Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:Enterovirus A71 (EV-A71) is a major cause of hand, foot, and mouth disease (HFMD) and is particularly prevalent in parts of Southeast Asia, affecting thousands of children and infants each year. Revealing the evolutionary and epidemiological dynamics of EV-A71 through time and space is central to understandi...

journal_title：Journal of virology

authors： Geoghegan JL,Tan le V,Kühnert D,Halpin RA,Lin X,Simenauer A,Akopov A,Das SR,Stockwell TB,Shrivastava S,Ngoc NM,Uyen le TT,Tuyen NT,Thanh TT,Hang VT,Qui PT,Hung NT,Khanh TH,Thinh le Q,Nhan le NT,Van HM,Viet do C

更新日期：2015-09-01 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:Ebola virus is the etiologic agent of a lethal hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Previous studies with Zaire Ebola virus (ZEBOV), mouse-adapted virus (MA-ZEBOV), and mutant viruses (ZEBOV-NP(ma), ZEBOV-VP24(ma), and ZEBOV-NP/VP24(ma)) allowed us to identify the mutati...

journal_title：Journal of virology

authors： Cilloniz C,Ebihara H,Ni C,Neumann G,Korth MJ,Kelly SM,Kawaoka Y,Feldmann H,Katze MG

更新日期：2011-09-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of the anogenital and oropharyngeal regions. The majority of HPV-induced tumors contain integrated copies of the normally episomal HPV genome that invariably reta...

journal_title：Journal of virology

authors： Kennedy EM,Kornepati AV,Goldstein M,Bogerd HP,Poling BC,Whisnant AW,Kastan MB,Cullen BR

更新日期：2014-10-01 00:00:00

abstract：UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

journal_title：Journal of virology

authors： Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

更新日期：2015-01-15 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:Adenovirus gene therapy is a promising tool in the clinical treatment of many genetic and acquired diseases. However, it has also caused pathogenic effects in organs such as the liver. The redox-sensitive transcription factors AP-1 and NF-kappaB have been implicated in these effects. To study the mechanisms of adenovi...

journal_title：Journal of virology

authors： Zhang HJ,Drake VJ,Xu L,Hu J,Domann FE,Oberley LW,Kregel KC

更新日期：2002-01-01 00:00:00

abstract：:Herein we demonstrate that chronic simian immunodeficiency virus (SIV) infection induces significant upregulation of the gut-homing marker alpha4beta7 on macaque NK cells, coupled with downregulation of the lymph node-trafficking marker, CCR7. Interestingly, in naïve animals, alpha4beta7 expression was associated with...

journal_title：Journal of virology

authors： Reeves RK,Evans TI,Gillis J,Johnson RP

更新日期：2010-09-01 00:00:00

abstract：:We have used a replication-competent shuttle vector based on the genome of Rous sarcoma virus to characterize genomic rearrangements that occur during retrovirus replication. The strategy involved cloning circular DNA that was generated during an acute infection. While analyzing a class of retroviral DNA clones that a...

journal_title：Journal of virology

authors： Dunn MM,Olsen JC,Swanstrom R

更新日期：1992-10-01 00:00:00

abstract：:Among the members of the paramyxovirus family, the transcription process and the components involved have been studied under in vitro conditions thus far. Here, we reexamined the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants. To el...

journal_title：Journal of virology

authors： Wiegand MA,Bossow S,Schlecht S,Neubert WJ

更新日期：2007-12-01 00:00:00

abstract：:The processes that facilitate transport of integral membrane proteins though the secretory pathway and subsequently target them to particular cellular membranes are relevant to almost every field of biology. These transport processes involve integration of proteins into the membrane of the endoplasmic reticulum (ER), ...

journal_title：Journal of virology

authors： Brock SC,Heck JM,McGraw PA,Crowe JE Jr

更新日期：2005-10-01 00:00:00

abstract：UNLABELLED:The emergence of Middle East respiratory syndrome-coronavirus (MERS-CoV) in the Middle East since 2012 has caused more than 900 human infections with ∼40% mortality to date. Animal models are needed for studying pathogenesis and for development of preventive and therapeutic agents against MERS-CoV infection....

journal_title：Journal of virology

authors： Agrawal AS,Garron T,Tao X,Peng BH,Wakamiya M,Chan TS,Couch RB,Tseng CT

更新日期：2015-04-01 00:00:00

abstract：:Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and Guillain-Barré syndrome in adults. The molecular mechanisms regulating ZIKV infection and pathogenic outcomes are incompletely understood. Signaling by the mechanistic (mammalian) target of ra...

journal_title：Journal of virology

authors： Sahoo BR,Pattnaik A,Annamalai AS,Franco R,Pattnaik AK

更新日期：2020-10-27 00:00:00

abstract：:Members of the tripartite interaction motif (TRIM) family of E3 ligases are emerging as critical regulators of innate immunity. To identify new regulators, we carried out a screen of 43 human TRIM proteins for the ability to activate NF-κB, AP-1, and interferon, hallmarks of many innate immune signaling pathways. We i...

journal_title：Journal of virology

authors： Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

更新日期：2013-01-01 00:00:00

abstract：:The effect of bacteriophage SPO1 infection of Bacillus subtilis and a deoxyribonucleic acid (DNA) polymerase-deficient (pol(-)) mutant of this microorganism on the synthesis of DNA has been examined. Soon after infection, the incorporation of deoxyribonucleoside triphosphates into acid-insoluble material by cell lysat...

journal_title：Journal of virology

authors： Yehle CO,Ganesan AT

更新日期：1972-02-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:Genotype 1 hepatitis E viruses (HEVs) are restricted to primate hosts, whereas genotype 3 HEVs predominantly infect swine, in addition to primates. In order to identify possible determinants of the host range, infectious recombinant viruses and chimeras of a genotype 1 isolate and a genotype 3 isolate were compared fo...

journal_title：Journal of virology

authors： Nguyen HT,Shukla P,Torian U,Faulk K,Emerson SU

更新日期：2014-01-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...

journal_title：Journal of virology

authors： Lund TC,Garcia R,Medveczky MM,Jove R,Medveczky PG

更新日期：1997-09-01 00:00:00

abstract：:HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging literature has implicated proinflammatory purinergic receptors and downstream signaling mediators in HIV-1 infection. This study probed ...

journal_title：Journal of virology

authors： Soare AY,Durham ND,Gopal R,Tweel B,Hoffman KW,Brown JA,O'Brien M,Bhardwaj N,Lim JK,Chen BK,Swartz TH

更新日期：2018-12-10 00:00:00

abstract：:Treatment of purified simian virus 40 large T antigen (LT) with protein phosphatase 2A stimulates LT-dependent DNA unwinding and replication (D. M. Virshup, M. G. Kauffman, and T. J. Kelly, EMBO J. 8: 3891-3898, 1989). The specificity of the catalytic subunit of protein phosphatase 2A toward LT was investigated by two...

journal_title：Journal of virology

authors： Scheidtmann KH,Virshup DM,Kelly TJ

更新日期：1991-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) is acquired by the oral route in children, and primary infection is associated with abundant mucosal replication, as well as the establishment of latency in myeloid cells that results in lifelong infection. The efficiency of primary CMV infection in humans following oral exposure, however, is unk...

journal_title：Journal of virology

authors： Mayer BT,Krantz EM,Swan D,Ferrenberg J,Simmons K,Selke S,Huang ML,Casper C,Corey L,Wald A,Schiffer JT,Gantt S

更新日期：2017-05-26 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:Several different forms of progeny viral DNA can be identified in polyoma virus (Py)-infected mouse L-cells. The majority comprise mature form I superhelical DNA and the circular, double-stranded "theta" replicating intermediates in which the progeny DNA strands never exceed the unit genome length of the template. The...

journal_title：Journal of virology

authors： Ganz PR,Sheinin R

更新日期：1983-06-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function sh...

journal_title：Journal of virology

authors： Zhao B,Sample CE

更新日期：2000-06-01 00:00:00

abstract：:Among prion infections, two scenarios of prion spread are generally observed: (i) early lymphoid tissue replication or (ii) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studi...

journal_title：Journal of virology

authors： Hoover CE,Davenport KA,Henderson DM,Denkers ND,Mathiason CK,Soto C,Zabel MD,Hoover EA

更新日期：2017-04-28 00:00:00

abstract：:Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem,...

journal_title：Journal of virology

authors： Arias CF,Silva-Ayala D,López S

更新日期：2015-01-15 00:00:00

abstract：:Primary human embryonic kidney (HEK) cells were transformed by a focus assay with BK virus (BKV) DNA molecularly cloned at its unique EcoRI site. Both viral DNA sequences and viral tumor antigens were present and expressed in all the foci that we examined. However, cells isolated from foci were incapable of growth in ...

journal_title：Journal of virology

authors： Pater A,Pater MM

更新日期：1986-05-01 00:00:00

abstract：UNLABELLED:In vitro, infection of polarized human intestinal epithelial cells by coxsackievirus B3 (CVB3) depends on virus interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface. Although mice are highly susceptible to CVB3 infection when virus is delivered by intraperitoneal ...

journal_title：Journal of virology

authors： Pan J,Zhang L,Odenwald MA,Shen L,Turner JR,Bergelson JM

更新日期：2015-04-01 00:00:00