Abstract:
:The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained. (i) Mammary tumors which appeared in C3H mice as a result of an infection with MTV contained more MTV DNA compared with noninfected organs; these mammary tumors also contained more MTV RNA than was present in lactating mammary gland cells. (ii) Hormonal stimulation by administration of excessive amounts of prolactin via hypophyseal isografts in C3Hf and O20 mice resulted in an increased expression of MTV RNA in the mammary glands. This elevated level of MTV RNA expression was, however, not maintained in the hormone-induced mammary tumors. (iii) Spontaneous mammary tumors in BALB/c mice contained similar levels of MTV DNA and MTV RNA sequences as were found in other cells of these animals.
journal_name
J Viroljournal_title
Journal of virologyauthors
Michalides R,van Deemter L,Nusse R,Röpcke G,Boot Ldoi
10.1128/JVI.27.3.551-559.1978subject
Has Abstractpub_date
1978-09-01 00:00:00pages
551-9issue
3eissn
0022-538Xissn
1098-5514journal_volume
27pub_type
杂志文章abstract::The U(L)17 protein (pU(L)17) of herpes simplex virus 1 (HSV-1) likely associates with the surfaces of DNA-containing capsids in a heterodimer with pU(L)25. pU(L)17 is also associated with viral light particles that lack capsid proteins, suggesting its presence in the tegument of the HSV-1 virion. To help determine how...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00277-10
更新日期:2010-08-01 00:00:00
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journal_title:Journal of virology
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doi:10.1128/JVI.02911-15
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.4442-4448.1991
更新日期:1991-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.6.3824-3830.1995
更新日期:1995-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02447-12
更新日期:2013-03-01 00:00:00
abstract::The HIV-1 spike is composed of three protomeric units, each containing a peripheral gp120 and a transmembrane gp41 subunit. Binding to the CD4 and the chemokine receptors triggers them to mediate virus entry into cells by membrane fusion. The spikes also represent the major target for neutralizing antibodies (Abs) aga...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00530-13
更新日期:2013-06-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.20.12979-12988.2005
更新日期:2005-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.3.621-626.1976
更新日期:1976-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.2.664-671.1991
更新日期:1991-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2017-09-12 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.3.3.290-296.1969
更新日期:1969-03-01 00:00:00
abstract::We have previously shown that expression of the adenovirus E1A 12S or 13S products in NIH 3T3 fibroblasts induces susceptibility to the cytotoxic actions of tumor necrosis factor alpha (TNF alpha). A large number of studies have mapped the multiple biological functions of the 12S and 13S products to three highly conse...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.9.4115-4122.1990
更新日期:1990-09-01 00:00:00
abstract::The identification of several simian immunodeficiency virus mac251 (SIV(mac251)) cytotoxic T-lymphocyte epitopes recognized by CD8(+) T cells of infected rhesus macaques carrying the Mamu-A*01 molecule and the use of peptide-major histocompatibility complex tetrameric complexes enable the study of the frequency, bread...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.23.11483-11495.2001
更新日期:2001-12-01 00:00:00
abstract::Recognition of virus infections by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation associated gene 5 (MDA5), activates signaling pathways, leading to the induction of inflammatory cytokines that limit viral replication. To d...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02008-08
更新日期:2009-01-01 00:00:00
abstract::Adeno-associated virus type 2 (AAV-2) gene expression is tightly controlled by functions of the helper virus as well as by the products of its own viral rep gene. Double-immunofluorescence studies of Rep and VP protein expression in cells coinfected with AAV-2 and adenovirus type 2 showed that a large proportion of th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.11.8437-8447.1997
更新日期:1997-11-01 00:00:00
abstract::A panel of seven monoclonal antibodies against the relatively conserved CD4-binding domain on human immunodeficiency virus type 1 (HIV-1) gp120 was generated by immunizing mice with purified gp120. These monoclonal antibodies reacted specifically with gp120 in an enzyme-linked immunosorbent assay and Western blots (im...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.9.3579-3585.1989
更新日期:1989-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01495-20
更新日期:2020-12-09 00:00:00
abstract::At a low pH, the influenza virus hemagglutinin (HA) undergoes conformational changes that promote membrane fusion. While the critical role of fusion peptide release from the trimer interface has been demonstrated previously, the role of globular head dissociation in the overall fusion mechanism remains unclear. To inv...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.8.4940-4950.1992
更新日期:1992-08-01 00:00:00