Functional characterization of Xenopus laevis p53: evidence of temperature-sensitive transactivation but not of repression.

abstract：:Purified rabies virions, unlabeled or labeled with radioactive amino acids or d-glucosamine, were dissociated into their polypeptides by treatment with sodium dodecyl sulfate in a reducing environment and fractionated by electroiphoresis in sodium dodecyl sulfate-containing polyacrylamide gel. The molecular weights of...

journal_title：Journal of virology

authors： Sokol F,Stancek D,Koprowski H

更新日期：1971-02-01 00:00:00

abstract：:Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...

journal_title：Journal of virology

authors： Chackerian B,Long EM,Luciw PA,Overbaugh J

更新日期：1997-05-01 00:00:00

abstract：:The genome RNA and six mRNA species of infectious hematopoietic necrosis virus were analyzed by denaturing gel electrophoresis. The following molecular weights were determined: genome RNA, 3.7 X 10(6); mRNA 1, 2.26 X 10(6); mRNA 2, 5.63 X 10(5); mRNA 3, 4.84 X 10(5); mRNA 4 (containing two different mRNA species), 3.0...

journal_title：Journal of virology

authors： Kurath G,Leong JC

更新日期：1985-02-01 00:00:00

abstract：:Integrins mediate cell adhesion and motility on the extracellular matrix, yet they also promote viral attachment and/or entry. Evidence is presented that adenovirus internalization by alpha(v) integrins requires activation of phosphoinositide-3-OH kinase (PI3K), whereas alpha(v) integrin-mediated cell motility depends...

journal_title：Journal of virology

authors： Li E,Stupack D,Klemke R,Cheresh DA,Nemerow GR

更新日期：1998-03-01 00:00:00

abstract：:The salivary glands of scrapie-affected sheep and healthy controls were investigated for the presence of the pathological prion protein (PrP(Sc)). PrP(Sc) was detected in major (parotid and mandibular) and minor (buccal, labial, and palatine) salivary glands of naturally and experimentally infected sheep. Using Wester...

journal_title：Journal of virology

authors： Vascellari M,Nonno R,Mutinelli F,Bigolaro M,Di Bari MA,Melchiotti E,Marcon S,D'Agostino C,Vaccari G,Conte M,De Grossi L,Rosone F,Giordani F,Agrimi U

更新日期：2007-05-01 00:00:00

abstract：:The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) harbors the enzyme active site and binds viral and chromosomal DNA during integration. Thirty-five CCD mutant viruses were constructed, paying particular attention to conserved residues in the Phe(139)-Gln(146) flexible loop ...

journal_title：Journal of virology

authors： Lu R,Limón A,Ghory HZ,Engelman A

更新日期：2005-02-01 00:00:00

abstract：:The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, te...

journal_title：Journal of virology

authors： Kawashima M,Jablonska S,Favre M,Obalek S,Croissant O,Orth G

更新日期：1986-02-01 00:00:00

abstract：:We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. ...

journal_title：Journal of virology

authors： Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C

更新日期：2013-12-01 00:00:00

abstract：:The fundamental event in prion disease is thought to be the posttranslational conversion of the cellular prion protein (PrPC) into a pathogenic isoform (PrPSc). The occurrence of PrPC on the cell surface and PrPSc in amyloid plaques in situ or in aggregates following purification complicates the study of the molecular...

journal_title：Journal of virology

authors： Williamson RA,Peretz D,Pinilla C,Ball H,Bastidas RB,Rozenshteyn R,Houghten RA,Prusiner SB,Burton DR

更新日期：1998-11-01 00:00:00

abstract：:An immunodominant envelope glycoprotein is encoded by the human herpesvirus 8 (HHV-8) (also termed Kaposi's sarcoma-associated herpesvirus) K8.1 gene. The functional role of glycoprotein K8.1 is unknown, and recognizable sequence homology to K8.1 is not detectable in the genomes of most other closely related gammaherp...

journal_title：Journal of virology

authors： Birkmann A,Mahr K,Ensser A,Yağuboğlu S,Titgemeyer F,Fleckenstein B,Neipel F

更新日期：2001-12-01 00:00:00

abstract：:Heron hepatitis B virus (HHBV) is an avian hepadnavirus that is closely related to duck hepatitis B virus (DHBV). To learn more about the mechanism of hepadnavirus replication, we characterized a clone of HHBV that contains a substitution of DHBV sequence from nucleotide coordinates 403 to 1364. This clone, named HDE1...

journal_title：Journal of virology

authors： Mueller-Hill K,Loeb DD

更新日期：1996-12-01 00:00:00

abstract：:We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the molecular basis of substrate-inhibitor specificity for lentivirus PRs, with a focus on human immunodeficiency virus type 1 (HIV-1) PR. Our previous mutagenesis studies demonstrated that discrete substitutions in the acti...

journal_title：Journal of virology

authors： Lin YC,Brik A,de Parseval A,Tam K,Torbett BE,Wong CH,Elder JH

更新日期：2006-08-01 00:00:00

abstract：:Inflammasomes are cytosolic protein complexes that regulate caspase-1 activation and the secretion of interleukin-1β (IL-1β) and IL-18. Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation. Recent work ...

journal_title：Journal of virology

authors： Rajan JV,Rodriguez D,Miao EA,Aderem A

更新日期：2011-05-01 00:00:00

abstract：:The small defective T particle of vesicular stomatitis virus (VSV-111) has no detectable enzyme activity when assayed at 31 C, although qualitatively it possesses all the virion proteins found in complete VSV-1 virions. With VSV-1 transcription product ribonucleic acid (RNA), it is shown that the VSV-111 RNA is identi...

journal_title：Journal of virology

authors： Roy P,Bishop DH

更新日期：1972-06-01 00:00:00

abstract：:The combinatorial nature of genetic recombination can potentially provide organisms with immediate access to many more positions in sequence space than can be reached by mutation alone. Recombination features particularly prominently in the evolution of a diverse range of viruses. Despite rapid progress having been ma...

journal_title：Journal of virology

authors： Lefeuvre P,Lett JM,Varsani A,Martin DP

更新日期：2009-03-01 00:00:00

abstract：:Recombinant retroviruses containing the trans activator genes of human T-cell leukemia virus (HTLV) type II and human T-cell lymphotropic virus type III were constructed. The trans activator genes tat II and tat III were inserted into the murine retroviral vector pZIPNEOSV(X)1. Recombinant plasmids were transfected in...

journal_title：Journal of virology

authors： Rosen CA,Sodroski JG,Campbell K,Haseltine WA

更新日期：1986-01-01 00:00:00

abstract：:The inclusion of Mimiviridae members in the putative monophyletic nucleocytoplasmic large DNA virus (NCLDV) group is based on genomic and phylogenomic patterns. This shows that, along with other viral families, they share a set of genes known as core or "hallmark genes," including the gene for the major capsid protein...

journal_title：Journal of virology

authors： Boratto PVM,Dornas FP,da Silva LCF,Rodrigues RAL,Oliveira GP,Cortines JR,Drumond BP,Abrahão JS

更新日期：2018-01-02 00:00:00

abstract：:Affinity-purified medium T antigen encoded by NG59, a nontransforming mutant of polyomavirus, is specifically associated with a protein of 72,000 daltons (72K protein). Medium T antigens of wild-type polyomavirus and the transformation-competent mutant dl8 are not associated with the 72K protein. Instead, they form a ...

journal_title：Journal of virology

authors： Walter G,Carbone A,Welch WJ

更新日期：1987-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is frequently attenuated after long-term culture in vitro. The attenuation process probably involves mutations of functions required for replication and pathogenicity in vivo. Analysis of attenuated HIV-1 for replication and pathogenicity in vivo will help to define these fu...

journal_title：Journal of virology

authors： Duus KM,Miller ED,Smith JA,Kovalev GI,Su L

更新日期：2001-04-01 00:00:00

abstract：:Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

journal_title：Journal of virology

authors： Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

更新日期：2005-12-01 00:00:00

abstract：:The bovine leukemia virus (BLV) is an oncogenic retrovirus that is associated with the development of persistent lymphocytosis (PL) and lymphoma in cattle. While B lymphocytes have been shown to be the primary cellular target of BLV, recent studies suggest that some T lymphocytes and monocytes may be infected by the v...

journal_title：Journal of virology

authors： Mirsky ML,Olmstead CA,Da Y,Lewin HA

更新日期：1996-04-01 00:00:00

abstract：:The global diversity of human immunodeficiency virus type 1 (HIV-1) genotypes, termed subtypes A to J, is considerable and growing. However, relatively few studies have provided evidence for an associated phenotypic divergence. Recently, we demonstrated subtype-specific functional differences within the long terminal ...

journal_title：Journal of virology

authors： Montano MA,Nixon CP,Essex M

更新日期：1998-10-01 00:00:00

abstract：:A total of 51 restriction sites were recognized within the BK virus genome by the combination of 10 different restriction endonucleases. These sites were mapped and oriented relative to one another as well as to the five fragments generated by the digestion of BK virus DNA with HindIII and EcoRI. The result was a comp...

journal_title：Journal of virology

authors： Freund J,di Mayorca G,Subramanian KN

更新日期：1979-03-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：:Large numbers of polymorphonuclear leukocytes (PMNs) infiltrated the murine vaginal mucosa within 24 h after intravaginal inoculation with an attenuated strain of herpes simplex virus type 2 (HSV-2). The role of these cells in resolution of a primary genital infection and in protection of HSV-immune animals against ch...

journal_title：Journal of virology

authors： Milligan GN

更新日期：1999-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosome binding regions. N-ter...

journal_title：Journal of virology

authors： Kelley-Clarke B,De Leon-Vazquez E,Slain K,Barbera AJ,Kaye KM

更新日期：2009-05-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：:The Friend or Moloney mink cell focus-forming (MCF) virus encodes a recombinant-type envelope glycoprotein, gp70, that is closely related to the membrane glycoprotein, gp55, of Friend spleen focus-forming virus (SFFV). We have shown previously that gp55 has the ability to activate cell growth by binding to the cellula...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1991-05-01 00:00:00

abstract：:Adenine residues of 70S avian myeloblastosis virus (AMV) RNA are modified when reacted with chloroacetaldehyde. This modification introduces characteristic fluorescent epsilon-adenosine (epsilonA) probes which were used to monitor the reaction. Under suitable conditions, modified 70S(epsilonA) RNA was maintained intac...

journal_title：Journal of virology

authors： Papas TS,Chirikjian JG,Pry TW,Massicot JG,Irwin RD,Chirigos MA

更新日期：1974-11-01 00:00:00

abstract：:We used previously characterized spleen necrosis virus-based retroviral vectors and helper cells to study the strand transfers that occur during the reverse-transcription phase of a single cycle of retroviral replication. The conditions used selected only for formation of an active provirus rather than for expression ...

journal_title：Journal of virology

authors： Jones JS,Allan RW,Temin HM

更新日期：1994-01-01 00:00:00