Epstein-Barr virus episome stability is coupled to a delay in replication timing.

abstract：:Vertebrates mount a strong innate immune response against viruses, largely by activating the interferon system. Double-stranded RNA (dsRNA), a common intermediate formed during the life cycle of many viruses, is a potent trigger of this response. In contrast, no general inducible antiviral defense mechanism has been r...

journal_title：Journal of virology

authors： Robalino J,Browdy CL,Prior S,Metz A,Parnell P,Gross P,Warr G

更新日期：2004-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) DNA clones were propagated from 57 carriers with antibody to hepatitis B e antigen (HBeAg) and sequenced within nucleotides (nt) 1685 to 1926 including the core promoter (nt 1742 to 1849) and the pre-C region (nt 1814 to 1900). Mutations in the core promoter or those in the pre-C region, or bot...

journal_title：Journal of virology

authors： Okamoto H,Tsuda F,Akahane Y,Sugai Y,Yoshiba M,Moriyama K,Tanaka T,Miyakawa Y,Mayumi M

更新日期：1994-12-01 00:00:00

abstract：:Poliovirus-infected cells undergo an increase in cytoplasmic calcium concentrations from the 4th h postinfection. The protein responsible for this effect was identified by the expression of different poliovirus nonstructural proteins in HeLa cells by using a recombinant vaccinia virus system. Synthesis of protein 2BC ...

journal_title：Journal of virology

authors： Aldabe R,Irurzun A,Carrasco L

更新日期：1997-08-01 00:00:00

abstract：:The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...

journal_title：Journal of virology

authors： Ros C,Gerber M,Kempf C

更新日期：2006-12-01 00:00:00

abstract：:The genome of infectious hematopoietic necrosis virus (IHNV), a salmonid novirhabdovirus, has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo By reverse genetics, eight recombinant IHNVs (rIHNVs), termed NxGy according to the respective po...

journal_title：Journal of virology

authors： Rouxel RN,Tafalla C,Mérour E,Leal E,Biacchesi S,Brémont M

更新日期：2016-11-14 00:00:00

abstract：:Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA head Abs can be highly potent, but they have limited breadth since the HA head is variable. There is great interest...

journal_title：Journal of virology

authors： Christensen SR,Toulmin SA,Griesman T,Lamerato LE,Petrie JG,Martin ET,Monto AS,Hensley SE

更新日期：2019-04-03 00:00:00

abstract：:It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-plasmid clustered reg...

journal_title：Journal of virology

authors： Langereis MA,Rabouw HH,Holwerda M,Visser LJ,van Kuppeveld FJ

更新日期：2015-11-01 00:00:00

abstract：:The cellular tropism of the feline immunodeficiency virus (FIV) is affected by changes in variable region 3 (V3) of the surface (SU) envelope glycoprotein (Verschoor, E. J., et al., J. Virol. 69:4752-4757, 1995). By using high-dose DNA transfection, an FIV molecular clone with a non-CRFK-tropic V3 acquired the ability...

journal_title：Journal of virology

authors： Vahlenkamp TW,Verschoor EJ,Schuurman NN,van Vliet AL,Horzinek MC,Egberink HF,de Ronde A

更新日期：1997-09-01 00:00:00

abstract：:Hepatitis E virus (HEV) replication is not well understood, mainly because the virus does not infect cultured cells efficiently. However, Huh-7 cells transfected with full-length genomes produce open reading frame 2 protein, indicative of genome replication (6). To investigate the role of 3'-terminal sequences in RNA ...

journal_title：Journal of virology

authors： Graff J,Nguyen H,Kasorndorkbua C,Halbur PG,St Claire M,Purcell RH,Emerson SU

更新日期：2005-01-01 00:00:00

abstract：:Viral interference studies have demonstrated the existence of four distinct murine leukemia virus (MuLV) receptors on NIH 3T3 mouse cells. The four viral interference groups are ecotropic MuLV; mink cell focus inducing virus (MCF); amphotropic MuLV; and 10A1, a recombinant derivative of amphotropic MuLV that uses a un...

journal_title：Journal of virology

authors： Ott D,Friedrich R,Rein A

更新日期：1990-02-01 00:00:00

abstract：:Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver dis...

journal_title：Journal of virology

authors： Cote PJ,Shapiro M,Engle RE,Popper H,Purcell RH,Gerin JL

更新日期：1986-12-01 00:00:00

abstract：:When Epstein-Barr virus (EBV) negative cells (Raji) were treated with iododeoxyuridine, only the early antigen (EA) component was induced. There was no significant increase in EBV DNA and no virus particles were observed. Somatic-cell hybrids were prepared from the fusion of Raji and D98 cells (D98/Raji). When these c...

journal_title：Journal of virology

authors： Glaser R,Nonoyama M

更新日期：1974-07-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) infects a number of different cell types, including mammary gland and lymphoid cells, in vivo. To identify the cellular receptor for this virus, a mouse cDNA expression library was transfected into Cos-7 monkey kidney cells, and those transfected cells able to bind virus were selected ...

journal_title：Journal of virology

authors： Golovkina TV,Dzuris J,van den Hoogen B,Jaffe AB,Wright PC,Cofer SM,Ross SR

更新日期：1998-04-01 00:00:00

abstract：:The region of the human cytomegalovirus (CMV) genome between the UL127 open reading frame and the major immediate-early (MIE) enhancer is referred to as the unique region. DNase I protection analysis with human cell nuclear extracts demonstrated multiple protein binding sites in this region of the viral genome (P. Gha...

journal_title：Journal of virology

authors： Lundquist CA,Meier JL,Stinski MF

更新日期：1999-11-01 00:00:00

abstract：:Transcriptional activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) by viral protein p40x requires a 21-base-pair (bp) sequence which is repeated three times within the LTR. This sequence contains a core octanucleotide (TGACGTCT) which has been attributed to be a cyclic-AMP (cAMP)-...

journal_title：Journal of virology

authors： Jeang KT,Boros I,Brady J,Radonovich M,Khoury G

更新日期：1988-12-01 00:00:00

abstract：:Escherichia coli RNA polymerase has been shown to bind to a limited number of Hind and Hae III restriction enzyme fragments. On S13 replicative form DNA there are three major binding sites, and the locations correlate with promoter sites at the beginning of genes a and B and a site overlapping gene D and the beginning...

journal_title：Journal of virology

authors： Rassart E,Spencer JH

更新日期：1978-09-01 00:00:00

abstract：:During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partia...

journal_title：Journal of virology

authors： Junjhon J,Edwards TJ,Utaipat U,Bowman VD,Holdaway HA,Zhang W,Keelapang P,Puttikhunt C,Perera R,Chipman PR,Kasinrerk W,Malasit P,Kuhn RJ,Sittisombut N

更新日期：2010-08-01 00:00:00

abstract：:Human immunodeficiency virus clade C (HIV-C) accounts for >56% of all HIV infections worldwide. To investigate vaccine safety and efficacy in nonhuman primates, a pathogenic, R5-tropic, neutralization-sensitive simian-human immunodeficiency virus (SHIV) carrying HIV-C env would be desirable. We have constructed SHIV-2...

journal_title：Journal of virology

authors： Siddappa NB,Song R,Kramer VG,Chenine AL,Velu V,Ong H,Rasmussen RA,Grisson RD,Wood C,Zhang H,Kankasa C,Amara RR,Else JG,Novembre FJ,Montefiori DC,Ruprecht RM

更新日期：2009-02-01 00:00:00

abstract：:This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escheric...

journal_title：Journal of virology

authors： Whitbeck JC,Knapp AC,Enquist LW,Lawrence WC,Bello LJ

更新日期：1996-11-01 00:00:00

abstract：:Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment ...

journal_title：Journal of virology

authors： Sharpe AH,Fields BN

更新日期：1981-04-01 00:00:00

abstract：:An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ec...

journal_title：Journal of virology

authors： Zhang HG,Bilbao G,Zhou T,Contreras JL,Gómez-Navarro J,Feng M,Saito I,Mountz JD,Curiel DT

更新日期：1998-03-01 00:00:00

abstract：:Mutations at amino acids 143, 148, and 155 in HIV-1 integrase (IN) define primary resistance pathways in subjects failing raltegravir (RAL)-containing treatments. Although each pathway appears to be genetically distinct, shifts in the predominant resistant virus population have been reported under continued drug press...

journal_title：Journal of virology

authors： Fransen S,Gupta S,Frantzell A,Petropoulos CJ,Huang W

更新日期：2012-07-01 00:00:00

abstract：:Intercellular adhesion molecule 1 (ICAM-1) mediates binding and entry of major group human rhinoviruses (HRVs). Whereas the entry pathway of minor group HRVs has been studied in detail and is comparatively well understood, the pathway taken by major group HRVs is largely unknown. Use of immunofluorescence microscopy, ...

journal_title：Journal of virology

authors： Khan AG,Pickl-Herk A,Gajdzik L,Marlovits TC,Fuchs R,Blaas D

更新日期：2010-04-01 00:00:00

abstract：:Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were n...

journal_title：Journal of virology

authors： Howard LM,Neville KL,Haynes LM,Dal Canto MC,Miller SD

更新日期：2003-02-01 00:00:00

abstract：:Among prion infections, two scenarios of prion spread are generally observed: (i) early lymphoid tissue replication or (ii) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studi...

journal_title：Journal of virology

authors： Hoover CE,Davenport KA,Henderson DM,Denkers ND,Mathiason CK,Soto C,Zabel MD,Hoover EA

更新日期：2017-04-28 00:00:00

abstract：:In infected cells, hepatitis C virus (HCV) induces the formation of membrane alterations referred to as membranous webs, which are sites of RNA replication. In addition, HCV RNA replication also occurs in smaller membrane structures that are associated with the endoplasmic reticulum. However, cellular mechanisms invol...

journal_title：Journal of virology

authors： Goueslain L,Alsaleh K,Horellou P,Roingeard P,Descamps V,Duverlie G,Ciczora Y,Wychowski C,Dubuisson J,Rouillé Y

更新日期：2010-01-01 00:00:00

abstract：:The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55(Gag) polyprotein. This rearrangement is thought to facilitate the establishment of specific CA-CA interactions that are required for the formation ...

journal_title：Journal of virology

authors： Rue SM,Roos JW,Amzel LM,Clements JE,Barber SA

更新日期：2003-07-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus type 1 (HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate ...

journal_title：Journal of virology

authors： Sandefur S,Varthakavi V,Spearman P

更新日期：1998-04-01 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：:Simian virus 40 tumor (T) antigen, an established viral oncoprotein, causes alterations in cell growth control through interacting with, and altering the function of, cellular proteins. To examine the effects of T antigen on cell growth control, and to identify the cellular proteins with which it may functionally inte...

journal_title：Journal of virology

authors： Nacht M,Reed SI,Alwine JC

更新日期：1995-02-01 00:00:00