Herpes simplex virus gD and virions accumulate in endosomes by mannose 6-phosphate-dependent and -independent mechanisms.

abstract：:The presence of complement-fixing (CF) antibody reactive with T antigen and with viral C antigen in hamsters bearing adenovirus 12-induced tumors has been confirmed. Antibody activity in serum obtained at a time when the host was bearing large tumors was found to be associated exclusively with 7S immunoglobulins. Two ...

journal_title：Journal of virology

authors： Fugmann RA,Sigel MM

更新日期：1967-08-01 00:00:00

abstract：:The mammalian tripartite motif protein, TRIM5α, recognizes retroviral capsids entering the cytoplasm and blocks virus infection. Depending on the particular TRIM5α protein and retrovirus, complete disruption of the TRIM5α RING domain decreases virus-restricting activity to various degrees. TRIM5α exhibits RING domain-...

journal_title：Journal of virology

authors： Kim J,Tipper C,Sodroski J

更新日期：2011-08-01 00:00:00

abstract：:The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures. When NSP5 was expressed in COS-7 cells in the absence of ...

journal_title：Journal of virology

authors： Blackhall J,Muñoz M,Fuentes A,Magnusson G

更新日期：1998-08-01 00:00:00

abstract：:A phylogenetic analysis of 52 published and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses. H1N1 human and classical swine viruses (i.e., those related to Swine/Iowa/15/30) share a single common ancestor, which was estimated to have occurred in 1912 t...

journal_title：Journal of virology

authors： Gorman OT,Bean WJ,Kawaoka Y,Donatelli I,Guo YJ,Webster RG

更新日期：1991-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) replicates through an error-prone process that may support the evolution of genetic variants resistant to the host cell antiviral response and interferon (IFN)-based therapy. We evaluated HCV-IFN interactions within a long-term culture system of Huh7 cell lines harboring different variants of a...

journal_title：Journal of virology

authors： Sumpter R Jr,Wang C,Foy E,Loo YM,Gale M Jr

更新日期：2004-11-01 00:00:00

abstract：:The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable complex with the endogenous platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxt...

journal_title：Journal of virology

authors： Klein O,Kegler-Ebo D,Su J,Smith S,DiMaio D

更新日期：1999-04-01 00:00:00

abstract：:Cells expressing the low pH-triggered class II viral fusion protein E1 of Semliki Forest virus (SFV) were fused to target cells. Fusion was monitored by electrical capacitance and aqueous dye measurements. Electrical voltage-clamp measurements showed that SFV E1-induced cell-cell fusion occurred quickly after acidific...

journal_title：Journal of virology

authors： Markosyan RM,Kielian M,Cohen FS

更新日期：2007-10-01 00:00:00

abstract：:Long-term ovine fibroblast cultures contain replicative-competent lentiviruses in a latent form. This in vitro phenomenon, never described previously for lentiviruses, was clearly demonstrated by activating the expression of latent viruses with various inducing cell treatments, some of which were efficient in inducing...

journal_title：Journal of virology

authors： Barban V,Quérat G,Sauze N,Filippi P,Vigne R,Russo P,Vitu C

更新日期：1984-11-01 00:00:00

abstract：:We studied the effect of filovirus infection on host cell gene expression by characterizing the regulation of gene expression responses in human liver cells infected with Zaire Ebolavirus (ZEBOV), Reston Ebolavirus (REBOV), and Marburgvirus (MARV), using transcriptional profiling and bioinformatics. Expression microar...

journal_title：Journal of virology

authors： Kash JC,Mühlberger E,Carter V,Grosch M,Perwitasari O,Proll SC,Thomas MJ,Weber F,Klenk HD,Katze MG

更新日期：2006-03-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

journal_title：Journal of virology

authors： Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

更新日期：1990-04-01 00:00:00

abstract：:We describe a modification of the polymerase chain reaction technique which allows amplification of cellular DNA adjacent to an integrated provirus given sequence information for the provirus only. The modified technique should be generally useful for studies of insertional mutagenesis and other situations in which on...

journal_title：Journal of virology

authors： Silver J,Keerikatte V

更新日期：1989-05-01 00:00:00

abstract：:The phenomenon whereby the host immune system responds to only a few of the many possible epitopes in a foreign protein is termed immunodominance. Immunodominance occurs not only during microbial infection but also following vaccination, and clarification of the underlying mechanism may permit the rational design of v...

journal_title：Journal of virology

authors： Rodriguez F,Harkins S,Slifka MK,Whitton JL

更新日期：2002-05-01 00:00:00

abstract：:Sindbis virus nonstructural polyproteins and their cleavage products are believed to be essential components of viral RNA replication and transcription complexes. Although numerous studies have investigated the effect of mutations in nsP1-, nsP2-, and nsP4-coding regions on Sindbis virus-specific RNA synthesis, relati...

journal_title：Journal of virology

authors： LaStarza MW,Lemm JA,Rice CM

更新日期：1994-09-01 00:00:00

abstract：:Theiler murine encephalomyelitis virus (TMEV) infection of a mouse's central nervous system is biphasic: first the virus infects motor neurons (acute phase), and this is followed by a chronic phase in which the virus infects glial cells (primarily microglia and macrophages [M]) of the spinal cord white matter, leading...

journal_title：Journal of virology

authors： Zhang J,Lipton HL,Perelson AS,Dahari H

更新日期：2013-04-01 00:00:00

abstract：:Interaction between viral proteins is necessary for viral replication and viral particle assembly. We used the yeast two-hybrid assay to identify interactions among all the mature proteins of the hepatitis C virus. The interaction between NS3 and NS3 was one of the strongest viral protein-protein interactions detected...

journal_title：Journal of virology

authors： Khu YL,Koh E,Lim SP,Tan YH,Brenner S,Lim SG,Hong WJ,Goh PY

更新日期：2001-01-01 00:00:00

abstract：:Taking advantage of the wide tropism of baculoviruses (BVs), we constructed a recombinant BV (BV(CAR)) pseudotyped with human coxsackie B-adenovirus receptor (CAR), the high-affinity attachment receptor for adenovirus type 5 (Ad5), and used the strategy of piggybacking Ad5-green fluorescent protein (Ad5GFP) vector on ...

journal_title：Journal of virology

authors： Granio O,Porcherot M,Corjon S,Kitidee K,Henning P,Eljaafari A,Cimarelli A,Lindholm L,Miossec P,Boulanger P,Hong SS

更新日期：2009-06-01 00:00:00

abstract：:The fusogenic properties of the uncleaved spike (S) protein of murine coronavirus JHMV variant cl-2 were studied by expressing the S protein with a deleted putative cleavage site. The amino acid sequence of the putative cleavage site, Arg-Arg-Ala-Arg-Arg, was replaced by Arg-Thr-Ala-Leu-Glu by in vitro mutagenesis of ...

journal_title：Journal of virology

authors： Taguchi F

更新日期：1993-03-01 00:00:00

abstract：UNLABELLED:Major histocompatibility complex class II (MHC-II) molecules play a central role in adaptive antiviral immunity by presenting viral peptides to CD4(+) T cells. Due to their key role in adaptive immunity, many viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV), have evolved multiple strategies ...

journal_title：Journal of virology

authors： Thakker S,Purushothaman P,Gupta N,Challa S,Cai Q,Verma SC

更新日期：2015-05-01 00:00:00

abstract：:The Graffi murine leukemia virus (MuLV) is a retroviral mixture that induces predominantly myeloid leukemia in several inbred strains of mice. To analyze the viral component responsible for the myeloid leukemogenesis, we cloned several proviruses from a Graffi MuLV-infected cell line. Several infectious molecular clon...

journal_title：Journal of virology

authors： Ru M,Shustik C,Rassart E

更新日期：1993-08-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) replication in dendritic cells (DCs) is restricted by SAMHD1. This factor is counteracted by the viral protein Vpx; Vpx is found in HIV-2 and simian immunodeficiency virus (SIV) from sooty mangabeys (SIVsm) or from macaques (SIVmac) but is absent from HIV-1. We pre...

journal_title：Journal of virology

authors： Su B,Biedma ME,Lederle A,Peressin M,Lambotin M,Proust A,Decoville T,Schmidt S,Laumond G,Moog C

更新日期：2014-05-01 00:00:00

abstract：UNLABELLED:Foamy viruses (FVs) are complex retroviruses that establish lifelong persistent infection without evident pathology. However, the roles of cellular factors in FV latency are poorly understood. This study revealed that N-Myc interactor (Nmi) could inhibit the replication of prototype foamy virus (PFV). Overex...

journal_title：Journal of virology

authors： Hu X,Yang W,Liu R,Geng Y,Qiao W,Tan J

更新日期：2014-06-01 00:00:00

abstract：:The affinity of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity. However, entry efficiency results from complex interactions between the viral envelope glycoprotein and both CD4 and CCR5, which limits attempt...

journal_title：Journal of virology

authors： Johnston SH,Lobritz MA,Nguyen S,Lassen K,Delair S,Posta F,Bryson YJ,Arts EJ,Chou T,Lee B

更新日期：2009-11-01 00:00:00

abstract：:Fatal infection with the highly pathogenic Lassa virus (LASV) is characterized by extensive viral dissemination, indicating broad tissue tropism. The major cellular receptor for LASV is the highly conserved extracellular matrix receptor dystroglycan (DG). Binding of LASV depends on DG's tissue-specific posttranslation...

journal_title：Journal of virology

authors： Fedeli C,Torriani G,Galan-Navarro C,Moraz ML,Moreno H,Gerold G,Kunz S

更新日期：2018-02-12 00:00:00

abstract：:Recently, efficient and long-term in vivo gene transfer by recombinant adeno-associated virus type 2 (rAAV) vectors has been demonstrated in a variety of tissues. Further improvement in vector titer and purity will expedite this in vivo exploration and provide preclinical information required for use in human gene the...

journal_title：Journal of virology

authors： Xiao X,Li J,Samulski RJ

更新日期：1998-03-01 00:00:00

abstract：:Lentiviruses have long been considered host-specific pathogens, but several recent observations demonstrated their capacity to conquer new hosts from different species, genera, and families. From these cross-species infections emerged new animal and human infectious diseases. The successful colonization and adaptation...

journal_title：Journal of virology

authors： Morin T,Guiguen F,Bouzar BA,Villet S,Greenland T,Grezel D,Gounel F,Gallay K,Garnier C,Durand J,Alogninouwa T,Mselli-Lakhal L,Mornex JF,Chebloune Y

更新日期：2003-06-01 00:00:00

abstract：:Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...

journal_title：Journal of virology

authors： Aandahl EM,Michaëlsson J,Moretto WJ,Hecht FM,Nixon DF

更新日期：2004-03-01 00:00:00

abstract：:The U(L)17 protein (pU(L)17) of herpes simplex virus 1 (HSV-1) likely associates with the surfaces of DNA-containing capsids in a heterodimer with pU(L)25. pU(L)17 is also associated with viral light particles that lack capsid proteins, suggesting its presence in the tegument of the HSV-1 virion. To help determine how...

journal_title：Journal of virology

authors： Scholtes LD,Yang K,Li LX,Baines JD

更新日期：2010-08-01 00:00:00

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:We previously reported the establishment of several lymphoid cell lines from X-ray-induced thymomas of C57BL/Ka mice, and all, except one, produce retroviruses (P. Sankar-Mistry and P. Jolicoeur, J. Virol.35:270-275, 1980). Biological characterization of five of these new primary radiation leukemia viruses (RadLVs) in...

journal_title：Journal of virology

authors： Rassart E,Sankar-Mistry P,Lemay G,DesGroseillers L,Jolicoeur P

更新日期：1983-02-01 00:00:00

abstract：:Sections of normal and diseased brain and kidney tissues were screened for the presence of JC virus (JCV) DNA by using the polymerase chain reaction. As expected, all samples obtained from patients with progressive multifocal leukoencephalopathy (PML) tested positive when multiple JCV-specific primer and probe combina...

journal_title：Journal of virology

authors： White FA 3rd,Ishaq M,Stoner GL,Frisque RJ

更新日期：1992-10-01 00:00:00