Abstract:
:Previously it was shown that the host-range gene of the Bratislava strain of avain sarcoma virus (B77 virus) spontaneously mutates with a very high rate. The wild-type B77 virus called B77 virus-II, mutates either to virus that efficiently infects duck cells (B77 virus-III) or to virus that does not mutate to the ability to infect duck cells (B77 virus-I) (Zarling and Temin, 1976). No significant differences in either the virion envelope glycoproteins or other major virion proteins were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. However, pseudotypes of B77 virus-I with proteins of a transformation-defective mutant of B77 virus-III formed foci efficiently in duck cells. An alteration in the envelope protein of B77 virus-I was demonstrated by experiments in which B77 firus-I was fused into duck cells with UV-irradiated Sendai virus and formed foci. Neutralization experiments further demonstrated that B77 virus host-range mutants have altered type-specific envelope antigens. Thus, the spontaneous mutations in the host-range gene of B77 virus involve changes in the type-specific virion envelope antigen.
journal_name
J Viroljournal_title
Journal of virologyauthors
Zarling DA,Mosser AG,Temin HMdoi
10.1128/JVI.21.1.105-112.1977subject
Has Abstractpub_date
1977-01-01 00:00:00pages
105-12issue
1eissn
0022-538Xissn
1098-5514journal_volume
21pub_type
杂志文章abstract::The RV144 HIV-1 vaccine trial (Thailand, 2003 to 2009), using immunogens genetically matched to the regional epidemic, demonstrated the first evidence of efficacy for an HIV-1 vaccine. Here we studied the molecular evolution of the HIV-1 epidemic from the time of immunogen selection to the execution of the efficacy tr...
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doi:10.1128/JVI.67.2.886-893.1993
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journal_title:Journal of virology
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doi:10.1128/jvi.74.17.7745-7754.2000
更新日期:2000-09-01 00:00:00
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doi:10.1128/JVI.68.10.6815-6819.1994
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.73.2.1350-1361.1999
更新日期:1999-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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