Toll-like receptor agonists synergistically increase proliferation and activation of B cells by epstein-barr virus.

abstract：:Hepatitis B viruses (HBVs) replicate by reverse transcription of an RNA intermediate. Packaging of this RNA pregenome into nucleocapsids and replication initiation depend crucially on the interaction of the reverse transcriptase, P protein, with the cis-acting, 5' end-proximal encapsidation signal epsilon. The overall...

journal_title：Journal of virology

authors： Beck J,Nassal M

更新日期：1997-07-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) productive replication in vitro is most often studied in fibroblasts. In vivo, fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. In vitro, the study of HCMV infection of epithelial cells has been al...

journal_title：Journal of virology

authors： Weng C,Lee D,Gelbmann CB,Van Sciver N,Nawandar DM,Kenney SC,Kalejta RF

更新日期：2018-07-31 00:00:00

abstract：:We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less than 5. Production...

journal_title：Journal of virology

authors： Gao M,Knipe DM

更新日期：1991-05-01 00:00:00

abstract：:Previous studies with a limited number of strains have indicated that there are two genotypes of yellow fever (YF) virus in Africa, one in west Africa and the other in east and central Africa. We have examined the prM/M and a portion of the E protein for a panel of 38 wild strains of YF virus from Africa representing ...

journal_title：Journal of virology

authors： Mutebi JP,Wang H,Li L,Bryant JE,Barrett AD

更新日期：2001-08-01 00:00:00

abstract：:We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the molecular basis of substrate-inhibitor specificity for lentivirus PRs, with a focus on human immunodeficiency virus type 1 (HIV-1) PR. Our previous mutagenesis studies demonstrated that discrete substitutions in the acti...

journal_title：Journal of virology

authors： Lin YC,Brik A,de Parseval A,Tam K,Torbett BE,Wong CH,Elder JH

更新日期：2006-08-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) major immediate-early (MIE) enhancer contains five functional cyclic AMP (cAMP) response elements (CRE). Because the CRE in their native context do not contribute appreciably to MIE enhancer/promoter activity in lytically infected human fibroblasts and NTera2 (NT2)-derived neurons, we ...

journal_title：Journal of virology

authors： Keller MJ,Wu AW,Andrews JI,McGonagill PW,Tibesar EE,Meier JL

更新日期：2007-06-01 00:00:00

abstract：:While a diversity of immunogens that elicit qualitatively different cellular immune responses are being assessed in clinical human immunodeficiency virus vaccine trials, the consequences of those varied responses for viral control remain poorly understood. In the present study, we evaluated the induction of virus-spec...

journal_title：Journal of virology

authors： Sun Y,Santra S,Schmitz JE,Roederer M,Letvin NL

更新日期：2008-09-01 00:00:00

abstract：:We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count, <100/microl) and stable viral...

journal_title：Journal of virology

authors： Nelson JA,Baribaud F,Edwards T,Swanstrom R

更新日期：2000-09-01 00:00:00

abstract：:Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). ...

journal_title：Journal of virology

authors： Kalams SA,Goulder PJ,Shea AK,Jones NG,Trocha AK,Ogg GS,Walker BD

更新日期：1999-08-01 00:00:00

abstract：:An in situ molecular hybridization system which will detect retrovirus RNA in the cytoplasm of individual virus-infected cells has been developed. The technique was applied to cells infected with simian sarcoma-leukemia virus, where the virus-specific RNA was detected by hybridization to simian sarcoma-leukemia virus ...

journal_title：Journal of virology

authors： Kaufman SL,Gallo RC,Miller NR

更新日期：1979-05-01 00:00:00

abstract：:Typical herpes simplex virus (HSV) capsids contain seven proteins that form a T=16 icosahedron of 1,250-A diameter. Infection of cells with recombinant baculoviruses expressing two of these proteins, VP5 (which forms the pentons and hexons in typical HSV capsids) and VP19C (a component of the triplexes that connect ad...

journal_title：Journal of virology

authors： Saad A,Zhou ZH,Jakana J,Chiu W,Rixon FJ

更新日期：1999-08-01 00:00:00

abstract：:Simian virus 40 large T antigen (large T) in the early and the late phases of infection differs significantly in its sequence-specific DNA-binding and ATPase activities, indicating that different large-T populations participate in virus-specific events at various stages of the infectious cycle. To further characterize...

journal_title：Journal of virology

authors： Schirmbeck R,Deppert W

更新日期：1989-05-01 00:00:00

abstract：:R325-beta TK+, a herpes simplex virus 1 mutant carrying a 500-base-pair deletion in the alpha 22 gene and the wild-type (beta) thymidine kinase (TK) gene, was previously shown to grow efficiently in HEp-2 and Vero cell lines. We report that in rodent cell lines exemplified by the Rat-1 line, plating efficiency was red...

journal_title：Journal of virology

authors： Sears AE,Halliburton IW,Meignier B,Silver S,Roizman B

更新日期：1985-08-01 00:00:00

abstract：:Expression of the region of the feline calicivirus (FCV) ORF1 encoded by nucleotides 3233 to 4054 in an in vitro rabbit reticulocyte system resulted in synthesis of an active proteinase that specifically processes the viral nonstructural polyprotein. Site-directed mutagenesis of the cysteine (Cys1193) residue in the p...

journal_title：Journal of virology

authors： Sosnovtseva SA,Sosnovtsev SV,Green KY

更新日期：1999-08-01 00:00:00

abstract：:Anelloviruses are a group of single-stranded circular DNA viruses infecting humans and other animal species. Animal models combined with reverse genetic systems of anellovirus have not been developed. We report here the construction and initial characterization of full-length DNA clones of a porcine anellovirus, torqu...

journal_title：Journal of virology

authors： Huang YW,Patterson AR,Opriessnig T,Dryman BA,Gallei A,Harrall KK,Vaughn EM,Roof MB,Meng XJ

更新日期：2012-06-01 00:00:00

abstract：:Recent studies have established the presence of human T-cell lymphoma/leukemia virus type I (HTLV-I) in Melanesia. An HTLV-I strain, PNG-1, has now been isolated from a healthy member of the Hagahai, a remote, recently contacted group in Papua New Guinea. To further characterize PNG-1, we employed polymerase chain rea...

journal_title：Journal of virology

authors： Sherman MP,Saksena NK,Dube DK,Yanagihara R,Poiesz BJ

更新日期：1992-04-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) has been shown to progress through a number of changes that lead to the emergence of pathogenic viral variants in macaques initially infected with a mildly cytopathic variant, SIVMneCL8. One of these late-stage isolates, SIVMne170, replicates to high levels in vivo and causes a rapi...

journal_title：Journal of virology

authors： Voronin Y,Overbaugh J,Emerman M

更新日期：2005-12-01 00:00:00

abstract：:Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8(+) T cells cr...

journal_title：Journal of virology

authors： Kraft AR,Wlodarczyk MF,Kenney LL,Selin LK

更新日期：2013-12-01 00:00:00

abstract：:Targeted vectors will be necessary for many gene therapy applications. To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope. ...

journal_title：Journal of virology

authors： Martin F,Neil S,Kupsch J,Maurice M,Cosset F,Collins M

更新日期：1999-08-01 00:00:00

abstract：UNLABELLED:The ATR kinase has essential functions in maintenance of genome integrity in response to replication stress. ATR is recruited to RPA-coated single-stranded DNA at DNA damage sites via its interacting partner, ATRIP, which binds to the large subunit of RPA. ATR activation typically leads to activation of the ...

journal_title：Journal of virology

authors： Adeyemi RO,Pintel DJ

更新日期：2014-09-01 00:00:00

abstract：:Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clinical trials shows great promise for the treatment of human immunodefic...

journal_title：Journal of virology

authors： Goethals O,Clayton R,Van Ginderen M,Vereycken I,Wagemans E,Geluykens P,Dockx K,Strijbos R,Smits V,Vos A,Meersseman G,Jochmans D,Vermeire K,Schols D,Hallenberger S,Hertogs K

更新日期：2008-11-01 00:00:00

abstract：:The phylogeny of reptilian herpesviruses (HVs) relative to mammalian and avian HVs was investigated by using available gene sequences and by alignment of encoded amino acid sequences and derivation of trees by maximum-likelihood and Bayesian methods. Phylogenetic loci were obtained for green turtle HV (GTHV) primarily...

journal_title：Journal of virology

authors： McGeoch DJ,Gatherer D

更新日期：2005-01-01 00:00:00

abstract：:The mechanism whereby picornaviruses inhibit host protein synthesis while their own synthetic processes proceed unabated has remained elusive. One of our approaches to this problem was to study the ability of cell-free extracts derived from uninfected and mengovirus-infected Ehrlich ascites tumor cells to translate vi...

journal_title：Journal of virology

authors： Abreu SL,Lucas-Lenard J

更新日期：1976-04-01 00:00:00

abstract：:It is shown that gene 5 protein of bacteriophage M13 is one of the major proteins synthesized in vitro under the direction of M13 replicative-form DNA. By means of DNA-cellulose chromatography, this protein has been purified to homogeneity and its biological characteristics have been compared with those of its native ...

journal_title：Journal of virology

authors： Konings RN,Jansen J,Cuypers T,Schoenmakers JG

更新日期：1973-12-01 00:00:00

abstract：:Although parvoviruses are found throughout the animal kingdom, only the human pathogenic B19 virus has so far been shown to possess a limited host range, with erythroid progenitor cells as the main target cells supporting B19 propagation. The underlying mechanism of such erythroid tropism is still unexplained. Synthes...

journal_title：Journal of virology

authors： Pallier C,Greco A,Le Junter J,Saib A,Vassias I,Morinet F

更新日期：1997-12-01 00:00:00

abstract：:While the cytoplasmic phase of the hepadnavirus replication cycle is well understood, very little is known about the nuclear phase. In contrast to retroviruses, proviral integration is not required for hepadnavirus replication; however, some of the viral DNAs in the nucleus are diverted into an integration pathway. Un...

journal_title：Journal of virology

authors： Gong SS,Jensen AD,Wang H,Rogler CE

更新日期：1995-12-01 00:00:00

abstract：:SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 antagonism occurred ...

journal_title：Journal of virology

authors： Trautz B,Pierini V,Wombacher R,Stolp B,Chase AJ,Pizzato M,Fackler OT

更新日期：2016-11-14 00:00:00

abstract：:Phage XP-12, which has complete substitution of the cytosine residues in its DNA with 5-methylcytosine residues, was shown to inhibit incorporation of uracil into host DNA and RNA during the latent period. This apparent inhibition of host macromolecular synthesis was not accompanied by extensive degradation of the hos...

journal_title：Journal of virology

authors： Ehrlich M,Lin FH,Ehrlich K,Brown SL,Mayo JA

更新日期：1977-09-01 00:00:00

abstract：:Recombinant interleukin-16 (rIL-16) has been found to inhibit human immunodeficiency virus type 1 (HIV-1) replication in acutely or endogenously infected CD4(+) T cells. However, the effect of rIL-16 on HIV-1 replication in antigen-presenting cells (APCs) is still unknown. We show here a potent HIV-suppressive activit...

journal_title：Journal of virology

authors： Truong MJ,Darcissac EC,Hermann E,Dewulf J,Capron A,Bahr GM

更新日期：1999-08-01 00:00:00

abstract：:To reliably infect a primate model for human immunodeficiency virus (HIV), approximately 10,000-fold more virus must be delivered vaginally than intravenously. However, the vaginal mechanisms that help protect against HIV are poorly understood. Here, we report that human cervicovaginal mucus (CVM), obtained from donor...

journal_title：Journal of virology

authors： Lai SK,Hida K,Shukair S,Wang YY,Figueiredo A,Cone R,Hope TJ,Hanes J

更新日期：2009-11-01 00:00:00