Purification, identification, and biochemical characterization of a host-encoded cysteine protease that cleaves a leishmaniavirus gag-pol polyprotein.

abstract：:The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were o...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Röpcke G,Boot L

更新日期：1978-09-01 00:00:00

abstract：:Vectors derived from lentiviruses provide a promising gene delivery system. We examined the in vivo gene transfer efficiency and tissue or cell tropism of a feline immunodeficiency virus (FIV)-based lentiviral vector pseudotyped with the glycoproteins from Ross River Virus (RRV). RRV glycoproteins were efficiently inc...

journal_title：Journal of virology

authors： Kang Y,Stein CS,Heth JA,Sinn PL,Penisten AK,Staber PD,Ratliff KL,Shen H,Barker CK,Martins I,Sharkey CM,Sanders DA,McCray PB Jr,Davidson BL

更新日期：2002-09-01 00:00:00

abstract：:The trans-activator Tat proteins coded by human immunodeficiency virus type 1 (HIV-1) and HIV-2 appear to be similar in structure and function. However, the Tat protein of HIV-2 (Tat2) activates the HIV-1 long terminal repeat (LTR) less efficiently than Tat1 (M. Emerman, M. Guyader, L. Montagnier, D. Baltimore, and M....

journal_title：Journal of virology

authors： Elangovan B,Subramanian T,Chinnadurai G

更新日期：1992-04-01 00:00:00

abstract：:The varicella-zoster virus (VZV) open reading frame 54 (ORF54) gene encodes an 87-kDa monomer that oligomerizes to form the VZV portal protein, pORF54. pORF54 was hypothesized to perform a function similar to that of a previously described herpes simplex virus 1 (HSV-1) homolog, pUL6. pUL6 and the associated viral ter...

journal_title：Journal of virology

authors： Visalli MA,House BL,Selariu A,Zhu H,Visalli RJ

更新日期：2014-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) readily infects both humans and chimpanzees, but the pathologic outcomes of infection in these two species differ greatly. In attempts to identify virus-cell interactions that might account for this differential pathogenicity, chimpanzee peripheral blood lymphocytes and ...

journal_title：Journal of virology

authors： Watanabe M,Ringler DJ,Fultz PN,MacKey JJ,Boyson JE,Levine CG,Letvin NL

更新日期：1991-06-01 00:00:00

abstract：:Six phages were isolated from sewage and from a lysogenic strain. Three of them, belonging to a new morphological group, had contractile tails and elongated heads with axial ratios of 2.4:1. Two phages, possessing short tails and very long heads with axial ratios of 3.5:1, were new isolates of an extremely rare group....

journal_title：Journal of virology

authors： Ackermann HW,Petrow S,Kasatiya SS

更新日期：1974-03-01 00:00:00

abstract：:We previously demonstrated that chimeric porcine parvovirus-like particles (PPV:VLP) carrying heterologous epitopes, when injected intraperitoneally into mice without adjuvant, activate strong CD4(+) and CD8(+) T-cell responses specific for the foreign epitopes. In the present study, we investigated the immunogenicity...

journal_title：Journal of virology

authors： Sedlik C,Dridi A,Deriaud E,Saron MF,Rueda P,Sarraseca J,Casal JI,Leclerc C

更新日期：1999-04-01 00:00:00

abstract：:The great majority of viral mRNAs in mouse C127 cells transformed by bovine papillomavirus type 1 (BPV) have a common 3' end at the early polyadenylation site which is 23 nucleotides (nt) downstream of a canonical poly(A) consensus signal. Twenty percent of BPV mRNA from productively infected cells bypasses the early ...

journal_title：Journal of virology

authors： Andrews EM,DiMaio D

更新日期：1993-12-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:On the basis of the conservation of neuraminidase (N) active-site residues in influenza virus N and paramyxovirus hemagglutinin-neuraminidase (HN), it has been suggested that the three-dimensional (3D) structures of the globular heads of the two proteins are broadly similar. In this study, details of this structural s...

journal_title：Journal of virology

authors： Langedijk JP,Daus FJ,van Oirschot JT

更新日期：1997-08-01 00:00:00

abstract：:The small envelope protein (E) plays a role of central importance in the assembly of coronaviruses. This was initially established by studies demonstrating that cellular expression of only E protein and the membrane protein (M) was necessary and sufficient for the generation and release of virus-like particles. To inv...

journal_title：Journal of virology

authors： Kuo L,Hurst KR,Masters PS

更新日期：2007-03-01 00:00:00

abstract：UNLABELLED:The accessory gene vpr, common to all primate lentiviruses, induces potent G2/M arrest in cycling cells. A recent study showed that human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) mediates this through activation of the SLX4/MUS81/EME1 exonuclease complex that forms part of the Fanconi anem...

journal_title：Journal of virology

authors： Berger G,Lawrence M,Hué S,Neil SJ

更新日期：2015-01-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SI...

journal_title：Journal of virology

authors： Schmitz JE,Ma ZM,Hagan EA,Wilks AB,Furr KL,Linde CH,Zahn RC,Brenchley JM,Miller CJ,Permar SR

更新日期：2012-10-01 00:00:00

abstract：:Nonenveloped viral capsids are metastable structures that undergo conformational changes during virus entry that lead to interactions of the capsid or capsid fragments with the cell membrane. For members of the Caliciviridae, neither the nature of these structural changes in the capsid nor the factor(s) responsible fo...

journal_title：Journal of virology

authors： Ossiboff RJ,Zhou Y,Lightfoot PJ,Prasad BV,Parker JS

更新日期：2010-06-01 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

journal_title：Journal of virology

authors： Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

更新日期：2014-12-01 00:00:00

abstract：:Proteins located in the tegument layer of herpesvirus particles play important roles in the replicative cycle at both early and late times after infection. As major constituents of the virion, they execute important functions in particular during formation of progeny virions. These functions have mostly been elucidate...

journal_title：Journal of virology

authors： Michael K,Klupp BG,Mettenleiter TC,Karger A

更新日期：2006-02-01 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells have recently been used for identification of receptors for several alphaherpesviruses, including pseudorabies virus (PrV) (R. J. Geraghty, C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear, Science 280:1618-1620, 1998). The experiments were based on the fact that CHO cel...

journal_title：Journal of virology

authors： Nixdorf R,Schmidt J,Karger A,Mettenleiter TC

更新日期：1999-10-01 00:00:00

abstract：:The use of different viral promoters for the expression of the EBNA1 gene product appears to be a critical step in the regulation of Epstein-Barr virus latent gene expression and may reflect the extent of differentiation of B-cell hosts. Low-passage Burkitt lymphoma cell lines resemble immature B cells in that they ex...

journal_title：Journal of virology

authors： Taylor KA,Wetzel S,Lyles DS,Pollok BA

更新日期：1994-10-01 00:00:00

abstract：:The use of adenovirus vectors for human gene therapy is limited by potent inflammatory responses that result in significant morbidity. In kidney-derived epithelial cells (REC), activation of extracellular signal-regulated kinase 1/2 (ERK) and p38 kinase (p38) pathways occurred within 20 min of transduction with the se...

journal_title：Journal of virology

authors： Tibbles LA,Spurrell JC,Bowen GP,Liu Q,Lam M,Zaiss AK,Robbins SM,Hollenberg MD,Wickham TJ,Muruve DA

更新日期：2002-02-01 00:00:00

abstract：:We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1 DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infec...

journal_title：Journal of virology

authors： Cho MW,Shibata R,Martin MA

更新日期：1996-10-01 00:00:00

abstract：:CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by the CD95 (APO-1/Fas)...

journal_title：Journal of virology

authors： Ehret A,Westendorp MO,Herr I,Debatin KM,Heeney JL,Frank R,Krammer PH

更新日期：1996-09-01 00:00:00

abstract：:H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying H9N2 AIV transmission to mammals remains unclear. We isolated more than 900 H9N2 AIVs in our 3-year surveillance in live bird markets in China from 2009 to 2012. Thirty-seven representative isolates were selected for furthe...

journal_title：Journal of virology

authors： Teng Q,Xu D,Shen W,Liu Q,Rong G,Li X,Yan L,Yang J,Chen H,Yu H,Ma W,Li Z

更新日期：2016-10-14 00:00:00

abstract：:Using a recently developed model for in vitro generation of pp65-positive polymorphonuclear leukocytes (PMNLs), we demonstrated that PMNLs from immunocompetent subjects may harbor both infectious human cytomegalovirus (HCMV) and viral products (pp65, p72, DNA, and immediate-early [IE] and pp67 late mRNAs) as early as ...

journal_title：Journal of virology

authors： Gerna G,Percivalle E,Baldanti F,Sozzani S,Lanzarini P,Genini E,Lilleri D,Revello MG

更新日期：2000-06-01 00:00:00

abstract：:Deer mice are the principal reservoir hosts of Sin Nombre virus, the etiologic agent of most hantavirus cardiopulmonary syndrome cases in North America. Infection of deer mice results in persistence without conspicuous pathology, and most, if not all, infected mice remain infected for life, with periods of viral shedd...

journal_title：Journal of virology

authors： Schountz T,Acuña-Retamar M,Feinstein S,Prescott J,Torres-Perez F,Podell B,Peters S,Ye C,Black WC 4th,Hjelle B

更新日期：2012-09-01 00:00:00

abstract：:In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Defects in hematopoietic compartments, such as impaired B-cell maturation, or in stromal compartments, such as abrogation of follicular dendritic cells, can delay or prevent lymphoreticular prion colonization. However, the...

journal_title：Journal of virology

authors： Kaeser PS,Klein MA,Schwarz P,Aguzzi A

更新日期：2001-08-01 00:00:00

abstract：:The virus-encoded proteins of tobacco etch virus (TEV), a plant potyvirus, arise by proteolytic processing of a large polyprotein precursor. The TEV genome codes for two proteinases, a 49-kilodalton proteinase and helper component proteinase (HC-Pro), which cleave the polyprotein at specific sites. The only known clea...

journal_title：Journal of virology

authors： Carrington JC,Freed DD,Sanders TC

更新日期：1989-10-01 00:00:00

abstract：:The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1 (HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell line H9 selected on the basis of its high level of cell surface CD4 expression. Semiquantitative PCR analysis revealed that enzymatic removal ...

journal_title：Journal of virology

authors： Roderiquez G,Oravecz T,Yanagishita M,Bou-Habib DC,Mostowski H,Norcross MA

更新日期：1995-04-01 00:00:00

abstract：:The enhancer within the long terminal repeats (LTRs) of acquired somatic mouse mammary tumor viruses (MMTV) can activate juxtaposed genes and induce mammary tumors. In contrast, germ line proviral MMTV genomes are integrated in the host genome and considered to be genetically confined transcription units. Here we demo...

journal_title：Journal of virology

authors： Stegalkina SS,Guerrero A,Walton KD,Liu X,Robinson GW,Hennighausen L

更新日期：1999-10-01 00:00:00

abstract：:We have analyzed the structure of rubella virus proteins labeled metabolically with [35S]methionine, [3H]mannose, and [3H]glucosamine or externally with [3H]borohydride after galactose oxidase treatment. Four structural proteins, with MrS of about 58,000 (E1), 47,000 (E2a), 42,000 (E2b), and 33,000 (C), were resolved ...

journal_title：Journal of virology

authors： Oker-Blom C,Kalkkinen N,Kääriäinen L,Pettersson RF

更新日期：1983-06-01 00:00:00