Two specific topoisomerase II inhibitors prevent replication of human cytomegalovirus DNA: an implied role in replication of the viral genome.

abstract：:Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct...

journal_title：Journal of virology

authors： Wilson SS,Wiens ME,Holly MK,Smith JG

更新日期：2016-05-12 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to ...

journal_title：Journal of virology

authors： Niemeyer D,Zillinger T,Muth D,Zielecki F,Horvath G,Suliman T,Barchet W,Weber F,Drosten C,Müller MA

更新日期：2013-11-01 00:00:00

abstract：:TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wild-type virus and NNRTI-resistant virus were performed to identify mut...

journal_title：Journal of virology

authors： Vingerhoets J,Azijn H,Fransen E,De Baere I,Smeulders L,Jochmans D,Andries K,Pauwels R,de Béthune MP

更新日期：2005-10-01 00:00:00

abstract：:Several C/EBP binding sites within the Rous sarcoma virus (RSV) long terminal repeat (LTR) and gag enhancers were mutated, and the effect of these mutations on viral gene expression was assessed. Minimal site-specific mutations in each of three adjacent C/EBP binding sites in the LTR reduced steady-state viral RNA lev...

journal_title：Journal of virology

authors： Ryden TA,de Mars M,Beemon K

更新日期：1993-05-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...

journal_title：Journal of virology

authors： Chang YE,Laimins LA

更新日期：2000-05-01 00:00:00

abstract：:Characterization of immune responses induced by live attenuated simian immunodeficiency virus (SIV) strains may yield clues to the nature of protective immunity induced by this vaccine approach. We investigated the ability of CD8(+) T lymphocytes from rhesus macaques immunized with the live, attenuated SIV strain SIVm...

journal_title：Journal of virology

authors： Gauduin MC,Glickman RL,Means R,Johnson RP

更新日期：1998-08-01 00:00:00

abstract：:The initiation of RNA transcription by the virion-bound RNA transcriptase of vesicular stomatitis virus has been examined. Multiple initiation sequences have been observed, two of which have been characterized (pppApCpGp... and pppGpCp...) suggestive of a transcription process which can start at different sites along ...

journal_title：Journal of virology

authors： Roy P,Bishop DH

更新日期：1973-04-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection causes the active degradation of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), and this process is reliant on the expression of the HSV-1 immediate-early protein Vmw110. In this study we investigated in more detail the mechanism by which the degradation...

journal_title：Journal of virology

authors： Parkinson J,Lees-Miller SP,Everett RD

更新日期：1999-01-01 00:00:00

abstract：:In December 2016, a low-pathogenic avian influenza (LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in the states of New York and Pennsylvania. One person with occupational exposure to infected cats became in...

journal_title：Journal of virology

authors： Belser JA,Pulit-Penaloza JA,Sun X,Brock N,Pappas C,Creager HM,Zeng H,Tumpey TM,Maines TR

更新日期：2017-07-12 00:00:00

abstract：UNLABELLED:Molluscum contagiosum virus (MOCV), the only circulating human-specific poxvirus, has a worldwide distribution and causes benign skin lesions that may persist for months in young children and severe infections in immunosuppressed adults. Studies of MOCV are restricted by the lack of an efficient animal model...

journal_title：Journal of virology

authors： Mendez-Rios JD,Yang Z,Erlandson KJ,Cohen JI,Martens CA,Bruno DP,Porcella SF,Moss B

更新日期：2016-04-14 00:00:00

abstract：:MxA is an abundant and ubiquitous cytoplasmic protein induced by alpha/beta interferon in human cells. Upon full induction, it can constitute 0.5 to 1% of cytosolic proteins. MxA can bind elements of the cytoskeleton, such as actin and tubulins, and several larger cellular proteins. However, these protein-protein inte...

journal_title：Journal of virology

authors： Horisberger MA

更新日期：1992-08-01 00:00:00

abstract：:The DNA molecules from T7 bacteriophage and a recently obtained mutant form of T4D were studied. The DNA of this T4 mutant contains cytosine in place of all of the glucosylated hydroxymethylcytosines normally present in T4. Molecular weights were measured with an electron microscope technique, and sedimentation coeffi...

journal_title：Journal of virology

authors： Clark RW,Wever GH,Wiberg JS

更新日期：1980-01-01 00:00:00

abstract：:Retroviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent base pairing and tertiary interactions. Viral maturation involves large-scale morphological changes in viral proteins and in genomic RNA dimer structures to yield infectious virions. Structural studies have largel...

journal_title：Journal of virology

authors： Gherghe C,Leonard CW,Gorelick RJ,Weeks KM

更新日期：2010-01-01 00:00:00

abstract：:We have cloned several prototypic members of the family of human endogenous retroviruslike elements having a histidine tRNA primer-binding site (RTVL-H) and have determined the nucleotide sequence of one of these clones (RTVL-H2). The RTVL-H2 sequence is 5,813 nucleotides long, with long terminal repeats of 450 nucleo...

journal_title：Journal of virology

authors： Mager DL,Freeman JD

更新日期：1987-12-01 00:00:00

abstract：:The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immunocompromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based and cell-free DNA replication systems, including the BK virus (BKV) monopolymerase DNA replicatio...

journal_title：Journal of virology

authors： Tikhanovich I,Nasheuer HP

更新日期：2010-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) encodes specific trafficking signals within its long cytoplasmic tail (CT) that regulate incorporation into HIV-1 particles. Rab11-family interacting protein 1C (FIP1C) and Rab14 are host trafficking factors required for Env particle incorpora...

journal_title：Journal of virology

authors： Kirschman J,Qi M,Ding L,Hammonds J,Dienger-Stambaugh K,Wang JJ,Lapierre LA,Goldenring JR,Spearman P

更新日期：2018-02-12 00:00:00

abstract：:In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...

journal_title：Journal of virology

authors： Cuppels DA,Van Etten JL,Burbank DE,Lane LC,Vidaver AK

更新日期：1980-07-01 00:00:00

abstract：:We have isolated a new type of temperature-sensitive mutant of simian virus 40 (SV40) that is capable of productive infection in permissive cells but not of maintenance of viral DNA integration in transformed cells at the conditional temperature. Virus development is induced when cells transformed by this mutant are s...

journal_title：Journal of virology

authors： Rothschild H,Lockwood MP

更新日期：1976-08-01 00:00:00

abstract：:Three serial passage series of simian virus 40 (SV40) in CV-1 cells were initiated by infection directly from the same wild-type plaque isolate, three series were initiated by infection with another plaque isolate, and two series were initiated with each of two other plaque isolates. Aberrant SV40 genomes were not det...

journal_title：Journal of virology

authors： Norkin LC,Tirrell SM

更新日期：1982-05-01 00:00:00

abstract：:To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions within putative domains. Immunofluorescence staining of transfected cells revealed that wild-type Vpr was localized predomin...

journal_title：Journal of virology

authors： Kamata M,Aida Y

更新日期：2000-08-01 00:00:00

abstract：:Parvovirus capsids are small but complex molecular machines responsible for undertaking many of the steps of cell infection, genome packing, and cell-to-cell as well as host-to-host transfer. The details of parvovirus infection of cells are still not fully understood, but the processes must involve small changes in th...

journal_title：Journal of virology

authors： Callaway HM,Feng KH,Lee DW,Allison AB,Pinard M,McKenna R,Agbandje-McKenna M,Hafenstein S,Parrish CR

更新日期：2017-01-03 00:00:00

abstract：:An adeno-associated virus (AAV) genome with a Lys-to-His (K340H) mutation in the consensus nucleotide triphosphate binding site of the rep gene has a dominant-negative DNA replication phenotype in vivo. We expressed both wild-type (Rep78) and mutant (Rep78NTP) proteins in two helper-free expression systems consisting ...

journal_title：Journal of virology

authors： Owens RA,Carter BJ

更新日期：1992-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) uses nasal mucosa-associated lymphoid tissue (NALT) as a portal of entry to establish life-long persistence in memory B cells. We previously showed that naïve and memory B cells from NALT are equally susceptible to EBV infection. Here we show that memory B cells from NALT are significantly mor...

journal_title：Journal of virology

authors： Dorner M,Zucol F,Alessi D,Haerle SK,Bossart W,Weber M,Byland R,Bernasconi M,Berger C,Tugizov S,Speck RF,Nadal D

更新日期：2010-07-01 00:00:00

abstract：:The major inducible 70-kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice. A significant level of protec...

journal_title：Journal of virology

authors： Kim MY,Shu Y,Carsillo T,Zhang J,Yu L,Peterson C,Longhi S,Girod S,Niewiesk S,Oglesbee M

更新日期：2013-01-01 00:00:00

abstract：:Recently, it was demonstrated that the coxsackievirus B3 variant PD (CVB3 PD) is able to infect coxsackievirus-adenovirus receptor (CAR)-lacking cells by using heparan sulfates (HS) as additional receptors (A. E. Zautner, U. Korner, A. Henke, C. Badorff, and M. Schmidtke, J. Virol. 77:10071-10077, 2003). For this stud...

journal_title：Journal of virology

authors： Zautner AE,Jahn B,Hammerschmidt E,Wutzler P,Schmidtke M

更新日期：2006-07-01 00:00:00

abstract：:The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells were shown to have greater than 10 times the serine esterase activity of T cells from normal mice, and high levels of seri...

journal_title：Journal of virology

authors： Welsh RM,Nishioka WK,Antia R,Dundon PL

更新日期：1990-08-01 00:00:00

abstract：:One common attribute of herpesviruses is the ability to establish latent, life-long infections. The role of virus-virus interaction in viral reactivation between or among herpesviruses has not been studied. Preliminary experiments in our laboratory had indicated that infection of Epstein-Barr virus (EBV) genome-positi...

journal_title：Journal of virology

authors： Flamand L,Stefanescu I,Ablashi DV,Menezes J

更新日期：1993-11-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) enables long-term suppression of plasma HIV-1 loads in infected persons, but low-level virus persists and rebounds following cessation of therapy. During HAART, this virus resides in latently infected cells, such as resting CD4(+) T cells, and in other cell types that may s...

journal_title：Journal of virology

authors： North TW,Higgins J,Deere JD,Hayes TL,Villalobos A,Adamson L,Shacklett BL,Schinazi RF,Luciw PA

更新日期：2010-03-01 00:00:00

abstract：UNLABELLED:The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenov...

journal_title：Journal of virology

authors： Bukh I,Calcedo R,Roy S,Carnathan DG,Grant R,Qin Q,Boyd S,Ratcliffe SJ,Veeder CL,Bellamy SL,Betts MR,Wilson JM

更新日期：2014-08-01 00:00:00