Abstract:
:Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the anti-SIV responses. The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines.
journal_name
J Viroljournal_title
Journal of virologyauthors
Maness NJ,Walsh AD,Piaskowski SM,Furlott J,Kolar HL,Bean AT,Wilson NA,Watkins DIdoi
10.1128/JVI.01419-10subject
Has Abstractpub_date
2010-11-01 00:00:00pages
11569-74issue
21eissn
0022-538Xissn
1098-5514pii
JVI.01419-10journal_volume
84pub_type
杂志文章abstract::Recently we reported that in vitro RNA transcripts complementary to the genome of hepatitis delta virus (HDV) contain a unique site at which self-cleavage can occur. Subsequent studies showed that a similar self-cleavage site was present on in vitro RNA transcripts of genomic HDV RNA. The same self-cleavage reactions ...
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.8.4830-4841.1995
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.11.8522-8530.1997
更新日期:1997-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.21.11546-11554.2003
更新日期:2003-11-01 00:00:00
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doi:10.1128/JVI.29.2.799-804.1979
更新日期:1979-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,收录出版
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更新日期:2004-05-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1973-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00