Monomer and multimer covalently closed circular forms of Rous sarcoma virus DNA.

abstract：:The sensitivity of highly purified human fibroblast interferon and partially purified human leukocyte interferon to several proteolytic and glycolytic enzymes was determined with respect to antiviral activity, isoelectric point, molecular weight, and thermal stability. Leucine aminopeptidase altered the distribution o...

journal_title：Journal of virology

authors： Otto MJ,Sedmak JJ,Grossberg SE

更新日期：1980-08-01 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...

journal_title：Journal of virology

authors： Fisher S,Genbacev O,Maidji E,Pereira L

更新日期：2000-08-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) and the closely related simian immunodeficiency virus (SIV) induce profound immune dysfunction in primate species. The present studies show that cell populations infected in vitro with SIV exhibit increases in major histocompatibility complex (MHC) class II antigen expression. Ce...

journal_title：Journal of virology

authors： Kannagi M,Kiyotaki M,King NW,Lord CI,Letvin NL

更新日期：1987-05-01 00:00:00

abstract：UNLABELLED:The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccinated individuals frequently produce antibodies specific for ...

journal_title：Journal of virology

authors： Acharya P,Tolbert WD,Gohain N,Wu X,Yu L,Liu T,Huang W,Huang CC,Kwon YD,Louder RK,Luongo TS,McLellan JS,Pancera M,Yang Y,Zhang B,Flinko R,Foulke JS Jr,Sajadi MM,Kamin-Lewis R,Robinson JE,Martin L,Kwong PD,Guan

更新日期：2014-11-01 00:00:00

abstract：:The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...

journal_title：Journal of virology

authors： Wagner R,Geyer H,Geyer R,Klenk HD

更新日期：1996-06-01 00:00:00

abstract：:The high rate of HIV-1 evolution contributes to immune escape, enables the virus to escape drug therapy, and may underlie the difficulty of producing an effective vaccine. Identifying constraints on HIV evolution is therefore of prime importance. To investigate this problem, we examined the relationships between seque...

journal_title：Journal of virology

authors： Woo J,Robertson DL,Lovell SC

更新日期：2010-12-01 00:00:00

abstract：:Direct evidence is presented for a host-specific role of the cucumovirus capsid protein in long-distance movement within infected plants. Cucumber (Cucumis sativus L.) is a systemic host for cucumber mosaic cucumovirus (CMV). Tomato aspermy cucumovirus, strain 1 (1-TAV), multiplied to the levels of CMV (i.e., replicat...

journal_title：Journal of virology

authors： Taliansky ME,García-Arenal F

更新日期：1995-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a major causative agent of posttransfusion non-A, non-B hepatitis, which often develops into malignant chronic diseases, including liver cirrhosis and hepatocellular carcinoma. We have cloned from human carriers overlapping cDNAs (9,416 bp) covering the entire coding region of the HCV genome...

journal_title：Journal of virology

authors： Takamizawa A,Mori C,Fuke I,Manabe S,Murakami S,Fujita J,Onishi E,Andoh T,Yoshida I,Okayama H

更新日期：1991-03-01 00:00:00

abstract：:The N-terminal domain of the bovine papillomavirus type 1 E2 protein is important for viral DNA replication, for transcriptional transactivation, and for interaction with the E1 protein. To determine which residues of this 200-amino-acid domain are important for these activities, single conservative amino acid substit...

journal_title：Journal of virology

authors： Brokaw JL,Blanco M,McBride AA

更新日期：1996-01-01 00:00:00

abstract：:Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better...

journal_title：Journal of virology

authors： Santos JJS,Finch C,Sutton T,Obadan A,Aguirre I,Wan Z,Lopez D,Geiger G,Gonzalez-Reiche AS,Ferreri L,Perez DR

更新日期：2017-05-26 00:00:00

abstract：:Varicella-zoster virus (VZV) is renowned for its very low titer when grown in cultured cells. There remains no single explanation for the low infectivity. In this study, viral particles on the surfaces of infected cells were examined by several imaging technologies. Few surface particles were detected at 48 h postinfe...

journal_title：Journal of virology

authors： Carpenter JE,Hutchinson JA,Jackson W,Grose C

更新日期：2008-03-01 00:00:00

abstract：:We have investigated the effect of Xenopus laevis p53 (Xp53) on transcription from a variety of promoters which are regulated by mouse p53 using a chloramphenicol acetyltransferase reporter system. Although Xp53 transactivated promoters that are up-regulated by mouse p53, it was unable to cause repression. This abilit...

journal_title：Journal of virology

authors： Ridgway PJ,Soussi T,Braithwaite AW

更新日期：1994-11-01 00:00:00

abstract：:Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as did the wild type. This...

journal_title：Journal of virology

authors： Wu TT,Condreay LD,Coates L,Aldrich C,Mason W

更新日期：1991-05-01 00:00:00

abstract：:To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with pathogenic simian/human immunodeficiency virus (SHIV) strain C2/1, an animal model of HIV infection. The relationship bet...

journal_title：Journal of virology

authors： Yamakami K,Honda M,Takei M,Ami Y,Kitamura N,Nishinarita S,Sawada S,Horie T

更新日期：2004-10-01 00:00:00

abstract：:Understanding the mechanism(s) of action of the hepatitis B virus (HBV)-encoded protein HBx is fundamental to elucidating the underlying mechanisms of chronic liver disease and hepatocellular carcinoma caused by HBV infection. In our continued attempts to identify cellular targets of HBx, we have previously reported t...

journal_title：Journal of virology

authors： Rahmani Z,Huh KW,Lasher R,Siddiqui A

更新日期：2000-03-01 00:00:00

abstract：:Most current diagnostic tests for transmissible spongiform encephalopathies (TSE) rely on the presence of proteinase K (PK)-resistant PrP(Sc) (PrP-res) in postmortem tissues as an indication of TSE disease. However, a number of studies have highlighted a discrepancy between TSE infectivity and PrP-res levels in both n...

journal_title：Journal of virology

authors： Dobie K,Barron R

更新日期：2013-05-01 00:00:00

abstract：:Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial ...

journal_title：Journal of virology

authors： Huang Y,Kong WP,Nabel GJ

更新日期：2001-05-01 00:00:00

abstract：:Chaperone-enriched domains are formed in the nuclei of cells lytically infected with herpes simplex virus type 1 (HSV-1). These domains, called VICE, for virus induced chaperone enriched, contain Hsc70, Hsp70, Hsp40, Hsp90, polyubiquitinated proteins, and components of the proteasome machinery. Accumulating evidence i...

journal_title：Journal of virology

authors： Mathew SS,Della Selva MP,Burch AD

更新日期：2009-09-01 00:00:00

abstract：:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentiv...

journal_title：Journal of virology

authors： Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot K

更新日期：2013-10-01 00:00:00

abstract：:Transcriptional activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) by viral protein p40x requires a 21-base-pair (bp) sequence which is repeated three times within the LTR. This sequence contains a core octanucleotide (TGACGTCT) which has been attributed to be a cyclic-AMP (cAMP)-...

journal_title：Journal of virology

authors： Jeang KT,Boros I,Brady J,Radonovich M,Khoury G

更新日期：1988-12-01 00:00:00

abstract：:tsAF8 cells are temperature-sensitive (ts) mutants of BHK-21 cells that arrest at the nonpermissive temperature in the G1 phase of the cell cycle. When made quiescent by serum restriction, they can be stimulated to enter the S phase by 10% serum at 34 degrees C, but not at 40.6 degrees C. Infection by adenovirus type ...

journal_title：Journal of virology

authors： Rossini M,Jonak GJ,Baserga R

更新日期：1981-06-01 00:00:00

abstract：:Type I interferon is induced shortly following viral infection and represents a first line of host defense against a majority of viral pathogens. Not surprisingly, both replication and latency of gammaherpesviruses, ubiquitous cancer-associated pathogens, are attenuated by type I interferon, although the mechanism of ...

journal_title：Journal of virology

authors： Mounce BC,Mboko WP,Kanack AJ,Tarakanova VL

更新日期：2014-02-01 00:00:00

abstract：:Cells infected by Rous-associated virus 61 (RAV-61) contained a precursor-like protein, pr90, that was specifically precipitated by antiserum directed against envelope glycoproteins, gp85 and gp35. Tryptic peptide mapping showed that pr90 contained tryptic sequences of both gp85 and gp35. Pactamycin mapping experiment...

journal_title：Journal of virology

authors： Shealy DJ,Rueckert RR

更新日期：1978-05-01 00:00:00

abstract：:By means of both electron microscopy and plaque assay techniques, 10(-3)m Zn(2+) has been shown to reduce the adsorption rate of male-specific filamentous deoxyribonucleic acid bacteriophages to the tips of F pili. In contrast, 10(-3)m Zn(2+) did not affect the adsorption of male-specific ribonucleic acid phages to th...

journal_title：Journal of virology

authors： Ou JT,Anderson TF

更新日期：1972-10-01 00:00:00

abstract：:The morphology of Safferman's virus of blue-green algae (phycovirus LPP-1) has been studied by electron microscopy and physicochemical methods. The virion has a short (100 to 200 A long, 150 A in diameter) forked tail, with an outer sheath, an inner core, and a capital attached to one of the vertices of a polyhedral h...

journal_title：Journal of virology

authors： Luftig R,Haselkorn R

更新日期：1967-04-01 00:00:00

abstract：:A method to study the function of individual African swine fever virus (ASFV) gene products utilizing the Escherichia coli lac repressor-operator system has been developed. Recombinant viruses containing both the lacI gene encoding the lac repressor and a strong virus late promoter modified by the insertion of one or ...

journal_title：Journal of virology

authors： García-Escudero R,Andrés G,Almazán F,Viñuela E

更新日期：1998-04-01 00:00:00

abstract：:Natural killer (NK) cells are an important component in the control of influenza virus infection, acting to both clear virus-infected cells and release antiviral cytokines. Engagement of CD16 on NK cells by antibody-coated influenza virus-infected cells results in antibody-dependent cellular cytotoxicity (ADCC). Incre...

journal_title：Journal of virology

authors： Jegaskanda S,Vanderven HA,Tan HX,Alcantara S,Wragg KM,Parsons MS,Chung AW,Juno JA,Kent SJ

更新日期：2019-02-19 00:00:00

abstract：:Poliovirus infection of HeLa cells results in a rapid inhibition of host protein synthesis by a mechanism that does not affect the translation of poliovirus RNA. It has been suggested that this virus-induced translational control results from inactivation of the cap-binding protein complex, and it has been shown that ...

journal_title：Journal of virology

authors： Lloyd RE,Jense HG,Ehrenfeld E

更新日期：1987-08-01 00:00:00

abstract：:Transcription of the terminal protein (TP) gene of Epstein-Barr virus (EBV) in Burkitt's lymphoma cells, in EBV-negative Burkitt's lymphoma cells converted with transformation-defective (P3HR1) and transformation-competent (B95-8, AG876) EBV strains, and in EBV-immortalized cell lines was studied. A TP1 cDNA probe spa...

journal_title：Journal of virology

authors： Zimber-Strobl U,Suentzenich KO,Laux G,Eick D,Cordier M,Calender A,Billaud M,Lenoir GM,Bornkamm GW

更新日期：1991-01-01 00:00:00