Modification and reorganization of the cytoprotective cellular chaperone Hsp27 during herpes simplex virus type 1 infection.

abstract：:Hepatitis E virus genotype 1 strain Sar55 replicated in subcloned Caco-2 intestinal cells and Huh7 hepatoma cells that had been transfected with in vitro transcribed viral genomes, and hepatitis E virions were released into the culture medium of both cell lines. Virus egress from cells depended on open reading frame 3...

journal_title：Journal of virology

authors： Emerson SU,Nguyen HT,Torian U,Burke D,Engle R,Purcell RH

更新日期：2010-09-01 00:00:00

abstract：:Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a CRISPR activation genome-wide screening to identify host genes that can inhibit murine norovirus (MNoV) replication in human cells. Our screens identified with hig...

journal_title：Journal of virology

authors： Orchard RC,Sullender ME,Dunlap BF,Balce DR,Doench JG,Virgin HW

更新日期：2018-12-10 00:00:00

abstract：:The recent identification of coreceptors that mediate efficient entry of human immunodeficiency virus type 1 (HIV-1) suggests new therapeutic and preventive strategies. We analyzed simian immunodeficiency virus (SIV) entry cofactors to investigate whether the macaque SIV model can be used as an experimental model to e...

journal_title：Journal of virology

authors： Kirchhoff F,Pöhlmann S,Hamacher M,Means RE,Kraus T,Uberla K,Di Marzio P

更新日期：1997-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) entry is dependent on the interaction of virion glycoprotein D (gD) with one of several cellular receptors. We previously showed that gD binds specifically to two structurally dissimilar receptors, HveA and HveC. We have continued our studies by using (i) a panel of baculovirus-produced gD m...

journal_title：Journal of virology

authors： Whitbeck JC,Muggeridge MI,Rux AH,Hou W,Krummenacher C,Lou H,van Geelen A,Eisenberg RJ,Cohen GH

更新日期：1999-12-01 00:00:00

abstract：:We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of...

journal_title：Journal of virology

authors： Cannon PM,Kim N,Kingsman SM,Kingsman AJ

更新日期：1996-11-01 00:00:00

abstract：:The v-src coding region was deleted from cloned Rous sarcoma virus DNA, and the deleted clones were tested for infectivity by transfection. All of the coding region, as well as most of the sequences lying between v-src and the unique 3' region (U3), could be deleted without affecting viability. However, at least 9 and...

journal_title：Journal of virology

authors： Sorge J,Hughes SH

更新日期：1982-08-01 00:00:00

abstract：:Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products al...

journal_title：Journal of virology

authors： Maruo S,Nanbo A,Takada K

更新日期：2001-10-01 00:00:00

abstract：:Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, respectively. After resolution of the primary disease, SVV and VZV establish latent infection of neural ganglia and may later reactivate to cause a sec...

journal_title：Journal of virology

authors： Ou Y,Davis KA,Traina-Dorge V,Gray WL

更新日期：2007-08-01 00:00:00

abstract：:The Sindbis virus minimal subgenomic mRNA promoter (spanning positions -19 to +5 relative to the subgenomic mRNA start site) is approximately three- to sixfold less active than the fully active -98 to +14 promoter region. We identified two elements flanking the -19 to +5 region which increase its transcription to leve...

journal_title：Journal of virology

authors： Wielgosz MM,Raju R,Huang HV

更新日期：2001-04-01 00:00:00

abstract：:Four isolates of human papovaviruses (RF, GS, DW, and MG viruses) obtained from the urine specimens of renal allograft recipients in widely separated locations were compared with BK virus. Hemagglutination inhibition tests and plaque neutralization assays showed that all were antigenically related to BK virus. All iso...

journal_title：Journal of virology

authors： Wright PJ,Bernhardt G,Major EO,di Mayorca G

更新日期：1976-03-01 00:00:00

abstract：:Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fund...

journal_title：Journal of virology

authors： Woodward AM,Mauris J,Argüeso P

更新日期：2013-05-01 00:00:00

abstract：:Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter and vacuolation and hypomyelination of some white matter tracts. Bas...

journal_title：Journal of virology

authors： Carlson GA,Banks S,Lund D,Reichert C,Groth D,Torchia M,Dearmond SJ,Prusiner SB

更新日期：1997-03-01 00:00:00

abstract：:Striking morphologic similarities between Machupo, Tacaribe, and lymphocytic choriomeningitis viruses were found by thin-section electron microscopy. It is proposed that these viruses be brought together into a single taxonomic group. ...

journal_title：Journal of virology

authors： Murphy FA,Webb PA,Johnson KM,Whitfield SG

更新日期：1969-10-01 00:00:00

abstract：:The role of autoimmunity in large-vessel vasculitis in humans remains unclear. We have previously shown that infection of gamma interferon receptor knockout (IFN-gamma R(-/-)) mice with gammaherpesvirus 68 (gamma HV68) results in severe inflammation of the large elastic arteries that is pathologically similar to the l...

journal_title：Journal of virology

authors： Dal Canto AJ,Virgin HW 4th,Speck SH

更新日期：2000-12-01 00:00:00

abstract：:The gene encoding glycoprotein B (gB) of murine cytomegalovirus (MCMV) strain Smith was identified, sequenced, and expressed by recombinant vaccinia virus. The gB gene was found adjacent to the polymerase gene, as it is in the genome of human cytomegalovirus (HCMV). The open reading frame consists of 2,784 nucleotides...

journal_title：Journal of virology

authors： Rapp M,Messerle M,Bühler B,Tannheimer M,Keil GM,Koszinowski UH

更新日期：1992-07-01 00:00:00

abstract：:RNA transfer (Northern) blot analysis was used to perform the physical characterization of the transcript expressed in murine sensory nerve ganglia latently infected with herpes simplex virus type 1. Most of this latency-associated transcript (LAT) was isolated in the poly(A)- fraction from ganglia. A smaller RNA spec...

journal_title：Journal of virology

authors： Wagner EK,Devi-Rao G,Feldman LT,Dobson AT,Zhang YF,Flanagan WM,Stevens JG

更新日期：1988-04-01 00:00:00

abstract：:The protein (VPg) linked to the 5' termini of poliovirus RNAs resolved into two species when subjected to non-equilibrium electrofocusing. The differently charged forms of VPg were not due to protein phosphorylation nor to variability of the number of phosphate residues associated with the nucleotide moiety remaining ...

journal_title：Journal of virology

authors： Richards OC,Hey TD,Ehrenfeld E

更新日期：1981-06-01 00:00:00

abstract：:Two serologically distinguishable primate herpesviruses, Herpesvirus aotus type 1 and type 3, were examined with regard to their genomes and structural polypeptides. The duplex DNA genomes of these two viruses were found to be essentially identical in molecular weight (Mr approximately equal to 145 X 10(6)) and guanin...

journal_title：Journal of virology

authors： Ebeling A,Keil G,Nowak B,Fleckenstein B,Berthelot N,Sheldrick P

更新日期：1983-02-01 00:00:00

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00

abstract：:The 70S RNA of Rous sarcoma virus contains 4S RNAs which serve as primers for the initiation of DNA synthesis in vitro by the RNA-directed DNA polymerase of the virus. We purified these primers in three different ways-by isolation of the covalent complex between primer and nascent DNA, by differential melting of the 7...

journal_title：Journal of virology

authors： Faras AJ,Dahlberg JE,Sawyer RC,Harada F,Taylor JM,Levinson WE,Bishop JM,Goodman HM

更新日期：1974-05-01 00:00:00

abstract：:Experiments were conducted to investigate the roles of Marek's disease virus serotype 1 (MDV-1) major tegument proteins VP11/12, VP13/14, VP16, and VP22 in viral growth in cultured cells. Based on a bacterial artificial chromosome clone of MDV-1 (BAC20), mutant viruses were constructed in which the MDV-1 homologs of U...

journal_title：Journal of virology

authors： Dorange F,Tischer BK,Vautherot JF,Osterrieder N

更新日期：2002-02-01 00:00:00

abstract：:Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells. Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T ...

journal_title：Journal of virology

authors： Valentin H,Lemasson I,Hamaia S,Cassé H,König S,Devaux C,Gazzolo L

更新日期：1997-11-01 00:00:00

abstract：:Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the immune response by disrupting their function. We have previously reported that VZV productively infects ...

journal_title：Journal of virology

authors： Morrow G,Slobedman B,Cunningham AL,Abendroth A

更新日期：2003-04-01 00:00:00

abstract：:In this paper, we report that the DNA of bovine mammillitis virus (BMV) consists of two covalently linked components that are 71.5 x 10(6) and 15.7 x 10(6) in molecular weight and designated L and S, respectively. We further report that the BMV DNA consists of four equimolar populations differing only in the orientati...

journal_title：Journal of virology

authors： Buchman TG,Roizman B

更新日期：1978-01-01 00:00:00

abstract：:Rodent fibroblasts infected with the ts371 Kirsten murine sarcoma virus (KiMuSV) are temperature sensitive for the maintenance of transformation because of the production of an abnormal p21 protein. We cloned the ts371 KiMuSV provirus from the genome of a conditionally transformed nonproducer cell line, ts371 KiMuSV N...

journal_title：Journal of virology

authors： Stein RB,Tai JY,Scolnick EM

更新日期：1986-11-01 00:00:00

abstract：:We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An en...

journal_title：Journal of virology

authors： Li QX,Fan H

更新日期：1991-08-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:Enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity and rate of evolution of EV71, we have determined and analyzed c...

journal_title：Journal of virology

authors： Brown BA,Oberste MS,Alexander JP Jr,Kennett ML,Pallansch MA

更新日期：1999-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is s...

journal_title：Journal of virology

authors： Laguette N,Brégnard C,Bouchet J,Benmerah A,Benichou S,Basmaciogullari S

更新日期：2009-07-01 00:00:00

abstract：:We describe initial genetic and structural characterizations of HK97, a temperate bacteriophage of Escherichia coli. We isolated 28 amber mutants, characterized them with respect to what phage-related structures they make, and mapped many of them to restriction fragments of genomic DNA. Sodium dodecyl sulfate-polyacry...

journal_title：Journal of virology

authors： Popa MP,McKelvey TA,Hempel J,Hendrix RW

更新日期：1991-06-01 00:00:00