Mutation of the C/EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers.

abstract：:In the spherical capsid of hepatitis B virus (HBV), intermolecular disulfide bonds cross-link the approximately 180 p21.5 capsid protein subunits into a stable lattice. In this study, we used mutant capsid proteins to investigate the role that disulfide bonds and the four p21.5 Cys residues (positions 48, 61, 107, and...

journal_title：Journal of virology

authors： Zhou S,Standring DN

更新日期：1992-09-01 00:00:00

abstract：:Synthesis of the fiber protein of human adenovirus serotype 2 (Ad2) is 100-fold lower in abortively infected monkey cells, compared with productive infections, despite only a 5- to 10-fold reduction in fiber mRNA levels. Previously Anderson and Klessig (Proc. Natl. Acad Sci. USA 81:4023-4027, 1984) demonstrated a dire...

journal_title：Journal of virology

authors： Silverman L,Klessig DF

更新日期：1989-10-01 00:00:00

abstract：:Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 40...

journal_title：Journal of virology

authors： Burns CC,Shaw J,Jorba J,Bukbuk D,Adu F,Gumede N,Pate MA,Abanida EA,Gasasira A,Iber J,Chen Q,Vincent A,Chenoweth P,Henderson E,Wannemuehler K,Naeem A,Umami RN,Nishimura Y,Shimizu H,Baba M,Adeniji A,Williams AJ,

更新日期：2013-05-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is divided into three subgroups, A, B, and C, based on sequence divergence at the left end of genomic DNA in which the saimiri transforming protein (STP) resides. Subgroup A and C strains transform primary common marmoset lymphocytes to interleukin-2-independent growth, whereas subgroup B str...

journal_title：Journal of virology

authors： Choi JK,Ishido S,Jung JU

更新日期：2000-09-01 00:00:00

abstract：:The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates the expression of specific cellular genes involved in the control of T-lymphocyte growth via effects on cellular transcription factors, including members of the NF-kappaB/cRel family. Immunoc...

journal_title：Journal of virology

authors： Bex F,McDowall A,Burny A,Gaynor R

更新日期：1997-05-01 00:00:00

abstract：:The amphotropic murine leukemia virus (MuLV) can infect cells from a number of mammals, including humans, via its specific receptor. Basic knowledge of amphotropic MuLV receptor expression is likely to be useful in the development and improvement of gene therapy protocols based on amphotropic-pseudotyped vectors. To i...

journal_title：Journal of virology

authors： Chien ML,Foster JL,Douglas JL,Garcia JV

更新日期：1997-06-01 00:00:00

abstract：:Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown ...

journal_title：Journal of virology

authors： Wong E,Wu TT,Reyes N,Deng H,Sun R

更新日期：2007-06-01 00:00:00

abstract：:The structures of DNAs present in various intracellular forms of simian virus 40 (SV40) nucleoprotein complexes were analyzed by micrococcal nuclease digestion. The results showed that the 70S SV40 chromatin was completely sensitive to nuclease digestion, whereas CsCl gradient-purified mature virion was completely res...

journal_title：Journal of virology

authors： Coca-Prados M,Yu HY,Hsu MT

更新日期：1982-11-01 00:00:00

abstract：:Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce...

journal_title：Journal of virology

authors： Cladel NM,Budgeon LR,Cooper TK,Balogh KK,Hu J,Christensen ND

更新日期：2013-08-01 00:00:00

abstract：:The innate and adaptive immune responses have evolved distinct strategies for controlling different viral pathogens. Encephalomyocarditis virus (EMCV) is a picornavirus that can cause paralysis, diabetes, and myocarditis within days of infection. The optimal innate immune response against EMCV in vivo requires CD1d. I...

journal_title：Journal of virology

authors： Ilyinskii PO,Wang R,Balk SP,Exley MA

更新日期：2006-07-01 00:00:00

abstract：:Monoclonal antibodies produced against the prototype cell-adapted Wyoming strain of equine infectious anemia virus (EIAV), a lentivirus, were studied for reactivity with the homologous prototype and 16 heterologous isolates. Eighteen hybridomas producing monoclonal antibodies (MAbs) were isolated. Western blot (immuno...

journal_title：Journal of virology

authors： Hussain KA,Issel CJ,Schnorr KL,Rwambo PM,Montelaro RC

更新日期：1987-10-01 00:00:00

abstract：:A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the CAP256 superinfecting viral envelope (CAP256 SU) protein delivered by modified vaccinia virus Ankara (MVA) and DNA vaccines in different prime-boost com...

journal_title：Journal of virology

authors： van Diepen MT,Chapman R,Douglass N,Galant S,Moore PL,Margolin E,Ximba P,Morris L,Rybicki EP,Williamson AL

更新日期：2019-04-03 00:00:00

abstract：:Hemorrhage is a common clinical manifestation in dengue patients. However, the pathogenic mechanism of dengue virus (DV)-induced hemorrhage awaits clarification. We established a mouse model of DV hemorrhage using immunocompetent C57BL/6 mice by injecting DV serotype 2 strain 16681 intradermally. While inoculation of ...

journal_title：Journal of virology

authors： Chen HC,Hofman FM,Kung JT,Lin YD,Wu-Hsieh BA

更新日期：2007-06-01 00:00:00

abstract：:Anelloviruses are a group of single-stranded circular DNA viruses infecting humans and other animal species. Animal models combined with reverse genetic systems of anellovirus have not been developed. We report here the construction and initial characterization of full-length DNA clones of a porcine anellovirus, torqu...

journal_title：Journal of virology

authors： Huang YW,Patterson AR,Opriessnig T,Dryman BA,Gallei A,Harrall KK,Vaughn EM,Roof MB,Meng XJ

更新日期：2012-06-01 00:00:00

abstract：:The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated ...

journal_title：Journal of virology

authors： Marjuki H,Mishin VP,Chai N,Tan MW,Newton EM,Tegeris J,Erlandson K,Willis M,Jones J,Davis T,Stevens J,Gubareva LV

更新日期：2016-11-14 00:00:00

abstract：:To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed ...

journal_title：Journal of virology

authors： Deng X,Agnihothram S,Mielech AM,Nichols DB,Wilson MW,StJohn SE,Larsen SD,Mesecar AD,Lenschow DJ,Baric RS,Baker SC

更新日期：2014-10-01 00:00:00

abstract：:Brome mosaic virus (BMV) RNA replication is directed by two virus-encoded proteins, 1a and 2a. The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1, which has been implicated in capping viral RNAs. In this study, we examined the enzymatic activities of BMV 1a expressed in yeast, ...

journal_title：Journal of virology

authors： Ahola T,Ahlquist P

更新日期：1999-12-01 00:00:00

abstract：:To examine the mode of transmission of BK polyomavirus (BKV), urine samples were collected from Japanese-Americans in Los Angeles and from other southern Californians. Subtype I was the main subtype found in samples from both groups. The subtype I subgroup Ib-2, which is predominant in Europe, was the primary subgroup...

journal_title：Journal of virology

authors： Yogo Y,Zhong S,Suzuki M,Shibuya A,Kitamura T

更新日期：2007-12-01 00:00:00

abstract：:Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Although IBDV-induced host cell apoptosis has been established, the underlying molecular mechanism is still unclear. We report here that IBDV viral protein 5 (VP5) is a major apoptosis induce...

journal_title：Journal of virology

authors： Li Z,Wang Y,Xue Y,Li X,Cao H,Zheng SJ

更新日期：2012-02-01 00:00:00

abstract：:Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) scr...

journal_title：Journal of virology

authors： Arita M,Wakita T,Shimizu H

更新日期：2012-05-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) establishes a persistent infection in the host despite a vigorous virus-specific immune response. Here we demonstrate that an HTLV-1-encoded protein, p12(I), resides in the endoplasmic reticulum (ER) and Golgi and physically binds to the free human major histocompatibility c...

journal_title：Journal of virology

authors： Johnson JM,Nicot C,Fullen J,Ciminale V,Casareto L,Mulloy JC,Jacobson S,Franchini G

更新日期：2001-07-01 00:00:00

abstract：:Previous work on the strict late (gamma) UL38 promoter of herpes simplex virus type 1 identified three cis-acting elements required for wild-type levels of transcription: a TATA box at -31, a consensus mammalian initiator element at the transcription start site, and a downstream activation sequence (DAS) at +20 to +33...

journal_title：Journal of virology

authors： Petroski MD,Wagner EK

更新日期：1998-10-01 00:00:00

abstract：:Two essential gene products of herpes simplex virus type 1, the viral DNA polymerase (pol) and UL42, its accessory protein, physically and functionally interact to form the core of the viral DNA replication complex. Understanding this essential interaction would provide a basis from which to develop novel anti-herpesv...

journal_title：Journal of virology

authors： Monahan SJ,Barlam TF,Crumpacker CS,Parris DS

更新日期：1993-10-01 00:00:00

abstract：:Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes resi...

journal_title：Journal of virology

authors： Wu J,Bera AK,Kuhn RJ,Smith JL

更新日期：2005-08-01 00:00:00

abstract：:Influenza A virus matrix protein M1 is involved in multiple stages of the viral infectious cycle. Despite its functional importance, our present understanding of this essential viral protein is limited. The roles of a small subset of specific amino acids have been reported, but a more comprehensive understanding of th...

journal_title：Journal of virology

authors： Hom N,Gentles L,Bloom JD,Lee KK

更新日期：2019-06-14 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly und...

journal_title：Journal of virology

authors： Zang N,Xie X,Deng Y,Wu S,Wang L,Peng C,Li S,Ni K,Luo Y,Liu E

更新日期：2011-12-01 00:00:00

abstract：:Adenovirus type 2 (Ad2) and Ad5 enter epithelial cells via the coxsackievirus B Ad receptor (CAR) and alpha(v) integrin coreceptors. In the absence of CAR, they can be directed to the Fcgamma receptor 1 of hematopoietic cells by an adaptor comprising the extracellular CAR domain and the Fc portion of a human immunoglo...

journal_title：Journal of virology

authors： Meier O,Gastaldelli M,Boucke K,Hemmi S,Greber UF

更新日期：2005-02-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the seme...

journal_title：Journal of virology

authors： Whitney JB,Luedemann C,Hraber P,Rao SS,Mascola JR,Nabel GJ,Letvin NL

更新日期：2009-10-01 00:00:00

abstract：:A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human...

journal_title：Journal of virology

authors： Chambers TJ,Nestorowicz A,Mason PW,Rice CM

更新日期：1999-04-01 00:00:00