Bovine papillomavirus E7 oncoprotein inhibits anoikis.

abstract：:Chronic infections with viruses such as hepatitis B virus, hepatitis C virus, and HIV constitute a major global public health problem. Studies of chronic viral infections in humans and mice show that persistent antigenic stimulation induces dysregulation of T cell responses; virus-specific T cells either undergo clona...

journal_title：Journal of virology

authors： Sullivan JA,Kim EH,Plisch EH,Suresh M

更新日期：2012-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) reorganizes intracellular membranes to establish sites of replication. How viral and cellular proteins target, bind, and rearrange specific membranes into the replication factory remains a mystery. We used a lentivirus-based RNA interference (RNAi) screening approach to identify the potential c...

journal_title：Journal of virology

authors： Chao TC,Su WC,Huang JY,Chen YC,Jeng KS,Wang HD,Lai MM

更新日期：2012-02-01 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) multifunctional regulatory protein ICP27 shuttles between the nucleus and cytoplasm in its role as a viral mRNA export factor. Arginine methylation on glycine- and arginine-rich motifs has been shown to regulate protein export. ICP27 contains an RGG box and has been shown to be methy...

journal_title：Journal of virology

authors： Souki SK,Gershon PD,Sandri-Goldin RM

更新日期：2009-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) does not replicate in murine cells. We investigated the basis of this block by infecting a murine NIH 3T3 reporter cell line that stably expressed human CD4, CCR5, and cyclin T1 and contained a transactivatable HIV-1 long terminal repeat (LTR)-green fluorescent protein (GFP)...

journal_title：Journal of virology

authors： Mariani R,Rutter G,Harris ME,Hope TJ,Kräusslich HG,Landau NR

更新日期：2000-04-01 00:00:00

abstract：:The human genome encodes over 500 microRNAs (miRNAs), small RNAs (19 to 26 nucleotides [nt]) that regulate the expressions of diverse cellular genes. Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection. We asked whether HCMV infection leads to changes in the ex...

journal_title：Journal of virology

authors： Wang FZ,Weber F,Croce C,Liu CG,Liao X,Pellett PE

更新日期：2008-09-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR. Introducing two CPV-specific changes into FPV (at VP2 residues 93 and 323) endowed that virus with the canine TfR binding property and allowed ca...

journal_title：Journal of virology

authors： Hueffer K,Govindasamy L,Agbandje-McKenna M,Parrish CR

更新日期：2003-09-01 00:00:00

abstract：:In order to clarify the effect of an accumulation of amino acid substitutions on the hemadsorption character of the influenza AH3 virus hemagglutinin (HA) protein, we introduced single-point amino acid changes into the HA1 domain of the HA proteins of influenza viruses isolated in 1968 (A/Aichi/2/68) and 1997 (A/Sydne...

journal_title：Journal of virology

authors： Nakajima K,Nobusawa E,Nagy A,Nakajima S

更新日期：2005-05-01 00:00:00

abstract：:The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection pr...

journal_title：Journal of virology

authors： Gonzalez SL,Stremlau M,He X,Basile JR,Münger K

更新日期：2001-08-01 00:00:00

abstract：:The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1 (HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell line H9 selected on the basis of its high level of cell surface CD4 expression. Semiquantitative PCR analysis revealed that enzymatic removal ...

journal_title：Journal of virology

authors： Roderiquez G,Oravecz T,Yanagishita M,Bou-Habib DC,Mostowski H,Norcross MA

更新日期：1995-04-01 00:00:00

abstract：:TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wild-type virus and NNRTI-resistant virus were performed to identify mut...

journal_title：Journal of virology

authors： Vingerhoets J,Azijn H,Fransen E,De Baere I,Smeulders L,Jochmans D,Andries K,Pauwels R,de Béthune MP

更新日期：2005-10-01 00:00:00

abstract：:Papillomaviruses (PVs) are a large family of small DNA viruses infecting mammals, reptiles, and birds. PV infection induces cell proliferation that may lead to the formation of orogenital or skin tumors. PV-induced cell proliferation has been related mainly to the expression of two small oncoproteins, E6 and E7. In ma...

journal_title：Journal of virology

authors： Van Doorslaer K,Sidi AO,Zanier K,Rybin V,Deryckère F,Rector A,Burk RD,Lienau EK,van Ranst M,Travé G

更新日期：2009-09-01 00:00:00

abstract：:The VP7 and VP4 genes of seven antigenic mutants of simian rotavirus SA11 4fM (serotype 3) selected after 39 passages in the presence of SA11 4fM hyperimmune antiserum, were sequenced. Nucleotide sequence analysis indicated the following. (i) Twice as many amino acid substitutions occurred in the VP7 protein than in V...

journal_title：Journal of virology

authors： Gorziglia M,Larralde G,Ward RL

更新日期：1990-09-01 00:00:00

abstract：:The architecture of a retroviral genome presents some unusual features for transcriptional regulation because of duplication of the transcriptional control sequences in the 5' and 3' long terminal repeats (LTRs). We have studied the transcriptional activity of the 5' and 3' LTRs of human immunodeficiency virus type 1 ...

journal_title：Journal of virology

authors： Klaver B,Berkhout B

更新日期：1994-06-01 00:00:00

abstract：:Dengue virus (DV) infection can cause either a self-limiting flu-like disease or a threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, and B cells, can be infected by DV. However, despite the role of T lymphocytes in the control of DV replication, the...

journal_title：Journal of virology

authors： Silveira GF,Wowk PF,Cataneo AHD,Dos Santos PF,Delgobo M,Stimamiglio MA,Lo Sarzi M,Thomazelli APFS,Conchon-Costa I,Pavanelli WR,Antonelli LRV,Báfica A,Mansur DS,Dos Santos CND,Bordignon J

更新日期：2018-04-27 00:00:00

abstract：:The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...

journal_title：Journal of virology

authors： Gretch DR,Kari B,Gehrz RC,Stinski MF

更新日期：1988-06-01 00:00:00

abstract：:Replication of poliovirus (PV) is restricted to a few sites, including the brain and spinal cord. However, this neurotropism is not conserved in cultured cells. Monkey kidney cells become susceptible to PV infection after cultivation in vitro, and cell lines of monolayer cultures from almost any tissue of primates are...

journal_title：Journal of virology

authors： Yoshikawa T,Iwasaki T,Ida-Hosonuma M,Yoneyama M,Fujita T,Horie H,Miyazawa M,Abe S,Simizu B,Koike S

更新日期：2006-05-01 00:00:00

abstract：:The adenovirus major late promoter (MLP) is active during both the early and late phases of infection. During the early phase the activity of the MLP is similar to those of the other early viral promoters, but during the late phase the rate of transcription from the MLP becomes much greater by comparison. We report he...

journal_title：Journal of virology

authors： Leong K,Lee W,Berk AJ

更新日期：1990-01-01 00:00:00

abstract：:The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on ...

journal_title：Journal of virology

authors： Joseph U,Linster M,Suzuki Y,Krauss S,Halpin RA,Vijaykrishna D,Fabrizio TP,Bestebroer TM,Maurer-Stroh S,Webby RJ,Wentworth DE,Fouchier RA,Bahl J,Smith GJ,CEIRS H2N2 Working Group.

更新日期：2015-02-01 00:00:00

abstract：:The synthesis of Sendai virus RNA species was examined after UV irradiation of cells late in infection. Compared with the inactivation of 50S genomic RNA synthesis, the synthesis of the group of mRNA species that sediments at 18S was inactivated at an average rate consistent with a process of sequential transcription ...

journal_title：Journal of virology

authors： Glazier K,Raghow R,Kingsbury DW

更新日期：1977-03-01 00:00:00

abstract：:The infection of human fetal thymus organ cultures (FTOC) with coxsackievirus B4 E2 (CVB4 E2) was investigated. Both positive- and negative-strand viral RNA were detected by real-time quantitative reverse transcription-PCR (RT-PCR) in CVB4 E2-infected FTOC, which supported high yields of virus production (approximatel...

journal_title：Journal of virology

authors： Brilot F,Geenen V,Hober D,Stoddart CA

更新日期：2004-09-01 00:00:00

abstract：:All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report ...

journal_title：Journal of virology

authors： Prassolov A,Hohenberg H,Kalinina T,Schneider C,Cova L,Krone O,Frölich K,Will H,Sirma H

更新日期：2003-02-01 00:00:00

abstract：:The V20 cultivar of Nicotiana tabacum was shown previously to exhibit a strain-specific restriction of long-distance movement of tobacco etch potyvirus (TEV). In V20, both TEV-HAT and TEV-Oxnard strains are capable of genome amplification and cell-to-cell movement, but only TEV-Oxnard is capable of systemic infection ...

journal_title：Journal of virology

authors： Schaad MC,Lellis AD,Carrington JC

更新日期：1997-11-01 00:00:00

abstract：:The roles of the capsid protein (CP) and the CP coding sequence of tobacco etch potyvirus (TEV) in genome amplification were analyzed. A series of frameshift-stop codon mutations that interrupted translation of the CP coding sequence at various positions were introduced into the TEV genome. A series of 3' deletion mut...

journal_title：Journal of virology

authors： Mahajan S,Dolja VV,Carrington JC

更新日期：1996-07-01 00:00:00

abstract：:Nonpermissive 3T3 cells were infected with purified superhelical simian virus 40 (SV40) deoxyribonucleic acid I (DNA I). One hour after infection, approximately 60% of the intracellular SV40 DNA was converted to relaxed forms. One day after infection, all intracellular SV40 DNA was present as slow-sedimenting material...

journal_title：Journal of virology

authors： Collins CJ,Sauer G

更新日期：1972-09-01 00:00:00

abstract：:The DA strain of Theiler's virus, a murine picornavirus, causes a persistent infection of glial cells of the white matter of the spinal cord, associated with chronic inflammation and primary demyelination. The GDVII strain causes an acute fatal grey matter encephalomyelitis. We characterized the target cells of GDVII ...

journal_title：Journal of virology

authors： Aubert C,Brahic M

更新日期：1995-05-01 00:00:00

abstract：:The primary pathophysiologic finding of the viral disease known as Korean hemorrhagic fever, the etiological agent of which is Hantaan virus (HTV), is vascular instability. To investigate whether HTV was able to infect cells derived from human vascular tissue and alter their behavior, we infected in vitro primary adul...

journal_title：Journal of virology

authors： Pensiero MN,Sharefkin JB,Dieffenbach CW,Hay J

更新日期：1992-10-01 00:00:00

abstract：:Reovirus serotype 1 Lang can be recovered in high titer from the intestines of neonatal mice up to day 8 after peroral inoculation. By contrast, reovirus serotype 3 Dearing cannot be recovered from intestinal tissue past day 4 after peroral inoculation. This difference between the two reoviruses was mapped by using re...

journal_title：Journal of virology

authors： Bodkin DK,Fields BN

更新日期：1989-03-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00

abstract：:Mutant recombinant respiratory syncytial viruses (RSV) which cannot express the NS1 and M2-2 proteins, designated rA2DeltaNS1 and rA2DeltaM2-2, respectively, were evaluated as live-attenuated RSV vaccines. The rA2DeltaNS1 virus contains a large deletion that should have the advantageous property of genetic stability d...

journal_title：Journal of virology

authors： Teng MN,Whitehead SS,Bermingham A,St Claire M,Elkins WR,Murphy BR,Collins PL

更新日期：2000-10-01 00:00:00

abstract：:In adenovirus-infected cells, the epidermal growth factor receptor (EGF-R) is internalized from the cell surface via endosomes and is degraded, and the E3 10,400-dalton protein (10.4K protein) is required for this effect (C. R. Carlin, A. E. Tollefson, H. A. Brady, B. L. Hoffman, and W. S. M. Wold, Cell 57:135-144, 19...

journal_title：Journal of virology

authors： Tollefson AE,Stewart AR,Yei SP,Saha SK,Wold WS

更新日期：1991-06-01 00:00:00