNAs are synthesized by a viral RNA-dependent RNA polymerase (RdRp) consisting of the large (L) protein and its cofactor phosphoprotein (P protein). The L protein is a multifunctional protein that catalyzes RNA synthesis, mRNA capping, and mRNA polyadenylation. Growing evidence shows that the stability o...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Katoh H,Kubota T,Nakatsu Y,Tahara M,Kidokoro M,Takeda M

    更新日期:2017-02-28 00:00:00

  • Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression.

    abstract::H2dl808 is a defective deletion mutant of human adenovirus 2 lacking most of transcriptional early region 4. Although the mutant can be grown in the complementing cell line W162, it is defective in human cell lines normally used to propagate adenovirus. In such nonpermissive cells, H2dl808 exhibits a severe defect in ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Weinberg DH,Ketner G

    更新日期:1986-03-01 00:00:00

  • Bacteriophage T4 virion dihydrofolate reductase: approaches to quantitation and assessment of function.

    abstract::This paper is concerned with the physiological role(s) of T4 phage-coded dihydrofolate reductase, which functions both in DNA precursor metabolism and as a virion protein. (i) We have detected enzyme activity in noninfectious particles produced under restrictive conditions by gene 11 mutants. This supports the conclus...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Mosher RA,DiRenzo AB,Mathews CK

    更新日期:1977-09-01 00:00:00

  • Peptide map comparison of the proteins of infectious bursal disease virus.

    abstract::The genome of infectious bursal disease virus consists of two segments of double-stranded RNA of 2.5 X 10(6) and 2.2 X 10(6) molecular weight. Polyacrylamide gel electrophoresis of purified virus resolved four structural polypeptides: VP-1 (90,000), VP-2 (41,000), VP-3 (35,000), and VP-4 (28,000). Peptide map comparis...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Dobos P

    更新日期:1979-12-01 00:00:00

  • Synthesis of potato virus X RNAs by membrane-containing extracts.

    abstract::Membrane-containing extracts isolated from tobacco plants infected with the plus-strand RNA virus, potato virus X (PVX), supported synthesis of four major, high-molecular-weight PVX RNA products (R1 to R4). Nuclease digestion and hybridization studies indicated that R1 and R2 are a mixture of partially single-stranded...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Doronin SV,Hemenway C

    更新日期:1996-07-01 00:00:00

  • Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells.

    abstract::Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of the aggressive and fatal disease adult T-cell leukemia. Previous studies have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p53 through a Tax-induced NF-kappaB pathway. Given these attributes, we were int...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Jung KJ,Dasgupta A,Huang K,Jeong SJ,Pise-Masison C,Gurova KV,Brady JN

    更新日期:2008-09-01 00:00:00

  • Intragenic complementation between temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4.

    abstract::Interallelic complementation between certain temperature-sensitive mutants of gene 42 of bacteriophage T4 was demonstrated by measuring the incorporation of labeled thymine into DNA. ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Chiu CS,Greenberg GR

    更新日期:1973-08-01 00:00:00

  • Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus.

    abstract::We previously showed that the 93-bp region between the enhancer and promoter (named DEN for downstream of enhancer) of the long terminal repeat (LTR) of the MCF13 murine leukemia virus is an important determinant of the ability of this virus to induce thymic lymphoma. In this study we observed that DEN plays a role in...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Yoshimura FK,Wang T,Cankovic M

    更新日期:1999-06-01 00:00:00

  • The polymerase-like core of brome mosaic virus 2a protein, lacking a region interacting with viral 1a protein in vitro, maintains activity and 1a selectivity in RNA replication.

    abstract::Brome mosaic virus (BMV), a member of the alphavirus-like super-family of positive-strand RNA viruses, encodes two proteins required for viral RNA replication: 1a and 2a. 1a contains m7G methyltransferase- and helicase-like domains, while 2a contains a polymerase (pol)-like core flanked by N- and C-terminal extensions...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Smirnyagina E,Lin NS,Ahlquist P

    更新日期:1996-07-01 00:00:00