Nature of hamster complement-fixing antibody to adenovirus 12 tumor antigen.

abstract：:Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To in...

journal_title：Journal of virology

authors： Chevalier MF,Jülg B,Pyo A,Flanders M,Ranasinghe S,Soghoian DZ,Kwon DS,Rychert J,Lian J,Muller MI,Cutler S,McAndrew E,Jessen H,Pereyra F,Rosenberg ES,Altfeld M,Walker BD,Streeck H

更新日期：2011-01-01 00:00:00

abstract：:JC polyomavirus (JCV) infection is highly prevalent and usually kept in a persistent state without clinical signs and symptoms. It is only during immunocompromise and especially impaired CD4(+) T cell function in the brain, as seen in AIDS patients or natalizumab-treated multiple sclerosis patients, that JCV may cause...

journal_title：Journal of virology

authors： Jelcic I,Aly L,Binder TM,Jelcic I,Bofill-Mas S,Planas R,Demina V,Eiermann TH,Weber T,Girones R,Sospedra M,Martin R

更新日期：2013-03-01 00:00:00

abstract：:The active site serine of the acetylesterase of influenza C virus was localized to amino acid 71 of the hemagglutinin-esterase protein by affinity labeling with 3H-labeled diisopropylfluorophosphate. This serine and the adjacent amino acids (Phe-Gly-Asp-Ser) are part of a consensus sequence motif found in serine hydro...

journal_title：Journal of virology

authors： Vlasak R,Muster T,Lauro AM,Powers JC,Palese P

更新日期：1989-05-01 00:00:00

abstract：UNLABELLED:Japanese encephalitis virus (JEV) membrane (M) protein plays important structural roles in the processes of fusion and maturation of progeny virus during cellular infection. The M protein is anchored in the viral membrane, and its ectodomain is composed of a flexible N-terminal loop and a perimembrane helix....

journal_title：Journal of virology

authors： de Wispelaere M,Khou C,Frenkiel MP,Desprès P,Pardigon N

更新日期：2015-12-09 00:00:00

abstract：:Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis. In the infected cells, alphaviruses express only four nonstructural pr...

journal_title：Journal of virology

authors： Gorchakov R,Garmashova N,Frolova E,Frolov I

更新日期：2008-10-01 00:00:00

abstract：:To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENV-1, -2, and -3 isolates collected in 2001 from children enrolled in a prospective school-based study in Kamphaeng Phet, Thailand, and diagnosed with...

journal_title：Journal of virology

authors： Jarman RG,Holmes EC,Rodpradit P,Klungthong C,Gibbons RV,Nisalak A,Rothman AL,Libraty DH,Ennis FA,Mammen MP Jr,Endy TP

更新日期：2008-06-01 00:00:00

abstract：:Canine parvovirus type 2 (CPV-2) is a severe enteric pathogen of dogs, causing high mortality in unvaccinated dogs. After emerging, CPV-2 spread rapidly worldwide. However, there is now some evidence to suggest that international transmission appears to be more restricted. In order to investigate the transmission and ...

journal_title：Journal of virology

authors： Clegg SR,Coyne KP,Parker J,Dawson S,Godsall SA,Pinchbeck G,Cripps PJ,Gaskell RM,Radford AD

更新日期：2011-08-01 00:00:00

abstract：:During studies of APOBEC3 (A3) anti-human immunodeficiency virus type 1 (anti-HIV-1) mechanisms, we identified a single cysteine at position 320 (C320) that disrupts A3DE activity. This residue is located in the recently identified DNA binding domain in A3G. Replacing C320 with a corresponding tyrosine from A3F (Y307)...

journal_title：Journal of virology

authors： Dang Y,Abudu A,Son S,Harjes E,Spearman P,Matsuo H,Zheng YH

更新日期：2011-06-01 00:00:00

abstract：:Mycophenolic acid (MPA), an inhibitor of IMP dehydrogenase, inhibits reovirus replication and viral RNA and protein production. In mouse L929 cells, antiviral effects were greatest at 30 microg of MPA/ml. At this dosage, MPA inhibited replication of reovirus strain T3D more than 1,000-fold and inhibited replication of...

journal_title：Journal of virology

authors： Hermann LL,Coombs KM

更新日期：2004-06-01 00:00:00

abstract：:Expression of mouse mammary tumor virus (MMTV)-encoded superantigens in B lymphocytes is required for viral transmission and pathogenesis. We have previously established a critical role of an enhancer element within the long terminal repeat (LTR) for MMTV sag gene expression in B-lymphoid progenitor cells. We now demo...

journal_title：Journal of virology

authors： Reuss FU,Coffin JM

更新日期：2000-09-01 00:00:00

abstract：:The ribonucleoprotein (RNP) internal components of influenza virus were separated into distinct size classes by sedimentation in glycerol gradients and examined by electron microscopy by using positive staining with uranyl acetate. The large RNP have a peak in length distribution at 90 to 110 nm, the medium, at 60 to ...

journal_title：Journal of virology

authors： Compans RW,Content J,Duesberg PH

更新日期：1972-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young and elderly worldwide. There is no safe and effective vaccine available, although it is possible to reduce the hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown to modify...

journal_title：Journal of virology

authors： Zhang W,Choi Y,Haynes LM,Harcourt JL,Anderson LJ,Jones LP,Tripp RA

更新日期：2010-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is an attractive molecule for active vaccination and passive immunoprophylaxis and therapy. Using human monoclonal an...

journal_title：Journal of virology

authors： Spindler N,Rücker P,Pötzsch S,Diestel U,Sticht H,Martin-Parras L,Winkler TH,Mach M

更新日期：2013-08-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:Latent Epstein-Barr virus (EBV) infection is associated with several lymphoproliferative disorders, including posttransplant lymphoma, Hodgkin's disease, and Burkitt's lymphoma, as well as nasopharyngeal carcinoma (NPC). Twenty-nine microRNAs (miRNAs) have been identified that are transcribed during latent infection f...

journal_title：Journal of virology

authors： Edwards RH,Marquitz AR,Raab-Traub N

更新日期：2008-09-01 00:00:00

abstract：:Striking morphologic similarities between Machupo, Tacaribe, and lymphocytic choriomeningitis viruses were found by thin-section electron microscopy. It is proposed that these viruses be brought together into a single taxonomic group. ...

journal_title：Journal of virology

authors： Murphy FA,Webb PA,Johnson KM,Whitfield SG

更新日期：1969-10-01 00:00:00

abstract：:Measles virus (MV) fusion requires the participation of both the fusion (F) and hemagglutinin (H) glycoproteins. The canine distemper virus fusion protein (CDVF) cannot substitute for the measles virus fusion protein (MVF) in this process. Introduction of restriction enzyme sites into the cDNAs of CDVF and MVF by site...

journal_title：Journal of virology

authors： Wild TF,Fayolle J,Beauverger P,Buckland R

更新日期：1994-11-01 00:00:00

abstract：UNLABELLED:Semen enhances HIV infection in vitro, but how long it retains this activity has not been carefully examined. Immediately postejaculation, semen exists as a semisolid coagulum, which then converts to a more liquid form in a process termed liquefaction. We demonstrate that early during liquefaction, semen exh...

journal_title：Journal of virology

authors： Roan NR,Liu H,Usmani SM,Neidleman J,Müller JA,Avila-Herrera A,Gawanbacht A,Zirafi O,Chu S,Dong M,Kumar ST,Smith JF,Pollard KS,Fändrich M,Kirchhoff F,Münch J,Witkowska HE,Greene WC

更新日期：2014-07-01 00:00:00

abstract：:The murine polyomavirus (Py) enters mouse fibroblasts and kidney epithelial cells via an endocytic pathway that is caveola-independent (as well as clathrin-independent). In contrast, uptake of simian virus 40 into the same cells is dependent on caveola. Following the initial uptake of Py, both microtubules and microfi...

journal_title：Journal of virology

authors： Gilbert JM,Goldberg IG,Benjamin TL

更新日期：2003-02-01 00:00:00

abstract：:Recent clinical trials examining 3'-azido-3'-deoxythymidine (AZT, zidovudine, or Retrovir) combined with L-2', 3'-dideoxy-3'-thiacytidine (3TC or lamivudine) have shown that combination therapy with these nucleoside analogs affords significant virological and clinical benefits. The addition of 3TC to AZT delays AZT re...

journal_title：Journal of virology

authors： Kemp SD,Shi C,Bloor S,Harrigan PR,Mellors JW,Larder BA

更新日期：1998-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) evokes a strong immune response, but the virus persists. Polymorphisms within known antigenic sites result in loss of immune recognition and can be positively selected. Amino acid variation outside known HLA class I restricted epitopes can also enable immune escape by interf...

journal_title：Journal of virology

authors： Zimbwa P,Milicic A,Frater J,Scriba TJ,Willis A,Goulder PJ,Pillay T,Gunthard H,Weber JN,Zhang HT,Phillips RE

更新日期：2007-02-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) establishes a persistent infection in the host despite a vigorous virus-specific immune response. Here we demonstrate that an HTLV-1-encoded protein, p12(I), resides in the endoplasmic reticulum (ER) and Golgi and physically binds to the free human major histocompatibility c...

journal_title：Journal of virology

authors： Johnson JM,Nicot C,Fullen J,Ciminale V,Casareto L,Mulloy JC,Jacobson S,Franchini G

更新日期：2001-07-01 00:00:00

abstract：:Activation of the interferon-inducible, double-stranded RNA-dependent protein kinase was monitored in monolayer cultures of control and interferon-treated HeLa cells infected with encephalomyocarditis virus. The extent of phosphorylation in the intact cell of the alpha-subunit of eucaryotic protein synthesis initiatio...

journal_title：Journal of virology

authors： Rice AP,Duncan R,Hershey JW,Kerr IM

更新日期：1985-06-01 00:00:00

abstract：:Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). In the present study, we identified a novel function of human cytomegalovirus (HCMV) that results in ...

journal_title：Journal of virology

authors： Jarvis MA,Borton JA,Keech AM,Wong J,Britt WJ,Magun BE,Nelson JA

更新日期：2006-06-01 00:00:00

abstract：:Utilization of internal ribosome entry segment (IRES) structures in the 5' noncoding region (5'NCR) of picornavirus RNAs for initiation of translation requires a number of host cell factors whose distribution may vary in different cells and whose requirement may vary for different picornaviruses. We have examined the ...

journal_title：Journal of virology

authors： Graff J,Cha J,Blyn LB,Ehrenfeld E

更新日期：1998-12-01 00:00:00

abstract：:Infection of primary or secondary cultures of Chinese hamster embryo cells with simian virus 40 at a multiplicity of 20 to 50 induced synthesis of the virus-specific intranuclear T antigen in 80 to 90% of the cells within 48 to 72 hr. In the infected cultures, 30 to 50% more cells were recruited into deoxyribonucleic ...

journal_title：Journal of virology

authors： Lehman JM,Defendi V

更新日期：1970-12-01 00:00:00

abstract：:Replication-defective vaccine vectors based on vesicular stomatitis virus (VSV) lacking its envelope glycoprotein gene (G) are highly effective in animal models. However, such ΔG vectors are difficult to grow because they require complementation with the VSV G protein. In addition, the complementing G protein induces ...

journal_title：Journal of virology

authors： Chattopadhyay A,Rose JK

更新日期：2011-03-01 00:00:00

abstract：:The full-length viral RNA of human immunodeficiency virus type 1 (HIV-1) functions both as the mRNA for the viral structural proteins Gag and Gag/Pol and as the genomic RNA packaged within viral particles. The packaging signal which Gag recognizes to initiate genome encapsidation is in the 5' untranslated region (UTR)...

journal_title：Journal of virology

authors： Anderson EC,Lever AM

更新日期：2006-11-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms of action of the tat-responsive sequence, mutational analysis of the tat-responsive sequence was carried out. The most critical region comprised nucleotides +18 to +44 and included the 3-nucleotide bulge at positions +23 to +25, the loop sequence, and an intact stem. In a...

journal_title：Journal of virology

authors： Roy S,Parkin NT,Rosen C,Itovitch J,Sonenberg N

更新日期：1990-03-01 00:00:00

abstract：:The assembly of hepatitis C virus (HCV) is poorly understood, largely due to the lack of mammalian cell culture systems that are easily manipulated and produce high titers of virus. This problem is highlighted by the inability of the recently established HCV replicon systems to support HCV capsid assembly despite high...

journal_title：Journal of virology

authors： Klein KC,Polyak SJ,Lingappa JR

更新日期：2004-09-01 00:00:00