Abstract:
:Anaplastic nasopharyngeal carcinoma (NPC) cells invariably harbor the Epstein-Barr virus (EBV) genome, an association that is unique among human virus-associated cancers. Although EBV is able to replicate in epithelial cells, results with expression of the EBV receptor (complement receptor type 2 [CR2]; also called CD21) in normal and malignant epithelial cells are conflicting. We grew five different EBV-associated NPC tumors in nude mice, and by using a sensitive transcriptional assay, we detected a very weak transcription signal of the EBV receptor CR2 gene in these cells. This suggests that low levels of EBV receptor may be expressed by malignant epithelial nasopharyngeal cells. The gene coding for Blast2/CD23, a B-cell activation molecule induced by EBV, was transcribed in three of the transplanted NPC tumors. The soluble form of the Blast2/CD23 protein was also detected in medium taken from short-term cultures of the same NPC cell lines. In contrast to the lymphoid system, in which Blast2/CD23 expression is associated with EBV nuclear antigen (EBNA2) expression, no EBNA2 protein could be detected in these NPC epithelial cells. Our study represents the first demonstration of Blast2/CD23 expression in epithelial cells. As the soluble form of the Blast2/CD23 protein possesses growth factor activity associated with EBV-induced B-cell immortalization, these results suggest a possible role for this molecule in the pathogenesis of NPC.
journal_name
J Viroljournal_title
Journal of virologyauthors
Billaud M,Busson P,Huang D,Mueller-Lantzch N,Rousselet G,Pavlish O,Wakasugi H,Seigneurin JM,Tursz T,Lenoir GMdoi
10.1128/JVI.63.10.4121-4128.1989subject
Has Abstractpub_date
1989-10-01 00:00:00pages
4121-8issue
10eissn
0022-538Xissn
1098-5514journal_volume
63pub_type
杂志文章abstract::We previously reported that human cytomegalovirus (HCMV) infection induces endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR). Although some normal consequences of UPR activation (e.g., translation attenuation) are detrimental to viral infection, we have previously shown ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.24.15388-15397.2005
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abstract::In search of an anti-transcriptase, antibody was raised in rabbits to partially purified, soluble NS protein present in cytoplasmic extracts of cells infected with the Indiana serotype of vesicular stomatitis (VSInd) virus. This antiserum gave specific reactions of identity by agar immunodiffusion with both cytoplasmi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.6.1357-1366.1975
更新日期:1975-06-01 00:00:00
abstract::Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.20.9771-9779.2001
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abstract::We previously reported that CD4C/human immunodeficiency virus (HIV)(Nef) transgenic (Tg) mice, expressing Nef in CD4(+) T cells and cells of the macrophage/dendritic cell (DC) lineage, develop a severe AIDS-like disease, characterized by depletion of CD4(+) T cells, as well as lung, heart, and kidney diseases. In orde...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00125-09
更新日期:2009-10-01 00:00:00
abstract::Turkeys inoculated with spleen extracts from lymphoproliferative disease (LPD)-affected birds developed viremia, followed by typical LPD lesions. Electron microscopy and biochemical characterization established that the virus present in the blood of infected turkeys is a type C retrovirus. The viral particles possess ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.30.1.351-357.1979
更新日期:1979-04-01 00:00:00
abstract::The nucleotide sequences of several sites of recombination between adenovirus DNA and hamster, mouse, or human cell DNAs were determined. These sites of recombination had been cloned from adenovirus type 2 (Ad2)- or type 12 (Ad12)-transformed cells, from Ad12-induced tumor cells, or from a symmetric recombinant betwee...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.2.344-353.1987
更新日期:1987-02-01 00:00:00
abstract::The virion RNA of Moloney murine leukemia virus (MuLV) has been translated in eukaryotic cell-free systems derived from mouse L- and human HeLa cells. In both systems at least three polypeptides, approximately 60,000, 70,000, and 180,000 in apparent molecular weight, were formed in response to the added 35S MuLV RNA. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.18.2.627-635.1976
更新日期:1976-05-01 00:00:00
abstract::Moloney murine leukemia virus (M-MuLV) and M-MuLV-derived retroviral vectors are not expressed in early mouse embryos or in embryonal carcinoma cells. M-MuLV-derived mutants or M-MuLV-related variants which transduce the neomycin phosphotransferase gene can, however, induce drug resistance in embryonal carcinoma cells...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.9.2742-2746.1987
更新日期:1987-09-01 00:00:00
abstract::Marek's disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas and tumors within 4 to 5 weeks of infection. Although the ability of MDV to induce tumors was demonstrated many years ago and although a number of viral oncogenic proteins have been identified, the mechanism by which the MDV is implicate...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.10.5985-5996.2003
更新日期:2003-05-01 00:00:00
abstract::The adenovirus fiber protein is used for attachment of the virus to a specific receptor on the cell surface. Structurally, the protein consists of a long, thin shaft that protrudes from the vertex of the virus capsid and terminates in a globular domain termed the knob. To verify that the knob is the domain which inter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.8.5239-5246.1994
更新日期:1994-08-01 00:00:00
abstract::Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02610-10
更新日期:2011-07-01 00:00:00
abstract::China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.24.13591-13599.2004
更新日期:2004-12-01 00:00:00
abstract::Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.22.11770-11774.2002
更新日期:2002-11-01 00:00:00
abstract::Previous reports (H. Delius and J. B. Clements, J. Gen. Virol. 33:125-134, 1976; G. S. Hayward, R. J. Jacob, S. C. Wadsworth, and B. Roizman, Proc. Natl. Acad. Sci. U.S.A. 72:4243-4247, 1975; B. Roizman, G. S. Hayward, R. Jacob, S. W. Wadsworth, and R. W. Honess, Excerpta Med. Int. Congr. Ser. 2:188-198, 1974) have sh...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.2.448-457.1979
更新日期:1979-02-01 00:00:00
abstract::Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including viral entry into host cells, cell-cell fusion, and viral budding from infected cells. Enveloped viruses acquire their membranes from their host cells. Though cholesterol has been associated with binding and ent...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02323-20
更新日期:2021-01-06 00:00:00
abstract::Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4(+) T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular rest...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00800-07
更新日期:2007-11-01 00:00:00
abstract::Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.11.9224-9232.1998
更新日期:1998-11-01 00:00:00
abstract::Myeloid differentiation factor 88 (MyD88) is an essential adaptor protein in the Toll-like receptor-mediated innate signaling pathway, as well as in interleukin-1 receptor (IL-1R) and IL-18R signaling. The importance of MyD88 in the regulation of innate immunity to microbial pathogens has been well demonstrated. Howev...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01770-08
更新日期:2009-02-01 00:00:00
abstract::Adenovirus infection and expression of E1A induces both proliferation and apoptosis, the latter of which is blocked by the adenovirus Bcl-2 homologue E1B 19K. The mechanism of apoptosis induction and the role that it plays in productive infection are not known. Unlike apoptosis mediated by death receptors, infection w...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
abstract::Alfalfa mosaic virus (AMV) and ilarvirus RNAs are infectious only in the presence of the viral coat protein; therefore, an understanding of coat protein's function is important for defining viral replication mechanisms. Based on in vitro replication experiments, the conformational switch model states that AMV coat pro...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.9.5752-5761.2005
更新日期:2005-05-01 00:00:00
abstract::Scavenger receptor class B type I (SR-BI) is an essential receptor for hepatitis C virus (HCV) and a cell surface high-density-lipoprotein (HDL) receptor. The mechanism of SR-BI-mediated HCV entry, however, is not clearly understood, and the specific protein determinants required for the recognition of the virus envel...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02199-08
更新日期:2010-01-01 00:00:00
abstract::Hepatitis delta virus (HDV) contains a circular RNA genome of 1.7 kb. HDV RNA replication is thought to proceed via a rolling-circle mechanism that is dependent on autocatalytic cleavage and ligation reactions. However, it has never been established that these ribozyme activities are indeed involved in HDV RNA replica...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.4.2228-2234.1993
更新日期:1993-04-01 00:00:00
abstract::Human noroviruses are one of the major causes of acute gastroenteritis in the developed world, yet our understanding of their molecular mechanisms of genome translation and replication lags behind that for many RNA viruses. Due to the nonculturable nature of human noroviruses, many related members of the Caliciviridae...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00432-12
更新日期:2012-11-01 00:00:00
abstract::Two live attenuated single-deletion mutant simian immunodeficiency virus (SIV) constructs, SIV239Deltanef and SIVPBj6.6Deltanef, were tested for their abilities to stimulate protective immunity in macaques. During the immunization period the animals were examined for specific immune responses and virus growth. Each co...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.2.1262-1270.1999
更新日期:1999-02-01 00:00:00
abstract::Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.6.2785-2789.1989
更新日期:1989-06-01 00:00:00
abstract::The UL3 protein of equine herpesvirus 1 (EHV-1) KyA strain is a homolog of the ICP27 alpha regulatory protein of herpes simplex virus type 1 (HSV-1) and the ORF 4 protein of varicella-zoster virus. To characterize the regulatory function of the UL3 gene product, a UL3 gene expression vector (pSVUL3) and a vector expre...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.5.2786-2793.1995
更新日期:1995-05-01 00:00:00
abstract::We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin (HIVIG) preparation for their abilities to neutralize a chimeric si...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.3235-3240.1998
更新日期:1998-04-01 00:00:00
abstract::Polydnaviridae is a unique family of DNA viruses that are symbiotically associated with parasitoid wasps. Upon oviposition, wasps inject these viruses into their hosts, where they cause several physiological alterations, including suppression of the cellular immune response. Here we report that expression of the glc1....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.3.1861-1870.2005
更新日期:2005-02-01 00:00:00
abstract::We previously described a monoclonal antibody (Y8-10C2) that binds influenza virus hemagglutinin (HA) monomers but not native trimers. In this study, we demonstrated that Y8-10C2 binds to the globular domain of HA and found evidence that its epitope is located at the interface of adjacent subunits. We further showed t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.2.933-942.1993
更新日期:1993-02-01 00:00:00
abstract::Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors directly related to human activities. These factors may additionally be favoring the emergence of novel pathogens. In this report, we have determined the complete genome sequence of the emerging...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.07108-11
更新日期:2012-04-01 00:00:00