Retrospective analysis of a local cessation of vaccination against poliomyelitis: a possible scenario for the future.

abstract：:Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside rev...

journal_title：Journal of virology

authors： Brown AJ,Precious HM,Whitcomb JM,Wong JK,Quigg M,Huang W,Daar ES,D'Aquila RT,Keiser PH,Connick E,Hellmann NS,Petropoulos CJ,Richman DD,Little SJ

更新日期：2000-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) exhibits a high level of genetic variation generated by frequent mutation and genetic recombination during reverse transcription. We have measured HIV-1 recombination rates in T cells in one round of virus replication. It was recently proposed that HIV-1 recombines far more ...

journal_title：Journal of virology

authors： Chen J,Rhodes TD,Hu WS

更新日期：2005-07-01 00:00:00

abstract：:We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT-->AAT, Ser-->Asn; designated 37...

journal_title：Journal of virology

authors： McKeating JA,Bennett J,Zolla-Pazner S,Schutten M,Ashelford S,Brown AL,Balfe P

更新日期：1993-09-01 00:00:00

abstract：:Virus entry into host cells is a complex process that is largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are ...

journal_title：Journal of virology

authors： Persson BD,Lenman A,Frängsmyr L,Schmid M,Ahlm C,Plückthun A,Jenssen H,Arnberg N

更新日期：2020-07-01 00:00:00

abstract：UNLABELLED:The noncovalent interactions that mediate trimerization of the influenza hemagglutinin (HA) are important determinants of its biological activities. Recent studies have demonstrated that mutations in the HA trimer interface affect the thermal and pH sensitivities of HA, suggesting a possible impact on vaccin...

journal_title：Journal of virology

authors： Yang H,Chang JC,Guo Z,Carney PJ,Shore DA,Donis RO,Cox NJ,Villanueva JM,Klimov AI,Stevens J

更新日期：2014-05-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep...

journal_title：Journal of virology

authors： Papsidero LD,Sheu M,Ruscetti FW

更新日期：1989-01-01 00:00:00

abstract：:We previously conducted a phase I/II study using arterial infusions of ONYX-015 (dl1520), a replication-selective adenoviral vector, with E1b deleted, for patients with metastatic colorectal cancer. No dose-limiting toxicities occurred, but >90% of the patients experienced fever. The effects of temperature on the repl...

journal_title：Journal of virology

authors： Thorne SH,Brooks G,Lee YL,Au T,Eng LF,Reid T

更新日期：2005-01-01 00:00:00

abstract：:Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...

journal_title：Journal of virology

authors： Chackerian B,Long EM,Luciw PA,Overbaugh J

更新日期：1997-05-01 00:00:00

abstract：:Co-infection of neonatal BALB/c mice with Friend virus (FV) complex (containing defective spleen focus-forming virus [SFFV] and endogenous N-tropic leukemia-inducing helper virus [LLV-F]) and B-tropic Tennant leukemia virus (TenLV) resulted in the inhibition of LLV-F by the Fv-1(b) gene and recovery of a TenLV pseudot...

journal_title：Journal of virology

authors： Eckner RJ

更新日期：1973-09-01 00:00:00

abstract：:Polyamine depletion produced by exogenous arginine in Escherichia coliK-12 cultures defective in agmatine ureohydrolase activity resulted in a marked inhibition of the rates of growth and nucleic acid synthesis. Addition of putrescine or spermidine to such depleted cultures restored the control rate of growth and nucl...

journal_title：Journal of virology

authors： Dion AS,Cohen SS

更新日期：1972-03-01 00:00:00

abstract：:Recently we showed that the membrane-proximal stem region of the vesicular stomatitis virus (VSV) G protein ectodomain (G stem [GS]), together with the transmembrane and cytoplasmic domains, was sufficient to mediate efficient VSV budding (C. S. Robison and M. A. Whitt, J. Virol. 74:2239-2246, 2000). Here, we show tha...

journal_title：Journal of virology

authors： Jeetendra E,Robison CS,Albritton LM,Whitt MA

更新日期：2002-12-01 00:00:00

abstract：:Disease-associated PrP fragments produced upon in vitro or in vivo proteolysis can provide significant insight into the causal strain of prion disease. Here we describe a novel molecular strain typing assay that used thermolysin digestion of caudal medulla samples to produce PrPres signatures on Western blots that rea...

journal_title：Journal of virology

authors： Owen JP,Rees HC,Maddison BC,Terry LA,Thorne L,Jackman R,Whitelam GC,Gough KC

更新日期：2007-10-01 00:00:00

abstract：:T7+ phage are unable to plate on a strain of Shigella sonnei D2 371-48. Spontaneous phage mutants arise (ss--mutants) that are able to plate on this strain of Shigella. We have shown by complementation studies and genetic crosses that the ss--mutation maps in gene 10, the structural gene for the major protein of the c...

journal_title：Journal of virology

authors： Vetter D,Roberts L,Jackowski JB,Sadowski PD

更新日期：1977-06-01 00:00:00

abstract：:A tetracycline-regulated gene expression system and a panel of novel monoclonal antibodies were used to examine the subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus (HCV) NS3-NS4A complex in inducible cell lines. The NS3 serine protease domain and the full-length NS3 protein ...

journal_title：Journal of virology

authors： Wölk B,Sansonno D,Kräusslich HG,Dammacco F,Rice CM,Blum HE,Moradpour D

更新日期：2000-03-01 00:00:00

abstract：:An active transcriptive complex was isolated from purified virions of Newcastle disease virus. After disruption with Triton X-100 and high salt, soluble and particulate fractions were separated by density gradient centrifugation. The transcriptive complex, recovered at a density of 1.275 g/cm3, appeared as a nucleocap...

journal_title：Journal of virology

authors： Colonno RJ,Stone HO

更新日期：1976-09-01 00:00:00

abstract：:It was recently shown that the 7a protein of severe acute respiratory syndrome coronavirus induces biochemical changes associated with apoptosis. In this study, the mechanism by which the 7a protein induces apoptosis was examined. The 7a protein was tested for the ability to inhibit cellular gene expression because se...

journal_title：Journal of virology

authors： Kopecky-Bromberg SA,Martinez-Sobrido L,Palese P

更新日期：2006-01-01 00:00:00

abstract：:The RNA polymerase of the influenza virus is responsible for the transcription and replication of the segmented RNA viral genome during infection of host cells. Polymerase function is known to be strictly dependent on interaction with its RNA promoter, but no attempts to investigate whether the virion RNA (vRNA) promo...

journal_title：Journal of virology

authors： Brownlee GG,Sharps JL

更新日期：2002-07-01 00:00:00

abstract：:Resistance or susceptibility of various mouse strains to central nervous system disease caused by different strains of coronavirus is well known. Data from the present study draw attention to an additional, genetically determined mechanism controlling CV infections. The resistance to A59 and JHM virus (JHMV) associate...

journal_title：Journal of virology

authors： Wilson GA,Dales S

更新日期：1988-09-01 00:00:00

abstract：:We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone or with QS21 adjuvant to 28 HIV-uninfected volunteers. One month later, after a fourth injection of the vaccine, B- ...

journal_title：Journal of virology

authors： Gahéry-Ségard H,Pialoux G,Figueiredo S,Igéa C,Surenaud M,Gaston J,Gras-Masse H,Lévy JP,Guillet JG

更新日期：2003-10-01 00:00:00

abstract：:Adeno-associated virus type 2 (AAV-2) gene expression is tightly controlled by functions of the helper virus as well as by the products of its own viral rep gene. Double-immunofluorescence studies of Rep and VP protein expression in cells coinfected with AAV-2 and adenovirus type 2 showed that a large proportion of th...

journal_title：Journal of virology

authors： Weger S,Wistuba A,Grimm D,Kleinschmidt JA

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels, ultimately leading to the formation of protein assemblies with hexagonal symmetry in vitro and cytoplasmic assemblies when expressed in cells. However, ...

journal_title：Journal of virology

authors： Sastri J,Johnsen L,Smolin N,Imam S,Mukherjee S,Lukic Z,Brandariz-Nuñez A,Robia SL,Diaz-Griffero F,Wiethoff C,Campbell EM

更新日期：2014-08-01 00:00:00

abstract：:Polypeptides synthesized in Newcastle disease virus (NDV)-infected CHO cells in the absence of glycosylation were characterized. Incorporation of either [3H]mannose of [3H]glucosamine into NDV polypeptides was inhibited to greater than 99% by the antibiotic tunicamycin. Under these conditions, infected cells synthesiz...

journal_title：Journal of virology

authors： Morrison TG,Simpson D

更新日期：1980-10-01 00:00:00

abstract：:Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 40...

journal_title：Journal of virology

authors： Burns CC,Shaw J,Jorba J,Bukbuk D,Adu F,Gumede N,Pate MA,Abanida EA,Gasasira A,Iber J,Chen Q,Vincent A,Chenoweth P,Henderson E,Wannemuehler K,Naeem A,Umami RN,Nishimura Y,Shimizu H,Baba M,Adeniji A,Williams AJ,

更新日期：2013-05-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：:PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox potyvirus (PPV). In addition to the well-known highly immunogenic N- and C-terminal domains of CP, regions within the core domain of the protein have also shown high immunogenicity. Moreover, the N ...

journal_title：Journal of virology

authors： Fernández-Fernández MR,Martínez-Torrecuadrada JL,Roncal F,Domínguez E,García JA

更新日期：2002-12-01 00:00:00

abstract：:The infectious entry pathway of duck hepatitis B virus (DHBV) was investigated with primary duck hepatocytes. Virus uptake was measured by a selective PCR technique which allows for the detection of a successful infection without the need for viral replication or gene expression. To test whether DHBV uptake occurs by ...

journal_title：Journal of virology

authors： Köck J,Borst EM,Schlicht HJ

更新日期：1996-09-01 00:00:00

abstract：:We used deep sequencing of poly(A) RNA to characterize the transcriptome of an economically important eel virus, anguillid herpesvirus 1 (AngHV1), at a stage during the lytic life cycle when infectious virus was being produced. In contrast to the transcription of mammalian herpesviruses, the overall level of antisense...

journal_title：Journal of virology

authors： van Beurden SJ,Gatherer D,Kerr K,Galbraith J,Herzyk P,Peeters BP,Rottier PJ,Engelsma MY,Davison AJ

更新日期：2012-09-01 00:00:00

abstract：:Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor...

journal_title：Journal of virology

authors： Child SJ,Geballe AP

更新日期：2009-02-01 00:00:00

abstract：:Currently there is limited information about the quality of immune responses elicited by candidate human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env)-based immunogens in primates. Here we describe a comprehensive analysis of neutralizing antibody and T-cell responses obtained in cynomolgus macaque...

journal_title：Journal of virology

authors： Mörner A,Douagi I,Forsell MN,Sundling C,Dosenovic P,O'Dell S,Dey B,Kwong PD,Voss G,Thorstensson R,Mascola JR,Wyatt RT,Karlsson Hedestam GB

更新日期：2009-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) UL84 is a phosphoprotein that shuttles from the nucleus to the cytoplasm and is required for oriLyt-dependent DNA replication and viral growth. UL84 was previously shown to interact with IE2 (IE86) in infected cells, and this interaction down-regulates IE2-mediated transcriptional activati...

journal_title：Journal of virology

authors： Gao Y,Colletti K,Pari GS

更新日期：2008-01-01 00:00:00