Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes.

abstract：:Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in ...

journal_title：Journal of virology

authors： Maness NJ,Sacha JB,Piaskowski SM,Weisgrau KL,Rakasz EG,May GE,Buechler MB,Walsh AD,Wilson NA,Watkins DI

更新日期：2009-10-01 00:00:00

abstract：:We have used immunofluorescence in parallel with transmission and scanning electron microscopy to characterize the unusual cytoplasmic and nucleolar accumulation of Simian virus 40 (SV40) virion protein (C antigen) at restrictive temperatures (39 to 41 C) in monkey cells infected with a temperature-sensitive mutant of...

journal_title：Journal of virology

authors： Widmer C,Robb JA

更新日期：1974-12-01 00:00:00

abstract：:Human noroviruses are one of the major causes of acute gastroenteritis in the developed world, yet our understanding of their molecular mechanisms of genome translation and replication lags behind that for many RNA viruses. Due to the nonculturable nature of human noroviruses, many related members of the Caliciviridae...

journal_title：Journal of virology

authors： Vashist S,Urena L,Chaudhry Y,Goodfellow I

更新日期：2012-11-01 00:00:00

abstract：UNLABELLED:In the last decade, novel tick-borne pathogenic phleboviruses in the family Bunyaviridae, all closely related to Uukuniemi virus (UUKV), have emerged on different continents. To reproduce the tick-mammal switch in vitro, we first established a reverse genetics system to rescue UUKV with a genome close to tha...

journal_title：Journal of virology

authors： Mazelier M,Rouxel RN,Zumstein M,Mancini R,Bell-Sakyi L,Lozach PY

更新日期：2016-07-11 00:00:00

abstract：:The vpr sequences from six human immunodeficiency virus type 1 (HIV-1)-infected mother-infant pairs following perinatal transmission were analyzed. We found that 153 of the 166 clones analyzed from uncultured peripheral blood mononuclear cell DNA samples showed a 92.17% frequency of intact vpr open reading frames. The...

journal_title：Journal of virology

authors： Yedavalli VR,Chappey C,Ahmad N

更新日期：1998-08-01 00:00:00

abstract：:The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated in Guangxi and Hong Kong, China. Genetic and epidemiological analyses suggest that these viruses have circulated in sw...

journal_title：Journal of virology

authors： Fan X,Zhu H,Zhou B,Smith DK,Chen X,Lam TT,Poon LL,Peiris M,Guan Y

更新日期：2012-02-01 00:00:00

abstract：:Two panels of monoclonal antibodies (MAbs) specific for the influenza A virus PA and PB2 polypeptides have been obtained from mice immunized with denatured proteins produced in Escherichia coli. All MAbs (13 specific for the PA polypeptide and 8 specific for the PB2 protein) reacted to the corresponding influenza viru...

journal_title：Journal of virology

authors： Bárcena J,Ochoa M,de la Luna S,Melero JA,Nieto A,Ortín J,Portela A

更新日期：1994-11-01 00:00:00

abstract：:The papillomavirus capsid mediates binding to the cell surface and passage of the virion to the perinuclear region during infection. To better understand how the virus traffics across the cell, we sought to identify cellular proteins that bind to the minor capsid protein L2. We have identified syntaxin 18 as a protein...

journal_title：Journal of virology

authors： Bossis I,Roden RB,Gambhira R,Yang R,Tagaya M,Howley PM,Meneses PI

更新日期：2005-06-01 00:00:00

abstract：:We recently demonstrated that members of the c-ets proto-oncogene family, Ets1 and Ets2, are sequence-specific transcriptional activators of the human T-lymphotropic virus type I (HTLV-I) long terminal repeat (LTR). We now report that the HTLV-I LTR contains two distinct Ets1-responsive regions, ERR-1 and ERR-2. Expre...

journal_title：Journal of virology

authors： Gitlin SD,Bosselut R,Gégonne A,Ghysdael J,Brady JN

更新日期：1991-10-01 00:00:00

abstract：:The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...

journal_title：Journal of virology

authors： Baradaran K,Dabrowski CE,Schaffer PA

更新日期：1994-07-01 00:00:00

abstract：:Highly pathogenic H5N1 influenza A virus remains a substantial threat to public health. To understand the molecular basis and host mechanism for the high virulence of H5N1 viruses in mammals, we compared two H5N1 isolates which have similar genetic backgrounds but greatly differ in their virulence in mice. A/Chicken/J...

journal_title：Journal of virology

authors： Hu J,Hu Z,Song Q,Gu M,Liu X,Wang X,Hu S,Chen C,Liu H,Liu W,Chen S,Peng D,Liu X

更新日期：2013-03-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:Secondary cultures of chicken embryo fibroblasts were infected with the Schmidt Ruppin strain of Rous sarcoma virus (RSV). Five days after infection, the medium was replaced at 2-h intervals with phosphate-free Eagle medium containing 50 muCi of [32P]orthophosphate per ml. Virus was collected by centrifugation, and th...

journal_title：Journal of virology

authors： Jacobson AB,Bromley PA

更新日期：1975-01-01 00:00:00

abstract：:RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The imp...

journal_title：Journal of virology

authors： You S,Stump DD,Branch AD,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of abou...

journal_title：Journal of virology

authors： Wiktor TJ,Dietzschold B,Leamnson RN,Koprowski H

更新日期：1977-02-01 00:00:00

abstract：:Five human recombinant Fab fragments (Fabs) specific for measles virus (MV) proteins were isolated from three antibody phage display libraries generated from RNAs derived from bone marrow or splenic lymphocytes from three MV-immune individuals. All Fabs reacted in an enzyme-linked immunosorbent assay with MV antigens....

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Williamson RA,Parren PW,Lundkvist A,Burton DR,Björling E

更新日期：2002-01-01 00:00:00

abstract：:Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC...

journal_title：Journal of virology

authors： Hung CH,Chen LW,Wang WH,Chang PJ,Chiu YF,Hung CC,Lin YJ,Liou JY,Tsai WJ,Hung CL,Liu ST

更新日期：2014-10-01 00:00:00

abstract：:Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation signal in HPV-16 plays a major role in the switch from the early to the late, productive stage of the viral life cycle. ...

journal_title：Journal of virology

authors： Oberg D,Fay J,Lambkin H,Schwartz S

更新日期：2005-07-01 00:00:00

abstract：:The gH-gL complex of herpes simplex virus type 1 (HSV-1) is essential for virion infectivity and virus-induced cell fusion, but functional domains of the gH molecule remain to be defined. We have addressed this question by mutagenesis. A set of linker insertion mutants in HSV-1 gH was generated and tested in transient...

journal_title：Journal of virology

authors： Galdiero M,Whiteley A,Bruun B,Bell S,Minson T,Browne H

更新日期：1997-03-01 00:00:00

abstract：:Neutralizing antibodies may have critical importance in immunity against human immunodeficiency virus type 1 (HIV-1) infection. However, the amount of protective antibody needed at mucosal surfaces has not been fully established. Here, we evaluated systemic and mucosal pharmacokinetics (PK) and pharmacodynamics (PD) o...

journal_title：Journal of virology

authors： Klein K,Veazey RS,Warrier R,Hraber P,Doyle-Meyers LA,Buffa V,Liao HX,Haynes BF,Shaw GM,Shattock RJ

更新日期：2013-11-01 00:00:00

abstract：:Spanins are bacteriophage lysis proteins responsible for disruption of the outer membrane, the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin gp11 that has an N-terminal lipoylation signal and a C-ter...

journal_title：Journal of virology

authors： Kongari R,Snowden J,Berry JD,Young R

更新日期：2018-10-29 00:00:00

abstract：UNLABELLED:Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing mumps cases. However, rece...

journal_title：Journal of virology

authors： Pickar A,Xu P,Elson A,Li Z,Zengel J,He B

更新日期：2014-04-01 00:00:00

abstract：:RNA plant viruses use various translational regulatory mechanisms to control their gene expression. Translational enhancement of viral mRNAs that leads to higher levels of protein synthesis from specific genes may be essential for the virus to successfully compete for cellular translational machinery. The control elem...

journal_title：Journal of virology

authors： Koh DC,Liu DX,Wong SM

更新日期：2002-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:Identification of cell surface viral binding proteins is important for understanding viral attachment and internalization. We have fused the pre-S domain of the duck hepatitis B virus (DHBV) large envelope protein to glutathione S-transferase and demonstrated a 170-kDa binding protein (p170) in [35S]methionine-labeled...

journal_title：Journal of virology

authors： Tong S,Li J,Wands JR

更新日期：1995-11-01 00:00:00

abstract：:The infection of cells which belong to the B-cell lineage is thought to be the primary event leading to the phenotypic and functional alterations seen in the murine AIDS (M. Huang, C. Simard, D. Kay, and P. Jolicoeur, J. Virol. 65:6562-6571, 1991). Using in situ hybridization, we studied the time course of the anatomi...

journal_title：Journal of virology

authors： Simard C,Huang M,Jolicoeur P

更新日期：1994-03-01 00:00:00

abstract：:Viruses actively interact with host metabolism because viral replication relies on host cells to provide nutrients and energy. Vaccinia virus (VACV; the prototype poxvirus) prefers glutamine to glucose for efficient replication to the extent that VACV replication is hindered in glutamine-free medium. Remarkably, our d...

journal_title：Journal of virology

authors： Pant A,Cao S,Yang Z

更新日期：2019-06-14 00:00:00

abstract：:The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circul...

journal_title：Journal of virology

authors： Korotkova EA,Park R,Cherkasova EA,Lipskaya GY,Chumakov KM,Feldman EV,Kew OM,Agol VI

更新日期：2003-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) exists as a complex population of multiple genotypic variants in persons with chronic infection. However, acute HIV-1 infection via sexual transmission is a low-probability event in which there is thought to be low genetic complexity in the initial inoculum. In order to asse...

journal_title：Journal of virology

authors： Ritola K,Pilcher CD,Fiscus SA,Hoffman NG,Nelson JA,Kitrinos KM,Hicks CB,Eron JJ Jr,Swanstrom R

更新日期：2004-10-01 00:00:00

abstract：:A general theme that has emerged from studies of DNA tumor viruses is that otherwise unrelated oncoproteins encoded by these viruses often target the same important cellular factors. Major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papillomaviruses (HPV) are the E4-ORF1 and E6 oncopro...

journal_title：Journal of virology

authors： Lee SS,Glaunsinger B,Mantovani F,Banks L,Javier RT

更新日期：2000-10-01 00:00:00