Levels of Epstein-Barr virus DNA in lymphoblastoid cell lines are correlated with frequencies of spontaneous lytic growth but not with levels of expression of EBNA-1, EBNA-2, or latent membrane protein.

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with ...

journal_title：Journal of virology

authors： Park J,Seo T,Hwang S,Lee D,Gwack Y,Choe J

更新日期：2000-12-01 00:00:00

abstract：:The natural life cycle of alphaviruses, a group of plus-strand RNA viruses, involves transmission to vertebrate hosts via mosquitoes. Chronic infections are established in mosquitoes (and usually in mosquito cell cultures), but infection of susceptible vertebrate cells typically results in rapid shutoff of host mRNA t...

journal_title：Journal of virology

authors： Frolov I,Agapov E,Hoffman TA Jr,Prágai BM,Lippa M,Schlesinger S,Rice CM

更新日期：1999-05-01 00:00:00

abstract：:Escherichia coli K-12 wild type and a uvrA mutant derivative were used to construct isogenic strains bearing one, two, three, or more phage lambda cI genomes and containing increasing concentration of lambda repressor as measured by in vitro operator DNA-binding assays. The survival and phage induction in response to ...

journal_title：Journal of virology

authors： Baluch J,Sussman R

更新日期：1978-06-01 00:00:00

abstract：:Abelson murine leukemia virus (Ab-MLV) encodes the v-Abl protein tyrosine kinase and induces transformation of immortalized fibroblast lines and pre-B cells. Temperature-sensitive mutations affecting the kinase domain of the protein have demonstrated that the kinase activity is absolutely required for transformation. ...

journal_title：Journal of virology

authors： Mainville CA,Parmar K,Unnikrishnan I,Gong L,Raffel GD,Rosenberg N

更新日期：2001-02-01 00:00:00

abstract：:Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells. Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T ...

journal_title：Journal of virology

authors： Valentin H,Lemasson I,Hamaia S,Cassé H,König S,Devaux C,Gazzolo L

更新日期：1997-11-01 00:00:00

abstract：:The matrix (M) protein of vesicular stomatitis virus (VSV) is a potent inhibitor in vivo of transcription by all three host RNA polymerases (RNAP). In the case of host RNA polymerase II (RNAPII), the inhibition is due to lack of activity of the TATA-binding protein (TBP), which is a subunit of the basal transcription ...

journal_title：Journal of virology

authors： Yuan H,Puckett S,Lyles DS

更新日期：2001-05-01 00:00:00

abstract：:The RNA genome of influenza virus is transcribed and replicated by the viral RNA polymerase complex in the cell nucleus. We have generated green fluorescent protein (GFP)-tagged polymerase subunits to study the assembly of the polymerase complex. Our results show that individually expressed polymerase basic protein 1 ...

journal_title：Journal of virology

authors： Fodor E,Smith M

更新日期：2004-09-01 00:00:00

abstract：:The experimental infection of newborn calves with bovine norovirus was used as a homologous large animal model to study the pathogenesis of norovirus infection and to determine target cells for viral replication. Six newborn calves were inoculated orally with Jena virus (JV), a bovine norovirus GIII.1 strain, and six ...

journal_title：Journal of virology

authors： Otto PH,Clarke IN,Lambden PR,Salim O,Reetz J,Liebler-Tenorio EM

更新日期：2011-11-01 00:00:00

abstract：:Tryptic digests of the internal proteins p30, p15, p12, and p10 of mouse xenotropic, ecotropic, and amphotropic type C viruses were subjected to cation-exchange chromatography. Analysis of these maps revealed that the p30 proteins from representative isolates of all three viral subgroups were distinguishable. The p15 ...

journal_title：Journal of virology

authors： Albino A,Korngold L,Mellors RC

更新日期：1979-01-01 00:00:00

abstract：:Lentiviruses have long been considered host-specific pathogens, but several recent observations demonstrated their capacity to conquer new hosts from different species, genera, and families. From these cross-species infections emerged new animal and human infectious diseases. The successful colonization and adaptation...

journal_title：Journal of virology

authors： Morin T,Guiguen F,Bouzar BA,Villet S,Greenland T,Grezel D,Gounel F,Gallay K,Garnier C,Durand J,Alogninouwa T,Mselli-Lakhal L,Mornex JF,Chebloune Y

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) regulatory protein ICP0 promotes viral gene expression and replication, we screened cells overexpressing ICP0 for ICP0-binding host cell proteins. Tandem affinity purification of transiently expressed ICP0 coupled with mass spe...

journal_title：Journal of virology

authors： Sato Y,Kato A,Maruzuru Y,Oyama M,Kozuka-Hata H,Arii J,Kawaguchi Y

更新日期：2016-01-06 00:00:00

abstract：:Influenza A viruses of the H9N2 subtype are endemic in poultry in many Eurasian countries and have occasionally caused clinical respiratory diseases in humans. While some avian H9N2 viruses have glutamine (Q) at amino acid position 226 of the hemagglutinin (HA) receptor-binding site, an increasing number of isolates h...

journal_title：Journal of virology

authors： Wan H,Perez DR

更新日期：2007-05-01 00:00:00

abstract：:To investigate the relation between the polyoma tumor-specific transplantation antigen and the virus-coded proteins, mice were immunized by inoculation of a variety of viable polyoma virus mutants and then challenged with polyoma virus-induced tumors. Two classes of early region mutants were used. One class produces a...

journal_title：Journal of virology

authors： Dalianis T,Magnusson G,Ito Y,Klein G

更新日期：1982-09-01 00:00:00

abstract：:To study the variability of human immunodeficiency virus type 1 (HIV-1), we used immunotoxins to select for variants within a population of H9 cells persistently infected with a molecular clone of HIV-1 designated NL4-3. Chimeric immunotoxin CD4-PE40 (a chimeric fusion protein consisting of the amino-terminal two doma...

journal_title：Journal of virology

authors： Fang H,Pincus SH

更新日期：1995-01-01 00:00:00

abstract：:Adenovirus E1B 55K protein cooperates with E1A gene products to induce cell transformation. E1B 55K mediates its effects by binding to and inhibiting the transcriptional activation and growth-suppression functions of the tumor suppressor p53. Previous studies in vivo have suggested that E1B 55K has an active role in r...

journal_title：Journal of virology

authors： Martin ME,Berk AJ

更新日期：1998-04-01 00:00:00

abstract：:Recognition of virus infections by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation associated gene 5 (MDA5), activates signaling pathways, leading to the induction of inflammatory cytokines that limit viral replication. To d...

journal_title：Journal of virology

authors： Guo H,Jiang D,Ma D,Chang J,Dougherty AM,Cuconati A,Block TM,Guo JT

更新日期：2009-01-01 00:00:00

abstract：:Lentiviruses are nononcogenic retroviruses that cause persistent infections and slowly progressive diseases. Visna virus, a lentivirus of sheep, persists in cells of the macrophage lineage despite the presence of neutralizing antibodies in the animal. These antibodies are measured by prevention of virus replication in...

journal_title：Journal of virology

authors： Kennedy-Stoskopf S,Narayan O

更新日期：1986-07-01 00:00:00

abstract：:By using T1 oligonucleotide fingerprinting and mapping techniques, we analyzed the genomic structure of retroviruses produced by thymocytes and splenocytes of reciprocal bone marrow-and thymus-grafted chimeras. We found that the genetic factor(s) derived from NZB mice that suppresses the development of thymic leukemia...

journal_title：Journal of virology

authors： Datta SK,Thomas CY,Nicklas JA,Coffin JM

更新日期：1983-07-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but pathogenically distinct human retroviruses. The antisense strand of the HTLV-1 genome encodes HTLV-1 basic leucine zipper (b-ZIP) protein (HBZ), a protein that inhibits Tax-mediated viral transcription, enhances T-cell proliferation, and pr...

journal_title：Journal of virology

authors： Yin H,Kannian P,Dissinger N,Haines R,Niewiesk S,Green PL

更新日期：2012-08-01 00:00:00

abstract：:Animals that naturally acquire the prion diseases have a well-developed olfactory sense that they utilize for a variety of basic behaviors. To assess the potential for the nasal cavity to serve as a point of entry for prion diseases, a small amount of prion-infected brain homogenate was placed inferior to the nostrils...

journal_title：Journal of virology

authors： Kincaid AE,Bartz JC

更新日期：2007-05-01 00:00:00

abstract：:The gastric mucosa is an important portal of entry for lymphocytic choriomeningitis virus (LCMV) infections. Within hours after intragastric (i.g.) inoculation, virus appears in the gastric epithelia, then in the mesenteric lymph nodes and spleen, and then in the liver and brain. By 72 h i.g.-inoculated virus is widel...

journal_title：Journal of virology

authors： Yin C,Djavani M,Schenkel AR,Schmidt DS,Pauza CD,Salvato MS

更新日期：1998-11-01 00:00:00

abstract：:We established a system for propagation of Sindbis virus (SIN)-based replicons in tissue culture in the form of a tricomponent genome virus. Three RNA fragments containing complementing genetic information required for virus replication are packaged into separate viral particles, and each cell produces at least 1,000 ...

journal_title：Journal of virology

authors： Fayzulin R,Gorchakov R,Petrakova O,Volkova E,Frolov I

更新日期：2005-01-01 00:00:00

abstract：:The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(-) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C. Heise, A. Sampson-J...

journal_title：Journal of virology

authors： Harada JN,Berk AJ

更新日期：1999-07-01 00:00:00

abstract：:We previously identified two novel endogenous murine leukemia virus proviruses, PreXMRV-1 and PreXMRV-2, and showed that they most likely recombined during xenograft passaging of a human prostate tumor in mice to generate xenotropic murine leukemia virus-related virus (XMRV). To determine the recombination potential o...

journal_title：Journal of virology

authors： Delviks-Frankenberry K,Paprotka T,Cingöz O,Wildt S,Hu WS,Coffin JM,Pathak VK

更新日期：2013-11-01 00:00:00

abstract：:The ability of B cells, B blasts, and macrophages to present Epstein-Barr virion antigens to autologous T cells and trigger their capacity to inhibit Epstein-Barr virus-induced B-cell transformation was tested. Macrophages were as efficient as B cells and B blasts in presenting the virus to T lymphocytes. This functio...

journal_title：Journal of virology

authors： Bejarano MT,Masucci MG,Morgan A,Morein B,Klein G,Klein E

更新日期：1990-03-01 00:00:00

abstract：:We reported previously that the movement protein (MP) of tomato mosaic tobamovirus is phosphorylated, and we proposed that MP phosphorylation is important for viral pathogenesis. Experimental data indicated that phosphorylation enhances the stability of MP in vivo and enables the protein to assume the correct intracel...

journal_title：Journal of virology

authors： Kawakami S,Hori K,Hosokawa D,Okada Y,Watanabe Y

更新日期：2003-01-01 00:00:00

abstract：:Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of a neutralizing antibody response to avoid the appearance of neutralization-resistant virus variants. Despite the fact t...

journal_title：Journal of virology

authors： Seiler P,Senn BM,Klenerman P,Kalinke U,Hengartner H,Zinkernagel RM

更新日期：2000-07-01 00:00:00

abstract：:To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminu...

journal_title：Journal of virology

authors： Karupiah G,Chen JH,Nathan CF,Mahalingam S,MacMicking JD

更新日期：1998-09-01 00:00:00

abstract：:Adenovirus infections cause significant morbidity and mortality in immunocompromised patients, yet little is known about the immune response to adenovirus infections. We established a system for the generation of a cytotoxic immune response to adenovirus in vitro. Cytotoxic T cells (CTLs) were derived from normal dono...

journal_title：Journal of virology

authors： Smith CA,Woodruff LS,Kitchingman GR,Rooney CM

更新日期：1996-10-01 00:00:00

abstract：:The structure of Bacillus subtilis bacteriophage phi25 and phi25 deoxyribonucleic acid (DNA) were studied by electron microscopy. The head of phi25 is a regular polyhedron measuring 75 nm in diameter. The uncontracted tail of phi25 is 130 nm in length and includes a large, complex tail plate. Phage phi25 DNA is double...

journal_title：Journal of virology

authors： Liljemark WF,Anderson DL

更新日期：1970-07-01 00:00:00