Transcription of DNA from the 70S RNA of Rous sarcoma virus. II. Structure of a 4S RNA primer.

abstract：:Reverse genetic analyses of negative-strand RNA (NSR) viruses have provided enormous advances in our understanding of animal viruses over the past 20 years, but technical difficulties have hampered application to plant NSR viruses. To develop a reverse genetic approach for analysis of plant NSR viruses, we have engine...

journal_title：Journal of virology

authors： Ganesan U,Bragg JN,Deng M,Marr S,Lee MY,Qian S,Shi M,Kappel J,Peters C,Lee Y,Goodin MM,Dietzgen RG,Li Z,Jackson AO

更新日期：2013-10-01 00:00:00

abstract：:The foot-and-mouth disease virus (FMDV) capsid is highly acid labile, but introduction of amino acid replacements, including an N17D change in VP1, can increase its acid resistance. Using mutant VP1 N17D as a starting point, we isolated a virus with higher acid resistance carrying an additional replacement, VP2 H145Y,...

journal_title：Journal of virology

authors： Vázquez-Calvo A,Caridi F,Sobrino F,Martín-Acebes MA

更新日期：2014-03-01 00:00:00

abstract：:The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...

journal_title：Journal of virology

authors： Zhang YN,Liu YY,Xiao FC,Liu CC,Liang XD,Chen J,Zhou J,Baloch AS,Kan L,Zhou B,Qiu HJ

更新日期：2018-07-17 00:00:00

abstract：:Endogenous retroviruses, records of past retroviral infections, are ubiquitous in vertebrate genomes. On occasion, vertebrate hosts have co-opted retroviral genes for their own biological functions. Here, we perform a phylogenomic survey of retroviral gag gene homologs within vertebrate genomes and identify two ancien...

journal_title：Journal of virology

authors： Wang J,Gong Z,Han GZ

更新日期：2019-06-28 00:00:00

abstract：:The investigation of papillomavirus chromatin has been hampered by the unavailability of a tissue culture system for vegetative growth of these viruses. We have used, therefore, bovine papillomavirus type 1-transformed hamster embryo fibroblasts containing 200 to 250 episomal genome equivalents per cell as a source of...

journal_title：Journal of virology

authors： Rösl F,Waldeck W,Sauer G

更新日期：1983-05-01 00:00:00

abstract：:Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with simian/human immuno...

journal_title：Journal of virology

authors： Vogel TU,Reynolds MR,Fuller DH,Vielhuber K,Shipley T,Fuller JT,Kunstman KJ,Sutter G,Marthas ML,Erfle V,Wolinsky SM,Wang C,Allison DB,Rud EW,Wilson N,Montefiori D,Altman JD,Watkins DI

更新日期：2003-12-01 00:00:00

abstract：:Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept...

journal_title：Journal of virology

authors： Xu P,Chen Z,Phan S,Pickar A,He B

更新日期：2014-03-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of an infectious cloned genome of ground squirrel hepatitis virus (GSHV), a nonpathogenic member of the hepadnavirus group. The genome is 3,311 base pairs long and contains the major open reading frames described for the related human and woodchuck hepatitis B viruse...

journal_title：Journal of virology

authors： Seeger C,Ganem D,Varmus HE

更新日期：1984-08-01 00:00:00

abstract：:BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells. The HIV-1-encoded Vpu protein effectively antagonizes the activity of BST-2. How Vpu accomplishes this task remai...

journal_title：Journal of virology

authors： Andrew AJ,Miyagi E,Strebel K

更新日期：2011-03-01 00:00:00

abstract：:To assess the heterogeneity of cytotoxic T lymphocytes (CTLs) directed against viral epitopes, we studied six class I major histocompatibility complex-restricted (H-2Db) CTL clones that recognize the same 9-amino-acid immunodominant epitope, amino acids 278 to 286 from envelope glycoprotein 2 (GP2) of lymphocytic chor...

journal_title：Journal of virology

authors： Joly E,Salvato M,Whitton JL,Oldstone MB

更新日期：1989-05-01 00:00:00

abstract：:Infection with human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell lymphoma/leukemia. This disease occurs in only a small minority of people infected with HTLV-I and manifests itself many years after infection. Therefore, it appears that a fine balance exists between HTLV-I and the host T-cell ...

journal_title：Journal of virology

authors： Clark NM,Smith MJ,Hilfinger JM,Markovitz DM

更新日期：1993-09-01 00:00:00

abstract：:Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the immune response by disrupting their function. We have previously reported that VZV productively infects ...

journal_title：Journal of virology

authors： Morrow G,Slobedman B,Cunningham AL,Abendroth A

更新日期：2003-04-01 00:00:00

abstract：:The neutralizing activities of polyclonal antibodies and monoclonal antibodies (MAbs) obtained by immunization of mice with L1 virus-like particles (VLPs) were investigated by using pseudovirion infectivity assays for human papillomavirus type 16 (HPV-16), HPV-31, HPV-33, HPV-45, HPV-58, and HPV-59 to obtain a better ...

journal_title：Journal of virology

authors： Combita AL,Touzé A,Bousarghin L,Christensen ND,Coursaget P

更新日期：2002-07-01 00:00:00

abstract：:The duck hepatitis B virus (DHBV) pregenomic RNA is a bicistronic mRNA encoding the core and polymerase proteins. Thirteen AUGs (C2 to C14) and 10 stop codons (S1 to S10) are located between the C1 AUG for the core protein and the P1 AUG that initiates polymerase translation. We previously found that the translation o...

journal_title：Journal of virology

authors： Cao F,Scougall CA,Jilbert AR,Tavis JE

更新日期：2009-02-01 00:00:00

abstract：:Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (M...

journal_title：Journal of virology

authors： Jeong YS,Makino S

更新日期：1994-04-01 00:00:00

abstract：:We have obtained a polyclonal antiserum, N-BE, against the denatured, amino-terminal half of the measles virus (MV) nucleocapsid (N) protein and a monoclonal antibody (MAb), N46, which recognizes a conformation-dependent epitope in the same region. Amino acid residues 23 to 239 were required and sufficient for the for...

journal_title：Journal of virology

authors： Gombart AF,Hirano A,Wong TC

更新日期：1993-07-01 00:00:00

abstract：UNLABELLED:Multiple cellular pathways are regulated by small ubiquitin-like modifier (SUMO) modification, including ubiquitin-mediated proteolysis, signal transduction, innate immunity, and antiviral defense. In the study described in this report, we investigated the effects of SUMO on the replication of two members of...

journal_title：Journal of virology

authors： Maarifi G,Hannoun Z,Geoffroy MC,El Asmi F,Zarrouk K,Nisole S,Blondel D,Chelbi-Alix MK

更新日期：2016-06-24 00:00:00

abstract：:Alphaviruses represent a serious public health threat and cause a wide variety of diseases, ranging from severe encephalitis, which can result in death or neurological sequelae, to mild infection, characterized by fever, skin rashes, and arthritis. In the infected cells, alphaviruses express only four nonstructural pr...

journal_title：Journal of virology

authors： Gorchakov R,Garmashova N,Frolova E,Frolov I

更新日期：2008-10-01 00:00:00

abstract：:Purified reovirus serotype 1, encapsulated in biodegradable aqueous microcapsules, was found to bypass maternal antibody passively transferred by suckling to neonates. Genetically identical, immunocompetent F1 scid/+ mice were generated by the reciprocal crosses of C.B17 scid/scid and normal congenic +/+ adult mice. T...

journal_title：Journal of virology

authors： Periwal SB,Speaker TJ,Cebra JJ

更新日期：1997-04-01 00:00:00

abstract：:Chloramphenicol affects several steps in the DNA replication of mycoplasma virus L51, a noncytocidal, naked, bullet-shaped virion containing circular single-stranded (SS) DNA of 1.5 X 10(6) daltons (4.5 kilobases). In the presence of chloramphenicol, adsorption was normal and parental SS DNA was converted to double-st...

journal_title：Journal of virology

authors： Das J,Maniloff J

更新日期：1982-12-01 00:00:00

abstract：:Glycans on human immunodeficiency virus (HIV) envelope protein play an important role in infection and evasion from host immune responses. To examine the role of specific glycans, we introduced single or multiple mutations into potential N-linked glycosylation sites in hypervariable regions (V1 to V3) of the env gene ...

journal_title：Journal of virology

authors： Li Y,Cleveland B,Klots I,Travis B,Richardson BA,Anderson D,Montefiori D,Polacino P,Hu SL

更新日期：2008-01-01 00:00:00

abstract：:We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa...

journal_title：Journal of virology

authors： Orsini MJ,Debouck CM

更新日期：1996-11-01 00:00:00

abstract：:Two hundred forty pyridazinamine derivatives were tested for the ability to stabilize the antigenicity and infectivity of oral poliovirus vaccine subjected to 45 degrees C for 2 h. Seven compounds stabilized the antigenicity of all three vaccine strains and neutralized the viral particles in a way that is reversible b...

journal_title：Journal of virology

authors： Andries K,Rombaut B,Dewindt B,Boeyé A

更新日期：1994-05-01 00:00:00

abstract：:The hepatitis B virus (HBV) core promoter regulates the transcription of two related RNA products named precore RNA and core RNA. Previous studies indicate that a double-nucleotide mutation that occurs frequently during chronic HBV infection converts a nuclear receptor binding site in the core promoter to the binding ...

journal_title：Journal of virology

authors： Li J,Xu Z,Zheng Y,Johnson DL,Ou JH

更新日期：2002-06-01 00:00:00

abstract：:A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of abou...

journal_title：Journal of virology

authors： Wiktor TJ,Dietzschold B,Leamnson RN,Koprowski H

更新日期：1977-02-01 00:00:00

abstract：:Our ability to rapidly respond to an emerging influenza pandemic is hampered somewhat by the lack of a susceptible small-animal model. To develop a more sensitive model, we pathotyped 18 low-pathogenic non-mouse-adapted influenza A viruses of human and avian origin in DBA/2 and C57BL/6 mice. The majority of the isolat...

journal_title：Journal of virology

authors： Boon AC,deBeauchamp J,Krauss S,Rubrum A,Webb AD,Webster RG,McElhaney J,Webby RJ

更新日期：2010-08-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR. Introducing two CPV-specific changes into FPV (at VP2 residues 93 and 323) endowed that virus with the canine TfR binding property and allowed ca...

journal_title：Journal of virology

authors： Hueffer K,Govindasamy L,Agbandje-McKenna M,Parrish CR

更新日期：2003-09-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:Under the immune pressure of cytotoxic T cells (CTLs), hepatitis B virus (HBV) evolves to accumulate mutations more likely within epitopes to evade immune detection. However, little is known about the specific patterns of the immune pressure-associated HBV mutation of T-cell epitopes and their link to disease progress...

journal_title：Journal of virology

authors： Zhang Y,Wu Y,Deng M,Xu D,Li X,Xu Z,Hu J,Zhang H,Liu K,Zhao Y,Gao F,Bi S,Gao GF,Zhao J,Liu WJ,Meng S

更新日期：2018-08-16 00:00:00

abstract：:An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

journal_title：Journal of virology

authors： Rittner K,Schultz H,Pavirani A,Mehtali M

更新日期：1997-04-01 00:00:00