Human Cytomegalovirus Productively Replicates In Vitro in Undifferentiated Oral Epithelial Cells.

abstract：:The genomic RNA of human T-cell leukemia virus type 1 encodes three polyproteins, Gag, Gag-Pro, and Gag-Pro-Pol, which are translated as a result of no, one, and two frameshifts, respectively. In this report we demonstrate that the 77 residues encoded at the C terminus of the Gag-Pro precursor can be collectively dete...

journal_title：Journal of virology

authors： Heidecker G,Hill S,Lloyd PA,Derse D

更新日期：2002-12-01 00:00:00

abstract：:With the rationale that the neuropathological similarities between scrapie and Alzheimer's disease reflect convergent pathological mechanisms involving altered gene expression, we set out to identify molecular events involved in both processes, using scrapie as a model to study the time course of these changes. We dif...

journal_title：Journal of virology

authors： Diedrich JF,Minnigan H,Carp RI,Whitaker JN,Race R,Frey W 2nd,Haase AT

更新日期：1991-09-01 00:00:00

abstract：:Previous work demonstrated that a herpes simplex virus type 1 (HSV-1) immediate-early function up-regulates beta interferon but not chloramphenicol acetyltransferase reporter genes driven by the strong simian virus 40 (SV40) or cytomegalovirus promoter-enhancer regions in both transient assays and stable cell lines. T...

journal_title：Journal of virology

authors： Brown CR,Nakamura MS,Mosca JD,Hayward GS,Straus SE,Perera LP

更新日期：1995-11-01 00:00:00

abstract：:Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful vector for human gene therapy, the transduction efficiencies of AAV vectors vary greatly in different cells and tissues in vitro and in vivo. We have documented that a cellular tyrosine phosphoprotein, designated the single-stran...

journal_title：Journal of virology

authors： Qing K,Hansen J,Weigel-Kelley KA,Tan M,Zhou S,Srivastava A

更新日期：2001-10-01 00:00:00

abstract：:The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa...

journal_title：Journal of virology

authors： Wernicke D,Trainin Z,Ungar-Waron H,Essex M

更新日期：1986-11-01 00:00:00

abstract：:The bacteriophage T5 is known to spontaneously generate deletion mutants (st mutants) exhibiting enhanced resistance to heat inactivation in citrate buffer. A series of such mutants has been isolated and the deletions visualized by electron microscopy of heteroduplex molecules. The deletions are found to cluster in on...

journal_title：Journal of virology

authors： Scheible PP,Rhoades M

更新日期：1975-05-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) DNA replication is associated with nuclear domains called ND10, which contain host recombination proteins such as RPA, RAD51, and NBS1 and participate in the cell's response to DNA damage. The stages of HSV-1 infection have been described previously. Infected cells at stage IIIa are...

journal_title：Journal of virology

authors： Wilkinson DE,Weller SK

更新日期：2004-05-01 00:00:00

abstract：:The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to ...

journal_title：Journal of virology

authors： Yu X,Shah S,Atanasov I,Lo P,Liu F,Britt WJ,Zhou ZH

更新日期：2005-01-01 00:00:00

abstract：:Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that reduces HIV-1 infectivity by an incompletely understood mechanism. We show here that viruses differing only in the envelope glycoprotein (Env) expressed on their surface have different sensitivities to IFITM3. Measurements of the sensitivity...

journal_title：Journal of virology

authors： Drouin A,Migraine J,Durand MA,Moreau A,Burlaud-Gaillard J,Beretta M,Roingeard P,Bouvin-Pley M,Braibant M

更新日期：2020-12-09 00:00:00

abstract：:Adenovirus infection and expression of E1A induces both proliferation and apoptosis, the latter of which is blocked by the adenovirus Bcl-2 homologue E1B 19K. The mechanism of apoptosis induction and the role that it plays in productive infection are not known. Unlike apoptosis mediated by death receptors, infection w...

journal_title：Journal of virology

authors： Cuconati A,Degenhardt K,Sundararajan R,Anschel A,White E

更新日期：2002-05-01 00:00:00

abstract：:We performed live cell visualization assays to directly assess the interaction between competing adeno-associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA replication. Our studies reveal the formation of separate AAV and HSV-1 replication compartments and the inhibition of HSV-1 replication compartment ...

journal_title：Journal of virology

authors： Glauser DL,Strasser R,Laimbacher AS,Saydam O,Clément N,Linden RM,Ackermann M,Fraefel C

更新日期：2007-05-01 00:00:00

abstract：:A human cell line (293) transformed by adenovirus type 5 encodes mRNA's and proteins from the early region 1 (E1) of the viral genome. These products correspond to those synthesized early after adenovirus infection of normal cells. This pattern of expression is different from that observed at later times in the lytic ...

journal_title：Journal of virology

authors： Spector DJ,Halbert DN,Raskas HJ

更新日期：1980-12-01 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 (HIV-1) encodes a basic Mr 23,000 protein that is necessary for production of infectious virions by nonpermissive cells (human lymphocytes and macrophages) but not by permissive cells such as HeLa-CD4. It had been proposed that permissive cells may contain an unident...

journal_title：Journal of virology

authors： Madani N,Kabat D

更新日期：1998-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on AAVS1 is thought to be an essential step, the mechanism of the site-specific integration, particularly, how the site of ...

journal_title：Journal of virology

authors： Yamamoto N,Suzuki M,Kawano MA,Inoue T,Takahashi RU,Tsukamoto H,Enomoto T,Yamaguchi Y,Wada T,Handa H

更新日期：2007-02-01 00:00:00

abstract：:There is controversy as to whether the cell entry mechanism of Sindbis virus (SIN) involves direct fusion of the viral envelope with the plasma membrane at neutral pH or uptake by receptor-mediated endocytosis and subsequent low-pH-induced fusion from within acidic endosomes. Here, we studied the membrane fusion activ...

journal_title：Journal of virology

authors： Smit JM,Bittman R,Wilschut J

更新日期：1999-10-01 00:00:00

abstract：:The genetic diversity among globally circulating human immunodeficiency virus type 1 (HIV-1) strains is a serious challenge for HIV-1 vaccine design. We have generated a synthetic group M consensus env gene (CON6) for induction of cross-subtype immune responses and report here a comparative study of T-cell responses t...

journal_title：Journal of virology

authors： Weaver EA,Lu Z,Camacho ZT,Moukdar F,Liao HX,Ma BJ,Muldoon M,Theiler J,Nabel GJ,Letvin NL,Korber BT,Hahn BH,Haynes BF,Gao F

更新日期：2006-07-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：:Viral infectivity factor (Vif) is required for lentivirus fitness and pathogenicity, except in equine infectious anemia virus (EIAV). Vif enhances viral infectivity by a Cullin5-Elongin B/C E3 complex to inactivate the host restriction factor APOBEC3. Core-binding factor subunit beta (CBF-β) is a cell factor that was ...

journal_title：Journal of virology

authors： Ai Y,Zhu D,Wang C,Su C,Ma J,Ma J,Wang X

更新日期：2014-10-01 00:00:00

abstract：:Sulfation is a posttranslational modification of proteins which occurs on either the tyrosine residues or the carbohydrate moieties of some glycoproteins. In the case of secretory proteins, sulfation has been hypothesized to act as a signal for export from the cell. We have shown that the human immunodeficiency virus ...

journal_title：Journal of virology

authors： Bernstein HB,Compans RW

更新日期：1992-12-01 00:00:00

abstract：:Measles is a highly contagious human disease caused by the measles virus (MeV). In this study, by proteomic analysis, we identified peroxiredoxin 1 (Prdx1) as a host factor that binds to the C-terminal region of the nucleoprotein (N; N(TAIL)) of MeV. Glutathione S-transferase (GST) pulldown experiments showed that the...

journal_title：Journal of virology

authors： Watanabe A,Yoneda M,Ikeda F,Sugai A,Sato H,Kai C

更新日期：2011-03-01 00:00:00

abstract：:Human metapneumovirus (hMPV), a recently described paramyxovirus, is a major etiological agent for lower respiratory tract disease in young children that can manifest with severe cough, bronchiolitis, and pneumonia. The hMPV fusion glycoprotein (F) shares conserved functional domains with other paramyxovirus F protein...

journal_title：Journal of virology

authors： Schickli JH,Kaur J,Ulbrandt N,Spaete RR,Tang RS

更新日期：2005-08-01 00:00:00

abstract：:Human bocavirus 1 (HBoV1) is a human parvovirus that causes acute respiratory tract infections in young children. In this study, we confirmed that, when polarized/well-differentiated human airway epithelia are infected with HBoV1 in vitro, they develop damage characterized by barrier function disruption and cell hypot...

journal_title：Journal of virology

authors： Deng X,Zou W,Xiong M,Wang Z,Engelhardt JF,Ye SQ,Yan Z,Qiu J

更新日期：2017-11-30 00:00:00

abstract：:Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4(+) T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular rest...

journal_title：Journal of virology

authors： Pion M,Stalder R,Correa R,Mangeat B,Towers GJ,Piguet V

更新日期：2007-11-01 00:00:00

abstract：:Three of thirty-six monoclonal antibodies were found to cause irreversible inactivation of type 1 poliovirus at 39 degrees C but not at 37 degrees C. Neutralization at 37 degrees C depended on aggregation and was reversible by acid-induced deaggregation; at 39 degrees C, the virions (N antigenic, 160S) were disrupted ...

journal_title：Journal of virology

authors： Delaet I,Boeyé A

更新日期：1993-09-01 00:00:00

abstract：:The gH-gL complex of herpes simplex virus type 1 (HSV-1) is essential for virion infectivity and virus-induced cell fusion, but functional domains of the gH molecule remain to be defined. We have addressed this question by mutagenesis. A set of linker insertion mutants in HSV-1 gH was generated and tested in transient...

journal_title：Journal of virology

authors： Galdiero M,Whiteley A,Bruun B,Bell S,Minson T,Browne H

更新日期：1997-03-01 00:00:00

abstract：:The gene encoding glycoprotein F (gF) of herpes simplex virus type 2 (HSV-2) was mapped to the region of the viral genome from 0.62 to 0.64 map units. This region is colinear with, and partially homologous to, the region of the HSV-1 genome previously shown to encode gC. Mapping of the gF gene was done by insertion of...

journal_title：Journal of virology

authors： Zezulak KM,Spear PG

更新日期：1984-03-01 00:00:00

abstract：:The activity of uracil-DNA glycosylase in Escherichia coli decreases dramatically to less than 10% of its original level after infection of the cells by phage T5. Phage-induced protein synthesis is required for this inhibition to occur, and the inhibition is induced by a mutant capable of injecting only the first 8% o...

journal_title：Journal of virology

authors： Warner HR,Johnson LK,Snustad DP

更新日期：1980-01-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

journal_title：Journal of virology

authors： Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

更新日期：1990-04-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) encodes several MIE proteins (MIEPs) produced as a result of alternative splicing and polyadenylation of the primary transcript. Previously we demonstrated that the HCMV MIEPs expressed from the entire MIE gene could rescue the temperature-sensitive ...

journal_title：Journal of virology

authors： Lukac DM,Alwine JC

更新日期：1999-04-01 00:00:00

abstract：:Herpesviruses utilize different origins of replication during lytic versus latent infection. Latent DNA replication depends on host cellular DNA replication machinery, whereas lytic cycle DNA replication requires virally encoded replication proteins. In lytic DNA replication, the lytic origin (ori-Lyt) is bound by a v...

journal_title：Journal of virology

authors： Lin CL,Li H,Wang Y,Zhu FX,Kudchodkar S,Yuan Y

更新日期：2003-05-01 00:00:00