Regeneration of herpesviruses from molecularly cloned subgenomic fragments.

abstract：:The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was present in the differentiated strata of several native squamous epithelia susceptible to HPV infection. I...

journal_title：Journal of virology

authors： Genovese NJ,Banerjee NS,Broker TR,Chow LT

更新日期：2008-05-01 00:00:00

abstract：UNLABELLED:Bean pod mottle virus (BPMV) is a bipartite, positive-sense (+) RNA plant virus in the Secoviridae family. Its RNA1 encodes proteins required for genome replication, whereas RNA2 primarily encodes proteins needed for virion assembly and cell-to-cell movement. However, the function of a 58-kDa protein (P58) e...

journal_title：Journal of virology

authors： Lin J,Guo J,Finer J,Dorrance AE,Redinbaugh MG,Qu F

更新日期：2014-03-01 00:00:00

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00

abstract：:The vaccinia virus H2R gene (VACWR 100) is conserved in all sequenced members of the poxvirus family and encodes a protein with a predicted transmembrane domain and four invariant cysteines. A recombinant vaccinia virus, in which expression of the H2 protein is stringently regulated, was unable to replicate without in...

journal_title：Journal of virology

authors： Senkevich TG,Moss B

更新日期：2005-04-01 00:00:00

abstract：:The Epstein-Barr virus oriP, when examined with the use of in vitro nucleosome reconstitution, was found to exhibit a partial sparing of nucleosome assembly within the 3' dyad. Analysis of the homologous region containing the origin of replication of herpesvirus papio disclosed that sparing of nucleosome assembly was ...

journal_title：Journal of virology

authors： Sexton CJ,Pagano JS

更新日期：1989-12-01 00:00:00

abstract：:The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8+ antiviral T-cell exhaustion and may contribute to inadequate pat...

journal_title：Journal of virology

authors： Radziewicz H,Ibegbu CC,Fernandez ML,Workowski KA,Obideen K,Wehbi M,Hanson HL,Steinberg JP,Masopust D,Wherry EJ,Altman JD,Rouse BT,Freeman GJ,Ahmed R,Grakoui A

更新日期：2007-03-01 00:00:00

abstract：:Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* p...

journal_title：Journal of virology

authors： Drappier M,Opperdoes FR,Michiels T

更新日期：2017-06-26 00:00:00

abstract：:Eucaryotic, viral, and bacteriophage DNA polymerases of the alpha-like family share blocks of sequence similarity, the most conserved of which has been designated region I. Region I includes a YGDTDS motif that is almost invariant within the alpha-like family and that is similar to a motif conserved among RNA-directed...

journal_title：Journal of virology

authors： Marcy AI,Hwang CB,Ruffner KL,Coen DM

更新日期：1990-12-01 00:00:00

abstract：UNLABELLED:The brown planthopper (BPH), Nilaparvata lugens (Hemiptera:Delphacidae), is one of the most destructive insect pests of rice crops in Asia. Nudivirus-like sequences were identified during the whole-genome sequencing of BPH. PCR examination showed that the virus sequences were present in all of the 22 BPH pop...

journal_title：Journal of virology

authors： Cheng RL,Xi Y,Lou YH,Wang Z,Xu JY,Xu HJ,Zhang CX

更新日期：2014-05-01 00:00:00

abstract：:Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) cells are predominantly infected with latent Kaposi's sarcoma-associated herpesvirus (KSHV), presenting a barrier to the destruction of tumor cells. Latent KSHV can be reactivated to undergo lytic replication. Here we report that in PEL cells, oxidative stress ...

journal_title：Journal of virology

authors： Li X,Feng J,Sun R

更新日期：2011-01-01 00:00:00

abstract：:Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion diseases, can result in the adaptation and selection of TSE strains with an expanded host range and increased virulence such as in the case of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. To investiga...

journal_title：Journal of virology

authors： Bartz JC,Bessen RA,McKenzie D,Marsh RF,Aiken JM

更新日期：2000-06-01 00:00:00

abstract：:The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable complex with the endogenous platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxt...

journal_title：Journal of virology

authors： Klein O,Kegler-Ebo D,Su J,Smith S,DiMaio D

更新日期：1999-04-01 00:00:00

abstract：:All presently available replication-competent proviral clones of human immunodeficiency virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is highly selective for viral strains with an in vitro growth advantage, such clones may not be representative of the biologically relevant vi...

journal_title：Journal of virology

authors： Li Y,Kappes JC,Conway JA,Price RW,Shaw GM,Hahn BH

更新日期：1991-08-01 00:00:00

abstract：:Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are associated with a variety of malignancies, including lymphomas. Interferon regulatory factor 7 (IRF-7) is an innate immune transcription factor that restricts acute replication of diverse viruses, including murine gammaherpesvirus 6...

journal_title：Journal of virology

authors： Johnson KE,Aurubin CA,Jondle CN,Lange PT,Tarakanova VL

更新日期：2020-11-23 00:00:00

abstract：:Recent clinical trials examining 3'-azido-3'-deoxythymidine (AZT, zidovudine, or Retrovir) combined with L-2', 3'-dideoxy-3'-thiacytidine (3TC or lamivudine) have shown that combination therapy with these nucleoside analogs affords significant virological and clinical benefits. The addition of 3TC to AZT delays AZT re...

journal_title：Journal of virology

authors： Kemp SD,Shi C,Bloor S,Harrigan PR,Mellors JW,Larder BA

更新日期：1998-06-01 00:00:00

abstract：:Adenovirus E1B 55K protein cooperates with E1A gene products to induce cell transformation. E1B 55K mediates its effects by binding to and inhibiting the transcriptional activation and growth-suppression functions of the tumor suppressor p53. Previous studies in vivo have suggested that E1B 55K has an active role in r...

journal_title：Journal of virology

authors： Martin ME,Berk AJ

更新日期：1998-04-01 00:00:00

abstract：:RmI, a circular chimera made of the polyomavirus (Py) genome with an insertion of mouse DNA (Ins), effectively undergoes intramolecular recombination in normal mouse cells, as indicated by the conversion of cloned RmI (RmIc) into unit-length Py DNA in transfected cultures. To follow the fate of the cellular component ...

journal_title：Journal of virology

authors： Piché A,Bourgaux P

更新日期：1987-03-01 00:00:00

abstract：:Open reading frame P (ORF P), located at the 3' terminus of the 8.5-kb DNA sequence transcribed during latency and almost completely antisense to the gamma(1)34.5 gene, is naturally repressed by infected cell protein 4 (ICP4), the major herpes simplex virus 1 regulatory protein. Earlier studies on cells infected with ...

journal_title：Journal of virology

authors： Randall G,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:A ribonucleoprotein particle containing about 20% ribonucleic acid (RNA), and containing little if any phospholipid or glucosamine, was recovered in high yield after treatment of Schmidt-Ruppin strain of Rous sarcoma virus and B77 virus with the nonionic detergent Nonidet P-40. This structure, which probably derives f...

journal_title：Journal of virology

authors： Davis NL,Rueckert RR

更新日期：1972-11-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) glycoprotein plays a critical role in parainfluenza virus replication. We recently found that in addition to the catalytic binding site, HN of human parainfluenza virus type 1 (hPIV-1) may have a second receptor-binding site covered by an N-linked glycan at residue 173, which is ne...

journal_title：Journal of virology

authors： Mishin VP,Watanabe M,Taylor G,Devincenzo J,Bose M,Portner A,Alymova IV

更新日期：2010-03-01 00:00:00

abstract：:Temperature-sensitive (ts) mutants were isolated from the baculovirus Autographa californica (alfalfa looper) MNPV, grown in Spodoptera frugiperda (fall armyworm) cells in the presence of N-methyl-N'-nitro-N-nitrosoguanidine. Of 567 plaque isolates screened, 27 were temperature sensitive (ts), representing a mutation ...

journal_title：Journal of virology

authors： Brown M,Crawford AM,Faulkner P

更新日期：1979-07-01 00:00:00

abstract：:Recognition of virus infections by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation associated gene 5 (MDA5), activates signaling pathways, leading to the induction of inflammatory cytokines that limit viral replication. To d...

journal_title：Journal of virology

authors： Guo H,Jiang D,Ma D,Chang J,Dougherty AM,Cuconati A,Block TM,Guo JT

更新日期：2009-01-01 00:00:00

abstract：:A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The proper...

journal_title：Journal of virology

authors： Howk RS,Troxler DH,Lowy D,Duesberg PH,Scolnick EM

更新日期：1978-01-01 00:00:00

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00

abstract：:The chimpanzee is the only animal model for investigating the pathogenesis of viral hepatitis types A through E in humans. Studies of the host response, including microarray analyses, have relied on the close relationship between these two primate species: chimpanzee samples are commonly tested with human-based reagen...

journal_title：Journal of virology

authors： Yu C,Boon D,McDonald SL,Myers TG,Tomioka K,Nguyen H,Engle RE,Govindarajan S,Emerson SU,Purcell RH

更新日期：2010-11-01 00:00:00

abstract：:Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulat...

journal_title：Journal of virology

authors： Tan J,Qiao W,Wang J,Xu F,Li Y,Zhou J,Chen Q,Geng Y

更新日期：2008-05-01 00:00:00

abstract：:A method to study the function of individual African swine fever virus (ASFV) gene products utilizing the Escherichia coli lac repressor-operator system has been developed. Recombinant viruses containing both the lacI gene encoding the lac repressor and a strong virus late promoter modified by the insertion of one or ...

journal_title：Journal of virology

authors： García-Escudero R,Andrés G,Almazán F,Viñuela E

更新日期：1998-04-01 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:Reduction of major histocompatibility complex class I cell surface expression occurs in adenovirus-, herpes simplex virus-, human cytomegalovirus (HCMV)-, and murine cytomegalovirus-infected cell systems. Recently, it was demonstrated that the down-regulation mediated by HCMV infection is posttranslational, as a resul...

journal_title：Journal of virology

authors： Jones TR,Hanson LK,Sun L,Slater JS,Stenberg RM,Campbell AE

更新日期：1995-08-01 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00