Poliovirus protein 2BC increases cytosolic free calcium concentrations.

abstract：:Our knowledge regarding immune-protective and immunopathogenic events in severe acute respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about the dynamics of the immune response at the primary site of disease. Here, an African green monkey (AGM) model was used to elucidate immune me...

journal_title：Journal of virology

authors： Clay C,Donart N,Fomukong N,Knight JB,Lei W,Price L,Hahn F,Van Westrienen J,Harrod KS

更新日期：2012-04-01 00:00:00

abstract：:Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cell...

journal_title：Journal of virology

authors： Lagaye S,Derrien M,Menu E,Coïto C,Tresoldi E,Mauclère P,Scarlatti G,Chaouat G,Barré-Sinoussi F,Bomsel M,European Network for the Study of In Utero Transmission of HIV-1.

更新日期：2001-05-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) produces multiple mRNAs through differential splicing and polyadenylation. Reverse transcriptase PCR was used to characterize transcripts from exons 1, 2, 3, and 4 (immediate-early 1 [IE1]). The expected IE72 and IE19 mRNAs were detected, as well as ...

journal_title：Journal of virology

authors： Awasthi S,Isler JA,Alwine JC

更新日期：2004-08-01 00:00:00

abstract：:Coronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of the spike glycoprotein (S) was replaced with the highly divergent ectodomain of the S protein of fel...

journal_title：Journal of virology

authors： Kuo L,Godeke GJ,Raamsman MJ,Masters PS,Rottier PJ

更新日期：2000-02-01 00:00:00

abstract：:By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [(3)H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have studied the fate of pulse-labeled viral RNA from cells at 45 h postinfection under these conditions. During a 5-min period of la...

journal_title：Journal of virology

authors： Chiu NH,Radonovich MF,Thoren MM,Salzman NP

更新日期：1978-11-01 00:00:00

abstract：:The bovine papillomavirus type 1 (BPV-1) E7 oncoprotein is required for the full transformation activity of the virus. Although BPV-1 E7 by itself is not sufficient to induce cellular transformation, it enhances the abilities of the other BPV-1 oncogenes to induce anchorage independence. We have been exploring the mec...

journal_title：Journal of virology

authors： DeMasi J,Chao MC,Kumar AS,Howley PM

更新日期：2007-09-01 00:00:00

abstract：:Simian virus 40 (SV40) infection of human diploid cells failed to cause an enhanced production of thymidine kinase during the first 10 days after infection. Thymidine kinase activities from extracts of SV40-transformed cultures (human or simian) were considerably higher than the activity levels in extracts from the no...

journal_title：Journal of virology

authors： Carp RI

更新日期：1967-10-01 00:00:00

abstract：:Coxsackievirus B3 (CB3) firmly attaches to HeLa cells, forming a specific complex between the virus and its receptor on the cell surface. We extracted this virus-receptor complex (VRC) with the detergents sodium deoxycholate and Triton X-100. The VRC was identified by its sedimentation coefficient (140S), which was le...

journal_title：Journal of virology

authors： Mapoles JE,Krah DL,Crowell RL

更新日期：1985-09-01 00:00:00

abstract：:To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs ...

journal_title：Journal of virology

authors： Faix PH,Feldman SA,Overbaugh J,Eiden MV

更新日期：2002-12-01 00:00:00

abstract：:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

journal_title：Journal of virology

authors： Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

更新日期：2005-07-01 00:00:00

abstract：:Ultrastructure was correlated with growth kinetics of bdellophage VL-1 infecting host-dependent ("parasitic") Bdellovibrio bacteriovorus 109J in its Escherichia coli B host (the three-membered system), as well as in the host-independent ("saprophytic") derivative of the Bdellovibrio. Electron microscope observations s...

journal_title：Journal of virology

authors： Kessel M,Varon M

更新日期：1973-12-01 00:00:00

abstract：:The biologically relevant form of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein is oligomeric, with the major points of contact between oligomeric partners located in the ectodomain of gp41. To identify and map conserved epitopes and regions in gp41 where structure is influenced by quater...

journal_title：Journal of virology

authors： Earl PL,Broder CC,Doms RW,Moss B

更新日期：1997-04-01 00:00:00

abstract：:Polyacrylamide gel electrophoresis and tryptic peptide fingerprint analysis of the proteins made in a cell-free system derived from L-cells and immunoprecipitated with simian virus 40 (SV40) anti-T serum demonstrated that both SV40 large-T and small-T antigens are synthesized in vitro in response to mRNA isolated from...

journal_title：Journal of virology

authors： Paucha E,Harvey R,Smith AE

更新日期：1978-10-01 00:00:00

abstract：:Two types of geminate structures were purified from African cassava mosaic geminivirus (ACMV)-infected Nicotiana benthamiana plants and analyzed by electron cryomicroscopy and image reconstruction. After cesium sulfate density gradient centrifugation, they were separated into lighter top (T) and heavier bottom (B) com...

journal_title：Journal of virology

authors： Böttcher B,Unseld S,Ceulemans H,Russell RB,Jeske H

更新日期：2004-07-01 00:00:00

abstract：:The V1V2 region of HIV-1 gp120 harbors a major vulnerable site targeted by a group of broadly neutralizing monoclonal antibodies (MAbs) such as PG9 through strand-strand recognition. However, this epitope region is structurally polymorphic as it can also form a helical conformation recognized by RV144 vaccine-induced ...

journal_title：Journal of virology

authors： Jiang X,Totrov M,Li W,Sampson JM,Williams C,Lu H,Wu X,Lu S,Wang S,Zolla-Pazner S,Kong XP

更新日期：2016-11-28 00:00:00

abstract：:Trigeminal ganglia (TG) from rabbits latently infected with either wild-type herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mutant 17DeltaPst were assessed for their viral chromatin profile and transcript abundance. The wild-type 17syn+ genomes were more enriched in th...

journal_title：Journal of virology

authors： Giordani NV,Neumann DM,Kwiatkowski DL,Bhattacharjee PS,McAnany PK,Hill JM,Bloom DC

更新日期：2008-06-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:Human CD4(+) T-helper 1 cell responses to Epstein-Barr virus (EBV) infection are likely to be important in the maintenance of virus-specific CD8(+) memory and/or as antiviral effectors in their own right. The present work has used overlapping peptides as stimulators of gamma interferon release (i) to identify CD4(+) e...

journal_title：Journal of virology

authors： Leen A,Meij P,Redchenko I,Middeldorp J,Bloemena E,Rickinson A,Blake N

更新日期：2001-09-01 00:00:00

abstract：:Using coimmunoprecipitation and glutathione S-transferase pulldown experiments, we found that polyomavirus large T antigen binds to p300 in vivo and in vitro. The N-terminal region of the viral protein, including the pRB binding motif, was dispensable for this interaction, which involved several regions within the C-t...

journal_title：Journal of virology

authors： Nemethova M,Wintersberger E

更新日期：1999-02-01 00:00:00

abstract：:A tetracycline-regulated gene expression system and a panel of novel monoclonal antibodies were used to examine the subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus (HCV) NS3-NS4A complex in inducible cell lines. The NS3 serine protease domain and the full-length NS3 protein ...

journal_title：Journal of virology

authors： Wölk B,Sansonno D,Kräusslich HG,Dammacco F,Rice CM,Blum HE,Moradpour D

更新日期：2000-03-01 00:00:00

abstract：UNLABELLED:The positive-sense RNA genome of Sweet potato feathery mottle virus (SPFMV) (genus Potyvirus, family Potyviridae) contains a large open reading frame (ORF) of 3,494 codons translatable as a polyprotein and two embedded shorter ORFs in the -1 frame: PISPO, of 230 codons, and PIPO, of 66 codons, located in the...

journal_title：Journal of virology

authors： Mingot A,Valli A,Rodamilans B,San León D,Baulcombe DC,García JA,López-Moya JJ

更新日期：2016-01-20 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) impacts multiple lineages of hematopoietic cells, including lymphocytes and macrophages, either by direct infection or indirectly by perturbations of cell networks, leading to generalized immune deficiency. We designed a study to discover, in primary human macrophages, senti...

journal_title：Journal of virology

authors： Coberley CR,Kohler JJ,Brown JN,Oshier JT,Baker HV,Popp MP,Sleasman JW,Goodenow MM

更新日期：2004-11-01 00:00:00

abstract：:Rotavirus plus-strand RNAs not only direct protein synthesis but also serve as templates for the synthesis of the segmented double-stranded RNA (dsRNA) genome. In this study, we identified short-interfering RNAs (siRNAs) for viral genes 5, 8, and 9 that suppressed the expression of NSP1, a nonessential protein; NSP2, ...

journal_title：Journal of virology

authors： Silvestri LS,Taraporewala ZF,Patton JT

更新日期：2004-07-01 00:00:00

abstract：:Envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is an important target for the development of an HIV vaccine. Extensive glycosylation of Env is an important feature that both protects the virus from antibody responses and serves as a target for some highly potent broadly neutralizing antibod...

journal_title：Journal of virology

authors： Wang S,Voronin Y,Zhao P,Ishihara M,Mehta N,Porterfield M,Chen Y,Bartley C,Hu G,Han D,Wells L,Tiemeyer M,Lu S

更新日期：2020-03-17 00:00:00

abstract：UNLABELLED:Virions vary in size by at least 4 orders of magnitude, yet the evolutionary forces responsible for this enormous diversity are unknown. We document a significant allometric relationship, with an exponent of approximately 1.5, between the genome length and virion volume of viruses and find that this relation...

journal_title：Journal of virology

authors： Cui J,Schlub TE,Holmes EC

更新日期：2014-06-01 00:00:00

abstract：:Klebsiella pneumoniae is a member of the family Enterobacteriaceae, opportunistic pathogens that are among the eight most prevalent infectious agents in hospitals. The emergence of multidrug-resistant strains of K. pneumoniae has became a public health problem globally. To develop an effective antimicrobial agent, we ...

journal_title：Journal of virology

authors： Cui Z,Shen W,Wang Z,Zhang H,Me R,Wang Y,Zeng L,Zhu Y,Qin J,He P,Guo X

更新日期：2012-12-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88...

journal_title：Journal of virology

authors： Seltzer J,Moorad R,Schifano JM,Landis JT,Dittmer DP

更新日期：2020-05-04 00:00:00

abstract：:Heterozygous replicative form molecules of bacteriophage phiX174 deoxyribonucleic acid (DNA) have been constructed in vitro. These are composed of viral strands extracted from purified preparations of phage bearing ts mutations and complementary strands of either half length or full length synthesized with purified DN...

journal_title：Journal of virology

authors： Merriam V,Dumas LB,Sinsheimer RL

更新日期：1971-05-01 00:00:00

abstract：:Selecting human immunodeficiency virus (HIV) sequences for inclusion within vaccines has been a difficult problem, as circulating HIV strains evolve relentlessly and become increasingly divergent over time. We report an assessment of this divergence from three perspectives: (i) across different hosts as a function of ...

journal_title：Journal of virology

authors： Herbeck JT,Nickle DC,Learn GH,Gottlieb GS,Curlin ME,Heath L,Mullins JI

更新日期：2006-02-01 00:00:00

abstract：:To determine the various roles of RNase H in reverse transcription, we generated a panel of mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase based on sequence alignments and the crystal structures of Escherichia coli and human immunodeficiency virus type 1 RNases H (S. W. Blain an...

journal_title：Journal of virology

authors： Blain SW,Goff SP

更新日期：1995-07-01 00:00:00