Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling.

abstract：:Mouse mammary tumor virus (MMTV) infects a number of different cell types, including mammary gland and lymphoid cells, in vivo. To identify the cellular receptor for this virus, a mouse cDNA expression library was transfected into Cos-7 monkey kidney cells, and those transfected cells able to bind virus were selected ...

journal_title：Journal of virology

authors： Golovkina TV,Dzuris J,van den Hoogen B,Jaffe AB,Wright PC,Cofer SM,Ross SR

更新日期：1998-04-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence ...

journal_title：Journal of virology

authors： Stephensen CB,Park JY,Blount SR

更新日期：1995-02-01 00:00:00

abstract：:Using in situ hybridization, we demonstrated that latent herpes simplex virus type 1 (HSV-1) gene expression is prevalent in human adult nodose ganglia. This suggests that infection of gastrointestinal sensory nerves, probably through swallowed virus-laden oral secretions, occurs commonly and that HSV-1 reactivating f...

journal_title：Journal of virology

authors： Gesser RM,Koo SC

更新日期：1997-05-01 00:00:00

abstract：:In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus. Hepatic HBV replication was not affected by overexpression of the envelope or X gene products when these animals were cross...

journal_title：Journal of virology

authors： Guidotti LG,Matzke B,Pasquinelli C,Shoenberger JM,Rogler CE,Chisari FV

更新日期：1996-10-01 00:00:00

abstract：:Recent clinical trials examining 3'-azido-3'-deoxythymidine (AZT, zidovudine, or Retrovir) combined with L-2', 3'-dideoxy-3'-thiacytidine (3TC or lamivudine) have shown that combination therapy with these nucleoside analogs affords significant virological and clinical benefits. The addition of 3TC to AZT delays AZT re...

journal_title：Journal of virology

authors： Kemp SD,Shi C,Bloor S,Harrigan PR,Mellors JW,Larder BA

更新日期：1998-06-01 00:00:00

abstract：:Spleen necrosis virus productively infects avian and rat cells. The average number of molecules of unintegrated and integrated viral DNA in cells at different times after infection was determined by hybridization and transfection assays. Shortly after infection, there was a transient accumulation of an average of abou...

journal_title：Journal of virology

authors： Keshet E,Temin HM

更新日期：1979-08-01 00:00:00

abstract：:Injection of conventional or axenic weanling mice with potent sheep or goat antibody to mouse interferon alpha/beta resulted in a decrease in the basal level of 2-5A synthetase in resting peritoneal macrophages and rendered these cells permissive for vesicular stomatitis virus. There was a good inverse correlation bet...

journal_title：Journal of virology

authors： Gresser I,Vignaux F,Belardelli F,Tovey MG,Maunoury MT

更新日期：1985-01-01 00:00:00

abstract：:In vitro mapping studies of the MD145 norovirus (Caliciviridae) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase). The goal of this study was to ...

journal_title：Journal of virology

authors： Belliot G,Sosnovtsev SV,Chang KO,Babu V,Uche U,Arnold JJ,Cameron CE,Green KY

更新日期：2005-02-01 00:00:00

abstract：UNLABELLED:The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the HIV-1 membrane and induce its disruption and/or deformation during the process. Howeve...

journal_title：Journal of virology

authors： Apellániz B,Rujas E,Carravilla P,Requejo-Isidro J,Huarte N,Domene C,Nieva JL

更新日期：2014-11-01 00:00:00

abstract：:Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier to successful infection. The adenovirus genome is packaged with protein...

journal_title：Journal of virology

authors： Avgousti DC,Della Fera AN,Otter CJ,Herrmann C,Pancholi NJ,Weitzman MD

更新日期：2017-09-27 00:00:00

abstract：:Examination of [3H]mannose-labeled glycopeptides from Prague C Rous sarcoma virus gp85 with gel filtration and sequential glycosidase digestions demonstrated the presence of hybrid-type asparaginyl-oligosaccharides. The major hybrid species had an oligomannosyl core (Man5GlcNAc2-ASN) characteristic of neutral structur...

journal_title：Journal of virology

authors： Hunt LA,Wright SE

更新日期：1981-08-01 00:00:00

abstract：:Infection of monkey cells with human adenovirus (Ad) is abortive, but the infection can be enhanced by coinfecting with simian virus 40 (SV40). However, in the coinfected monkey cells, Ad interferes strongly with SV40 DNA biosynthesis. This interference was found to be a reproducible, delicately controlled phenomenon ...

journal_title：Journal of virology

authors： van Roy F,Fiers W

更新日期：1978-08-01 00:00:00

abstract：:Rickard's strain of feline leukemia virus (FeLV) contains two large glycoproteins and five smaller polypeptides of molecular weights 100,000 (gp >/= 100), 70,000 (gp70), 30,000 (p30), 21,000 (p21), 15,000 (p15), 11,200 (p11), and 10,000 (p10) when chromatographed on 6% agarose in the presence of 6 M guanidine hydrochl...

journal_title：Journal of virology

authors： Graves DC,Velicer LF

更新日期：1974-08-01 00:00:00

abstract：:An unusual set of 3' coterminal, spliced mRNAs transcribed through the BamHI A fragment have been previously identified in nasopharyngeal carcinoma (NPC) tissues. These RNAs have also been detected at low levels in Burkitt's lymphoma (BL) cell lines and Epstein-Barr virus (EBV)-transformed lymphocytes. Sequence analys...

journal_title：Journal of virology

authors： Fries KL,Sculley TB,Webster-Cyriaque J,Rajadurai P,Sadler RH,Raab-Traub N

更新日期：1997-04-01 00:00:00

abstract：:Anaplastic nasopharyngeal carcinoma (NPC) cells invariably harbor the Epstein-Barr virus (EBV) genome, an association that is unique among human virus-associated cancers. Although EBV is able to replicate in epithelial cells, results with expression of the EBV receptor (complement receptor type 2 [CR2]; also called CD...

journal_title：Journal of virology

authors： Billaud M,Busson P,Huang D,Mueller-Lantzch N,Rousselet G,Pavlish O,Wakasugi H,Seigneurin JM,Tursz T,Lenoir GM

更新日期：1989-10-01 00:00:00

abstract：:H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...

journal_title：Journal of virology

authors： Zhao WD,Wimmer E,Lahser FC

更新日期：1999-02-01 00:00:00

abstract：UNLABELLED:The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral genome in...

journal_title：Journal of virology

authors： Bierle CJ,Anderholm KM,Wang JB,McVoy MA,Schleiss MR

更新日期：2016-07-11 00:00:00

abstract：:The protein kinase inhibitor H7 blocks influenza virus replication, inhibits production of the matrix protein (M1), and leads to a retention of the viral ribonucleoproteins (vRNPs) in the nucleus at late times of infection (K. Martin and A. Helenius, Cell 67:117-130, 1991). We show here that production of assembled vR...

journal_title：Journal of virology

authors： Bui M,Wills EG,Helenius A,Whittaker GR

更新日期：2000-02-01 00:00:00

abstract：:CM2 is the second membrane protein of the influenza C virus and has been demonstrated to play a role in the uncoating and genome packaging processes in influenza C virus replication. Although the effects of N-linked glycosylation, disulfide-linked oligomerization, and palmitoylation of CM2 on virus replication have be...

journal_title：Journal of virology

authors： Goto T,Shimotai Y,Matsuzaki Y,Muraki Y,Sho R,Sugawara K,Hongo S

更新日期：2017-10-27 00:00:00

abstract：:To investigate E7-dependent biochemical changes which are involved in cellular transformation, we analyzed the influence of human papillomavirus type 16 (HPV-16) E7 on the expression of cell cycle regulatory proteins. Expression of E7 in established rodent fibroblasts (NIH 3T3), which was shown to be sufficient for tr...

journal_title：Journal of virology

authors： Zerfass K,Schulze A,Spitkovsky D,Friedman V,Henglein B,Jansen-Dürr P

更新日期：1995-10-01 00:00:00

abstract：UNLABELLED:Airway epithelium is the primary target of many respiratory viruses. However, virus induction and antagonism of host responses by human airway epithelium remains poorly understood. To address this, we developed a model of respiratory syncytial virus (RSV) infection based on well-differentiated pediatric prim...

journal_title：Journal of virology

authors： Villenave R,Broadbent L,Douglas I,Lyons JD,Coyle PV,Teng MN,Tripp RA,Heaney LG,Shields MD,Power UF

更新日期：2015-12-01 00:00:00

abstract：:The architecture of a retroviral genome presents some unusual features for transcriptional regulation because of duplication of the transcriptional control sequences in the 5' and 3' long terminal repeats (LTRs). We have studied the transcriptional activity of the 5' and 3' LTRs of human immunodeficiency virus type 1 ...

journal_title：Journal of virology

authors： Klaver B,Berkhout B

更新日期：1994-06-01 00:00:00

abstract：:All human influenza pandemics have originated from avian influenza viruses. Although multiple changes are needed for an avian virus to be able to transmit between humans, binding to human-type receptors is essential. Several research groups have reported mutations in H5N1 viruses that exhibit specificity for human-typ...

journal_title：Journal of virology

authors： Peng W,Bouwman KM,McBride R,Grant OC,Woods RJ,Verheije MH,Paulson JC,de Vries RP

更新日期：2018-04-27 00:00:00

abstract：:The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins. We report that RS...

journal_title：Journal of virology

authors： Wiegand HL,Cullen BR

更新日期：2007-12-01 00:00:00

abstract：:Translation of picornavirus RNAs is mediated by internal ribosomal entry site (IRES) elements and requires both standard eukaryotic translation initiation factors (eIFs) and IRES-specific cellular trans-acting factors (ITAFs). Unr, a cytoplasmic RNA-binding protein that contains five cold-shock domains and is encoded ...

journal_title：Journal of virology

authors： Boussadia O,Niepmann M,Créancier L,Prats AC,Dautry F,Jacquemin-Sablon H

更新日期：2003-03-01 00:00:00

abstract：:Ebola viruses (EboV) are enveloped RNA viruses infecting cells by a pH-dependent process mediated by viral glycoproteins (GP) involving endocytosis of virions and their routing into acidic endosomes. As with well-characterized pH-dependent viral entry proteins, in particular influenza virus hemagglutinin, it is though...

journal_title：Journal of virology

authors： Bär S,Takada A,Kawaoka Y,Alizon M

更新日期：2006-03-01 00:00:00

abstract：:We have demonstrated that Epstein-Barr virus (EBV) confers enhanced growth capability in soft agarose, tumorigenesis in the SCID mouse, and resistance to apoptosis in the Burkitt's lymphoma cell line Akata. Subsequently, we have shown that EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. We constan...

journal_title：Journal of virology

authors： Komano J,Takada K

更新日期：2001-02-01 00:00:00

abstract：:The current therapy for hepatitis B and C is based on systemic administration of recombinant human alpha interferon (r-hIFN-alpha). However, systemic delivery of r-hIFN-alpha is associated with severe side effects, but more importantly, it is effective in only a small percentage of patients. In an effort to maximize I...

journal_title：Journal of virology

authors： Aurisicchio L,Delmastro P,Salucci V,Paz OG,Rovere P,Ciliberto G,La Monica N,Palombo F

更新日期：2000-05-01 00:00:00