Human immunodeficiency virus type 1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs.

abstract：:After isolation, the DNA of simian virus 40 appeared as a negative supertwist (form I) or as an open circle with at least one single-strand scission (form II). Under the denaturation conditions usually applied, such as heating in the presence of formaldehyde or application of alkali, form I molecules could appear as "...

journal_title：Journal of virology

authors： Mayer F,Mazaitis AJ,Pühler A

更新日期：1975-03-01 00:00:00

abstract：:Bacteriophages of the C3 morphotype, characterized by very long heads that exceed their width several times, are extremely rare among the Podoviridae family members and constitute only 0.5% of over 5,500 phages that have been examined by the electron microscope (H. W. Ackermann, Arch. Virol. 152:227-243, 2007; H. W. A...

journal_title：Journal of virology

authors： Li Y,Chen M,Tang F,Yao H,Lu C,Zhang W

更新日期：2012-12-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease. The HCV polyprotein contains a hypervariable region (HVR1) located at the N terminus of the second envelope glycoprotein E2. The strong variability of this 27-amino-acid region is due to its apparent tolerance of amino acid substitutions toge...

journal_title：Journal of virology

authors： Penin F,Combet C,Germanidis G,Frainais PO,Deléage G,Pawlotsky JM

更新日期：2001-06-01 00:00:00

abstract：:Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection ...

journal_title：Journal of virology

authors： Hao X,Kim TS,Braciale TJ

更新日期：2008-05-01 00:00:00

abstract：:Therapeutic vaccination has the potential to boost immune responses and enhance viral control during chronic infections. However, many therapeutic vaccination approaches have fallen short of expectations, and effective boosting of antiviral T-cell responses is not always observed. To examine these issues, we studied t...

journal_title：Journal of virology

authors： Wherry EJ,Blattman JN,Ahmed R

更新日期：2005-07-01 00:00:00

abstract：:Previously it was shown that the host-range gene of the Bratislava strain of avain sarcoma virus (B77 virus) spontaneously mutates with a very high rate. The wild-type B77 virus called B77 virus-II, mutates either to virus that efficiently infects duck cells (B77 virus-III) or to virus that does not mutate to the abil...

journal_title：Journal of virology

authors： Zarling DA,Mosser AG,Temin HM

更新日期：1977-01-01 00:00:00

abstract：:The majority of T-cell clones derived from a donor who experienced dengue illness following receipt of a live experimental dengue virus type 3 (DEN3) vaccine cross-reacted with all four serotypes of dengue virus, but some were serotype specific or only partially cross-reactive. The nonstructural protein, NS3, was immu...

journal_title：Journal of virology

authors： Zeng L,Kurane I,Okamoto Y,Ennis FA,Brinton MA

更新日期：1996-05-01 00:00:00

abstract：:Avian reovirus, an important avian pathogen, expresses eight structural and four nonstructural proteins. The structural sigmaA protein is a major component of the inner capsid, clamping together lambdaA building blocks. sigmaA has also been implicated in the resistance of avian reovirus to the antiviral action of inte...

journal_title：Journal of virology

authors： Guardado-Calvo P,Vazquez-Iglesias L,Martinez-Costas J,Llamas-Saiz AL,Schoehn G,Fox GC,Hermo-Parrado XL,Benavente J,van Raaij MJ

更新日期：2008-11-01 00:00:00

abstract：:Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the seme...

journal_title：Journal of virology

authors： Whitney JB,Luedemann C,Hraber P,Rao SS,Mascola JR,Nabel GJ,Letvin NL

更新日期：2009-10-01 00:00:00

abstract：:The Gag-Pol polyprotein of human immunodeficiency virus type 1 (HIV-1) is not required for efficient viral particle production. However, premature termination codons in pol, particularly in the integrase (IN)-coding region, can markedly impair HIV-1 particle formation, apparently due to the premature activation of the...

journal_title：Journal of virology

authors： Popov S,Strack B,Sanchez-Merino V,Popova E,Rosin H,Göttlinger HG

更新日期：2011-04-01 00:00:00

abstract：:Engineered alphavirus vectors expressing reporters of infection have been used for a number of years due to their relatively low costs for analysis of virus replication and the capacity to utilize imaging systems for longitudinal measurements of growth within single animals. In general, these vectors have been derived...

journal_title：Journal of virology

authors： Sun C,Gardner CL,Watson AM,Ryman KD,Klimstra WB

更新日期：2014-02-01 00:00:00

abstract：:As nonacademic careers in science have become less and less "alternative," one field that has consistently attracted early-career virologists is public health research. The desire to make tangible contributions to public health needs and better protect the public from infectious disease often motivates the transition....

journal_title：Journal of virology

authors： Konopka-Anstadt JL,Burns CC

更新日期：2017-04-13 00:00:00

abstract：:Alternative splicing of the human immunodeficiency virus type 1 (HIV-1) genomic mRNA produces more than 40 unique viral mRNA species, of which more than half remain incompletely spliced within an HIV-1-infected cell. Regulation of splicing at HIV-1 3' splice sites (3'ss) requires suboptimal polypyrimidine tracts, and ...

journal_title：Journal of virology

authors： Madsen JM,Stoltzfus CM

更新日期：2005-08-01 00:00:00

abstract：:Our knowledge regarding immune-protective and immunopathogenic events in severe acute respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about the dynamics of the immune response at the primary site of disease. Here, an African green monkey (AGM) model was used to elucidate immune me...

journal_title：Journal of virology

authors： Clay C,Donart N,Fomukong N,Knight JB,Lei W,Price L,Hahn F,Van Westrienen J,Harrod KS

更新日期：2012-04-01 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00

abstract：:Vaccine-induced memory is necessary for protective immunity to pathogens, but many viruses induce a state of transient immune suppression that might contribute to the inability of a vaccine to elicit immunity. We evaluated here the fate of bystander T cells activated by third party cognate antigens during acute viral ...

journal_title：Journal of virology

authors： Marshall HD,Urban SL,Welsh RM

更新日期：2011-06-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Study of active-site mutations (the V82A single mutation and the V82F I84V double mutation) in the less-studied South African HIV type 1 subtype C (C-SA) protease indicated that neither mutation had a signific...

journal_title：Journal of virology

authors： Mosebi S,Morris L,Dirr HW,Sayed Y

更新日期：2008-11-01 00:00:00

abstract：:The ability of HIV-1 to establish a latent infection presents a barrier to curing HIV. The best-studied reservoir of latent virus in vivo is resting memory CD4(+) T cells, but it has recently been shown that CD34(+) hematopoietic progenitor cells (HPCs) can also become latently infected by HIV-1 in vitro and in vivo. ...

journal_title：Journal of virology

authors： McNamara LA,Ganesh JA,Collins KL

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:A balance between the functions of the influenza virus surface proteins hemagglutinin (HA) and neuraminidase (NA) is thought to be important for the transmission of viruses between humans. Here we describe two pandemic H1N1 viruses, A/swine/Virginia/1814-1/2012 and A/swine/Virginia/1814-2/2012 (pH1N1low-1 an...

journal_title：Journal of virology

authors： Zanin M,Marathe B,Wong SS,Yoon SW,Collin E,Oshansky C,Jones J,Hause B,Webby R

更新日期：2015-06-01 00:00:00

abstract：:A vaccinia-directed deoxyribonucleic acid (DNA) polymerase has been partially purified from the cytoplasmic fractions of virus-infected HeLa cells. The utilization of natural and synthetic templates by this enzyme resembles that of the host cell DNA-dependent DNA polymerases. The vaccinia DNA polymerase cannot copy ri...

journal_title：Journal of virology

authors： Citarella RV,Muller R,Schlabach A,Weissbach A

更新日期：1972-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) protein pUL38 has been shown to prevent premature cell death by antagonizing cellular stress responses; however, the underlying mechanism remains unknown. In this study, we identified the host protein ubiquitin-specific protease 24 (USP24) as an interaction partner of pUL38. Mutagenesis an...

journal_title：Journal of virology

authors： Sun Y,Bao Q,Xuan B,Xu W,Pan D,Li Q,Qian Z

更新日期：2018-06-13 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus (AcMNPV) is a double-stranded DNA virus that expresses several immediate-early genes under the control of different promoters. The expression of one of these transcription units, IE-N, is shown here, by a transient expression assay, to be regulated by both cis- and tra...

journal_title：Journal of virology

authors： Carson DD,Summers MD,Guarino LA

更新日期：1991-02-01 00:00:00

abstract：:ts1 and ts7, two temperature-sensitive mutants of Moloney murine leukemia virus strain TB induce hind-limb paralysis in 100% of CFW/D mice injected. These two paralytogenic mutants also share a defect in their inability to process the env precursor protein, Pr80env, at the restrictive temperature. To identify the muta...

journal_title：Journal of virology

authors： Yuen PH,Malehorn D,Knupp C,Wong PK

更新日期：1985-05-01 00:00:00

abstract：:Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as high as the equiva...

journal_title：Journal of virology

authors： Quan Y,Gu Z,Li X,Li Z,Morrow CD,Wainberg MA

更新日期：1996-08-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) gene was altered so that it encoded a truncated glycoprotein lacking a cytoplasmic domain but retaining 20 of 23 amino acids of the transmembrane domain. No additional amino acid residues were introduced into the glycoprotein encoded by the altered gene. The ...

journal_title：Journal of virology

authors： Holland TC,Lerch RJ,Earhart K

更新日期：1988-05-01 00:00:00

abstract：UNLABELLED:The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by most of these mutations to virulence attenuation and vacci...

journal_title：Journal of virology

authors： Gromowski GD,Firestone CY,Whitehead SS

更新日期：2015-06-01 00:00:00

abstract：:Rous sarcoma virus protein p10 is a gag component of the virion present in stoichiometric amount but of unknown function. To characterize this protein, a series of mutants of p10 with linker insertions or deletions was generated by site-directed mutagenesis of a cloned proviral DNA. The deletions and two of the linker...

journal_title：Journal of virology

authors： Dupraz P,Spahr PF

更新日期：1993-07-01 00:00:00

abstract：:Lentivectors stimulate potent immune responses to antigen transgenes and are being developed as novel genetic vaccines. To improve safety while retaining efficacy, we constructed a lentivector in which transgene expression was restricted to antigen-presenting cells using the mouse dectin-2 gene promoter. This lentivec...

journal_title：Journal of virology

authors： Lopes L,Dewannieux M,Gileadi U,Bailey R,Ikeda Y,Whittaker C,Collin MP,Cerundolo V,Tomihari M,Ariizumi K,Collins MK

更新日期：2008-01-01 00:00:00

abstract：:To replicate its segmented, double-stranded RNA (dsRNA) genome, the rotavirus RNA-dependent RNA polymerase, VP1, must recognize viral plus-strand RNAs (+RNAs) and guide them into the catalytic center. VP1 binds to the conserved 3' end of rotavirus +RNAs via both sequence-dependent and sequence-independent contacts. Se...

journal_title：Journal of virology

authors： Ogden KM,Ramanathan HN,Patton JT

更新日期：2011-03-01 00:00:00

abstract：:Beta interferon (IFN-beta) expression is triggered by double-stranded RNA, a common intermediate in the replication of many viruses including hepatitis C virus (HCV). The recent development of cell culture-grown HCV allowed us to analyze the IFN signaling pathway following virus infection. In this study, we have exami...

journal_title：Journal of virology

authors： Kanda T,Steele R,Ray R,Ray RB

更新日期：2007-11-01 00:00:00