Identification of GBF1 as a cellular factor required for hepatitis C virus RNA replication.

abstract：:The process of Epstein-Barr virus (EBV)-induced transformation of human B lymphocytes results in a cell line that is a mixture of latently and lytically infected cells, with the lytic cells composing roughly 5% to less than 0.0001% of the overall population. A set of nine normal lymphoblastoid cell lines that span a 1...

journal_title：Journal of virology

authors： Metzenberg S

更新日期：1990-01-01 00:00:00

abstract：:The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. One variant contained a Lys174-Glu substitution and another contained ...

journal_title：Journal of virology

authors： Lai CJ,Goncalvez AP,Men R,Wernly C,Donau O,Engle RE,Purcell RH

更新日期：2007-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a member of the Parvoviridae, belonging to the Dependovirus genus. Currently, several distinct isolates of AAV are in development for use in human gene therapy applications due to their ability to transduce different target cells. The need to manipulate AAV capsids for specific tissue d...

journal_title：Journal of virology

authors： Padron E,Bowman V,Kaludov N,Govindasamy L,Levy H,Nick P,McKenna R,Muzyczka N,Chiorini JA,Baker TS,Agbandje-McKenna M

更新日期：2005-04-01 00:00:00

abstract：:The infection of a bacterium by a phage starts with attachment to a receptor molecule on the host cell surface by the phage. Since receptor-phage interactions are crucial to successful infections, they are major determinants of phage host range and, by extension, of the broader effects that phages have on bacterial co...

journal_title：Journal of virology

authors： de Jonge PA,Smit Sibinga DJC,Boright OA,Costa AR,Nobrega FL,Brouns SJJ,Dutilh BE

更新日期：2020-11-09 00:00:00

abstract：UNLABELLED:The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral strains. ...

journal_title：Journal of virology

authors： Asokan M,Rudicell RS,Louder M,McKee K,O'Dell S,Stewart-Jones G,Wang K,Xu L,Chen X,Choe M,Chuang G,Georgiev IS,Joyce MG,Kirys T,Ko S,Pegu A,Shi W,Todd JP,Yang Z,Bailer RT,Rao S,Kwong PD,Nabel GJ,Mascola JR

更新日期：2015-12-01 00:00:00

abstract：:Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fund...

journal_title：Journal of virology

authors： Woodward AM,Mauris J,Argüeso P

更新日期：2013-05-01 00:00:00

abstract：:The accumulation of an abnormal, protease-resistant form of the protein PrP (PrP-res) in hosts with scrapie and related transmissible spongiform encephalopathies appears to be important in disease pathogenesis. To gain insight into the mechanism of PrP-res accumulation and the in vivo antiscrapie activity of certain p...

journal_title：Journal of virology

authors： Caughey B,Raymond GJ

更新日期：1993-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) RNA genome replicates within the ribonucleoprotein (RNP) complex in the modified membranous structures extended from endoplasmic reticulum. A proteomic analysis of HCV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the components of these complexes. OSBP in...

journal_title：Journal of virology

authors： Amako Y,Sarkeshik A,Hotta H,Yates J 3rd,Siddiqui A

更新日期：2009-09-01 00:00:00

abstract：:In this study, we show that human cytomegalovirus DNA synthesis is inhibited in infected confluent human embryonic lung cells treated with the DNA-intercalative topoisomerase II inhibitor 4-9'-(acridinylamino)methanesulfon-m-anisidide (m-AMSA). Similar inhibitory effects were observed with VM-26, a nonintercalative to...

journal_title：Journal of virology

authors： Benson JD,Huang ES

更新日期：1988-12-01 00:00:00

abstract：:Experiments with St. Louis encephalitis (SLE) virus have shown that neutral red enhances the plaque size in duck embryo cell cultures. This may represent a new method for genetic studies of SLE virus population. In a mosquito pool specimen NR(+) and NR(-) particles were demonstrated. By intracerebral passage in mice, ...

journal_title：Journal of virology

authors： Marcovici M,Prier JE

更新日期：1968-03-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) encodes several unique group-specific open reading frames (ORFs) relative to other known coronaviruses. To determine the significance of the SARS-CoV group-specific ORFs in virus replication in vitro and in mice, we systematically deleted five of the eight group-specific ORFs, ORF3a, OF3b, ...

journal_title：Journal of virology

authors： Yount B,Roberts RS,Sims AC,Deming D,Frieman MB,Sparks J,Denison MR,Davis N,Baric RS

更新日期：2005-12-01 00:00:00

abstract：:In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that include the recently described type 3 SREKPYKEVTEDLLHLNSLF sequence. We examined the requirements for the type 3 sequence motif in simian immunodeficiency virus SIV(smE543) and identified the (499)LNSLF(503) sequence as a key functional...

journal_title：Journal of virology

authors： Bello NF,Wu F,Sette P,Dussupt V,Hirsch VM,Bouamr F

更新日期：2011-11-01 00:00:00

abstract：:T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici...

journal_title：Journal of virology

authors： Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

更新日期：1999-06-01 00:00:00

abstract：:We have examined the pathway of rhinovirus interaction with soluble intercellular adhesion molecule 1 (sICAM-1). Binding of sICAM-1 to rhinovirus serotypes 3 and 14 gives particles with sedimentation coefficients from 145 to 120S, depending on the amount of sICAM-1 bound. The formation of 120S particles is faster and ...

journal_title：Journal of virology

authors： Casasnovas JM,Springer TA

更新日期：1994-09-01 00:00:00

abstract：:Autophagy and the effects of its inhibition or induction were investigated during the entire infectious cycle of varicella-zoster virus (VZV), a human herpesvirus. As a baseline, we first enumerated the number of autophagosomes per cell after VZV infection compared with the number after induction of autophagy followin...

journal_title：Journal of virology

authors： Buckingham EM,Carpenter JE,Jackson W,Grose C

更新日期：2014-01-01 00:00:00

abstract：:The four temperature-sensitive (ts) loci identified in the PB1 and PB2 gene segments of cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for influenza A virus (MDV-A) FluMist vaccines, were introduced into a divergent A/Puerto Rico/8/34 influenza virus strain. Recombinant A/Puerto Rico/8/34 virus ...

journal_title：Journal of virology

authors： Jin H,Zhou H,Lu B,Kemble G

更新日期：2004-01-01 00:00:00

abstract：:We previously described a monoclonal antibody (Y8-10C2) that binds influenza virus hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8-10C2 binds to the globular domain of HA and found evidence that its epitope is located at the interface of adjacent subunits. We further showed t...

journal_title：Journal of virology

authors： Yewdell JW,Taylor A,Yellen A,Caton A,Gerhard W,Bächi T

更新日期：1993-02-01 00:00:00

abstract：:The RV144 HIV-1 vaccine trial (Thailand, 2003 to 2009), using immunogens genetically matched to the regional epidemic, demonstrated the first evidence of efficacy for an HIV-1 vaccine. Here we studied the molecular evolution of the HIV-1 epidemic from the time of immunogen selection to the execution of the efficacy tr...

journal_title：Journal of virology

authors： Kijak GH,Tovanabutra S,Rerks-Ngarm S,Nitayaphan S,Eamsila C,Kunasol P,Khamboonruang C,Thongcharoen P,Namwat C,Premsri N,Benenson M,Morgan P,Bose M,Sanders-Buell E,Paris R,Robb ML,Birx DL,De Souza MS,McCutchan FE,Mic

更新日期：2013-07-01 00:00:00

abstract：:Physiological microenvironments such as blood, seminal plasma, mucosal secretions, or lymphatic fluids may influence the biology of the virus-host cell and immune interactions for human immunodeficiency virus type 1 (HIV-1). Relative to media, physiological levels of human plasma were found to enhance the infectivity ...

journal_title：Journal of virology

authors： Wu SC,Spouge JL,Conley SR,Tsai WP,Merges MJ,Nara PL

更新日期：1995-10-01 00:00:00

abstract：:The herpes simplex virus (HSV) virion host shutoff (vhs) protein (UL41 gene product) is a component of the HSV virion tegument that triggers shutoff of host protein synthesis and accelerated mRNA degradation during the early stages of HSV infection. vhs displays weak amino acid sequence similarity to the fen-1 family ...

journal_title：Journal of virology

authors： Elgadi MM,Smiley JR

更新日期：1999-11-01 00:00:00

abstract：UNLABELLED:The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an endoplasmic reticulum (ER)-resident enzyme that synthesizes phosphatidylinositol 4-phosphate (PI4P). PI4KIIIα is an essential host factor for hepatitis C virus (HCV) replication. Interaction with HCV nonstructural protein 5A (NS5A) lea...

journal_title：Journal of virology

authors： Harak C,Radujkovic D,Taveneau C,Reiss S,Klein R,Bressanelli S,Lohmann V

更新日期：2014-09-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...

journal_title：Journal of virology

authors： Lund TC,Garcia R,Medveczky MM,Jove R,Medveczky PG

更新日期：1997-09-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) specifies and unspliced early 2.6-kb RNA (ER2.6) which is 3' coterminal with exon 2 of the 2.9-kb immediate-early (IE) RNA. The two transcripts have a common open reading frame (676 codons). The predicted protein, designated BHV-1 infected cell protein 0 (BICP0), contains a zinc finger dom...

journal_title：Journal of virology

authors： Fraefel C,Zeng J,Choffat Y,Engels M,Schwyzer M,Ackermann M

更新日期：1994-05-01 00:00:00

abstract：UNLABELLED:The interferon (IFN)-mediated antiviral response is a central aspect of host defense; however, viruses have evolved multiple strategies to counteract IFN-mediated responses in order to successfully infect the host. Herpes simplex virus 1 (HSV-1), a typical human-restricted DNA virus, is capable of counteract...

journal_title：Journal of virology

authors： Zhang D,Su C,Zheng C

更新日期：2016-05-27 00:00:00

abstract：:Inhibition of host-directed gene expression by the matrix (M) protein of vesicular stomatitis virus (VSV) effectively blocks host antiviral responses, promotes virus replication, and disables the host cell. However, dendritic cells (DC) have the capacity to resist these effects and remain functional during VSV infecti...

journal_title：Journal of virology

authors： Westcott MM,Ahmed M,Smedberg JR,Rajani KR,Hiltbold EM,Lyles DS

更新日期：2013-11-01 00:00:00

abstract：:A total of 103 amber mutants of coliphage P1 were tested for lysis of nonpermissive cells. Of these, 83 caused cell lysis at the normal lysis time and have defects in particle morphogenesis. Five amber mutants, with mutations in the same gene (gene 2), caused premature lysis and may have a defect in a lysis regulator....

journal_title：Journal of virology

authors： Walker JT,Walker DH

更新日期：1980-08-01 00:00:00

abstract：:Purified replicative form (RF) and replicative intermediate (RI) prepared from Escherichia coli cells infected with the ribonucleic acid (RNA) bacteriophage R17 were denatured with dimethyl sulfoxide at 37 C or in aqueous solvents of low ionic strength at 97 C. Denaturation was demonstrated for RF and RI by an increas...

journal_title：Journal of virology

authors： Franklin RM

更新日期：1967-06-01 00:00:00

abstract：:Viral particles purified from species of the protozoan parasite Leishmania braziliensis subsp. guyanensis by centrifugation in CsCl gradients were examined for the presence of viral polymerase. We demonstrated that RNA-dependent RNA polymerase is associated with viral particles. Viral transcription was studied in vitr...

journal_title：Journal of virology

authors： Widmer G,Keenan MC,Patterson JL

更新日期：1990-08-01 00:00:00

abstract：:The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immunocompromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based and cell-free DNA replication systems, including the BK virus (BKV) monopolymerase DNA replicatio...

journal_title：Journal of virology

authors： Tikhanovich I,Nasheuer HP

更新日期：2010-07-01 00:00:00