Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus.

abstract：:Although picornavirus RNA genomes contain a 3'-terminal poly(A) tract that is critical for their replication, the impact of encephalomyocarditis virus (EMCV) infection on the host poly(A)-binding protein (PABP) remains unknown. Here, we establish that EMCV infection stimulates site-specific PABP proteolysis, resulting...

journal_title：Journal of virology

authors： Kobayashi M,Arias C,Garabedian A,Palmenberg AC,Mohr I

更新日期：2012-10-01 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein D (gD) is modified with mannose 6-phosphate (M6P) and binds to M6P receptors (MPRs). MPRs are involved in the well-characterized pathway by which lysosomal enzymes are directed to lysosomes via a network of endosomal membranes. Based on the impaired ability of HSV to form plaque...

journal_title：Journal of virology

authors： Brunetti CR,Dingwell KS,Wale C,Graham FL,Johnson DC

更新日期：1998-04-01 00:00:00

abstract：:During the years or decades of prion disease incubation, at-risk individuals are certain to encounter diverse pathological insults, such as viral and bacterial infections, autoimmune diseases, or inflammatory processes. Whether prion disease incubation time and clinical signs or otherwise the pathology of intercurrent...

journal_title：Journal of virology

authors： Friedman-Levi Y,Ovadia H,Hoftberger R,Einstein O,Abramsky O,Budka H,Gabizon R

更新日期：2007-09-01 00:00:00

abstract：:Reverse transcription in avian sarcoma virus (ASV) initiates from the 3' end of a tRNA(Trp) primer, which anneals near the 5' end of the RNA genome. The region around the primer-binding site (PBS) forms an elaborate stem structure composed of the U5-inverted repeat (U5-IR) stem, the U5-leader stem, and the association...

journal_title：Journal of virology

authors： Morris S,Johnson M,Stavnezer E,Leis J

更新日期：2002-08-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification ...

journal_title：Journal of virology

authors： Freeman ML,Lanzer KG,Cookenham T,Peters B,Sidney J,Wu TT,Sun R,Woodland DL,Sette A,Blackman MA

更新日期：2010-03-01 00:00:00

abstract：:We have designed a ribozyme that cleaves human immunodeficiency virus type 1 (HIV-1) RNA in U5 (at nucleotide +115). This ribozyme was tested in vitro and was found to give efficient and specific digestion of RNA containing the HIV-1 U5 sequence. When the U5 ribozyme was placed into the HIV-1 genome, virus replication...

journal_title：Journal of virology

authors： Dropulić B,Lin NH,Martin MA,Jeang KT

更新日期：1992-03-01 00:00:00

abstract：:Group A rotaviruses are major pathogens causing acute gastroenteritis in children and animals. To determine if group A rotavirus replicates and induces disease in rats, antibody-negative Lewis neonatal or adult rats were inoculated orally with tissue culture-adapted human (Wa, WI61, and HAL1166), simian (rhesus rotavi...

journal_title：Journal of virology

authors： Ciarlet M,Conner ME,Finegold MJ,Estes MK

更新日期：2002-01-01 00:00:00

abstract：:The evolution of human immunodeficiency virus (HIV) type 1 nef quasispecies in a patient clonally infected with a contaminated batch of blood clotting factor IX was monitored. nef sequences were derived at 11, 25, and 41 months postinfection from infected peripheral blood mononuclear cells after molecular cloning of P...

journal_title：Journal of virology

authors： Plikat U,Nieselt-Struwe K,Meyerhans A

更新日期：1997-06-01 00:00:00

abstract：:We previously reported that CD4C/human immunodeficiency virus (HIV)(Nef) transgenic (Tg) mice, expressing Nef in CD4(+) T cells and cells of the macrophage/dendritic cell (DC) lineage, develop a severe AIDS-like disease, characterized by depletion of CD4(+) T cells, as well as lung, heart, and kidney diseases. In orde...

journal_title：Journal of virology

authors： Hanna Z,Priceputu E,Chrobak P,Hu C,Dugas V,Goupil M,Marquis M,de Repentigny L,Jolicoeur P

更新日期：2009-10-01 00:00:00

abstract：:A recombinant Epstein-Barr virus (EBV) was constructed, with a positive-selection marker inserted at the site of a deletion of a DNA segment which encodes the first five transmembrane domains of LMP2A and LMP2B. Despite the mutation, the mutant recombinant EBV was able to initiate and maintain primary B-lymphocyte gro...

journal_title：Journal of virology

authors： Longnecker R,Miller CL,Tomkinson B,Miao XQ,Kieff E

更新日期：1993-08-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

journal_title：Journal of virology

authors： Tong X,Wang F,Thut CJ,Kieff E

更新日期：1995-01-01 00:00:00

abstract：:Human papillomavirus type 11 (HPV-11) and HPV-16 contain an E5 gene that can induce c-fos gene expression in mouse fibroblasts. This study investigated the human c-fos promoter characteristics by mapping the c-fos promoter sequence with several deletion and point mutants that confer responsiveness to E5 of HPV-11 or H...

journal_title：Journal of virology

authors： Chen SL,Lin YK,Li LY,Tsao YP,Lo HY,Wang WB,Tsai TC

更新日期：1996-12-01 00:00:00

abstract：:The use of adenovirus vectors for human gene therapy is limited by potent inflammatory responses that result in significant morbidity. In kidney-derived epithelial cells (REC), activation of extracellular signal-regulated kinase 1/2 (ERK) and p38 kinase (p38) pathways occurred within 20 min of transduction with the se...

journal_title：Journal of virology

authors： Tibbles LA,Spurrell JC,Bowen GP,Liu Q,Lam M,Zaiss AK,Robbins SM,Hollenberg MD,Wickham TJ,Muruve DA

更新日期：2002-02-01 00:00:00

abstract：:Hepatitis A virus (HAV), an atypical member of the Picornaviridae, grows poorly in cell culture. To define determinants of HAV growth, we introduced a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high concentrations of Bsd. The mutants grew fast and had increased rates of ...

journal_title：Journal of virology

authors： Konduru K,Kaplan GG

更新日期：2010-08-01 00:00:00

abstract：:The entry of enveloped viruses into cells is normally mediated by fusion between viral and cellular membranes, in which the fusion peptide plays a crucial role. The fusion peptides of group II nucleopolyhedrovirus (NPV) F proteins are quite conserved, with a hydrophobic region located at the N terminal of the F(1) fra...

journal_title：Journal of virology

authors： Tan Y,Jiang L,Wang M,Yin F,Deng F,Liu M,Hu Z,Wang H

更新日期：2008-08-01 00:00:00

abstract：:The type I interferon (IFN) response is part of the first-line defense against viral infection. To initiate replication, viruses have developed powerful evasion strategies to counteract host IFN responses. In the present study, we found that the Japanese encephalitis virus (JEV) NS5 protein could inhibit double-strand...

journal_title：Journal of virology

authors： Ye J,Chen Z,Li Y,Zhao Z,He W,Zohaib A,Song Y,Deng C,Zhang B,Chen H,Cao S

更新日期：2017-03-29 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. However, the mechanisms involved in the induction and maintenance of CD8(+...

journal_title：Journal of virology

authors： Borrow P,Tough DF,Eto D,Tishon A,Grewal IS,Sprent J,Flavell RA,Oldstone MB

更新日期：1998-09-01 00:00:00

abstract：:Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma virus types 1, 2, 3, 4, 5, and 8 showed no homology under stringent hybridization conditions. Human papilloma virus type 6 D...

journal_title：Journal of virology

authors： Gissmann L,Diehl V,Schultz-Coulon HJ,zur Hausen H

更新日期：1982-10-01 00:00:00

abstract：:Capsid (core) assembly is essential for hepatitis B virus (HBV) replication. We hypothesize that assembly kinetics and stability are tuned for optimal viral replication, not maximal assembly. Assembly effectors (AEfs) are small molecules proposed to disrupt this balance by inappropriately enhancing core assembly. Guid...

journal_title：Journal of virology

authors： Tan Z,Maguire ML,Loeb DD,Zlotnick A

更新日期：2013-03-01 00:00:00

abstract：:Woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV) are closely similar with respect to genomic organization, host antiviral responses, and pathobiology of the infection. T-cell immunity against viral nucleocapsid (HBcAg or WHcAg) has been shown to play a critical role in viral clearance and protection against...

journal_title：Journal of virology

authors： García-Navarro R,Blanco-Urgoiti B,Berraondo P,Sánchez de la Rosa R,Vales A,Hervás-Stubbs S,Lasarte JJ,Borrás F,Ruiz J,Prieto J

更新日期：2001-10-01 00:00:00

abstract：:Glycosylation of the envelope glycoprotein of vesicular stomatitis virus was examined using virus-infected HeLa cells that were pulse-labeled with radioactive sugar precursors. The intracellular sites of glycosylation and the stepwise elongation of the carbohydrate side chains of the G protein were monitored by membra...

journal_title：Journal of virology

authors： Hunt LA,Summers DF

更新日期：1976-12-01 00:00:00

abstract：:The various strains of BK virus (BKV) exhibit a remarkable degree of heterogeneity in the transcriptional control region, which may affect the biological characteristics of a BKV strain. We describe the detection and sequencing of BKV control regions directly from urine samples and after propagation in cell culture. A...

journal_title：Journal of virology

authors： Sundsfjord A,Johansen T,Flaegstad T,Moens U,Villand P,Subramani S,Traavik T

更新日期：1990-08-01 00:00:00

abstract：:The current studies demonstrate complex and seemingly contradictory effects by gamma interferon (IFN-gamma) on Friend virus (FV) infection. Both temporal and tissue-specific effects were observed. During the first week of infection, IFN-gamma-deficiency caused increased levels of FV infection in multiple tissues. Surp...

journal_title：Journal of virology

authors： Stromnes IM,Dittmer U,Schumacher TN,Schepers K,Messer RJ,Evans LH,Peterson KE,Race B,Hasenkrug KJ

更新日期：2002-03-01 00:00:00

abstract：:Mice homozygous for mutant alleles at the gray tremor (gt) locus develop a marked non-intention tremor beginning at 8 days of age. Most homozygous mice die by 3 months. Homozygotes exhibit intense vacuolation of the central nervous system gray matter and vacuolation and hypomyelination of some white matter tracts. Bas...

journal_title：Journal of virology

authors： Carlson GA,Banks S,Lund D,Reichert C,Groth D,Torchia M,Dearmond SJ,Prusiner SB

更新日期：1997-03-01 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:The kinetics of retroviral DNA and RNA synthesis are parameters vital to understanding viral growth, especially for human immunodeficiency virus (HIV), which encodes several of its own regulatory genes. We have established a single-cycle growth condition for HIV in H9 cells, a human CD4+ lymphocyte line. The full-leng...

journal_title：Journal of virology

authors： Kim SY,Byrn R,Groopman J,Baltimore D

更新日期：1989-09-01 00:00:00

abstract：:The ability to manipulate the genomes of herpesviruses is of eminent importance for obtaining insight into gene function and regulation of gene expression of these complex viruses. Here we report the use of in vivo overlap recombination to generate pseudorabies virus mutants. Cotransfection of up to five overlapping c...

journal_title：Journal of virology

authors： van Zijl M,Quint W,Briaire J,de Rover T,Gielkens A,Berns A

更新日期：1988-06-01 00:00:00

abstract：:The family of giant viruses is still expanding, and evidence of a translational machinery is emerging in the virosphere. The Klosneuvirinae group of giant viruses was first reconstructed from in silico studies, and then a unique member was isolated, Bodo saltans virus. Here we describe the isolation of a new member in...

journal_title：Journal of virology

authors： Bajrai LH,Mougari S,Andreani J,Baptiste E,Delerce J,Raoult D,Azhar EI,La Scola B,Levasseur A

更新日期：2019-12-12 00:00:00

abstract：UNLABELLED:While a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV)-infected rhesus macaque provides a powerful model for the study of hu...

journal_title：Journal of virology

authors： Lamers SL,Nolan DJ,Rife BD,Fogel GB,McGrath MS,Burdo TH,Autissier P,Williams KC,Goodenow MM,Salemi M

更新日期：2015-08-01 00:00:00