Abstract:
:The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, tentatively named HPV34. In relaxed hybridization conditions, the highest cross-hybridization was observed with HPV16 DNA. The physical map of HPV34 DNA was aligned with the genetic map of HPV16 DNA by heteroduplex mapping. HPV34 was not detected in 12 additional patients with Bowen's disease of the skin, but a closely related HPV DNA was found in one patient with penile Bowenoid papulosis.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kawashima M,Jablonska S,Favre M,Obalek S,Croissant O,Orth Gdoi
10.1128/JVI.57.2.688-692.1986subject
Has Abstractpub_date
1986-02-01 00:00:00pages
688-92issue
2eissn
0022-538Xissn
1098-5514journal_volume
57pub_type
杂志文章abstract::Mechanisms by which the plus-sense RNA genomes of picornaviruses are replicated remain poorly defined, but existing models do not suggest a role for sequences encoding the capsid proteins. However, candidate RNA replicons (delta P1 beta gal and delta P1Luc), representing the sequence of human rhinovirus 14 virus (HRV-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.3.1941-1952.1996
更新日期:1996-03-01 00:00:00
abstract::Human immunodeficiency virus clade C (HIV-C) accounts for >56% of all HIV infections worldwide. To investigate vaccine safety and efficacy in nonhuman primates, a pathogenic, R5-tropic, neutralization-sensitive simian-human immunodeficiency virus (SHIV) carrying HIV-C env would be desirable. We have constructed SHIV-2...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02066-08
更新日期:2009-02-01 00:00:00
abstract::Normal levels of the hypermodified pyrimidine, alpha-putrescinylthymine, which is formed from hydhydroxymethyluracil at the polynucleotide level (Maltman et al., J. Virol. 34:354-359, 1984), are not required in bacteriophage luminal diameterW-14 DNA for the DNA to serve as a replicative template in luminal diameterW-1...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.52.3.1036-1038.1984
更新日期:1984-12-01 00:00:00
abstract::Galectin-9 is a pleiotropic immune modulator affecting numerous cell types of innate and adaptive immunity. Patients with chronic infection with either hepatitis C virus (HCV) or HIV have elevated circulating levels. Limited data exist on the regulation of natural killer (NK) cell function through interaction with gal...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01085-12
更新日期:2013-05-01 00:00:00
abstract::Engineered recombinant viruses expressing reporter genes have been developed for real-time monitoring of replication and for mass screening of antiviral inhibitors. Recently, we reported using a reverse genetics system to develop the first recombinant reporter rotaviruses (RVs) that expressed NanoLuc (NLuc) luciferase...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01774-18
更新日期:2019-02-05 00:00:00
abstract::A closed circular, double-stranded infectious DNA of Moloney leukemia virus has been described previously. The present report characterizes a second type of infectious, unintegrated viral DNA which is linear, largely double stranded, and of mass comparable to that of the closed circular viral DNA. The linear form is o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.3.621-626.1976
更新日期:1976-12-01 00:00:00
abstract::Vpu is a 16-kDa membrane-associated phosphoprotein that is expressed from the same, singly spliced message as the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor, gp160. Previous studies suggest that Vpu functions in the late stages of viral replication, possibly in virus egression from the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.7.4190-4194.1993
更新日期:1993-07-01 00:00:00
abstract::NF-κB-interacting long noncoding RNA (NKILA) was recently identified as a negative regulator of NF-κB signaling and plays an important role in the development of various cancers. It is well known that NF-κB-mediated activation of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-driven gene expres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01057-20
更新日期:2020-08-17 00:00:00
abstract::To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.5.3247-3250.1992
更新日期:1992-05-01 00:00:00
abstract::All presently available replication-competent proviral clones of human immunodeficiency virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is highly selective for viral strains with an in vitro growth advantage, such clones may not be representative of the biologically relevant vi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.3973-3985.1991
更新日期:1991-08-01 00:00:00
abstract::The development of a reproducible model system for the study of hepatitis C virus (HCV) infection has the potential to significantly enhance the study of virus-host interactions and provide future direction for modeling the pathogenesis of HCV. While there are studies describing global gene expression changes associat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.12.7558-7569.2005
更新日期:2005-06-01 00:00:00
abstract::Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.5.3932-3939.1997
更新日期:1997-05-01 00:00:00
abstract::The Epstein-Barr virus (EBV) is an oncogenic human herpesvirus. EBV latent membrane protein 1 (LMP-1) is a viral oncogene that manifests its oncogenic phenotype through activation of cellular signaling pathways involved in cell growth, survival, differentiation, and transformation. Lytic LMP-1 (lyLMP-1) is a related E...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00180-06
更新日期:2006-08-01 00:00:00
abstract::The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor 3 (FGFR3) kinase. In this study, we generated quasiviruses containing G418-selectable HPV-31 gen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00488-20
更新日期:2020-07-01 00:00:00
abstract::In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05284-11
更新日期:2011-11-01 00:00:00
abstract::Cell-to-cell spread of tobacco mosaic virus is facilitated by the virus-encoded 30-kDa movement protein (MP). This process involves interaction of viral proteins with host components, including the cytoskeleton and the endoplasmic reticulum (ER). During virus infection, high-molecular-weight forms of MP were detected ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.7.3330-3337.2000
更新日期:2000-04-01 00:00:00
abstract::Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.2.757-765.1992
更新日期:1992-02-01 00:00:00
abstract::Parapoxviruses can be morphologically distinguished from other poxviruses in conventional negative staining electron microscopy (EM) by their ovoid appearance and the spiral tubule surrounding the virion's surface. However, this technique may introduce artifacts. We have examined Orf virus (ORFV; the prototype species...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.15.8085-8093.2004
更新日期:2004-08-01 00:00:00
abstract::RNA-dependent RNA polymerases were found to be associated with two salmonid rhabdoviruses: infectious hematopoietic necrosis (IHN) virus and the virus of hemorrhagic septicemia (VHS). The protein composition of these rhabdoviruses closely resembles that of rabies virus rather than that of vesicular stomatitis virus (M...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.22.3.839-843.1977
更新日期:1977-06-01 00:00:00
abstract::Replication and transcription activator (RTA) (also referred to as ORF50), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/(human herpesvirus 8), plays a critical role in balancing the viral life cycle between latency and lytic replication. RTA has been shown to act as a strong transc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.17.9451-9462.2003
更新日期:2003-09-01 00:00:00
abstract::The nucleic acids of influenza A, B, and C viruses were compared. Susceptibility to nucleases demonstrates that influenza C virus, just as influenza A and B viruses, possesses single-stranded RNA as its genome. The base compositions of the RNAs of influenza A, B, and influenza C virus are almost identical and comparat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.18.2.738-744.1976
更新日期:1976-05-01 00:00:00
abstract::Prior studies have demonstrated that a small proportion of blood lymphocytes from patients with human cytomegalovirus (HCMV) infection express only the viral immediate-early (IE) genes (L. Einhorn and A. Ost, J. Infect. Dis. 149:207-214, 1984; G. P. A. Rice, R. D. Schrier, and M. B. A. Oldstone, Proc. Natl. Acad. Sci....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.7.3026-3033.1989
更新日期:1989-07-01 00:00:00
abstract::Severe complications of Zika virus (ZIKV) infection might be caused by inflammation, but how ZIKV induces proinflammatory cytokines is not understood. In this study, we show opposite regulatory effects of the ZIKV NS5 protein on interferon (IFN) signaling. Whereas ZIKV and its NS5 protein were potent suppressors of ty...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00163-17
更新日期:2017-06-26 00:00:00
abstract::Cowpox virus, in contrast to vaccinia virus, can multiply in Chinese hamster ovary cells. To study the genetic basis for this difference in host range, recombinants between vaccinia and cowpox viruses were isolated and their DNA restriction patterns were examined. The ability to multiply in Chinese hamster ovary cells...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.4.1297-1304.1988
更新日期:1988-04-01 00:00:00
abstract::Primary RNA transcripts from the human immunodeficiency virus type 1 (HIV-1) are processed into mature mRNA by a complex series of splicing events. Viral structural proteins and reverse transcriptase are translated from unspliced or singly spliced transcripts. Proteins which control virus replication, including tat, r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.7.3391-3398.1990
更新日期:1990-07-01 00:00:00
abstract::Hepatitis delta virus (HDV) replicates by RNA-dependent RNA synthesis according to a double rolling circle model. Also synthesized during replication is a 0.8-kb, polyadenylated mRNA encoding the hepatitis delta antigen (HDAg). It has been proposed that this mRNA species represents the initial product of HDV RNA repli...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.7.5449-5456.1998
更新日期:1998-07-01 00:00:00
abstract::Infectious hematopoietic necrosis virus (IHNV) is an important fish pathogen that infects both wild and cultured salmonids. As a species of the genus Novirhabdovirus, IHNV is a valuable model system for exploring the host entry mechanisms of rhabdoviruses. In this study, quantum dots (QDs) were used as fluorescent lab...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00109-11
更新日期:2011-07-01 00:00:00
abstract::The extracellular virion form (EV) of vaccinia virus (VACV) is essential for viral pathogenesis and is difficult to neutralize with antibodies. Why this is the case and how the smallpox vaccine overcomes this challenge remain incompletely understood. We previously showed that high concentrations of anti-B5 antibodies ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02152-12
更新日期:2013-02-01 00:00:00
abstract::Marek's disease virus DNA appears to be wound around a central structure connecting the two inner poles of the capsid. Based on electron micrographs of Marek's disease virions, a diagram of spatial configuration of virus DNA is presented. This diagram may explain the pleomorphic character of the herpesvirus core obser...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.5.1148-1150.1974
更新日期:1974-05-01 00:00:00
abstract::Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.23.11298-11306.2001
更新日期:2001-12-01 00:00:00