Induction of antiviral immunity by double-stranded RNA in a marine invertebrate.

abstract：:Translation of early RNA specific for the leftmost early region 1 of adenovirus type 5 DNA in a rabbit reticulocyte cell-free system resulted in the synthesis of proteins with the following molecular weights: 65,000 (65K), 54K, 42 to 34K, 29K, 25K, 19K, and 18K. All of these proteins could be immunoprecipitated with h...

journal_title：Journal of virology

authors： Lupker JH,Davis A,Jochemsen H,van der Eb AJ

更新日期：1981-01-01 00:00:00

abstract：:Smallpox was eradicated more than 10 years ago, but infection with another Orthopoxvirus, monkeypox virus, can result in a clinical picture resembling smallpox. Human infection with monkeypox virus is extremely rare, not easily transmitted, and confined to the rain forest belt of Africa (Z. Jezek and F. Fenner, p. 81-...

journal_title：Journal of virology

authors： Douglass N,Dumbell K

更新日期：1992-12-01 00:00:00

abstract：:The mitogen-activated protein (MAP) kinase signal transduction pathway is an intracellular signaling cascade which mediates cellular responses to growth and differentiation factors. The MAP kinase pathway can be activated by a wide range of stimuli dependent on the cell types, and this is normally a transient response...

journal_title：Journal of virology

authors： Gu Z,Matlashewski G

更新日期：1995-12-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years. Since then, significant efforts have been made to better understand the biology of this virus, but we still have poor knowledge of CHIKV interactions with host c...

journal_title：Journal of virology

authors： Bouraï M,Lucas-Hourani M,Gad HH,Drosten C,Jacob Y,Tafforeau L,Cassonnet P,Jones LM,Judith D,Couderc T,Lecuit M,André P,Kümmerer BM,Lotteau V,Desprès P,Tangy F,Vidalain PO

更新日期：2012-03-01 00:00:00

abstract：:Lymphomas induced by pure HIX murine leukemia virus in two mouse strains contained large amounts of virus with amphotropic properties. Analysis of tumor derived virus purified by limiting dilution techniques indicated that its interference and neutralization spectra were essentially identical to parental HIX virus and...

journal_title：Journal of virology

authors： Fischinger PJ,Dunlop NM,Blevins CS

更新日期：1978-05-01 00:00:00

abstract：:n-(n-Nonyl)-deoxygalactonojirimycin (n,n-DGJ), an alkylated imino sugar, reduces the amount of HBV DNA produced within the stably transfected HBV-producing HepG2.2.15 line in culture and is under consideration for development as a human therapeutic. n,n-DGJ does not appear to inhibit HBV DNA polymerase activity or env...

journal_title：Journal of virology

authors： Lu X,Tran T,Simsek E,Block TM

更新日期：2003-11-01 00:00:00

abstract：UNLABELLED:Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen speci...

journal_title：Journal of virology

authors： Unger BL,Ganesan S,Comstock AT,Faris AN,Hershenson MB,Sajjan US

更新日期：2014-04-01 00:00:00

abstract：:Duck embryo fibroblast (DEF) and chicken embryo fibroblast (CEF) cultures infected with Marek's disease virus were studied by combined fluorescent antibody and electron microscopy techniques. In both DEF and CEF cultures, cells containing immunofluorescent (IF) antigen also contained herpesvirus particles; conversely,...

journal_title：Journal of virology

authors： Nazerian K,Purchase HG

更新日期：1970-01-01 00:00:00

abstract：UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

journal_title：Journal of virology

authors： Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

更新日期：2015-01-15 00:00:00

abstract：:The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...

journal_title：Journal of virology

authors： Poon AP,Roizman B

更新日期：2005-07-01 00:00:00

abstract：:Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to esta...

journal_title：Journal of virology

authors： Nishizawa T,Okamoto H,Tsuda F,Aikawa T,Sugai Y,Konishi K,Akahane Y,Ukita M,Tanaka T,Miyakawa Y,Mayumi M

更新日期：1999-11-01 00:00:00

abstract：:Spleen necrosis virus productively infects avian and rat cells. The average number of molecules of unintegrated and integrated viral DNA in cells at different times after infection was determined by hybridization and transfection assays. Shortly after infection, there was a transient accumulation of an average of abou...

journal_title：Journal of virology

authors： Keshet E,Temin HM

更新日期：1979-08-01 00:00:00

abstract：:A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...

journal_title：Journal of virology

authors： Takeuchi K,Nagata N,Kato SI,Ami Y,Suzaki Y,Suzuki T,Sato Y,Tsunetsugu-Yokota Y,Mori K,Van Nguyen N,Kimura H,Nagata K

更新日期：2012-03-01 00:00:00

abstract：:A method to study the function of individual African swine fever virus (ASFV) gene products utilizing the Escherichia coli lac repressor-operator system has been developed. Recombinant viruses containing both the lacI gene encoding the lac repressor and a strong virus late promoter modified by the insertion of one or ...

journal_title：Journal of virology

authors： García-Escudero R,Andrés G,Almazán F,Viñuela E

更新日期：1998-04-01 00:00:00

abstract：UNLABELLED:Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently...

journal_title：Journal of virology

authors： Ilinykh PA,Shen X,Flyak AI,Kuzmina N,Ksiazek TG,Crowe JE Jr,Bukreyev A

更新日期：2016-03-28 00:00:00

abstract：UNLABELLED:Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular proteins to execute their functions. Identification and understanding of these factors would increase our knowledge of the molecular mechanisms manipulated by the viruses. In this s...

journal_title：Journal of virology

authors： Gao S,Wu J,Liu RY,Li J,Song L,Teng Y,Sheng C,Liu D,Yao C,Chen H,Jiang W,Chen S,Huang W

更新日期：2015-01-01 00:00:00

abstract：:Infection of human dermal microvascular endothelial (HMVEC-d) cells and human foreskin fibroblast (HFF) cells in vitro by Kaposi's sarcoma-associated herpesvirus (KSHV) provides an excellent in vitro model system to study viral latency. KSHV infection is characterized by the induction of preexisting host signal cascad...

journal_title：Journal of virology

authors： Sharma-Walia N,Raghu H,Sadagopan S,Sivakumar R,Veettil MV,Naranatt PP,Smith MM,Chandran B

更新日期：2006-07-01 00:00:00

abstract：:RNA viruses within a host exist as dynamic distributions of closely related mutants and recombinant genomes. These closely related mutants and recombinant genomes, which are subjected to a continuous process of genetic variation, competition, and selection, act as a unit of selection, termed viral quasispecies. Charac...

journal_title：Journal of virology

authors： Lozano G,Grande-Pérez A,Navas-Castillo J

更新日期：2009-12-01 00:00:00

abstract：:Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus ...

journal_title：Journal of virology

authors： Ren Y,Li C,Feng L,Pan W,Li L,Wang Q,Li J,Li N,Han L,Zheng X,Niu X,Sun C,Chen L

更新日期：2015-10-14 00:00:00

abstract：:Previous analysis of hepatitis B virus (HBV) indicated base pairing between two cis-acting sequences, the 5' half of the upper stem of epsilon and phi, contributes to the synthesis of minus-strand DNA. Our goal was to identify other cis-acting sequences on the pregenomic RNA (pgRNA) involved in the synthesis of minus-...

journal_title：Journal of virology

authors： Abraham TM,Loeb DD

更新日期：2007-11-01 00:00:00

abstract：:The gene encoding glycoprotein F (gF) of herpes simplex virus type 2 (HSV-2) was mapped to the region of the viral genome from 0.62 to 0.64 map units. This region is colinear with, and partially homologous to, the region of the HSV-1 genome previously shown to encode gC. Mapping of the gF gene was done by insertion of...

journal_title：Journal of virology

authors： Zezulak KM,Spear PG

更新日期：1984-03-01 00:00:00

abstract：:The oligosaccharide processing and secretion of hepatitis B surface antigen (HBsAg) was studied in Chinese hamster ovary cells stably transfected with the gene coding HBsAg. HBsAg was secreted from cells with a relatively long half time (ca. 5 h). This appeared to be a characteristic of HBsAg itself, since HBsAg-produ...

journal_title：Journal of virology

authors： Patzer EJ,Nakamura GR,Yaffe A

更新日期：1984-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) subtype C viruses have been found to almost exclusively use the chemokine receptor CCR5 as a coreceptor for entry, even in patients with advanced AIDS. We have characterized subtype C virus isolates from 28 patients from Harare, Zimbabwe, 20 of whom were receiving antiretrov...

journal_title：Journal of virology

authors： Johnston ER,Zijenah LS,Mutetwa S,Kantor R,Kittinunvorakoon C,Katzenstein DA

更新日期：2003-07-01 00:00:00

abstract：:The Moloney sarcoma virus-specific onc gene, referred to as v-mos, was used as probe to hybridize to restricted DNAs from various mouse-Chinese hamster hybrid cell lines. These hybrid cells contain, in addition to all of the Chinese hamster chromosomes, various numbers (less than a full complement) of mouse chromosome...

journal_title：Journal of virology

authors： Swan D,Oskarsson M,Keithley D,Ruddle FH,D'Eustachio P,Vande Woude GF

更新日期：1982-11-01 00:00:00

abstract：:Temperature-sensitive COS cells, clone E540, have been stably transformed at a restrictive temperature with plasmid pVA1, which contains the adenovirus type 5 virus-associated (VA) genes in addition to the Neor marker. Transformed cell clones, named EVA cells, contained adenovirus DNA in an integrated form while grown...

journal_title：Journal of virology

authors： Martínez C,de la Luna S,Peláez F,Lopez-Turiso A,Valcárcel J,de Haro C,Ortín J

更新日期：1989-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:The Ebola filoviruses are aggressive pathogens that cause severe and often lethal hemorrhagic fever syndromes in humans and nonhuman primates. To date, no effective therapies have been identified. To analyze the entry and fusion properties of Ebola virus, we adapted a human immunodeficiency virus type 1 (HIV-1) virion...

journal_title：Journal of virology

authors： Yonezawa A,Cavrois M,Greene WC

更新日期：2005-01-01 00:00:00

abstract：:A strategy involving polymerase chain reaction amplification of cDNAs was designed to study the expression of the hamster polyomavirus (HaPV) early region in HaPV-transformed rat fibroblasts, productively HaPV-infected cells, and HaPV-induced lymphoma. We identified three mRNAs resulting from alternative splicing of o...

journal_title：Journal of virology

authors： Goutebroze L,Feunteun J

更新日期：1992-04-01 00:00:00

abstract：:Superinfection exclusion is the ability of an established viral infection to interfere with a second viral infection. Using West Nile virus (WNV) as a model, we show that replicating replicons in BHK-21 cells suppress subsequent WNV infection. The WNV replicon also suppresses superinfections of other flaviviruses but ...

journal_title：Journal of virology

authors： Zou G,Zhang B,Lim PY,Yuan Z,Bernard KA,Shi PY

更新日期：2009-11-01 00:00:00

abstract：:Like almost all of the positive-strand RNA viruses, hepatitis C virus (HCV) induces host intracellular membrane modification to form the membrane-bound viral replication complex (RC), within which viral replicases amplify the viral RNA genome. Despite accumulated information about how HCV co-opts host factors for vira...

journal_title：Journal of virology

authors： Yi Z,Fang C,Zou J,Xu J,Song W,Du X,Pan T,Lu H,Yuan Z

更新日期：2016-10-14 00:00:00