A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.

abstract：:The temperature-sensitive and attenuated phenotypes of the Sabin type 1 vaccine strain of poliovirus result from numerous point mutations which occurred in the virulent Mahoney virus parent. One of these mutations is located in a 3D polymerase (3Dpol) codon (U-6203-->C, Tyr-73-->His) and is involved in attenuation in ...

journal_title：Journal of virology

authors： Georgescu MM,Tardy-Panit M,Guillot S,Crainic R,Delpeyroux F

更新日期：1995-09-01 00:00:00

abstract：:Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic cells and T lymphocytes, transmit EHV1 to endothelial cells of t...

journal_title：Journal of virology

authors： Poelaert KCK,Van Cleemput J,Laval K,Favoreel HW,Couck L,Van den Broeck W,Azab W,Nauwynck HJ

更新日期：2019-03-21 00:00:00

abstract：UNLABELLED:Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study,...

journal_title：Journal of virology

authors： Lin KL,Twenhafel NA,Connor JH,Cashman KA,Shamblin JD,Donnelly GC,Esham HL,Wlazlowski CB,Johnson JC,Honko AN,Botto MA,Yen J,Hensley LE,Goff AJ

更新日期：2015-10-01 00:00:00

abstract：:The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...

journal_title：Journal of virology

authors： Zhang YN,Liu YY,Xiao FC,Liu CC,Liang XD,Chen J,Zhou J,Baloch AS,Kan L,Zhou B,Qiu HJ

更新日期：2018-07-17 00:00:00

abstract：:Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better...

journal_title：Journal of virology

authors： Santos JJS,Finch C,Sutton T,Obadan A,Aguirre I,Wan Z,Lopez D,Geiger G,Gonzalez-Reiche AS,Ferreri L,Perez DR

更新日期：2017-05-26 00:00:00

abstract：:Approximately 20 to 22 copies of adenovirus type 12 (Ad12) DNA per cell were integrated into the genome of the cell line T637. Only a few of these copies seemed to remain intact and colinear with virion DNA. All other persisting viral genomes exhibited deletions or inversions or both in the right-hand part of Ad12 DNA...

journal_title：Journal of virology

authors： Eick D,Doerfler W

更新日期：1982-04-01 00:00:00

abstract：:Inoculation of 3-day-old (3D) or 3-week-old (3W) ducklings with duck hepatitis B virus results in chronic or transient infection, respectively. We previously showed that rapid production of neutralizing antibody following inoculation of 3W ducklings prevents virus from spreading in the liver and leads to a transient i...

journal_title：Journal of virology

authors： Zhang YY,Theele DP,Summers J

更新日期：2005-08-01 00:00:00

abstract：:Information was sought on the temporal distribution of transmissible mink encephalopathy virus in royal pastel mink inoculated subcutaneously with 10(3.0) 50% intracerebral lethal doses of the Idaho strain. As determined by intracerebral assay in mink, extremely little replication of the virus occurred during the prec...

journal_title：Journal of virology

authors： Hadlow WJ,Race RE,Kennedy RC

更新日期：1987-10-01 00:00:00

abstract：UNLABELLED:The immunoglobulin superfamily protein receptors for poliovirus, human rhinovirus, and coxsackievirus B (CVB) serve to bind the viruses to target cells and to facilitate the release of the virus genome by catalyzing the transition from the mature infectious virus to the A-particle uncoating intermediate. Rec...

journal_title：Journal of virology

authors： Carson SD

更新日期：2014-10-01 00:00:00

abstract：:Systemic application of first-generation adenovirus induces pathogenic effects in the liver. To begin unraveling the mechanisms underlying early liver toxicity after adenovirus infusion, particularly the role of macrophage activation and expression of viral genes in transduced target cells, first-generation adenovirus...

journal_title：Journal of virology

authors： Lieber A,He CY,Meuse L,Schowalter D,Kirillova I,Winther B,Kay MA

更新日期：1997-11-01 00:00:00

abstract：:The human genome contains more than half a million human endogenous retrovirus (HERV) long terminal repeats (LTRs) that can be regarded as mobile regulatory modules. Many of these HERV LTRs have been recruited during evolution as transcriptional control elements for cellular gene expression. We have cloned LTR sequenc...

journal_title：Journal of virology

authors： Schön U,Diem O,Leitner L,Günzburg WH,Mager DL,Salmons B,Leib-Mösch C

更新日期：2009-12-01 00:00:00

abstract：:The double-stranded-DNA bacteriophages employ powerful molecular motors to translocate genomic DNA into preformed capsids during the packaging step in phage assembly. Bacillus subtilis bacteriophage 29 has an oligomeric prohead RNA (pRNA) that is an essential component of its packaging motor. The crystal structure of ...

journal_title：Journal of virology

authors： Zhao W,Saha M,Ke A,Morais MC,Jardine PJ,Grimes S

更新日期：2012-11-01 00:00:00

abstract：:Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...

journal_title：Journal of virology

authors： Chang J,Naif HM,Li S,Sullivan JS,Randle CM,Cunningham AL

更新日期：1996-11-01 00:00:00

abstract：:Q beta phage RNAs with inactivating insertion (8-base) or deletion (17-base) mutations within their replicase genes were prepared from modified Q beta cDNAs and transfected into Escherichia coli spheroplasts containing Q beta replicase provided in trans by a resident plasmid. Replicase-defective (Rep-) Q beta phage pr...

journal_title：Journal of virology

authors： Palasingam K,Shaklee PN

更新日期：1992-04-01 00:00:00

abstract：:Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation signal in HPV-16 plays a major role in the switch from the early to the late, productive stage of the viral life cycle. ...

journal_title：Journal of virology

authors： Oberg D,Fay J,Lambkin H,Schwartz S

更新日期：2005-07-01 00:00:00

abstract：:Previous studies have indicated that B cells make a significant contribution to the resolution of influenza virus infection. To determine how B cells participate in the control of the infection, we transferred intact, major histocompatibility complex class II (MHC-II)-negative or B-cell receptor (BCR)-transgenic splee...

journal_title：Journal of virology

authors： Mozdzanowska K,Furchner M,Zharikova D,Feng J,Gerhard W

更新日期：2005-05-01 00:00:00

abstract：:Productively infected bovine fibropapillomas were examined for bovine papillomavirus type 1 (BPV-1) E7 localization. BPV-1 E7 was observed in the cytoplasm of basal and lower spinous epithelial cells, coexpressed in the cytoplasm of basal cells with the E5 oncoprotein. E7 was also observed in nucleoli throughout the b...

journal_title：Journal of virology

authors： Bohl J,Hull B,Vande Pol SB

更新日期：2001-01-01 00:00:00

abstract：:The putative role of nitric oxide in the neuropathogenesis of Borna disease was investigated by determining changes in the expression of inducible nitric oxide synthase (iNOS) mRNA and constitutively expressed NOS (cNOS) mRNA in brains of Borna disease virus (BDV)-infected rats. iNOS mRNA was not detected in normal ra...

journal_title：Journal of virology

authors： Zheng YM,Schäfer MK,Weihe E,Sheng H,Corisdeo S,Fu ZF,Koprowski H,Dietzschold B

更新日期：1993-10-01 00:00:00

abstract：:Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did ...

journal_title：Journal of virology

authors： Markine-Goriaynoff D,Coutelier JP

更新日期：2002-01-01 00:00:00

abstract：:Expression of the region of the feline calicivirus (FCV) ORF1 encoded by nucleotides 3233 to 4054 in an in vitro rabbit reticulocyte system resulted in synthesis of an active proteinase that specifically processes the viral nonstructural polyprotein. Site-directed mutagenesis of the cysteine (Cys1193) residue in the p...

journal_title：Journal of virology

authors： Sosnovtseva SA,Sosnovtsev SV,Green KY

更新日期：1999-08-01 00:00:00

abstract：:Adenovirus infection affects the nuclear distribution of host splicing factors. Late phase-infected cells contain discrete clusters of small nuclear ribonucleoproteins (snRNPs) that are separate from centers containing the viral 72-kilodalton DNA-binding protein (72K protein). In the present study, we demonstrate that...

journal_title：Journal of virology

authors： Bridge E,Xia DX,Carmo-Fonseca M,Cardinali B,Lamond AI,Pettersson U

更新日期：1995-01-01 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV), a pestivirus of the Flaviviridae family, is an economically important cattle pathogen with a worldwide distribution. Both noncytopathic (ncp) and cytopathic (cp) biotypes of BVDV can be isolated from persistently infected cattle suffering from the lethal mucosal disease. The cp biot...

journal_title：Journal of virology

authors： Schweizer M,Peterhans E

更新日期：2001-05-01 00:00:00

abstract：:The efficient attachment of pseudorabies virus to cultured cells is dependent on an electrostatic interaction between negatively charged cell surface heparan sulfate and the viral envelope glycoprotein gC. Deletion of the first one-third of gC severely impairs virus attachment, but the mutant virions are still capable...

journal_title：Journal of virology

authors： Flynn SJ,Ryan P

更新日期：1995-02-01 00:00:00

abstract：:The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were o...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Röpcke G,Boot L

更新日期：1978-09-01 00:00:00

abstract：:We report the complete genome sequence of Pseudomonas aeruginosa siphophage MP1412, which displays synteny to those of P. aeruginosa phages M6 and YuA. However, the presence of two homing endonucleases of the GIY-YIG family is unique to MP1412, suggesting their unique role in the phage life cycle of the bacterial host...

journal_title：Journal of virology

authors： Bae HW,Chung IY,Sim N,Cho YH

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:Ebola virus (EBOV) belongs to the group of nonsegmented negative-sense RNA viruses. The seven EBOV genes are separated by variable gene borders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide) IR, and gene overlaps, where the neighboring gene end and start signal...

journal_title：Journal of virology

authors： Brauburger K,Boehmann Y,Tsuda Y,Hoenen T,Olejnik J,Schümann M,Ebihara H,Mühlberger E

更新日期：2014-11-01 00:00:00

abstract：:The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to be active in at least patients infected with HCV of subtypes 1a and 1...

journal_title：Journal of virology

authors： Nyanguile O,Devogelaere B,Vijgen L,Van den Broeck W,Pauwels F,Cummings MD,De Bondt HL,Vos AM,Berke JM,Lenz O,Vandercruyssen G,Vermeiren K,Mostmans W,Dehertogh P,Delouvroy F,Vendeville S,VanDyck K,Dockx K,Cleiren E,R

更新日期：2010-03-01 00:00:00

abstract：:Cell-to-cell movement of beet yellows closterovirus requires four structural proteins and a 6-kDa protein (p6) that is a conventional, nonstructural movement protein. Here we demonstrate that either virus infection or p6 overexpression results in association of p6 with the rough endoplasmic reticulum. The p6 protein p...

journal_title：Journal of virology

authors： Peremyslov VV,Pan YW,Dolja VV

更新日期：2004-04-01 00:00:00

abstract：:EBNA2 transcriptional activation and regulated EBNALP coactivation are critical for Epstein-Barr virus-infected primary B-lymphocyte growth transformation. EBNALP coactivation requires the EBNA2 acidic activation domain (E2AD); EBNALP can bind to E2AD. EBNALP has now been found to bind less well to EBNA2 amino acids 1...

journal_title：Journal of virology

authors： Peng CW,Zhao B,Kieff E

更新日期：2004-10-01 00:00:00

abstract：:The RNA polymerase in the nucleocapsid of Pseudomonas phaseolicola bacteriophage phi 6 transcribed large, medium, and small single-stranded RNA from the viral double-stranded RNA genome by a semiconservative (displacement) mechanism. Approximately 23%, 63%, and 65% of the nucleocapsid particles in the assay mixture sy...

journal_title：Journal of virology

authors： Van Etten JL,Burbank DE,Cuppels DA,Lane LC,Vidaver AK

更新日期：1980-02-01 00:00:00