Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.

abstract：:Integrin-using rotaviruses bind MA104 cell surface alpha2beta1 integrin via the Asp-Gly-Glu (DGE) sequence in virus spike protein VP4 and interact with alphaxbeta2 integrin during cell entry through outer capsid protein VP7. Infection is inhibited by the alpha2beta1 ligand Asp-Gly-Glu-Ala (DGEA) and the alphaxbeta2 li...

journal_title：Journal of virology

authors： Graham KL,Zeng W,Takada Y,Jackson DC,Coulson BS

更新日期：2004-11-01 00:00:00

abstract：:cis-Acting elements in the viral genome RNA (vRNA) are essential for the translation, replication, and/or encapsidation of RNA viruses. In this study, a novel conserved cis-acting element was identified in the capsid-coding region of mosquito-borne flavivirus. The downstream of 5' cyclization sequence (5'CS) pseudokno...

journal_title：Journal of virology

authors： Liu ZY,Li XF,Jiang T,Deng YQ,Zhao H,Wang HJ,Ye Q,Zhu SY,Qiu Y,Zhou X,Qin ED,Qin CF

更新日期：2013-06-01 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：:The influenza A virus NS1 protein contains a conserved 4-amino-acid-residue PDZ-ligand binding motif (PBM) at the carboxyl terminus that can function as a virulence determinant by targeting cellular PDZ proteins. The NS1 proteins from avian and human viral isolates have consensus PBM sequences ESEV and RSKV, respectiv...

journal_title：Journal of virology

authors： Golebiewski L,Liu H,Javier RT,Rice AP

更新日期：2011-10-01 00:00:00

abstract：:Nonconservative substitutions for Tyr-115 in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) lead to enzymes displaying lower affinity for deoxynucleoside triphosphates (dNTPs) (A. M. Martín-Hernández, E. Domingo, and L. Menéndez-Arias, EMBO J. 15:4434-4442, 1996). Several mutations at th...

journal_title：Journal of virology

authors： Olivares I,Sánchez-Merino V,Martínez MA,Domingo E,López-Galíndez C,Menéndez-Arias L

更新日期：1999-08-01 00:00:00

abstract：:Growth kinetics in lymphocytic H9 and M8166 cells of two mutants of human immunodeficiency virus type 1 (HIV-1) with deleted gp41 cytoplasmic tails were examined. While the mutant viruses designated CTdel-44 and CTdel-144 were able to grow in M8166 cells, they were unable to grow in H9 cells. Transfection and single-r...

journal_title：Journal of virology

authors： Akari H,Fukumori T,Adachi A

更新日期：2000-05-01 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00

abstract：:Transcriptionally active replication complexes bound to smooth membrane vesicles were isolated from poliovirus-infected cells. In electron microscopic, negatively stained preparations, the replication complex appeared as an irregularly shaped, oblong structure attached to several virus-induced vesicles of a rosettelik...

journal_title：Journal of virology

authors： Bienz K,Egger D,Troxler M,Pasamontes L

更新日期：1990-03-01 00:00:00

abstract：:Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...

journal_title：Journal of virology

authors： Aandahl EM,Michaëlsson J,Moretto WJ,Hecht FM,Nixon DF

更新日期：2004-03-01 00:00:00

abstract：:An unusual set of 3' coterminal, spliced mRNAs transcribed through the BamHI A fragment have been previously identified in nasopharyngeal carcinoma (NPC) tissues. These RNAs have also been detected at low levels in Burkitt's lymphoma (BL) cell lines and Epstein-Barr virus (EBV)-transformed lymphocytes. Sequence analys...

journal_title：Journal of virology

authors： Fries KL,Sculley TB,Webster-Cyriaque J,Rajadurai P,Sadler RH,Raab-Traub N

更新日期：1997-04-01 00:00:00

abstract：:Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgen...

journal_title：Journal of virology

authors： Caldwell RG,Brown RC,Longnecker R

更新日期：2000-02-01 00:00:00

abstract：:The herpes simplex virus type 1 UL28 gene contains a 785-amino-acid open reading frame that codes for an essential protein. Studies with temperature-sensitive mutants which map to the UL28 gene indicate that the UL28 gene product (ICP18.5) is required for packaging of viral DNA and for expression of viral glycoprotein...

journal_title：Journal of virology

authors： Tengelsen LA,Pederson NE,Shaver PR,Wathen MW,Homa FL

更新日期：1993-06-01 00:00:00

abstract：:Infection of Escherichia coli with the satellite virus P4 without its helper bacteriophage P2 leads either to the immune integrated state or to the nonimmune multicopy plasmid condition. We analyzed the transcription pattern of the phage plasmid P4 early and late after infection and during the stable plasmid or lysoge...

journal_title：Journal of virology

authors： Dehó G,Zangrossi S,Ghisotti D,Sironi G

更新日期：1988-05-01 00:00:00

abstract：:The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have been determined. These nonlytic temperate viruses were isolated from hyperthermophilic Sulfolobus hosts, and both viruses share the spindle-shap...

journal_title：Journal of virology

authors： Wiedenheft B,Stedman K,Roberto F,Willits D,Gleske AK,Zoeller L,Snyder J,Douglas T,Young M

更新日期：2004-02-01 00:00:00

abstract：:Because immunologic classification of human immunodeficiency virus type 1 (HIV) might be more relevant than genotypic classification for designing polyvalent vaccines, studies were undertaken to determine whether immunologically defined groups of HIV ("immunotypes") could be identified. For these experiments, the V3 r...

journal_title：Journal of virology

authors： Zolla-Pazner S,Gorny MK,Nyambi PN,VanCott TC,Nádas A

更新日期：1999-05-01 00:00:00

abstract：:The relationship between virus-specific CD8(+)-T-cell responses and viral persistence was studied in mice by using Hantaan virus (HTNV). We first established a simple method for measuring levels of virus-specific CD8(+) T cells by flow cytometry. Next, to produce a mouse model of persistent HTNV infection, newborn mic...

journal_title：Journal of virology

authors： Araki K,Yoshimatsu K,Lee BH,Kariwa H,Takashima I,Arikawa J

更新日期：2003-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) entry into target cells requires folding of two heptad-repeat regions (N-HR and C-HR) of gp41 into a trimer of N-HR and C-HR hairpins, which brings viral and target cell membranes together to facilitate membrane fusion. Peptides corresponding to the N-HR and C-HR of gp41 are...

journal_title：Journal of virology

authors： He Y,Vassell R,Zaitseva M,Nguyen N,Yang Z,Weng Y,Weiss CD

更新日期：2003-02-01 00:00:00

abstract：:The utility of the present generation of adenovirus (Ad) vectors for gene therapy applications could be improved by restricting native viral tropism to selected cell types. In order to achieve modification of Ad tropism, we proposed to exploit a minor component of viral capsid, protein IX (pIX), for genetic incorporat...

journal_title：Journal of virology

authors： Dmitriev IP,Kashentseva EA,Curiel DT

更新日期：2002-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) gp41 plays a critical role in the viral fusion process, and its N- and C-terminal heptad repeat domains serve as important targets for developing anti-HIV-1 drugs, like T-20 (generic name, enfuvirtide; brand name, Fuzeon). Here, we conducted a yeast two-hybrid screening on a...

journal_title：Journal of virology

authors： Zhu Y,Lu L,Xu L,Yang H,Jiang S,Chen YH

更新日期：2010-09-01 00:00:00

abstract：:The DA strain of Theiler's virus, a murine picornavirus, causes a persistent infection of glial cells of the white matter of the spinal cord, associated with chronic inflammation and primary demyelination. The GDVII strain causes an acute fatal grey matter encephalomyelitis. We characterized the target cells of GDVII ...

journal_title：Journal of virology

authors： Aubert C,Brahic M

更新日期：1995-05-01 00:00:00

abstract：:Modification of proteins by ubiquitin is essential for numerous cellular processes. The RING-H2 finger motif has been implicated in ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Four proteins, WSSV199, WSSV222, WSSV249, and WSSV403, from white spot syndrome virus (WSSV) contain the RING-H2 motif. Here we...

journal_title：Journal of virology

authors： Wang Z,Chua HK,Gusti AA,He F,Fenner B,Manopo I,Wang H,Kwang J

更新日期：2005-07-01 00:00:00

abstract：:The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins. We report that RS...

journal_title：Journal of virology

authors： Wiegand HL,Cullen BR

更新日期：2007-12-01 00:00:00

abstract：:A ribonucleic acid (RNA)-dependent RNA polymerase was induced in chick embryo fibroblast cells after infection with Sendai virus (parainfluenza 1 virus). The enzyme was associated with the microsomal fraction of infected cells and reached maximum detectable activity at 18 hr after virus infection. The activity of the ...

journal_title：Journal of virology

authors： Mahy BW,Hutchinson JE,Barry RD

更新日期：1970-06-01 00:00:00

abstract：:Recombinant human metapneumovirus (HMPV) in which the SH, G, or M2 gene or open reading frame was deleted by reverse genetics was evaluated for replication and vaccine efficacy following topical administration to the respiratory tract of African green monkeys, a permissive primate host. Replication of the deltaSH viru...

journal_title：Journal of virology

authors： Biacchesi S,Pham QN,Skiadopoulos MH,Murphy BR,Collins PL,Buchholz UJ

更新日期：2005-10-01 00:00:00

abstract：:Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...

journal_title：Journal of virology

authors： Tang XL,Tregear GW,White DO,Jackson DC

更新日期：1988-12-01 00:00:00

abstract：:The assembly of human cytomegalovirus (HCMV) is thought to be similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented subviral particles at the nuclear membrane followed by export from the cell by a poorly defined pathway. However, several studies have shown that at least t...

journal_title：Journal of virology

authors： Sanchez V,Greis KD,Sztul E,Britt WJ

更新日期：2000-01-01 00:00:00

abstract：:To generate a null U(L)49 gene mutant of herpes simplex virus 1 (HSV-1), we deleted from the viral DNA, encoded as a bacterial artificial chromosome (BAC), the U(L)49 open reading frame and, in a second step, restored it. Upon transfection into Vero cells, the BAC-DeltaU(L)49 DNA yielded foci of degenerated cells that...

journal_title：Journal of virology

authors： Sciortino MT,Taddeo B,Giuffrè-Cuculletto M,Medici MA,Mastino A,Roizman B

更新日期：2007-10-01 00:00:00

abstract：:Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repre...

journal_title：Journal of virology

authors： Ward RL

更新日期：1978-05-01 00:00:00

abstract：:The simian virus 40 large T antigen is a promiscuous transcriptional activator of many viral and cellular promoters. We show that the promoter structure necessary for T antigen-mediated transcriptional activation is very simple. A TATA or initiator element is required, in addition to an upstream factor-binding site, w...

journal_title：Journal of virology

authors： Gilinger G,Alwine JC

更新日期：1993-11-01 00:00:00

abstract：:Walleye dermal sarcoma (WDS) and walleye epidermal hyperplasia (WEH) are skin diseases of walleye fish that appear and regress on a seasonal basis. We report here that the complex retroviruses etiologically associated with WDS (WDS virus [WDSV]) and WEH (WEH viruses 1 and 2 [WEHV1 and WEHV2, respectively]) encode D-ty...

journal_title：Journal of virology

authors： LaPierre LA,Casey JW,Holzschu DL

更新日期：1998-11-01 00:00:00