Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：:By using in situ hybridization, we localized three endogenous chicken retrovirus loci associated with the gs- chf- phenotype to distinct regions on chromosome 1. These three loci, ev4, ev5, and ev8, along with the two other known gs- chf--associated loci in White Leghorn chickens, ev1 and ev13, appear to be evenly dis...

journal_title：Journal of virology

authors： Tereba A,Astrin SM

更新日期：1982-08-01 00:00:00

abstract：:Accumulation of the interferon-stimulated gene 15 (ISG15) protein product, which is reversibly conjugated to numerous polypeptide targets, impacts the proteome and physiology of uninfected and infected cells. While many viruses, including human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expr...

journal_title：Journal of virology

authors： Bianco C,Mohr I

更新日期：2017-04-13 00:00:00

abstract：:The primary herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) promoter influences LAT expression and rates of virus reactivation. We explored the biological importance of particular neuronally responsive regions within the promoter by creating new recombinant viruses bearing a targeted deletion (...

journal_title：Journal of virology

authors： Wang K,Pesnicak L,Straus SE

更新日期：1997-10-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infects human cells by binding to surface CD4 molecules and directly fusing with the cell membrane. Although mouse cells expressing human CD4 bind HIV, they do not become infected, apparently because of a block in membrane fusion. To study this problem, we constructed a recombinant v...

journal_title：Journal of virology

authors： Ashorn PA,Berger EA,Moss B

更新日期：1990-05-01 00:00:00

abstract：:Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-speci...

journal_title：Journal of virology

authors： Maness NJ,Walsh AD,Piaskowski SM,Furlott J,Kolar HL,Bean AT,Wilson NA,Watkins DI

更新日期：2010-11-01 00:00:00

abstract：:The pandemic H1N1 virus of 2009 (2009 H1N1) continues to cause illness worldwide, primarily in younger age groups. To better understand the pathogenesis of these viruses in mammals, we used a mouse model to evaluate the relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple...

journal_title：Journal of virology

authors： Belser JA,Wadford DA,Pappas C,Gustin KM,Maines TR,Pearce MB,Zeng H,Swayne DE,Pantin-Jackwood M,Katz JM,Tumpey TM

更新日期：2010-05-01 00:00:00

abstract：:Picornaviruses are a family of positive-strand RNA viruses that are responsible for a variety of devastating human and animal diseases. An attenuated strain of mengovirus (vMC24) is serologically indistinguishable from the lethal murine wild-type mengovirus and encephalomyocarditis virus (EMCV). Immunogen-specific sti...

journal_title：Journal of virology

authors： Neal ZC,Splitter GA

更新日期：1995-08-01 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:The APOBEC3 (A3) enzymes, A3G and A3F, are coordinately expressed in CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of the viral infectivity factor (Vif). A3F and A3G are deoxycytidine deaminases that inhibit HIV-1 replication by inducing guanine-to-adenine hypermutation throug...

journal_title：Journal of virology

authors： Ara A,Love RP,Follack TB,Ahmed KA,Adolph MB,Chelico L

更新日期：2017-01-18 00:00:00

abstract：:The synthesis of viral RNA by wild-type vesicular stomatitis virus (L(1)VSV) and a small, plaque-size mutant (S(2)VSV) was studied in vitro and in chicken embryo (CE) and mouse L-cell cultures. Virus-specific RNA synthesized in CE or L cells infected with either L(1) or S(2)VSV at low multiplicity was of the same size...

journal_title：Journal of virology

authors： Wertz GW,Levine M

更新日期：1973-08-01 00:00:00

abstract：:Rhesus monkey rhadinovirus (RRV), a simian gamma-2 herpesvirus closely related to the Kaposi sarcoma-associated herpesvirus, replicates lytically in cultured rhesus monkey fibroblasts and establishes persistence in B cells. Overlapping cosmid clones were generated that encompass the entire 130-kilobase-pair genome of ...

journal_title：Journal of virology

authors： Bilello JP,Morgan JS,Damania B,Lang SM,Desrosiers RC

更新日期：2006-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a recently discovered human gamma herpesvirus strongly implicated in AIDS-related neoplasms. We report here the identification in the KSHV genome of a gene for a protein designated K-bZIP and belonging to the basic-leucine zipper (bZIP) family of transcription factors....

journal_title：Journal of virology

authors： Lin SF,Robinson DR,Miller G,Kung HJ

更新日期：1999-03-01 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). After the primary infection, the virus remains latent in sensory ganglia and reactivates upon weakening of the cellular immune system due to various conditions, erupting from sensory neurons and infecting the corresponding ...

journal_title：Journal of virology

authors： Selariu A,Cheng T,Tang Q,Silver B,Yang L,Liu C,Ye X,Markus A,Goldstein RS,Cruz-Cosme RS,Lin Y,Wen L,Qian H,Han J,Dulal K,Huang Y,Li Y,Xia N,Zhu H

更新日期：2012-08-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：:Extrachromosomal DNA purified from mink cells acutely infected with the Snyder-Theilen strain of feline sarcoma virus (FeSV) was digested with restriction endonucleases, and the DNA fragments were electrophoretically separated, transferred to a solid substrate, and hybridized with radiolabeled DNA transcripts compleme...

journal_title：Journal of virology

authors： Sherr CJ,Fedele LA,Donner L,Turek LP

更新日期：1979-12-01 00:00:00

abstract：:Woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV) are closely similar with respect to genomic organization, host antiviral responses, and pathobiology of the infection. T-cell immunity against viral nucleocapsid (HBcAg or WHcAg) has been shown to play a critical role in viral clearance and protection against...

journal_title：Journal of virology

authors： García-Navarro R,Blanco-Urgoiti B,Berraondo P,Sánchez de la Rosa R,Vales A,Hervás-Stubbs S,Lasarte JJ,Borrás F,Ruiz J,Prieto J

更新日期：2001-10-01 00:00:00

abstract：:Linear hepadnavirus DNA in primary hepatocyte cultures efficiently participates in intra- and intermolecular nonhomologous recombination at its ends. The products of this recombination are (i) monomeric covalently closed circular DNAs (cccDNAs) with deletions and insertions around the site of joining and (ii) oligomer...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1995-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the first human virus found to encode many microRNAs. It is etiologically linked to nasopharyngeal carcinoma and EBV-associated gastric carcinoma. During the latent infection period, there are only a few EBV proteins expressed, whereas EBV microRNAs, such as the BamHI-A region rightward tra...

journal_title：Journal of virology

authors： Zheng X,Wang J,Wei L,Peng Q,Gao Y,Fu Y,Lu Y,Qin Z,Zhang X,Lu J,Ou C,Li Z,Zhang X,Liu P,Xiong W,Li G,Yan Q,Ma J

更新日期：2018-11-12 00:00:00

abstract：:Natural killer (NK) cells are an important component in the control of influenza virus infection, acting to both clear virus-infected cells and release antiviral cytokines. Engagement of CD16 on NK cells by antibody-coated influenza virus-infected cells results in antibody-dependent cellular cytotoxicity (ADCC). Incre...

journal_title：Journal of virology

authors： Jegaskanda S,Vanderven HA,Tan HX,Alcantara S,Wragg KM,Parsons MS,Chung AW,Juno JA,Kent SJ

更新日期：2019-02-19 00:00:00

abstract：:The nucleic acids of influenza A, B, and C viruses were compared. Susceptibility to nucleases demonstrates that influenza C virus, just as influenza A and B viruses, possesses single-stranded RNA as its genome. The base compositions of the RNAs of influenza A, B, and influenza C virus are almost identical and comparat...

journal_title：Journal of virology

authors： Ritchey MB,Palese P,Kilbourne ED

更新日期：1976-05-01 00:00:00

abstract：:To determine which sequences or structures in the poliovirus 5' noncoding region (5'NCR) are involved in binding proteins used for internal ribosome binding and protein synthesis initiation, translation competition assays were performed in rabbit reticulocyte lysates in the presence and absence of HeLa cell extract. T...

journal_title：Journal of virology

authors： Gebhard JR,Ehrenfeld E

更新日期：1992-05-01 00:00:00

abstract：:The human papillomavirus (HPV) E6 oncoproteins recruit the cellular ubiquitin ligase E6AP/UBE3A to target cellular substrates for proteasome-mediated degradation, and one consequence of this activity is the E6 stimulation of E6AP autoubiquitination and degradation. Recent studies identified an autism-linked mutation w...

journal_title：Journal of virology

authors： Thatte J,Banks L

更新日期：2017-10-27 00:00:00

abstract：:The presence of complement-fixing (CF) antibody reactive with T antigen and with viral C antigen in hamsters bearing adenovirus 12-induced tumors has been confirmed. Antibody activity in serum obtained at a time when the host was bearing large tumors was found to be associated exclusively with 7S immunoglobulins. Two ...

journal_title：Journal of virology

authors： Fugmann RA,Sigel MM

更新日期：1967-08-01 00:00:00

abstract：:Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited the degradation of A3G, and reduced the ...

journal_title：Journal of virology

authors： Miyagi E,Welbourn S,Sukegawa S,Fabryova H,Kao S,Strebel K

更新日期：2020-03-17 00:00:00

abstract：:A comparison has been made of the membrane glycoproteins and glycopeptides from two enveloped viruses, Sindbis virus and vesicular stomatitis virus (VSV). Glycopeptides isolated from Sindbis virus and VSV grown in the same host appear to differ principally in the number of sialic acid residues per glycopeptide; when s...

journal_title：Journal of virology

authors： Burge BW,Huang AS

更新日期：1970-08-01 00:00:00

abstract：:A single phosphorylation event at T-antigen residue Thr124 regulates initiation of simian virus 40 DNA replication. To explore this regulatory process, a series of peptides were synthesized, centered on Thr124. These peptides contain a nuclear localization signal (NLS) and a recognition site for cyclin/Cdk kinases. Wh...

journal_title：Journal of virology

authors： Kim RJ,Moine S,Reese DK,Bullock PA

更新日期：2002-12-01 00:00:00

abstract：:Previously it was shown that the host-range gene of the Bratislava strain of avain sarcoma virus (B77 virus) spontaneously mutates with a very high rate. The wild-type B77 virus called B77 virus-II, mutates either to virus that efficiently infects duck cells (B77 virus-III) or to virus that does not mutate to the abil...

journal_title：Journal of virology

authors： Zarling DA,Mosser AG,Temin HM

更新日期：1977-01-01 00:00:00

abstract：:In this study, we show that human cytomegalovirus DNA synthesis is inhibited in infected confluent human embryonic lung cells treated with the DNA-intercalative topoisomerase II inhibitor 4-9'-(acridinylamino)methanesulfon-m-anisidide (m-AMSA). Similar inhibitory effects were observed with VM-26, a nonintercalative to...

journal_title：Journal of virology

authors： Benson JD,Huang ES

更新日期：1988-12-01 00:00:00