The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.

abstract：:An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an "elongation" mutant that destabilizes PA-RNA template int...

journal_title：Journal of virology

authors： Fodor E,Mingay LJ,Crow M,Deng T,Brownlee GG

更新日期：2003-04-01 00:00:00

abstract：:Resistance to erythroleukemia induced by infection with the Friend virus complex (FV) has been mapped to several genes residing both within and outside the murine major histocompatibility complex (MHC). MHC genes located in the A, D, and Qa/Tla regions of the murine H-2 complex have been shown to affect disease resist...

journal_title：Journal of virology

authors： Perry LL,Miyazawa M,Hasenkrug K,Wehrly K,David CS,Chesebro B

更新日期：1994-08-01 00:00:00

abstract：:Immune precipitation with monospecific antiserum was employed to study the intracellular synthesis of viral glycoproteins gp85 and gp37. Labeled gp85 and gp37 were detected from lysates of cells transformed with Rous sacroma virus, strain B77, after long-term labeling with radioactive glucosamine or phenylalanine. Imm...

journal_title：Journal of virology

authors： Moelling K,Hayami M

更新日期：1977-06-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) downregulates major histocompatibility complex (MHC) class I complexes from the plasma membrane via two of its genes, K3 and K5. The N termini of K3 and K5 contain a plant homeodomain (PHD) predicted to be structurally similar to RING domains found in E3 ubiquitin ligases. In view of the imp...

journal_title：Journal of virology

authors： Lorenzo ME,Jung JU,Ploegh HL

更新日期：2002-06-01 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:Following infection by pairs of reovirus isolates consisting of combinations of reovirus T1 Lang, T2 Jones, or T3 Dearing, we found that one of the isolates interfered with the yield of progeny RNA derived from the other parents. The most significant interference was produced by T2 Jones or T3 Dearing, when mixed with...

journal_title：Journal of virology

authors： Rozinov MN,Fields BN

更新日期：1994-10-01 00:00:00

abstract：:In vitro transcription by vesicular stomatitis virus nucleocapsids is inhibited by enzymatic dephosphorylation of the NS protein. We provide evidence that specific, partial dephosphorylation of NS molecules is the only detectable change in nucleocapsids treated with bacterial alkaline phosphatase under conditions that...

journal_title：Journal of virology

authors： Hsu CH,Morgan EM,Kingsbury DW

更新日期：1982-07-01 00:00:00

abstract：:Cyclosporine (CsA) and its derivatives potently suppress hepatitis C virus (HCV) replication. Recently, CsA-resistant HCV replicons have been identified in vitro. We examined the dependence of the wild-type and CsA-resistant replicons on various cyclophilins for replication. A strong correlation between CsA resistance...

journal_title：Journal of virology

authors： Yang F,Robotham JM,Nelson HB,Irsigler A,Kenworthy R,Tang H

更新日期：2008-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key regulators in many biological processes, from development to defense, at almost all organismal levels. Recently, their role has been highlighted in pathogen-host interactions. Emerging evidence from a variety of virus-host systems indicates that cellular as well as virally encode...

journal_title：Journal of virology

authors： Hussain M,Asgari S

更新日期：2010-01-01 00:00:00

abstract：:Multiple mutations were found in the human immunodeficiency virus pol gene following treatment of an AIDS patient with antiretroviral drugs. After approximately 2.5 years of monthly alternating therapy with 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC), most of the pol sequences amplified from the p...

journal_title：Journal of virology

authors： Fitzgibbon JE,Farnham AE,Sperber SJ,Kim H,Dubin DT

更新日期：1993-12-01 00:00:00

abstract：:Norovirus immunity is poorly understood as the limited data available on protection after infection are often contradictory. In contrast to the more prominent GII noroviruses, GI norovirus infections are less frequent in outbreaks. The GI noroviruses display very complex patterns of heterotypic immune responses follow...

journal_title：Journal of virology

authors： Lindesmith LC,Donaldson E,Leon J,Moe CL,Frelinger JA,Johnston RE,Weber DJ,Baric RS

更新日期：2010-02-01 00:00:00

abstract：:Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) was modified to encode targeting signals known to localize proteins to either the endoplasmic reticulum (ER) or the trans-Golgi network. These motifs conferred the predicted targeting properties on gD in transfected cells as judged by immunofluorescence staini...

journal_title：Journal of virology

authors： Whiteley A,Bruun B,Minson T,Browne H

更新日期：1999-11-01 00:00:00

abstract：:Influenza A virus matrix protein M1 is involved in multiple stages of the viral infectious cycle. Despite its functional importance, our present understanding of this essential viral protein is limited. The roles of a small subset of specific amino acids have been reported, but a more comprehensive understanding of th...

journal_title：Journal of virology

authors： Hom N,Gentles L,Bloom JD,Lee KK

更新日期：2019-06-14 00:00:00

abstract：:The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viru...

journal_title：Journal of virology

authors： Hurt AC,Holien JK,Parker M,Kelso A,Barr IG

更新日期：2009-10-01 00:00:00

abstract：:The mammalian tripartite motif protein, TRIM5α, recognizes retroviral capsids entering the cytoplasm and blocks virus infection. Depending on the particular TRIM5α protein and retrovirus, complete disruption of the TRIM5α RING domain decreases virus-restricting activity to various degrees. TRIM5α exhibits RING domain-...

journal_title：Journal of virology

authors： Kim J,Tipper C,Sodroski J

更新日期：2011-08-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes a lifelong latent infection in peripheral nerve ganglia. Periodically, the virus reactivates from this latent reservoir and is transported to the original site of infection. Strains of HSV-1 have been noted to vary greatly in their virulence and reactivation efficiencies in a...

journal_title：Journal of virology

authors： Grams TR,Edwards TG,Bloom DC

更新日期：2020-07-16 00:00:00

abstract：:The functions of delta antigens (HDAgs) in the morphogenesis of hepatitis delta virus (HDV) have been studied previously. The C terminus of large HDAg has been shown to complex with the small surface antigen (HBsAg) of helper hepatitis B virus, whereas the assembly of small HDAg requires interaction with the N terminu...

journal_title：Journal of virology

authors： Chang MF,Chen CH,Lin SL,Chen CJ,Chang SC

更新日期：1995-04-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) infection is required for the development of several AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The high incidence of AIDS-KS has been ascribed to the interaction of KSHV and HIV-1. We have previously shown th...

journal_title：Journal of virology

authors： Yan Q,Shen C,Qin J,Li W,Hu M,Lu H,Qin D,Zhu J,Gao SJ,Lu C

更新日期：2016-09-12 00:00:00

abstract：:The synthesis of different viral ribonucleic acid (RNA) species was studied in chick embryo (CE) and mouse L-cell cultures infected with the Herts strain of Newcastle disease virus (NDV(o)) and a mutant isolated from persistently infected L cells (NDV(pi)). In CE cell cultures, both viruses synthesized significant amo...

journal_title：Journal of virology

authors： Thacore HR,Youngner JS

更新日期：1972-03-01 00:00:00

abstract：:The specificity of herpes simplex virus type 1-specific cytotoxic T cells was examined with target cells expressing either input viral structural antigens or antigens resulting from permissive infection or cells from an interrupted infection in which they expressed predominantly nonstructural immediate-early proteins....

journal_title：Journal of virology

authors： Martin S,Courtney RJ,Fowler G,Rouse BT

更新日期：1988-07-01 00:00:00

abstract：:We previously identified two novel endogenous murine leukemia virus proviruses, PreXMRV-1 and PreXMRV-2, and showed that they most likely recombined during xenograft passaging of a human prostate tumor in mice to generate xenotropic murine leukemia virus-related virus (XMRV). To determine the recombination potential o...

journal_title：Journal of virology

authors： Delviks-Frankenberry K,Paprotka T,Cingöz O,Wildt S,Hu WS,Coffin JM,Pathak VK

更新日期：2013-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) efficiently drives proliferation of human primary B cells in vitro, a process relevant for human diseases such as infectious mononucleosis and posttransplant lymphoproliferative disease. Human B-cell proliferation is also driven by ligands of Toll-like receptors (TLRs), notably viral or bacter...

journal_title：Journal of virology

authors： Iskra S,Kalla M,Delecluse HJ,Hammerschmidt W,Moosmann A

更新日期：2010-04-01 00:00:00

abstract：:Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus (HCV). Earlier, we demonstrated that the RNA recognition motif (RRM) encompassing residues 112 to 184 of La protein [La (112-184)] interacts with the HCV IRES near the initiator AUG codon....

journal_title：Journal of virology

authors： Mondal T,Ray U,Manna AK,Gupta R,Roy S,Das S

更新日期：2008-12-01 00:00:00

abstract：:We isolated and characterized two spontaneous, weakly leukemogenic mutants of Rauscher spleen focus-forming virus (R-SFFV) that contain mutations in nonoverlapping regions of the membrane envelope (env) glycoprotein gene. As reported previously (M. Ruta and D. Kabat, J. Virol. 35:844-853, 1980), the replication-defect...

journal_title：Journal of virology

authors： Machida CA,Bestwick RK,Kabat D

更新日期：1984-02-01 00:00:00

abstract：:TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 ...

journal_title：Journal of virology

authors： Maggi F,Pistello M,Vatteroni M,Presciuttini S,Marchi S,Isola P,Fornai C,Fagnani S,Andreoli E,Antonelli G,Bendinelli M

更新日期：2001-12-01 00:00:00

abstract：:Wild-type simian virus 40 A protein (large T antigen) bound to three tandem regions of simian virus 40 DNA. The binding regions were defined by the ability of A protein to protect simian virus 40 DNA from digestion with limited (footprint assay) or excess (fragment assay) amounts of DNase I. At low concentrations, pro...

journal_title：Journal of virology

authors： Wilson VG,Tevethia MJ,Lewton BA,Tegtmeyer P

更新日期：1982-11-01 00:00:00

abstract：:Chronic viruses such as herpes simplex virus 1 (HSV-1) evade the hosts' immune system by inducing the exhaustion of antiviral T cells. In the present study, we found that exhausted HSV-specific CD8+ T cells, with elevated expression of programmed death ligand-1 (PD-1) and lymphocyte activation gene-3 (LAG-3) receptors...

journal_title：Journal of virology

authors： Roy S,Coulon PG,Prakash S,Srivastava R,Geertsema R,Dhanushkodi N,Lam C,Nguyen V,Gorospe E,Nguyen AM,Salazar S,Alomari NI,Warsi WR,BenMohamed L

更新日期：2019-08-28 00:00:00

abstract：:Latent Epstein-Barr virus (EBV) infection is associated with several lymphoproliferative disorders, including posttransplant lymphoma, Hodgkin's disease, and Burkitt's lymphoma, as well as nasopharyngeal carcinoma (NPC). Twenty-nine microRNAs (miRNAs) have been identified that are transcribed during latent infection f...

journal_title：Journal of virology

authors： Edwards RH,Marquitz AR,Raab-Traub N

更新日期：2008-09-01 00:00:00

abstract：:We report here that sex hormones modulate susceptibility to a sexually transmitted viral agent, herpes simplex virus type 2 (HSV-2), in a mouse model. Ovariectomized mice were administered either saline (control), estradiol (E(2)), progesterone (P(4)), or a combination of both estradiol and progesterone (E+P) and infe...

journal_title：Journal of virology

authors： Gillgrass AE,Fernandez SA,Rosenthal KL,Kaushic C

更新日期：2005-03-01 00:00:00

abstract：:Influenza A virus NS2 protein, also called nuclear export protein (NEP), is crucial for the nuclear export of viral ribonucleoproteins. However, the molecular mechanisms of NEP mediation in this process remain incompletely understood. A leucine-rich nuclear export signal (NES2) in NEP, located at the predicted N2 heli...

journal_title：Journal of virology

authors： Huang S,Chen J,Chen Q,Wang H,Yao Y,Chen J,Chen Z

更新日期：2013-01-01 00:00:00