Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation.

abstract：:It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus ...

journal_title：Journal of virology

authors： Manuel ER,Yeh WW,Balachandran H,Clarke RH,Lifton MA,Letvin NL

更新日期：2010-12-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) genomes are associated with the repressive heterochromatic marks H3K9me2/me3 and H3K27me3 during latency. Previous studies have demonstrated that inhibitors of H3K9me2/me3 histone demethylases reduce the ability of HSV-1 to reactivate from latency. Here we demonstrate that GSK-J4, a spec...

journal_title：Journal of virology

authors： Messer HG,Jacobs D,Dhummakupt A,Bloom DC

更新日期：2015-03-01 00:00:00

abstract：:Foxp3(+) CD4(+) regulatory T cells (Tregs) represent a highly suppressive T cell subset with well-characterized immunosuppressive effects during immune homeostasis and chronic infections, although the role of these cells in acute viral infections is poorly understood. The present study sought to examine the induction ...

journal_title：Journal of virology

authors： Betts RJ,Prabhu N,Ho AW,Lew FC,Hutchinson PE,Rotzschke O,Macary PA,Kemeny DM

更新日期：2012-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) can be reactivated from latency into the lytic cycle by many stimuli believed to operate by different mechanisms. Cell lines containing EBV differ in their responses to inducing stimuli, yet all stimuli require de novo protein synthesis (44). A crucial step preliminary to identifying these pro...

journal_title：Journal of virology

authors： Countryman J,Gradoville L,Bhaduri-McIntosh S,Ye J,Heston L,Himmelfarb S,Shedd D,Miller G

更新日期：2009-10-01 00:00:00

abstract：:Alfalfa mosaic virus (AMV) and ilarvirus RNAs are infectious only in the presence of the viral coat protein; therefore, an understanding of coat protein's function is important for defining viral replication mechanisms. Based on in vitro replication experiments, the conformational switch model states that AMV coat pro...

journal_title：Journal of virology

authors： Guogas LM,Laforest SM,Gehrke L

更新日期：2005-05-01 00:00:00

abstract：:Two of 25 healthy pet sooty mangabey (SM) monkeys (Cercocebus atys) living in West Africa were seropositive by immunoblot when surveyed for antibody to simian immunodeficiency virus of macaques (SIVmac). SIVsmLIB1 was isolated from one of the pet sooty mangabeys. Nucleotide sequence data showed that this isolate is a ...

journal_title：Journal of virology

authors： Marx PA,Li Y,Lerche NW,Sutjipto S,Gettie A,Yee JA,Brotman BH,Prince AM,Hanson A,Webster RG

更新日期：1991-08-01 00:00:00

abstract：:To examine the prerequisites for cleavage activation of the hemagglutinin of human influenza viruses, a cDNA clone obtained from strain A/Port Chalmers/1/73 (serotype H3) was subjected to site-directed mutagenesis and expressed in CV-1 cells by using a simian virus 40 vector. The number of basic residues at the cleava...

journal_title：Journal of virology

authors： Ohuchi R,Ohuchi M,Garten W,Klenk HD

更新日期：1991-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-...

journal_title：Journal of virology

authors： Karsten CB,Buettner FF,Cajic S,Nehlmeier I,Neumann B,Klippert A,Sauermann U,Reichl U,Gerardy-Schahn R,Rapp E,Stahl-Hennig C,Pöhlmann S

更新日期：2015-11-01 00:00:00

abstract：:We have previously shown that the herpes simplex virus immediate-early regulatory protein ICP27 acts posttranscriptionally to affect mRNA processing (R. M. Sandri-Goldin and G. E. Mendoza, Genes Dev. 6:848-863, 1992). Specifically, in the presence of ICP27, spliced target mRNAs were decreased 5- to 10-fold in transfec...

journal_title：Journal of virology

authors： Hardwicke MA,Sandri-Goldin RM

更新日期：1994-08-01 00:00:00

abstract：:The attachment of lymphocytic choriomeningitis virus (LCMV) to murine and primate cell lines was quantitated by a fluorescence-activated cell sorter assay in which binding of biotinylated virus was detected with streptavidin-fluorescein isothiocyanate. Cell lines that were readily infected by LCMV (e.g., MC57, Rin, BH...

journal_title：Journal of virology

authors： Borrow P,Oldstone MB

更新日期：1992-12-01 00:00:00

abstract：:Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. However, the mechanism by which influenza induces hypercytokinemia is not fully understood...

journal_title：Journal of virology

authors： Ma N,Li X,Jiang H,Dai Y,Xu G,Zhang Z

更新日期：2021-01-13 00:00:00

abstract：:The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the ma...

journal_title：Journal of virology

authors： Dekker S,Toussaint W,Panayotou G,de Wit T,Visser P,Grosveld F,Drabek D

更新日期：2003-11-01 00:00:00

abstract：:The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J. ...

journal_title：Journal of virology

authors： He J,Choe S,Walker R,Di Marzio P,Morgan DO,Landau NR

更新日期：1995-11-01 00:00:00

abstract：:The Ad2+ND4 virus is an adenovirus type 2 (Ad2)-simian virus 40 (SV40) recombination. The Ad2 genome of this recombinant has a rearrangement within early region 3; Ad2 DNA sequences between map positions 81.3 and 85.5 have been deleted, and the SV40 DNA sequences between map positions 0.11 and 0.626 have been inserted...

journal_title：Journal of virology

authors： Lewis AM Jr,Westphal H

更新日期：1983-08-01 00:00:00

abstract：:The role of the T4 bacteriophage regA gene in stabilizing early mRNA was investigated by assaying the level of functional mRNA from eight prereplicative genes (56 [dCMP hydroxymethylase], cd [dCMP deaminase], 1 [deoxynucleotide kinase], rIIA, rIIB, 46 [DNA arrest], and 45) during extended infection of Escherichia coli...

journal_title：Journal of virology

authors： Trimble RB,Maley

更新日期：1976-02-01 00:00:00

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly und...

journal_title：Journal of virology

authors： Zang N,Xie X,Deng Y,Wu S,Wang L,Peng C,Li S,Ni K,Luo Y,Liu E

更新日期：2011-12-01 00:00:00

abstract：:Purified preparations of human adenovirus type 12 showed two bands when subjected to isopycnic centrifugation in a density gradient of cesium chloride. Their density difference was about 0.003 g/ml, suggesting a small difference in their deoxyribonucleic acid to protein ratio. Virions with a lighter density can kill h...

journal_title：Journal of virology

authors： Mak S

更新日期：1971-04-01 00:00:00

abstract：:By using in situ hybridization, we localized three endogenous chicken retrovirus loci associated with the gs- chf- phenotype to distinct regions on chromosome 1. These three loci, ev4, ev5, and ev8, along with the two other known gs- chf--associated loci in White Leghorn chickens, ev1 and ev13, appear to be evenly dis...

journal_title：Journal of virology

authors： Tereba A,Astrin SM

更新日期：1982-08-01 00:00:00

abstract：:Ribosomes are observed intimately associated with nucleocapsids of vesicular, stomatitis virus, especially those that line structures that are either cytoplasmic vesicles or invaginations of the plasma membrane. ...

journal_title：Journal of virology

authors： Orenstein J,Shelton E,Lazzarini RA

更新日期：1975-08-01 00:00:00

abstract：:By using temperature-sensitive (ts) and suppressor-sensitive (sus) mutants, 11 essential genes have been identified in phage phi105. The order of the genes has been established in two- and three-factor crosses. The genes can be arranged in a linear order; this order is identical in the vegetative phage and in the prop...

journal_title：Journal of virology

authors： Armentrout RW,Rutberg L

更新日期：1970-12-01 00:00:00

abstract：:The effect DNA repair might have on the integration of exogenous proviral DNA into host cell DNA was investigated by comparing the efficiency of proviral DNA integration in normal chicken embryonic fibroblasts and in chicken embryonic fibroblasts treated with UV or 4-nitroquinoline-1-oxide. The cells were treated with...

journal_title：Journal of virology

authors： Tsuruo T,Baluda MA

更新日期：1977-09-01 00:00:00

abstract：:The RNA elements that are required for replication of defective interfering (DI) RNA of the JHM strain of mouse hepatitis virus (MHV) consist of three discontinuous genomic regions: about 0.46 to 0.47 kb from both terminal sequences and an internal 58-nucleotide (nt)-long sequence (58-nt region) present at about 0.9 k...

journal_title：Journal of virology

authors： Repass JF,Makino S

更新日期：1998-10-01 00:00:00

abstract：:To facilitate the determination of the genomic location of the vaccinia virus gene(s) encoding alpha-amanitin resistance (alpha r) (Villarreal et al., J. Virol. 51:359-366, 1984), a collection of alpha r, temperature-sensitive (ts) mutants were isolated. The premise of these experiments was that mutants might be found...

journal_title：Journal of virology

authors： Villarreal EC,Hruby DE

更新日期：1986-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is s...

journal_title：Journal of virology

authors： Laguette N,Brégnard C,Bouchet J,Benmerah A,Benichou S,Basmaciogullari S

更新日期：2009-07-01 00:00:00

abstract：:A number of human immunodeficiency type 1 (HIV-1)-based vectors have recently been shown to transduce nondividing cells in vivo as well as in vitro. However, if these vectors are to be considered for eventual clinical use, a major consideration is to reduce the probability of unintended generation of replication-compe...

journal_title：Journal of virology

authors： Gasmi M,Glynn J,Jin MJ,Jolly DJ,Yee JK,Chen ST

更新日期：1999-03-01 00:00:00

abstract：:The nucleotide and deduced amino acid sequences of the P1 region of the genomes of 10 independent equine rhinitis A virus (ERAV) isolates were determined and found to be very closely related. A panel of seven monoclonal antibodies to the prototype virus ERAV.393/76 that bound to nonneutralization epitopes conserved am...

journal_title：Journal of virology

authors： Varrasso A,Drummer HE,Huang JA,Stevenson RA,Ficorilli N,Studdert MJ,Hartley CA

更新日期：2001-11-01 00:00:00

abstract：:Recent studies suggest the existence of cancer stem cells (CSC) and cancer progenitor cells (CPC), although strict definitions of neither CSC nor CPC have been developed. We have produced evidence that the principal oncoprotein of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1), which is associated with hum...

journal_title：Journal of virology

authors： Kondo S,Wakisaka N,Muramatsu M,Zen Y,Endo K,Murono S,Sugimoto H,Yamaoka S,Pagano JS,Yoshizaki T

更新日期：2011-11-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BMRF1 protein is a DNA polymerase processivity factor. We have deleted the BMRF1 open reading frame from the EBV genome and assessed the DeltaBMRF1 EBV phenotype. DeltaBMRF1 viruses were replication deficient, but the wild-type phenotype could be restored by BMRF1 trans-complementation. Th...

journal_title：Journal of virology

authors： Neuhierl B,Delecluse HJ

更新日期：2006-05-01 00:00:00