Abstract:
:Interleukin-15 (IL-15), natural killer (NK) cells, and NK T (NKT) cells, components of the innate immune system, are known to contribute to defense against pathogens, including viruses. Here we report that IL-15(-/-) (NK(-) and NKT(-/+)) mice and RAG-2(-/-)/gamma(c)(-/-) (NK(-) and NKT(-)) mice that lack all lymphoid cells were very susceptible to vaginal infection with a low dose of herpes simplex virus type 2 (HSV-2). IL-15(-/-) and RAG-2(-/-)/gamma(c)(-/-) mice were 100-fold more susceptible and RAG-2(-/-), CD-1(-/-) (NKT(-)), and gamma interferon (IFN-gamma)(-/-) mice were 10-fold more susceptible to vaginal HSV-2 infection than control C57BL/6 mice. NK and/or NKT cells were the early source of IFN-gamma in vaginal secretions following genital HSV-2 infection. This study demonstrates that IL-15 and NK-NKT cells are critical for innate protection against genital HSV-2.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ashkar AA,Rosenthal KLdoi
10.1128/jvi.77.18.10168-10171.2003subject
Has Abstractpub_date
2003-09-01 00:00:00pages
10168-71issue
18eissn
0022-538Xissn
1098-5514journal_volume
77pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.68.3.1697-1705.1994
更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.02484-05
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.00201-14
更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-23 00:00:00
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.69.11.6925-6931.1995
更新日期:1995-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.42.1.317-321.1982
更新日期:1982-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.02726-06
更新日期:2007-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01205-10
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.21.3.902-905.1977
更新日期:1977-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00235-16
更新日期:2016-06-10 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.18.9993-10003.2003
更新日期:2003-09-01 00:00:00
abstract::During cell entry, native poliovirus (160S) converts to a cell-entry intermediate (135S) particle, resulting in the externalization of capsid proteins VP4 and the amino terminus of VP1 (residues 1 to 53). Externalization of these entities is followed by release of the RNA genome (uncoating), leaving an empty (80S) par...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05013-11
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.5.4.507-512.1970
更新日期:1970-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1979-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.12.2.415-416.1973
更新日期:1973-08-01 00:00:00